K. Brigham

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Optimization of cationic liposome-mediated gene transfer to human bronchial epithelial cells expressing wild-type or abnormal cystic fibrosis transmembrane conductance regulator (CFTR).

B. Meyrick, M. Peters, K. Brigham, 1999, Experimental lung research.

In Vivo Expression of Human Genes

A. Canonico, K. Brigham, 1993 .

Expression of human growth hormone fusion genes in cultured lung endothelial cells and in the lungs of mice.

B. Meyrick, K. Brigham, G. King, 1993, American journal of respiratory cell and molecular biology.

Overview: In Vivo Expression of Human Genes

A. Canonico, K. Brigham, 1993 .

Cationic Liposomes and DNA Delivery

H. Schreier, K. Brigham, 1993 .

Mediator Gene Expression in Sepsis: Implications for Therapy

A. Canonico, K. Brigham, J. Conary, 1992 .

In vivo transfection of murine lungs with a functioning prokaryotic gene using a liposome vehicle.

M. Magnuson, B. Meyrick, K. Brigham, 1989, The American journal of the medical sciences.

Cationic liposome plasmid DNA complexes : In vitro cell entry and transgene expression augmented by synthetic signal peptides

H. Schreier, K. Brigham, L. Gagné, 1996 .

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.

M. Lamy, G. Bernard, J. Legall, 1994, American journal of respiratory and critical care medicine.

Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation.

Luke R. Lloyd-Jones, P. Visscher, G. Gibson, 2019, Genetics.

Role of the SDF-1/CXCR4 axis in the pathogenesis of lung injury and fibrosis.

M. Rojas, H. Shim, K. Brigham, 2007, American journal of respiratory cell and molecular biology.

Endotoxin and lung injury.

B. Meyrick, K. Brigham, Brigham Kl, 1986, The American review of respiratory disease.

Multilevel Simulations of Health Delivery Systems: A Prospective Tool for Policy, Strategy, Planning, and Management

Rahul C. Basole, W. Rouse, Trustin Clear, 2012 .

Predictive Health: The Imminent Revolution in Health Care

K. Brigham, 2010, Journal of the American Geriatrics Society.

Developing a synthetic control group using electronic health records: Application to a single-arm lifestyle intervention study

L. Waller, A. Quyyumi, Y. Ko, 2021, Preventive medicine reports.

Relation of Changes in Body Fat Distribution to Oxidative Stress.

Dean P. Jones, G. Martin, A. Quyyumi, 2017, The American journal of cardiology.

Vitamin D status is independently associated with plasma glutathione and cysteine thiol/disulphide redox status in adults

Dean P. Jones, G. Martin, J. Binongo, 2014, Clinical endocrinology.

Replacement of water and electrolyte losses in cholera by an oral glucose-electrolyte solution.

R. Sack, N. Pierce, K. Brigham, 1969, Annals of internal medicine.

Activation of alveolar macrophages via the alternative pathway in herpesvirus-induced lung fibrosis.

M. Rojas, J. Roman, K. Brigham, 2006, American journal of respiratory cell and molecular biology.

Prevention by granulocyte depletion of increased vascular permeability of sheep lung following endotoxemia.

K. Brigham, A. Heflin, 1981, The Journal of clinical investigation.

Increased sheep lung vascular permeability caused by pseudomonas bacteremia.

K. Brigham, N. Staub, L. H. Blake, 1974, The Journal of clinical investigation.

Increased pulmonary vascular permeability follows intracranial hypertension in sheep.

K. Brigham, R. Bowers, C. R. McKeen, 1979, The American review of respiratory disease.

Septicemia and lung injury.

G R Bernard, G. Bernard, J. Newman, 1983, Clinics in Laboratory Medicine.

Endotoxin-induced lung injury in mice: structural, functional, and biochemical responses.

M. Rojas, K. Brigham, C. Woods, 2005, American journal of physiology. Lung cellular and molecular physiology.

The Clinical Profile of Sepsis and the Adult Respiratory Distress Syndrome

K. Brigham, 1991 .

Corticosteroids Inhibit Endotoxin‐Induced Lung Lymph Neutrophil Stimulating Activity in Sheep

K. Brigham, W. D. Lucht, B. Butka, 1988, The American journal of the medical sciences.

Endotoxin-induced neutrophilic alveolitis and macrophage chemotaxin production in sheep.

J. Loyd, K. Brigham, S. S. Duke, 1988, The American journal of the medical sciences.

Role of free radicals in lung injury.

K. Brigham, 1986, Chest.

Effects of aerosol vs IV UT-15 on prostaglandin H2 analog-induced pulmonary hypertension in sheep.

K. Brigham, R. Parker, E. C. Lawrence, 2005, Chest.

Herpesvirus DNA Is Consistently Detected in Lungs of Patients with Idiopathic Pulmonary Fibrosis

J. Oates, B. Graham, P. Browning, 2003, Journal of Clinical Microbiology.

Increased bleomycin-induced lung injury in mice deficient in the transcription factor T-bet.

M. Rojas, K. Brigham, A. Mora, 2006, American journal of physiology. Lung cellular and molecular physiology.

Bone marrow-derived mesenchymal stem cells in repair of the injured lung.

M. Rojas, J. Roman, K. Brigham, 2005, American journal of respiratory cell and molecular biology.

Altered prostanoid production by fibroblasts cultured from the lungs of human subjects with idiopathic pulmonary fibrosis

R. Pierson, R. Dworski, J. Loyd, 2002, Respiratory research.

Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice.

M. Rojas, J. Roman, K. Brigham, 2007, American journal of respiratory and critical care medicine.

Lung infection with γ-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice

M. Rojas, J. Roman, K. Brigham, 2005 .

Effect of N-acetylcysteine on the pulmonary response to endotoxin in the awake sheep and upon in vitro granulocyte function.

G. Bernard, M. Niedermeyer, J. Snapper, 1984, The Journal of clinical investigation.

Effect of histamine on lung mechanics in sheep. Comparison of aerosol and parenteral administration.

J. Snapper, K. Brigham, A. Hutchison, 1982, The American review of respiratory disease.

Effect of Positive Pressure Breathing on Lung Lymph Flow and Water Content in Sheep

K. Brigham, N. Staub, W. Woolverton, 1978, Circulation research.

Attenuation of obliterative bronchiolitis by a CXCR4 antagonist in the murine heterotopic tracheal transplant model.

M. Rojas, H. Shim, K. Brigham, 2008, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Fluid flux and clearance in acute lung injury.

G. Martin, K. Brigham, 2012, Comprehensive Physiology.

Prevention of endotoxin-induced systemic response by bone marrow-derived mesenchymal stem cells in mice.

M. Rojas, K. Brigham, C. Woods, 2007, American journal of physiology. Lung cellular and molecular physiology.

Comparison of sodium and urea as indicators of pulmonary vascular permeability.

K. Brigham, T. Harris, B. Peterson, 1983, Experimental lung research.

Antioxidants protect cultured bovine lung endothelial cells from injury by endotoxin.

B. Meyrick, J. Repine, K. Brigham, 1987, Journal of applied physiology.

Morphologic changes in lungs of anesthetized sheep following intravenous infusion of recombinant tumor necrosis factor alpha.

B. Meyrick, K. Brigham, G. Jesmok, 1991, The American review of respiratory disease.

Infusion of freshly isolated autologous bone marrow derived mononuclear cells prevents endotoxin-induced lung injury in an ex-vivo perfused swine model

M. Rojas, K. Brigham, A. Stecenko, 2013, Stem Cell Research & Therapy.

Distribution of proteins in pulmonary edema. The value of fractional concentrations.

C. Sprung, R. Schein, K. Brigham, 1987, The American review of respiratory disease.

Effects of 100% oxygen on lung vascular function in awake sheep.

W. Fulkerson, J. Newman, J. Loyd, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Verapamil attenuates lung vascular responses to endotoxin in sheep.

K. Brigham, R. Parker, J. Hardin, 1988, Journal of applied physiology.

Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition.

J. Oates, R. Dworski, G. Fitzgerald, 1989, The American review of respiratory disease.

bleomycin-induced lung fibrosis Oxidation of extracellular cysteine/cystine redox state in

Dean P. Jones, M. Rojas, J. Roman, 2016 .

Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis.

Dean P. Jones, M. Rojas, J. Roman, 2009, American journal of physiology. Lung cellular and molecular physiology.

Studies on Group B β-Hemolytic Streptococcus. II. Effects on Pulmonary Hemodynamics and Vascular Permeability in Unanesthetized Sheep

R. Green, C. Hellerqvist, K. Brigham, 1981, Pediatric Research.

Endotoxemia-induced leukopenia in sheep. Correlation with lung vascular permeability and hypoxemia but not with pulmonary hypertension.

G. Bernard, J. Snapper, J. Loyd, 1983, American Review of Respiratory Disease.

Lung vascular effects of phorbol myristate acetate in awake sheep.

J. Newman, B. Meyrick, J. Loyd, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

RATIONALE FOR THE USE OF GENE THERAPY FOR CRITICAL ILLNESS

K. Brigham, R. Cruz-Gervis, 2001 .

Protection of rabbit lungs from endotoxin injury by in vivo hyperexpression of the prostaglandin G/H synthase gene.

B. Meyrick, K. Brigham, G. King, 1994, The Journal of clinical investigation.

Gene Therapy for Diseases of the Lung

K. Brigham, 1997 .

Human recombinant interleukin 2-activated sheep lymphocytes lyse sheep pulmonary microvascular endothelial cells.

L. King, J. Newman, K. Brigham, 1989, Cellular immunology.

Pulmonary hypertension and increased vasoreactivity caused by repeated indomethacin in sheep.

M. Niedermeyer, B. Meyrick, K. Brigham, 1985, Journal of applied physiology.

Increased plasma oncotic pressure inhibits pulmonary fluid transport when pulmonary pressures are elevated.

J. Hammon, K. Brigham, T. H. Wareing, 1989, The Journal of surgical research.

Pulmonary edema: cardiac and noncardiac.

K. Brigham, 1979, American journal of surgery.

Intestinal microflora in Asiatic cholera. II. The small bowel.

K. Brigham, S. Gorbach, R. Mitra, 1970, The Journal of infectious diseases.

Pulmonary vascular effects of fat emulsion infusion in unanesthetized sheep. Prevention by indomethacin.

K. Brigham, T. Harris, R. Bowers, 1978, The Journal of clinical investigation.

Permeability Pulmonary Edema: Diagnosis and Management

J. Loyd, K. Brigham, J. Newman, 1984 .

Gene Therapy Progress and Prospects: Alpha-1 antitrypsin

K. Brigham, A. Stecenko, 2003, Gene Therapy.

The adult respiratory distress syndrome.

G. Bernard, D. Simmons, K. Brigham, 1985, Annual review of medicine.

Prevention of Release of Granulocyte Aggregants into Sheep Lung Lymph Following Endotoxemia by N-Acetylcysteine

G. Bernard, K. Brigham, Denis K. English, 1987, The American journal of the medical sciences.

Mechanisms of Lung Endothelial Injury1

K. Brigham, 1987 .

BRIEF REVIEWS Interactions of Granulocytes with the Lungs

B. Meyrick, K. Brigham, 2005 .

Transfection of nasal mucosa with a normal alpha1-antitrypsin gene in alpha1-antitrypsin-deficient subjects: comparison with protein therapy.

B. Meyrick, A. Canonico, K. Brigham, 2000, Human gene therapy.

, Roberto Pulmonary Fibrosis in Lungs of Patients with Idiopathic Herpesvirus DNA Is Consistently Detected

J. Oates, B. Graham, P. Browning, 2003 .

Tumor necrosis factor's effects on lung mechanics, gas exchange, and airway reactivity in sheep.

A. Wheeler, K. Brigham, G. Jesmok, 1990, Journal of applied physiology.

Direct effects of E coli endotoxin on structure and permeability of pulmonary endothelial monolayers and the endothelial layer of intimal explants.

B. Meyrick, U. Ryan, K. Brigham, 1986, The American journal of pathology.

Pulmonary complications of chronic renal failure

G. Bernard, K. Brigham, 1981 .

Exaggerated Activation of Nuclear Factor- κ B and Altered I κ B- β Processing in Cystic Fibrosis Bronchial Epithelial Cells

J. Christman, T. Blackwell, K. Brigham, 2000 .

Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep.

K. Brigham, R. Bowers, C. R. McKeen, 1981, The Journal of clinical investigation.

Role of chest wall mechanoreceptors in inhibition of inspiration during mechanical ventilation in humans

J. Snapper, K. Brigham, M. Ogletree, 1981 .

Arachidonate raises vascular resistance but not permeability in lungs of awake sheep.

K. Brigham, M. Ogletree, 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

Leukotrienes and ARDS

J. Sheller, K. Brigham, 2004, Intensive Care Medicine.

Airway responsiveness in isolated perfused rat lungs: effect of thoracic irradiation.

G. Shields, J. Newman, J. Sheller, 1989, Respiration physiology.

Aerosol and intravenous transfection of human alpha 1-antitrypsin gene to lungs of rabbits.

B. Meyrick, A. Canonico, K. Brigham, 1994, American journal of respiratory cell and molecular biology.

Effect of endotoxemia on hypoxic pulmonary vasoconstriction in unanesthetized sheep.

J. Snapper, K. Brigham, M. Ogletree, 1985, Journal of applied physiology.

Pulmonary Hemodynamic and Ultrastructural Changes Associated with Group B Streptococcal Toxemia in Adult Sheep and Newborn Lambs

C. Hellerqvist, K. Brigham, M. Stahlman, 1983, Pediatric Research.

Acute effects of thoracic irradiation on lung function and structure in awake sheep.

J. Sheller, B. Meyrick, J. Loyd, 1987, Journal of applied physiology.

Effect of endotoxin on airway responsiveness to aerosol histamine in sheep.

J. Snapper, K. Brigham, J. Hinson, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Dysregulated Cytokine Production in Human Cystic Fibrosis Bronchial Epithelial Cells

J. Christman, R. Breyer, R. Dworski, 2001, Inflammation.

Saline compared to plasma volume replacement after volume depletion in sheep: Lung fluid balance

K. Brigham, T. Harris, R. Bowers, 1986 .

Correlation of oxygenation with vascular permeability-surface area but not with lung water in humans with acute respiratory failure and pulmonary edema.

G. Bernard, S. Young, J. Snapper, 1983, The Journal of clinical investigation.

Effects of red cell exchange on calculated sheep lung vascular permeability to 14C-urea and 14C-thiourea.

R. Roselli, K. Brigham, T. Harris, 1982, Respiration physiology.

THE EXCHANGE OF SMALL MOLECULES AS A MEASURE OF NORMAL AND ABNORMAL LUNG MICROVASCULAR FUNCTION *

K. Brigham, T. Harris, 1982, Annals of the New York Academy of Sciences.

Effects of prostaglandin cyclic endoperoxides on the lung circulation of unanesthetized sheep.

J. Oates, E. Ellis, K. Brigham, 1979, The Journal of clinical investigation.

Lung Water and Vascular Permeability in Sheep: Newborns Compared with Adults

K. Brigham, T. Harris, M. Stahlman, 1978, Circulation research.

The identification of pulmonary capillary permeability from multiple-indicator data. Effects of increased capillary pressure and alloxan treatment in the dog.

K. Brigham, T. Harris, R. Rowlett, 1976, Microvascular research.

No lung toxicity after repeated aerosol or intravenous delivery of plasmid-cationic liposome complexes.

B. Meyrick, A. Canonico, K. Brigham, 1994, Journal of applied physiology.

Plasmid-liposome transfer of the alpha 1 antitrypsin gene to cystic fibrosis bronchial epithelial cells prevents elastase-induced cell detachment and cytokine release.

J. Christman, A. Canonico, K. Brigham, 1996, American journal of respiratory cell and molecular biology.

Human recombinant tumor necrosis factor alpha infusion mimics endotoxemia in awake sheep.

B. Meyrick, K. Brigham, G. Jesmok, 1989, Journal of applied physiology.

today's practice otcardiopulmonary medicine

G. Bernard, K. Brigham, 2017 .

Pulmonary edema and acute lung injury research.

K. Brigham, N. Staub, 1998, American journal of respiratory and critical care medicine.

Pulmonary edema. Pathophysiologic mechanisms and new approaches to therapy.

G. Bernard, K. Brigham, Kenneth L. Brigham, 1986, Chest.

Indicator Dilution Lung Water and Vascular Permeability in Humans: Effects of Pulmonary Vascular Pressure

K. Brigham, T. Harris, J. Snell, 1979, Circulation research.

Reversible increase in pulmonary vascular permeability after Pseudomonas aeruginosa bacteremia in unanesthetized sheep.

K. Brigham, N. Staub, W. Woolverton, 1974, Chest.

On Defining the Pulmonary Extravascular Water Volume

C. R. Merritt, K. Brigham, J. Snell, 1971, Circulation research.

Direct Lung Injury Fat embolism syndrome Pulmonary contusion Radiation therapy Oxygen toxicity Pulmonary infection Drugs Paraquat Heroin Salicylates

G. Bernard, K. Brigham, 2022 .

Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans.

A. Quyyumi, J. Murrow, Riyaz S. Patel, 2011, Journal of the American College of Cardiology.

Abstract 1723: Vitamin D Levels Are Associated With Exercise Capacity and Measures of Endothelial Function in Healthy Humans

A. Quyyumi, R. Alexander, K. Brigham, 2009 .

The effect of a single infusion of zymosan-activated plasma on the pulmonary microcirculation of sheep. Structure-function relationships.

B. Meyrick, K. Brigham, 1984, The American journal of pathology.

Increased circulating endothelial progenitor cells are associated with survival in acute lung injury.

A. Quyyumi, M. Rojas, M. Moss, 2005, American journal of respiratory and critical care medicine.

Potent effects of aerosol compared with intravenous treprostinil on the pulmonary circulation.

K. Brigham, R. Parker, E. C. Lawrence, 2005, Journal of applied physiology.

Isoproterenol and aminophylline reduce lung capillary filtration during high permeability.

K. Brigham, T. Harris, T. Foy, 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

Effects of histamine on lung transvascular fluid and protein movement in awake sheep.

K. Brigham, 1975, Chest.

Lung infection with gamma-herpesvirus induces progressive pulmonary fibrosis in Th2-biased mice.

M. Rojas, J. Roman, K. Brigham, 2005, American journal of physiology. Lung cellular and molecular physiology.

Human gene marker/therapy clinical protocols.

R. Haubrich, K. Cornetta, J. Roth, 1999, Human gene therapy.

Cyclooxygenase inhibition during phorbol-induced granulocyte stimulation in awake sheep.

J. Newman, B. Meyrick, J. Loyd, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

Evidence for pulmonary release of 5-hydroxyeicosatetraenoic acid (5-hete) during endotoxemia in unanesthetized sheep.

J. Oates, W. Hubbard, K. Brigham, 1982, Prostaglandins.

Gene Therapy for Acute Diseases of the Lungs

K. Brigham, 2020 .

Effects of inspiratory resistance loading on lung fluid balance in awake sheep.

K. Nolop, J. Loyd, R. Roselli, 1986, Journal of applied physiology.

In vitro effects of endotoxin on bovine and sheep lung microvascular and pulmonary artery endothelial cells

B. Meyrick, K. Brigham, L. Berry, 1989, Journal of cellular physiology.

Endotoxin and the Lungs

K. Brigham, 1994 .

Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury

K. Brigham, 2005, Current infectious disease reports.

Gene therapy in acute critical illness.

K. Brigham, A. Stecenko, 1995, New horizons.

Influence of steroidal and nonsteroidal anti-inflammatory agents on the accumulation of arachidonic acid metabolites in plasma and lung lymph after endotoxemia in awake sheep. Measurements of prostacyclin and thromboxane metabolites and 12-HETE.

K. Brigham, G. King, M. Ogletree, 2015, The American review of respiratory disease.

Effect of granulocyte depletion on altered lung mechanics after endotoxemia in sheep.

J. Snapper, K. Brigham, M. Ogletree, 1983, Journal of applied physiology: respiratory, environmental and exercise physiology.

Effects of granulocyte depletion on pulmonary responsiveness to aerosol histamine.

J. Snapper, B. Meyrick, K. Brigham, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

Effects of Cyclooxygenase Inhibition on the Response to Group B Streptococcal Toxin in Sheep

K. Brigham, M. Stahlman, M. Ogletree, 1983, Pediatric Research.

Lung water and vascular permeability-surface area in premature newborn lambs with hyaline membrane disease.

R. Green, K. Brigham, T. Harris, 1987, Circulation research.

Exaggerated activation of nuclear factor-kappaB and altered IkappaB-beta processing in cystic fibrosis bronchial epithelial cells.

J. Christman, T. Blackwell, K. Brigham, 2000, American journal of respiratory cell and molecular biology.

Pulmonary capillary leukostasis: a complement (C') mediated complication of hemodialysis

J. Fehr, K. Brigham, H. Jacob, 1975 .

Endotoxin-induced acute lung injury requires interaction with the liver.

K. Brigham, A. Stecenko, B. Christman, 2005, American journal of physiology. Lung cellular and molecular physiology.

Oxidant stress and adult respiratory distress syndrome.

K. Brigham, 1990, The European respiratory journal. Supplement.

The role of mitochondrial oxidation in endotoxin-induced liver-dependent swine pulmonary edema.

K. Brigham, A. Stecenko, R. Parker, 2012, Pulmonary pharmacology & therapeutics.

Prostaglandin E2 attenuation of sheep lung responses to endotoxin.

J. Oates, B. Meyrick, I. Blair, 1988, Journal of applied physiology.

Lung microvascular transport properties measured by multiple indicator dilution methods in patients with adult respiratory distress syndrome. A comparison between patients reversing respiratory failure and those failing to reverse.

C. Sprung, W. Sibbald, G. Bernard, 1990, The American review of respiratory disease.

Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis.

R S Kronenberg, R. Kronenberg, J. Fehr, 1977, The New England journal of medicine.

Preparation of chronic lung lymph fistulas in sheep.

K. Brigham, N. Staub, R. Bland, 1975, Journal of Surgical Research.

Effect of Increased Vascular Pressure on Lung Fluid Balance in Unanesthetized Sheep

K. Brigham, N. Staub, T. Vaughan, 1975, Circulation research.

Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep.

J. Snapper, K. Brigham, K L Brigham, 1983, The Journal of clinical investigation.

Cytokine Antibodies and Antagonists in the Treatment of Sepsis

A. Wheeler, K. Brigham, 1995 .

Increased Sheep Lung Vascular Permeability Caused by Escherichia coli Endotoxin

K. Brigham, J. Haynes, R. Bowers, 1979, Circulation research.

Plasma 6-keto prostaglandin F1α and thromboxane B2 in sick preterm neonates

A. Fleischer, K. Brigham, B. Leheup, 1985 .

Increased Sheep Lung Vascular Permeability Caused by Histamine

K. Brigham, P. Owen, 1975, Circulation research.

Mechanism of the Serotonin Effect on Lung Transvascular Fluid and Protein Movement in Awake Sheep

K. Brigham, P. Owen, 1975, Circulation Research.

Net and unidirectional transmucosal flux of sodium and water in acute human diarrheal disease.

N. Pierce, K. Brigham, S. Gorbach, 1972, The Journal of laboratory and clinical medicine.

Use of senescence-accelerated mouse model in bleomycin-induced lung injury suggests that bone marrow-derived cells can alter the outcome of lung injury in aged mice.

Valerie Mac, M. Rojas, K. Brigham, 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

Prostaglandins, leukotrienes, and lung fluid balance

R. Bizios, A. Ford-hutchinson, J. Cooper, 1985 .

Report of the American-European consensus conference on ARDS: Definitions, mechanisms, relevant outcomes and clinical trial coordination

A. Artigas, M. Lamy, G. Bernard, 1994, Intensive Care Medicine.

Whole genome sequencing in support of wellness and health maintenance

Jing Zhao, Alexander A. Morgan, Rong Chen, 2013, Genome Medicine.

Blood-Informative Transcripts Define Nine Common Axes of Peripheral Blood Gene Expression

Greg Gibson, Dalia Arafat, G. Gibson, 2013, PLoS genetics.

Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation

Joseph E. Powell, Andres Metspalu, Peter M. Visscher, 2019, Genetics.

Intestinal fluid and electrolyte transport in human cholera.

R. Sack, K. Brigham, S. Gorbach, 1970, The Journal of clinical investigation.

The God particle, personalized medicine, and the tragedy of the commons.

K. Brigham, M. Johns, 2013, The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha.

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

Andres Metspalu, Arshed A Quyyumi, Jian Yang, 2016, G3: Genes, Genomes, Genetics.

Oral replacement of water and electrolyte losses in cholera.

R. Sack, N. Pierce, K. Brigham, 1969, The Indian journal of medical research.

Hepatic cryoablation-induced acute lung injury: pulmonary hemodynamic and permeability effects in a sheep model.

W. Chapman, J. Christman, J. Debelak, 2000, Archives of surgery.

Respiratory failure after endotoxin infusion in sheep: lung mechanics and lung fluid balance.

J. Newman, K. Brigham, H. Jolles, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

EXCHANGE OF MACROMOLECULES IN THE PULMONARY MICROCIRCULATION *

R. Roselli, K. Brigham, T. Harris, 1982, Annals of the New York Academy of Sciences.

Diphenhydramine reduces endotoxin effects on lung vascular permeability in sheep.

K. Brigham, R. Bowers, C. R. McKeen, 1980, Journal of applied physiology: respiratory, environmental and exercise physiology.

Lung vascular permeability: inferences from measurements of plasma to lung lymph protein transport.

R. Roselli, K. Brigham, T. Harris, 1979, Lymphology.

Effects of hypoproteinemia on lung microvascular protein sieving and lung lymph flow.

R. Roselli, K. Brigham, T. Harris, 1986, Journal of applied physiology.

Attenuation of the pulmonary vascular response to endotoxin by a thromboxane synthesis inhibitor (UK-38485) in unanesthetized sheep.

J. Hammon, K. Brigham, M. Ogletree, 1991, The Journal of surgical research.

Effects of Graded Increases in Pulmonary Vascular Pressures on Lung Fluid Balance in Unanesthetized Sheep

R. Roselli, K. Brigham, T. Harris, 1981, Circulation research.

Comparison of the effects of saline and homologous plasma infusion on lung fluid balance during endotoxemia in the unanesthetized sheep.

J. Hammon, H. Bender, R. Roselli, 1981, Surgery.

Intestinal microflora in Asiatic cholera. I. "Rice-water" stool.

K. Brigham, S. Gorbach, R. Mitra, 1970, The Journal of infectious diseases.

Genetic risk prediction in a small cohort of healthy adults in Atlanta.

G. Gibson, J. Zhao, D. Arafat, 2013, Genetics research.

High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring.

Dean P. Jones, Dean P Jones, Kichun Lee, 2012, Toxicology.

Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee.

M. Lamy, G. Bernard, J. Legall, 1994, Journal of critical care.

Increased lung lymph transport without heart failure after coronary ligation in sheep.

K. Brigham, T. Harris, J. Collins, 1979, Journal of applied physiology: respiratory, environmental and exercise physiology.

Increased permeability of sheep lung vessels to proteins after Pseudomonas bacteremia.

K. Brigham, R. Bowers, P. Owen, 1976, Microvascular research.

Prevention of NF-κB activation in vivo by a cell-permeable NF-κB inhibitor peptide

M. Rojas, K. Brigham, A. Stecenko, 2005 .

Effects of Methylprednisolone on the Response to Group B Streptococcal Toxin in Sheep

C. Hellerqvist, K. Brigham, M. Stahlman, 1984, Pediatric Research.

Effects of platelet depletion on the unanesthetized sheep's pulmonary response to endotoxemia.

J. Snapper, K. Brigham, M. Ogletree, 1984, The Journal of clinical investigation.

Relation of blood-free to blood-inclusive postmortem lung water measurements in sheep.

W. Vaughn, J. Newman, J. Snapper, 1985, Journal of applied physiology.

Lung Water and Urea Indicator Dilution Studies in Cardiac Surgery Patients: Comparisons of Measurements in Aortocoronary Bypass and Mitral Valve Replacement

H. Bender, K. Brigham, S. Faulkner, 1976, Circulation.

Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Endotoxin-Induced Oxidation of Plasma Cysteine and Glutathione in Mice

Dean P. Jones, M. Rojas, K. Brigham, 2010, Stem cells international.

Prostaglandins and lung injury.

J. Snapper, K. Brigham, K L Brigham, 1983, Chest.

Vascular Endothelial Function and Self-reported Sleep

A. Quyyumi, D. Bliwise, K. Brigham, 2014, The American journal of the medical sciences.

Salicylate pulmonary edema: the mechanism in sheep and review of the clinical literature.

K. Brigham, R. Bowers, P. Owen, 1977, The American review of respiratory disease.

Effects of a Health‐Partner Intervention on Cardiovascular Risk

G. Gibson, G. Martin, A. Quyyumi, 2016, Journal of the American Heart Association.

A Longitudinal Study of Health Improvement in the Atlanta CHDWB Wellness Cohort

G. Gibson, R. Tabassum, K. Brigham, 2014, Journal of personalized medicine.

Animal Models of Lung Injury: Role for Mesenchymal Stem Cells

M. Rojas, K. Brigham, S. Iyer, 2010 .

Circulating endothelial progenitor cells inversely associate with organ dysfunction in sepsis

G. Martin, Kirk A Easley, M. Rojas, 2012, Intensive Care Medicine.

Psychosocial factors associated with diet quality in a working adult population.

Carolyn M. Reilly, T. Ziegler, K. Brigham, 2013, Research in nursing & health.

Oxidative stress is associated with impaired arterial elasticity.

Dean P. Jones, A. Quyyumi, K. Dabhadkar, 2011, Atherosclerosis.

The ventilatory response to acute base deficit in humans. Time course during development and correction of metabolic acidosis.

R. Sack, N. Pierce, K. Brigham, 1970, Annals of internal medicine.

In vivo assessment of pulmonary vascular integrity in experimental pulmonary edema.

K. Brigham, J. Snell, 1973, The Journal of clinical investigation.

Inflammation and airway reactivity.

J. Snapper, K. Brigham, 1984, Experimental Lung Research.

Effects of cyclooxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep.

K. Brigham, M. Ogletree, 1982, Prostaglandins, leukotrienes, and medicine.

Pulmonary hypertension correlated to pulmonary thromboxane synthesis.

K. Brigham, M. Ogletree, B. Peskar, 1980, Advances in prostaglandin and thromboxane research.

Effects of endotoxemia on pulmonary vascular resistances in unanesthetized sheep.

K. Brigham, R. Parker, 1987, Journal of applied physiology.

Mediator Systems of Lung Injury

G. Bernard, K. Brigham, P. Wright, 1992 .

Effect of naloxone on the pulmonary vascular responses to graded levels of intracranial hypertension in anesthetized sheep.

J. C. Ross, K. Brigham, B. Peterson, 1983, The American review of respiratory disease.

Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury.

Dean P. Jones, M. Rojas, K. Brigham, 2009, American journal of respiratory cell and molecular biology.

Effects of antihistamines on the lung vascular response to histamine in unanesthetized sheep. Diphenhydramine prevention of pulmonary edema and increased permeability.

K. Brigham, R. Bowers, P. Owen, 1976, The Journal of clinical investigation.

Unilateral radiation pneumonitis in sheep: physiological changes and bronchoalveolar lavage.

J. Loyd, K. Brigham, A. Malcolm, 1989, Journal of applied physiology.

Effects of left atrial pressure elevation and histamine infusion on lung lymph in awake sheep.

G. Bernard, J. Snapper, K. Brigham, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

Endotoxin increases superoxide dismutase in cultured bovine pulmonary endothelial cells.

B. Meyrick, K. Brigham, I. Burr, 1987, The American journal of physiology.

Prostaglandins in Lung Disease: Adult Respiratory Distress Syndrome

K. Brigham, S. S. Duke, 1985 .

Mechanisms of lung injury.

K. Brigham, 1982, Clinics in chest medicine.

Effects of endotoxemia on cyclic nucleotides in the unanesthetized sheep.

J. Snapper, K. Brigham, J. D. Bomboy, 1983, The Journal of laboratory and clinical medicine.

Relation of ventilation during base deficit to acid-base values in blood and spinal fluid.

S. Permutt, N. Pierce, K. Brigham, 1971, Journal of applied physiology.

1728 LUNG WATER AND VASCULAR PERMEABILITY-SURFACE AREA IN LAMBS WITH HYALINE MEMBRANE DISEASE (HMD)

R. Green, K. Brigham, M. Stahlman, 1981, Pediatric Research.

Pulmonary dysfunction in hemodialysis.

K. Brigham, H. Jacob, P. Craddock, 1978, New England Journal of Medicine.

Oxygen radicals—An important mediator of sepsis and septic shock

K. Brigham, 1991, Klinische Wochenschrift.

When and why do people die?

K. Brigham, 1989, Intensive Care Medicine.

Mechanisms of Endotoxin Induced Endothelial Injury

K. Brigham, 1992 .

Corticosteroids prevent acute lung dysfunction caused by thoracic irradiation in unanesthetized sheep.

J. Loyd, K. Brigham, A. Malcolm, 1988, The American review of respiratory disease.

Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep.

J. Newman, K. Brigham, B. Butka, 1986, Journal of applied physiology.

Effects of prolonged elevated microvascular pressure on lung fluid balance in sheep.

R. Roselli, K. Brigham, R. Parker, 1985, Journal of applied physiology.

Effect of changing lung mass on lung water and permeability-surface area in sheep.

J. Snapper, K. Brigham, T. Harris, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Effects of alveolar hypoxia during partial mitral valve obstruction in unanesthetized sheep.

G. Bernard, J. Newman, J. Snapper, 1985, The American review of respiratory disease.

Integrating Comparative Effectiveness Research Programs Into Predictive Health: A Unique Role for Academic Health Centers

K. Rask, K. Brigham, M. Johns, 2011, Academic medicine : journal of the Association of American Medical Colleges.

Gated Regional Spirometry (GRS)

J. Jones, R. Price, K. Brigham, 1978 .

Permeability pulmonary edema. Diagnosis and management.

K. Brigham, J. Boyd, J. H. Bewman, 1984, Archives of internal medicine.

The Role of Systems Biology in Predictive Health and Personalized Medicine

Eberhard O. Voit, E. Voit, K. Brigham, 2008 .

Effects of methylprednisolone on lung oxygen toxicity in awake sheep.

W. Fulkerson, J. Newman, B. Meyrick, 1986, Journal of applied physiology.

Equilibration of intravascular albumin with lung lymph in unanesthetized sheep.

K. Brigham, N. Staub, T. Vaughan, 1979, Lymphology.

M. Rojas, K. Brigham, M. Johns, 2007, The Annals of otology, rhinology, and laryngology.

Gene therapy for acute lung injury

K. Brigham, A. Stecenko, K. L. Brigham, 2000, Intensive Care Medicine.

Constraints on eQTL fine mapping in the presence of multi-site local regulation of gene expression

P. Visscher, G. Gibson, A. Quyyumi, 2016, bioRxiv.

High-dose corticosteroids in patients with the adult respiratory distress syndrome.

C. Sprung, W. Sibbald, G. Bernard, 1987, The New England journal of medicine.

Sociodemographic and Genetic Influences on Dietary Patterns and Their Influence on Health Outcomes in the Atlanta Center for Health Discovery and Well Being Cohort

Dean P. Jones, G. Gibson, A. Quyyumi, 2020 .

Comparisons of [14C]urea and [3H]mannitol as lung vascular permeability indicators in awake sheep: evidence against red cell urea trapping.

K. Brigham, T. Harris, R. Rowlett, 1977, Microvascular research.

Effects of changing hemodynamics on the extra plasma space in the lungs of sheep.

K. Brigham, N. Staub, W. Woolverton, 1975, Microvascular research.

Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.

A. Dalmasso, J. Fehr, K. Brigham, 1977, The Journal of clinical investigation.

Increased circulating endothelial progenitor cells are associated with survival in acute lung injury.

A. Quyyumi, M. Rojas, M. Moss, 2005, American journal of respiratory and critical care medicine.

Bronchomotor responses of isolated sheep airways to electrical field stimulation.

J. Sheller, K. Brigham, 1982, Journal of applied physiology: respiratory, environmental and exercise physiology.

Modification of pulmonary responses to endotoxemia in awake sheep by steroidal and nonsteroidal anti-inflammatory agents.

B. Meyrick, K. Brigham, M. Ogletree, 2015, The American review of respiratory disease.

Potential for Gene Therapy in the Treatment of Sepsis

B. Meyrick, A. Canonico, H. Schreier, 1994 .

Therapy of Pulmonary Edema

K. Brigham, 1983 .

Direct and indirect effects of leukotriene D4 on the lungs of unanesthetized sheep.

J. Snapper, K. Brigham, M. Ogletree, 1987, Respiration; international review of thoracic diseases.

Lung vascular permeability changes in lambs with hyaline membrane disease.

K. Brigham, J. Grøgaard, H. Sundell, 1989, Journal of developmental physiology.

Effect of aerosol histamine on lung lymph in awake sheep.

G. Bernard, J. Snapper, K. Brigham, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

Respiratory Distress Syndromes: Molecules to Man

K. Brigham, M. Stahlman, 1991 .

Effects of prostaglandins and related compounds on lung vascular permeability.

K. Brigham, M. Ogletree, 1981, Bulletin europeen de physiopathologie respiratoire.

Expression of a prokaryotic gene in cultured lung endothelial cells after lipofection with a plasmid vector.

B. Meyrick, K. Brigham, G. King, 1989, American journal of respiratory cell and molecular biology.

Gene therapy for inflammatory diseases.

B. Meyrick, A. Canonico, H. Schreier, 1994, Progress in clinical and biological research.

Diethylcarbamazine on pulmonary vascular response to endotoxin in awake sheep.

J. Newman, K. Brigham, T. Kobayashi, 1986, Journal of applied physiology.

Chemotaxis of granulocytes across bovine pulmonary artery intimal explants without endothelial cell injury.

B. Meyrick, K. Brigham, K. Brigham, 1984, Tissue & cell.

Oxidative stress is associated with impaired arterial elasticity.

Dean P. Jones, A. Quyyumi, W. Hooper, 2011, Atherosclerosis.

Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis.

Dean P. Jones, M. Rojas, J. Roman, 2009, American journal of physiology. Lung cellular and molecular physiology.

Health Care Expenditures for University and Academic Medical Center Employees Enrolled in a Pilot Workplace Health Partner Intervention

G. Martin, K. Rask, J. Hockenberry, 2015, Journal of occupational and environmental medicine.

Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression

P. Visscher, G. Gibson, A. Quyyumi, 2016, G3: Genes, Genomes, Genetics.

On Defining the Pulmonary Extravascular Water Volume

K. Brigham, J. Snell, L. H. Ramsey, 1971, Circulation Research.

Rapid CommunicationRapid Communication: In vivo Transfection of Murine Lungs with a Functioning Prokaryotic Gene using a Liposome Vehicle

M. Magnuson, B. Meyrick, K. Brigham, 1989 .