N. Moran

发表

Surface expression of glycoprotein ib alpha is dependent on glycoprotein ib beta: evidence from a novel mutation causing Bernard-Soulier syndrome.

D. Fitzgerald, N. Moran, P. Morateck, 2000, Blood.

Surface expression of glycoprotein Ibα is dependent on glycoprotein Ibβ: evidence from a novel mutation causing Bernard-Soulier syndrome

D. Fitzgerald, N. Moran, P. Morateck, 2000 .

Integrins as therapeutic targets: lessons and opportunities

Marian Brennan, Niamh Moran, Dermot Cox, 2010, Nature Reviews Drug Discovery.

Computational and experimental analysis of bioactive peptide linear motifs in the integrin adhesome

Kevin T. O'Brien, D. Shields, Tilen Kranjc, 2019, PloS one.

Regulation of platelet activity in a changing redox environment.

N. Moran, D. Murphy, E. Reddy, 2014, Antioxidants & redox signaling.

The Role of Platelet-Derived ADP and ATP in Promoting Pancreatic Cancer Cell Survival and Gemcitabine Resistance

M. Falasca, P. Metharom, N. Moran, 2017, Cancers.

Protein interactions with the platelet integrin αIIb regulatory motif

Richard J. Edwards, D. Murphy, N. Moran, 2010, Proteomics.

Peptide-Mediated Platelet Capture at Gold Micropore Arrays.

R. Forster, N. Moran, T. Keyes, 2016, ACS applied materials & interfaces.

A Sequence within the Cytoplasmic Tail of GpIIb Independently Activates Platelet Aggregation and Thromboxane Synthesis*

D. Reilly, D. Fitzgerald, N. Moran, 1998, The Journal of Biological Chemistry.

Bacitracin reveals a role for multiple thiol isomerases in platelet function

N. Moran, Niaobh M O'Donoghue, A. Kiernan, 2006, British journal of haematology.

Cadherin juxtamembrane region derived peptides inhibit TGFβ1 induced gene expression

D. Shields, F. Martin, N. Moran, 2014, Bioarchitecture.

Peptides derived from cadherin juxtamembrane region inhibit platelet function

D. Shields, N. Moran, K. Golla, 2018, Royal Society Open Science.

Increased thrombin generation potential in symptomatic versus asymptomatic moderate or severe carotid stenosis and relationship with cerebral microemboli

J. Harbison, D. Collins, T. Coughlan, 2014, Journal of Neurology, Neurosurgery & Psychiatry.

Assessment of ‘on-treatment platelet reactivity’ and relationship with cerebral micro-embolic signals in asymptomatic and symptomatic carotid stenosis

J. Harbison, D. Collins, T. Coughlan, 2017, Journal of the Neurological Sciences.

Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic‐signal‐negative patient subgroups

J. Harbison, T. Coughlan, C. Doherty, 2014, European journal of neurology.

Electrochemical desorption of fibrinogen from gold.

Colm T. Mallon, R. Forster, N. Moran, 2010, Langmuir : the ACS journal of surfaces and colloids.

Thrombin-induced reactive oxygen species generation in platelets: A novel role for protease-activated receptor 4 and GPIbα

P. Metharom, N. Moran, M. Berndt, 2015, Redox biology.

RN181, a novel ubiquitin E3 ligase that interacts with the KVGFFKR motif of platelet integrin alpha(IIb)beta3.

N. Moran, A. Chubb, A. Treumann, 2008, Biochemical and biophysical research communications.

COVID-19 induces a hyperactive phenotype in circulating platelets

K. O'Reilly, N. Moran, B. Kevane, 2020, medRxiv.

Increased platelet activation in early symptomatic vs. asymptomatic carotid stenosis and relationship with microembolic status: results from the Platelets and Carotid Stenosis Study

J. Harbison, D. Collins, T. Coughlan, 2013, Journal of thrombosis and haemostasis : JTH.

Pregnancy-Specific Glycoproteins Bind Integrin αIIbβ3 and Inhibit the Platelet—Fibrinogen Interaction

P. Kiely, T. Moore, N. Moran, 2013, PloS one.

A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.

N. Moran, S. Kerrigan, Annachiara Mitrugno, 2014, Blood.

Compartmentalization regulates the interaction between the platelet integrin αIIbβ3 and ICln

D. Murphy, N. Moran, A. Treumann, 2009, British journal of haematology.

Conformation-Specific Blockade of the Integrin GPIIb/IIIa: A Novel Antiplatelet Strategy That Selectively Targets Activated Platelets

C. Bode, K. Peter, D. Fitzgerald, 2006, Circulation research.

Evidence for a differential functional regulation of the two β3-integrins αVβ3 and αIIbβ3

C. Bode, D. Fitzgerald, N. Moran, 2006 .

The lateral diffusion and fibrinogen induced clustering of platelet integrin αIIbβ3 reconstituted into physiologically mimetic GUVs.

R. Forster, N. Moran, S. Lopez, 2015, Integrative biology : quantitative biosciences from nano to macro.

Chapter 8 A Role for Platelets in Normal Pregnancy

N. Moran, B. Lwaleed, C. Regan, 2017 .

A peptide affinity column for the identification of integrin αIIb-binding proteins

N. Moran, M. Devocelle, Elise Bernard, 2008 .

Integrin αIIbβ3 exists in an activated state in subjects with elevated plasma homocysteine levels

I. Graham, N. Moran, M. Cooney, 2011, Platelets.

Continued thromboxane A2 formation despite administration of a platelet glycoprotein IIb/IIIa antagonist in patients undergoing coronary angioplasty.

D. Fitzgerald, N. Moran, P. Crean, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Platelet signalling networks: Pathway perturbation demonstrates differential sensitivity of ADP secretion and fibrinogen binding

D. Shields, N. Moran, C. De Chaumont, 2012, Platelets.

Calreticulin-independent regulation of the platelet integrin αIIbβ3 by the KVGFFKR αIIb-cytoplasmic motif

Dermot F. Reilly, D. Reilly, D. Fitzgerald, 2004, Platelets.

The Platelet Integrin αIIbβ3 Has an Endogenous Thiol Isomerase Activity*

D. Fitzgerald, N. Moran, A. Deering, 2000, The Journal of Biological Chemistry.

A novel functional role for the highly conserved α‐subunit KVGFFKR motif distinct from integrin αIIbβ3 activation processes

N. Moran, M. Devocelle, G. Meade, 2006 .

activation induced platelet - RIIa in cancer cell γ A novel and essential role for Fc

N. Moran, S. Kerrigan, David Williams, 2014 .

Abstracts presented at the Ireland-UK Platelet Conference, 4–6 September, 2005, Dublin, Ireland

N. Moran, D. Kenny, G. Meade, 2006 .

Redox modulation of integrin [correction of integin] alpha IIb beta 3 involves a novel allosteric regulation of its thiol isomerase activity.

D. Sheehan, N. Moran, A. Kinsella, 2004, Biochemistry.

A Val193Met mutation in GPIIIa results in a GPIIb/IIIa receptor with a constitutively high affinity for a small ligand

D. Fitzgerald, N. Moran, R. Murphy, 2001, British journal of haematology.

Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities

David J Brayden, N. Moran, M. Devocelle, 2014, Molecules.

Poly(Ethylene Glycol)-Based Backbones with High Peptide

David J Brayden, N. Moran, M. Devocelle, 2014 .

Virtual Screening Using Combinatorial Cyclic Peptide Libraries Reveals Protein Interfaces Readily Targetable by Cyclic Peptides

Marc Devocelle, Denis C. Shields, Fergal J. Duffy, 2015, J. Chem. Inf. Model..

Platelets — Allies of Tumour Cells

P. Metharom, N. Moran, Annachiara Mitrugno, 2015 .

Monitoring modulators of platelet aggregation in a microtiter plate assay.

D. Shields, N. Moran, D. Kenny, 2006, Analytical biochemistry.

A palmitylated peptide derived from the glycoprotein Ibβ cytoplasmic tail inhibits platelet activation

D. Shields, N. Moran, D. Kenny, 2003, Journal of thrombosis and haemostasis : JTH.

Bioinformatic discovery of novel bioactive peptides.

Richard J. Edwards, Marc Devocelle, Niamh Moran, 2007, Nature chemical biology.

ICln, a Novel Integrin αIIbβ3-Associated Protein, Functionally Regulates Platelet Activation*

Niamh Moran, Dolores J. Cahill, Dermot F. Reilly, 2004, Journal of Biological Chemistry.

Novel integrin-specific targets for anti-platelet therapies.

N. Moran, S. O’Neill, A. Robinson, 2004, Current pharmaceutical design.

Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene

R. Stallings, T. Chan, D. Murphy, 2012, Molecular Cancer.

A novel assay of thrombotic risk

N. Moran, M. Alobaidly, F. Buskandar, 2013, BMC Proceedings.

Cell Adhesion Molecules: Therapeutic Targets for Inhibition of Inflammatory States

N. Moran, S. Allen, 2015, Seminars in Thrombosis & Hemostasis.

ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation.

D. Cahill, D. Reilly, D. Murphy, 2004, The Journal of biological chemistry.

Aggregation and Thromboxane Synthesis GpIIb Independently Activates Platelet A Sequence within the Cytoplasmic Tail of STRUCTURE

D. Fitzgerald, N. Moran, B. Walker, 2013 .

Absolute Net Charge and the Biological Activity of Oligopeptides

Richard J. Edwards, Marc Devocelle, Denis C. Shields, 2006, J. Chem. Inf. Model..

Discovering Anti-platelet Drug Combinations with an Integrated Model of Activator-Inhibitor Relationships, Activator-Activator Synergies and Inhibitor-Inhibitor Synergies

Fergal P. Casey, Denis C. Shields, Federica Lombardi, 2015, PLoS Comput. Biol..

Application of proteomics to the study of platelet regulatory mechanisms.

G. Cagney, D. Fitzgerald, N. Moran, 2004, Trends in cardiovascular medicine.

Relationship between ‘on-treatment platelet reactivity’, shear stress, and micro-embolic signals in asymptomatic and symptomatic carotid stenosis

J. Harbison, D. Collins, T. Coughlan, 2019, Journal of Neurology.

A platelet dense‐granule secretion defect may lead to a muted inflammatory cell mobilization response in cystic fibrosis patients

N. McElvaney, N. Moran, K. Molloy, 2013, Journal of thrombosis and haemostasis : JTH.

Case Report: Hypergranular Platelets in Vaccine-Induced Thrombotic Thrombocytopenia After ChAdOx1 nCov-19 Vaccination

N. Moran, B. Kevane, F. Ní Áinle, 2022, Frontiers in Cardiovascular Medicine.

A Novel Hemizygous Bernard-Soulier Syndrome (BSS) Mutation in the Amino Terminal Domain of Glycoprotein (GP)Ibβ- Platelet Characterization and Transfection Studies

P. Nurden, N. Moran, D. Kenny, 2002, Thrombosis and Haemostasis.

RGD labeled Ru(II) polypyridyl conjugates for platelet integrin αIIbβ3 recognition and as reporters of integrin conformation.

R. Forster, N. Moran, T. Keyes, 2014, Bioconjugate chemistry.

The Non-Thrombotic Role of Platelets in Health and Disease

N. Moran, S. Kerrigan, 2015 .

The platelet integrin alpha IIbbeta 3 has an endogenous thiol isomerase activity.

D. Fitzgerald, N. Moran, A. Deering, 2000, The Journal of biological chemistry.

Increased Leucocyte–Platelet Complex Formation in Recently Symptomatic versus Asymptomatic Carotid Stenosis Patients and in Micro-emboli Negative Subgroups

J. Harbison, D. Collins, T. Coughlan, 2019, Thrombosis and Haemostasis.

Differential binding of ICln in platelets to integrin-derived activating and inhibitory peptides.

Niamh Moran, Laavanya Parthasarathi, Achim Treumann, 2010, Biochemical and biophysical research communications.

Ligand switching in cell-permeable peptides: manipulation of the alpha-integrin signature motif.

D. Shields, N. Moran, M. Devocelle, 2009, ACS Chemical Biology.

Ligand capture and activation of human platelets at monolayer modified gold surfaces.

R. Forster, N. Moran, T. Keyes, 2014, Biomaterials science.

S-Nitrosylation of platelet alphaIIbbeta3 as revealed by Raman spectroscopy.

R. Forster, N. Moran, D. Kenny, 2007, Biochemistry.

Ruthenium polypyridyl peptide conjugates: membrane permeable probes for cellular imaging.

Marc Devocelle, Niamh Moran, Yann Pellegrin, 2008, Chemical communications.

A novel and essential role for FcγRIIa in cancer cell-induced platelet activation.

N. Moran, S. Kerrigan, Annachiara Mitrugno, 2014, Blood.