A. Tsuji

发表

Cellular and molecular mechanisms of dietary regulation on rat intestinal H+/Peptide transporter PepT1.

H. Yamamoto, E. Takeda, H. Tanaka, 1999, Gastroenterology.

Physiologically Based Pharmacokinetic Model for β-Lactam Antibiotics I: Tissue Distribution and Elimanation Rates

T. Terasaki, A. Tsuji, E. Miyamoto, 1983 .

Structure-tissue distribution relationship based on physiological pharmacokinetics for NY-198, a new antimicrobial agent, and the related pyridonecarboxylic acids.

T. Terasaki, A. Tsuji, E. Okezaki, 1988, Drug metabolism and disposition: the biological fate of chemicals.

T. Terasaki, I. Tamai, A. Tsuji, 1989, Journal of pharmaceutical sciences.

Physiological pharmacokinetics of a new muscle-relaxant, inaperisone, combined with its pharmacological effect on blood flow rate.

T. Terasaki, A. Tsuji, O. Nagata, 1990, Drug Metabolism And Disposition.

Genetic deficiency of carnitine/organic cation transporter 2 (slc22a5) is associated with altered tissue distribution of its substrate pyrilamine in mice

Y. Kato, A. Tsuji, T. Sugiura, 2009, Biopharmaceutics & drug disposition.

Characterization of the transdermal transport of flurbiprofen and indomethacin.

Y. Kato, Y. Sai, A. Tsuji, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Effect of extracellular water volume on the distribution kinetics of beta-lactam antibiotics as a function of age.

T. Terasaki, A. Tsuji, E. Nakashima, 1985, Journal of pharmacobio-dynamics.

Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.

Y. Sai, K. Naruhashi, I. Tamai, 2000, The Journal of pharmacology and experimental therapeutics.

Intestinal absorption mechanism of amino-beta-lactam antibiotics. III. Kinetics of carrier-mediated transport across the rat small intestine in situ.

S. Kagatani, A. Tsuji, E. Nakashima, 1984, Journal of pharmacobio-dynamics.

Carrier-mediated transport of oligopeptides in the human fibrosarcoma cell line HT1080.

T. Nakanishi, Y. Sai, Takuma Sasaki, 1997, Cancer research.

Physiological pharmacokinetics of Mactam antibiotics: penicillin V distribution and elimination after intravenous administration in rats

T. Terasaki, A. Tsuji, E. Miyamoto, 1979, The Journal of pharmacy and pharmacology.

Kinetics of peritoneal drug transport in rats: an application of the pore theory of transcapillary exchange.

I. Tamai, A. Tsuji, E. Nakashima, 1988, Journal of pharmaceutical sciences.

Importance of receptor-mediated endocytosis in peptide delivery and targeting: kinetic aspects

Y. Sugiyama, Hitoshi Sato, A. Tsuji, 1996 .

Receptor-recycling model of clearance and distribution of insulin in the perfused mouse liver

T. Terasaki, A. Tsuji, H. Sato, 1991, Diabetologia.

Receptor-mediated endocytosis of A14-125I-insulin by the nonfiltering perfused rat kidney.

T. Terasaki, A. Tsuji, H. Sato, 1991, Biochimica et biophysica acta.

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.

J. Nezu, I. Tamai, A. Tsuji, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Carnitine/Organic Cation Transporter OCTN2 (Slc22a5) Is Responsible for Renal Secretion of Cephaloridine in Mice

Kimihiro Ito, Y. Kato, A. Tsuji, 2009, Drug Metabolism and Disposition.

PREDOMINANT CONTRIBUTION OF ORGANIC ANION TRANSPORTING POLYPEPTIDE OATP-B (OATP2B1) TO APICAL UPTAKE OF ESTRONE-3-SULFATE BY HUMAN INTESTINAL CACO-2 CELLS

P. Artursson, Y. Kato, Y. Sai, 2006, Drug Metabolism and Disposition.

Transport mechanism of a new behaviorally highly potent adrenocorticotropic hormone (ACTH) analog, ebiratide, through the blood-brain barrier.

T. Terasaki, A. Tsuji, T. Shimura, 1991, The Journal of pharmacology and experimental therapeutics.

In‐vivo Blood‐brain Barrier Transport of a Novel Adrenocorticotropic Hormone Analogue, Ebiratide, Demonstrated by Brain Microdialysis and Capillary Depletion Methods

T. Terasaki, A. Tsuji, Y. Deguchi, 1992, The Journal of pharmacy and pharmacology.

Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier.

Y. Sai, I. Tamai, A. Tsuji, 1997, The Journal of pharmacology and experimental therapeutics.

Design and Synthesis of Peptides Passing through the Blood-Brain Barrier

Y. Sai, S. Kusumoto, I. Tamai, 1998 .

Absorptive-Mediated Endocytosis of an Adrenocorticotropic Hormone (ACTH) Analogue, Ebiratide, into the Blood–Brain Barrier: Studies with Monolayers of Primary Cultured Bovine Brain Capillary Endothelial Cells

T. Terasaki, A. Tsuji, A. Saheki, 1992, Pharmaceutical Research.

In Vivo Transport of a Dynorphin-like Analgesic Peptide, E-2078, Through the Blood–Brain Barrier: An Application of Brain Microdialysis

T. Terasaki, Hitoshi Sato, A. Tsuji, 1991, Pharmaceutical Research.

Specific Mechanisms for Transporting Drugs Into Brain

A. Tsuji, 2000 .

P-glycoprotein-mediated efflux transport of anticancer drugs at the blood-brain barrier.

A. Tsuji, Akira Tsuji, 1998, Therapeutic drug monitoring.

Novel Drug Development Utilizing Transport Function of P-glycoprotein

A. Tsuji, 1998 .

Carrier-mediated mechanism for the biliary excretion of the quinolone antibiotic grepafloxacin and its glucuronide in rats.

H. Sasabe, Y. Sugiyama, A. Tsuji, 1998, The Journal of pharmacology and experimental therapeutics.

Uptake of benzylpenicillin, cefpiramide and cefazolin by freshly prepared rat hepatocytes. Evidence for a carrier-mediated transport system.

T. Terasaki, I. Tamai, A. Tsuji, 1986, Biochemical pharmacology.

Membrane potential-dependent and carrier-mediated transport of cefpiramide, a cephalosporin antibiotic, in canalicular rat liver plasma membrane vesicles.

I. Tamai, A. Tsuji, T. Maekawa, 1990, The Journal of pharmacology and experimental therapeutics.

An application of microdialysis to drug tissue distribution study: in vivo evidence for free-ligand hypothesis and tissue binding of beta-lactam antibiotics in interstitial fluids.

T. Terasaki, A. Tsuji, Y. Deguchi, 1992, Journal of pharmacobio-dynamics.

Studies on the Stability of Amides. I. Hydrolysis Mechanism of N-Substituted Aliphatic Amides

A. Tsuji, T. Yamana, Y. Mizukami, 1972 .

cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter.

H. Yamamoto, H. Takanaga, Y. Sai, 1995, Biochemical and biophysical research communications.

ION CHANNELS - MEMBRANE TRANSPORT - INTEGRATIVE PHYSIOLOGY

P. Forrer, A. Tsuji, L. Sabourin, 2002 .

Entry of the new quinolone antibacterial agents of ofloxacin and NY-198 into the central nervous system in rats.

A. Tsuji, E. Okezaki, O. Nagata, 1988, Journal of pharmacobio-dynamics.

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.

J. Nezu, A. Oku, M. Shimane, 2000, Biochemical and biophysical research communications.

Title Involvement of influx and efflux transport systems in gastrointestinalabsorption of celiprolol

Y. Kato, A. Tsuji, T. Sugiura, 2017 .

PDZK1 regulates organic anion transporting polypeptide Oatp1a in mouse small intestine.

N. Nakamichi, Y. Kato, A. Tsuji, 2010, Drug metabolism and pharmacokinetics.

DMD # 19125-1-Involvement of multidrug resistance-associated protein 2 ( Abcc 2 ) in molecular weight-dependent biliary excretion of ß-lactam antibiotics

Y. Kato, Y. Sai, I. Tamai, 2008 .

Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics

Y. Kato, Y. Sai, I. Tamai, 2008, Drug Metabolism and Disposition.

Impact of transporter-mediated drug absorption, distribution, elimination and drug interactions in antimicrobial chemotherapy

A. Tsuji, 2006, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Characterization of the Uptake Mechanism for a Novel Loop Diuretic, M17055, in Caco-2 Cells: Involvement of Organic Anion Transporting Polypeptide (OATP)-B

Y. Kato, Y. Sai, A. Tsuji, 2006, Pharmaceutical Research.

Suppression of Cell Proliferation by Inhibition of Estrone-3-Sulfate Transporter in Estrogen-Dependent Breast Cancer Cells

I. Tamai, A. Tsuji, Masato Suzuki, 2005, Pharmaceutical Research.

Functional Characterization of Human Organic Anion Transporting Polypeptide B (OATP-B) in Comparison with Liver-Specific OATP-C

J. Nezu, Y. Sai, I. Tamai, 2001, Pharmaceutical Research.

Characterization of renal excretion mechanism for a novel diuretic, M17055, in rats.

Y. Kato, Y. Sai, A. Tsuji, 2004, Journal of pharmaceutical sciences.

Involvement of Estrone-3-Sulfate Transporters in Proliferation of Hormone-Dependent Breast Cancer Cells

I. Tamai, A. Tsuji, Masato Suzuki, 2004, Journal of Pharmacology and Experimental Therapeutics.

The genetic polymorphism of drug transporters: functional analysis approaches.

T. Ishikawa, Y. Sai, H. Endou, 2004, Pharmacogenomics.

Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1.

Y. Sai, I. Tamai, A. Tsuji, 2002, The Journal of pharmacology and experimental therapeutics.

[Biopharmaceutical studies on molecular mechanisms of membrane transport].

A. Tsuji, 2002, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

GENETIC POLYMORPHISM OF DRUG TRANSPORTERS

J. Nezu, A. Oku, M. Shimane, 2000 .

Kinetic evidence for a common transport route of benzylpenicillin and probenecid by freshly prepared hepatocytes in rats. Influence of sodium ion, organic anions, amino acids and peptides on benzylpenicillin uptake.

T. Terasaki, I. Tamai, A. Tsuji, 1986, Journal of pharmacobio-dynamics.

In vivo evidence for carrier-mediated uptake of beta-lactam antibiotics through organic anion transport systems in rat kidney and liver.

T. Terasaki, I. Tamai, A. Tsuji, 1990, The Journal of pharmacology and experimental therapeutics.

Cloning and characterization of a novel human pH‐dependent organic cation transporter, OCTN1

J. Nezu, A. Oku, M. Shimane, 1997, FEBS letters.

Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1.

E. Takeda, K. Miyamoto, K. Morita, 1998, The Journal of pharmacology and experimental therapeutics.

Muscle distribution of antimicrobial agents after a single intravenous administration to rats.

Yasuo Watanabe, I. Tamai, A. Tsuji, 2002, Drug metabolism and pharmacokinetics.

USEFULNESS AND LIMITATION OF THE MICRODIALYSIS FIBER IMPLANTATION TECHNIQUE FOR THE DETERMINATION OF THE CONCENTRATION IN THE TISSUE INTERSTITIAL FLUID

T. Terasaki, A. Tsuji, Y. Deguchi, 1991 .

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats.

J. Terao, K. Miyamoto, A. Tsuji, 2011, Free radical biology & medicine.

Role of Anion Exchange Transporter PAT1 (SLC26A6) in Intestinal Absorption of Organic Anions

I. Tamai, A. Tsuji, S. Sugiura, 2004, Journal of drug targeting.

Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, prulifloxacin.

Y. Kato, Y. Sai, A. Tsuji, 2003, Drug metabolism and pharmacokinetics.

Carrier-mediated hepatic uptake of quinolone antibiotics in the rat.

H. Sasabe, Y. Sugiyama, T. Terasaki, 1997, The Journal of pharmacology and experimental therapeutics.

Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier.

I. Tamai, A. Tsuji, O. Nagata, 1999, The Journal of pharmacology and experimental therapeutics.

Site-dependent contributions of P-glycoprotein and CYP3A to cyclosporin A absorption, and effect of dexamethasone in small intestine of mice.

T. Shimada, K. Miyamoto, Y. Kato, 2006, Biochemical pharmacology.

Contributions of intestinal P-glycoprotein and CYP3A to oral bioavailability of cyclosporin A in mice treated with or without dexamethasone.

T. Shimada, K. Miyamoto, Y. Kato, 2006, International journal of pharmaceutics.

Transporter-mediated hepatic uptake of ulifloxacin, an active metabolite of a prodrug-type new quinolone antibiotic prulifloxacin, in rats.

Y. Kato, A. Tsuji, M. Aoki, 2007, Drug metabolism and pharmacokinetics.

Regulation of drug transporters by PDZ adaptor proteins and nuclear receptors.

Y. Kato, A. Tsuji, Chizuru Watanabe, 2006, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Role of SLC xenobiotic transporters and their regulatory mechanisms PDZ proteins in drug delivery and disposition.

Y. Kato, A. Tsuji, T. Sugiura, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700.

Keiko Nakamura, Y. Kato, Y. Sai, 2006, Journal of pharmaceutical sciences.

New Strategies on Drug Transporter Research and Drug Development

A. Tsuji, 2005 .

Screening of the Interaction Between Xenobiotic Transporters and PDZ Proteins

Y. Kato, Y. Sai, A. Tsuji, 2004, Pharmaceutical Research.

Cancer cell‐targeted drug delivery utilizing oligopeptide transport activity

T. Nakanishi, I. Tamai, A. Tsuji, 2000, International journal of cancer.

P-Glycoprotein-Dependent Disposition Kinetics of Tacrolimus: Studies in mdr la Knockout Mice

K. Miyamoto, M. Nomura, I. Tamai, 1999, Pharmaceutical Research.

Proton-Cotransport of Pravastatin Across Intestinal Brush-Border Membrane

H. Takanaga, I. Tamai, A. Tsuji, 1995, Pharmaceutical Research.

Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2).

Y. Sugiyama, X. Chu, I. Tamai, 2000, The Journal of pharmacology and experimental therapeutics.

Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency

E. Mayatepek, J. Nezu, A. Oku, 2000, Human mutation.

Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.

J. Nezu, A. Oku, M. Shimane, 2001, Molecular pharmacology.

Molecular and Physiological Evidence for Multifunctionality of Carnitine / Organic Cation Transporter OCTN 2

J. Nezu, A. Oku, M. Shimane, 2001 .

Transport mechanism of cephalexin in isolated hepatocytes.

I. Tamai, A. Tsuji, 1987, Journal of pharmacobio-dynamics.

Faropenem Transport across the Renal Epithelial Luminal Membrane via Inorganic Phosphate Transporter Npt1

E. Takeda, K. Miyamoto, I. Tamai, 2000, Antimicrobial Agents and Chemotherapy.

Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells.

Y. Sai, I. Tamai, A. Tsuji, 1998, American journal of physiology. Gastrointestinal and liver physiology.

PDZ Adaptor Protein PDZK2 Stimulates Transport Activity of Organic Cation/Carnitine Transporter OCTN2 by Modulating Cell Surface Expression

Y. Kato, A. Tsuji, T. Sugiura, 2006, Drug Metabolism and Disposition.

Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.

J. Nezu, Y. Sai, I. Tamai, 2007, Reproduction.

Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.

T. Nakanishi, J. Nezu, Y. Sai, 2004, Molecular pharmaceutics.

Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney.

J. Nezu, Y. Sai, I. Tamai, 2001, Biochimica et biophysica acta.

Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells.

I. Tamai, A. Tsuji, Tomoji Maeda, 2005, Reproduction.

PDZK1 Directly Regulates the Function of Organic Cation/Carnitine Transporter OCTN2

Y. Kato, Y. Sai, A. Tsuji, 2005, Molecular Pharmacology.

Loss of wild‐type carrier‐mediated L‐carnitine transport activity in hepatocytes of juvenile visceral steatosis mice

K. Miyamoto, J. Nezu, A. Oku, 1999, Hepatology.

Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse

Y. Kato, Y. Sai, I. Tamai, 2006, Molecular Pharmacology.

Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart.

Y. Kato, Y. Sai, A. Tsuji, 2008, Drug metabolism and pharmacokinetics.

PDZK1 Regulates Two Intestinal Solute Carriers (Slc15a1 and Slc22a5) in Mice

Y. Kato, A. Tsuji, D. Silver, 2008, Drug Metabolism and Disposition.

Molecular and Functional Characterization of Organic Cation/Carnitine Transporter Family in Mice*

J. Nezu, A. Oku, M. Shimane, 2000, The Journal of Biological Chemistry.

OCTN2-mediated transport of carnitine in isolated Sertoli cells.

J. Nezu, I. Tamai, A. Tsuji, 2005, Reproduction.

Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population.

Y. Kato, Y. Sai, A. Tsuji, 2004, Journal of pharmaceutical sciences.

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.

Y. Kato, A. Tsuji, T. Sugiura, 2006, Drug metabolism and pharmacokinetics.

Involvement of Multidrug Resistance-Associated Protein 1 in Intestinal Toxicity of Methotrexate

Y. Kato, A. Tsuji, Y. Kubo, 2009, Pharmaceutical Research.

Transport of monocarboxylic acids at the blood-brain barrier: studies with monolayers of primary cultured bovine brain capillary endothelial cells.

T. Terasaki, A. Tsuji, S. Takakuwa, 1991, The Journal of pharmacology and experimental therapeutics.

Comparative distribution kinetics of cefazolin and tobramycin in children.

A. Tsuji, E. Nakashima, F. Ichimura, 1987, Journal of pharmacobio-dynamics.

The Rab8 GTPase regulates apical protein localization in intestinal cells

A. Harada, Y. Kato, K. Ozono, 2007, Nature.

Absorptive-mediated endocytosis of a dynorphin-like analgesic peptide, E-2078 into the blood-brain barrier.

T. Terasaki, A. Tsuji, Y. Kang, 1989, The Journal of pharmacology and experimental therapeutics.

Experimental Approaches to the Study of Drug Transporters

Y. Kato, A. Tsuji, Y. Kubo, 2014 .

Blood-Brain Barrier Transport of H1-Antagonist Ebastine and its Metabolite Carebastine

Y. Sai, I. Tamai, A. Tsuji, 2000, Journal of drug targeting.

Intestinal Brush‐border Membrane Transport of Monocarboxylic Acids Mediated by Proton‐coupled Transport and Anion Antiport Mechanisms

H. Takanaga, Y. Sai, I. Tamai, 1997, The Journal of pharmacy and pharmacology.

Uptake of drugs and expression of P-glycoprotein in the rat 9L glioma

T. Yamashima, T. Terasaki, A. Tsuji, 2004, Experimental Brain Research.

Transport mechanism for aluminum citrate at the blood-brain barrier: kinetic evidence implies involvement of system Xc- in immortalized rat brain endothelial cells.

I. Tamai, A. Tsuji, S. Ito, 2005, Toxicology letters.

Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier.

T. Terasaki, I. Tamai, A. Tsuji, 1993, The Journal of pharmacology and experimental therapeutics.

Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation.

S. Aizawa, J. Nezu, I. Tamai, 2004, Experimental hematology.

Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

M. Tomita, T. Matsui, S. Kaneko, 2010, Pharmaceutical Research.

Mutual interaction between bilirubin and cefazolin in binding to human serum albumin.

A. Tsuji, F. Ichimura, Y. Deguchi, 1990, Journal of pharmaceutical sciences.

Title Site-dependent contributions of P-glycoprotein and CYP 3 A to cyclosporinA absorption , and effect of dexamethasone in small intestine of mice

T. Shimada, K. Miyamoto, Y. Kato, 2017 .

Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

T. Soga, Kazuhiro Suzuki, N. Nakamichi, 2010, Drug Metabolism and Disposition.

Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters.

Y. Sai, I. Tamai, A. Tsuji, 1997, The Journal of pharmacology and experimental therapeutics.

PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.

P. Forrer, Zhuo-shen Zhao, A. Tsuji, 2003, Kidney international.

Expression and Functional Characterization of the Adhesion Molecule Spermatogenic Immunoglobulin Superfamily in the Mouse Testis1

Miyuki Yamamoto, Y. Sai, A. Tsuji, 2003, Biology of reproduction.

Secretory transport of p‐aminohippuric acid across intestinal epithelial cells in Caco‐2 cells and isolated intestinal tissue

Y. Sai, K. Naruhashi, I. Tamai, 2001, The Journal of pharmacy and pharmacology.

Physicochemical properties of amphoteric beta-lactam antibiotics I: Stability, solubility, and dissolution behavior of amino penicillins as a function of pH.

A. Tsuji, E. Nakashima, T. Yamana, 1978, Journal of pharmaceutical sciences.

Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells.

Y. Kato, A. Tsuji, S. Nishimura, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.

T. Hasegawa, K. Miyamoto, K. Takagi, 2004, European journal of pharmacology.

Stereoselective and Carrier-Mediated Transport of Monocarboxylic Acids Across Caco-2 Cells

H. Takanaga, Y. Sai, I. Tamai, 1996, Pharmaceutical Research.

Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane.

H. Takanaga, I. Tamai, A. Tsuji, 2000, Biochimica et biophysica acta.

Immunohistochemical and Functional Characterization of pH‐dependent Intestinal Absorption of Weak Organic Acids by the Monocarboxylic Acid Transporter MCT1

H. Takanaga, Y. Sai, I. Tamai, 1999, The Journal of pharmacy and pharmacology.

Multidrug Resistance—Associated Protein 1 Functions as an Efflux Pump of Xenobiotics in the Skin

T. Imai, Y. Kato, Y. Sai, 2005, Pharmaceutical Research.

Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy.

I. Tamai, A. Tsuji, H. Sato, 1990, Drug metabolism and disposition: the biological fate of chemicals.

Physiologically based pharmacokinetic model for beta-lactam antibiotics I: Tissue distribution and elimination in rats.

T. Terasaki, A. Tsuji, E. Miyamoto, 1983, Journal of pharmaceutical sciences.

Physiologically based pharmacokinetic model for cefazolin in rabbits and its preliminary extrapolation to man.

T. Terasaki, A. Tsuji, E. Nakashima, 1985, Drug metabolism and disposition: the biological fate of chemicals.

Sodium and Chloride Ion‐Dependent Transport of β‐Alanine Across the Blood‐Brain Barrier

T. Terasaki, Y. Sai, I. Tamai, 1996, Journal of neurochemistry.

Stereoselective hepatobiliary transport of the quinolone antibiotic grepafloxacin and its glucuronide in the rat.

H. Sasabe, Y. Sugiyama, Y. Kato, 1998, The Journal of pharmacology and experimental therapeutics.

Effect of Receptor Up-Regulation on Insulin Pharmacokinetics in Streptozotocin-Treated Diabetic Rats

T. Terasaki, Hitoshi Sato, A. Tsuji, 1991, Pharmaceutical Research.

Transporter-mediated renal handling of nafamostat mesilate.

Y. Kato, Y. Sai, I. Tamai, 2004, Journal of pharmaceutical sciences.

Study on Regulation of Pharmacokinetics of Drugs Based on the Membrane Transport Mechanisms

A. Tsuji, 2000 .

Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system.

T. Terasaki, I. Tamai, A. Tsuji, 1991, Journal of pharmacobio-dynamics.

Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of β‐lactam antibiotics

T. Nakanishi, Y. Sai, I. Tamai, 1996, FEBS letters.

Cationic polyrotaxanes effectively inhibit uptake via carnitine/organic cationic transporters without cytotoxicity.

Y. Kato, N. Yui, Ryo Katoono, 2008, Macromolecular bioscience.

Entrapping Efficiency and Drug Release Profile of an Oil-in-Water (o/w) Emulsion Formulation Using a Polydimethylsiloxane-Coated Glass Bead Assay

A. Tsuji, T. Suwa, Y. Kohno, 1994, Pharmaceutical Research.

[Strategies for drug delivery to the brain across the blood-brain barrier].

A. Tsuji, 1998, Nihon rinsho. Japanese journal of clinical medicine.

Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier.

T. Terasaki, I. Tamai, A. Tsuji, 1995, Biochemical pharmacology.

Characterization of cesium uptake mediated by a potassium transport system of bacteria in a soil conditioner.

H. Arakawa, A. Tsuji, T. Ogihara, 2014, Biological & pharmaceutical bulletin.

Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes.

T. Nakanishi, Y. Sai, I. Tamai, 2002, Drug metabolism and pharmacokinetics.

Heterophilic Binding of the Adhesion Molecules Poliovirus Receptor and Immunoglobulin Superfamily 4A in the Interaction Between Mouse Spermatogenic and Sertoli Cells1

Y. Kitamura, Y. Kato, Y. Sai, 2007, Biology of reproduction.

Determinant of the distribution volume at steady state for novel quinolone pazufloxacin in rats

A. Tsuji, Kyoko Takagi, Y. Kawamura, 2002, The Journal of pharmacy and pharmacology.

Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction.

Y. Kato, I. Tamai, A. Tsuji, 2009, Biological & pharmaceutical bulletin.

Cancer Detection Using a PET Tracer, 11C-Glycylsarcosine, Targeted to H+/Peptide Transporter

Y. Kato, A. Tsuji, Yukio Nakamura, 2008, Journal of Nuclear Medicine.

PDZK 1 Regulates Two Intestinal Solute Carriers ( Slc 15 a 1 and Slc 22 a 5 ) in Mice

Y. Kato, A. Tsuji, D. Silver, 2008 .

Delivery of Peptide Drugs to the Brain by Adenovirus-Mediated Heterologous Expression of Human Oligopeptide Transporter at the Blood-Brain Barrier

Y. Sai, I. Tamai, A. Tsuji, 2003, Journal of Pharmacology and Experimental Therapeutics.

Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.

H. Yamamoto, Y. Sai, E. Takeda, 1996, Biochimica et biophysica acta.

Functional expression of transporter for beta-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines.

H. Higashida, I. Tamai, A. Tsuji, 1995, The Journal of pharmacology and experimental therapeutics.

Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes.

T. Terasaki, H. Higashida, I. Tamai, 1994, Biochemical pharmacology.

H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.

T. Terasaki, I. Tamai, A. Tsuji, 1987, The Journal of pharmacology and experimental therapeutics.

Stereospecific Absorption and Degradation of Cephalexin

I. Tamai, A. Tsuji, He Ling, 1988, The Journal of pharmacy and pharmacology.

Influence of Drugs and Nutrients on Transporter Gene Expression Levels in Caco-2 and LS180 Intestinal Epithelial Cell Lines

Y. Kato, Y. Sai, I. Tamai, 2003, Pharmaceutical Research.

Effect of stress on the pharmacokinetics of amikacin and ticarcillin.

A. Tsuji, J. Mordenti, R. Quintiliani, 1987, Journal of pharmaceutical sciences.

PepT1 mRNA Expression Is Induced by Starvation and Its Level Correlates with Absorptive Transport of Cefadroxil Longitudinally in the Rat Intestine

Y. Sai, K. Naruhashi, I. Tamai, 2002, Pharmaceutical Research.

Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells.

Y. Sai, I. Tamai, A. Tsuji, 1998, The American journal of physiology.

Nicotinic Acid Transport Mediated by pH‐dependent Anion Antiporter and Proton Cotransporter in Rabbit Intestinal Brush‐border Membrane

H. Takanaga, H. Higashida, I. Tamai, 1996, The Journal of pharmacy and pharmacology.

Effects of Surfactants on the GI Absorption of β-Lactam Antibiotics in Rats

A. Tsuji, E. Miyamoto, T. Yamana, 1983 .

Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood‐brain barrier

Y. Sai, I. Tamai, A. Tsuji, 2001, The Journal of pharmacy and pharmacology.

Drug delivery to the brain utilizing blood-brain barrier transport systems

T. Terasaki, A. Tsuji, 1994 .

In‐vitro Evidence for Carrier‐mediated Uptake of Acidic Drugs by Isolated Bovine Brain Capillaries

T. Terasaki, A. Tsuji, Young-Sook Kang, 1991, The Journal of pharmacy and pharmacology.

In vivo and in vitro evidence for a common carrier mediated transport of choline and basic drugs through the blood-brain barrier.

T. Terasaki, A. Tsuji, Y. Kang, 1990, Journal of pharmacobio-dynamics.

Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice

A. Harada, Y. Kato, A. Tsuji, 2009, Drug Metabolism and Disposition.

Intestinal brush‐border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits

T. Terasaki, I. Tamai, A. Tsuji, 1993, The Journal of pharmacy and pharmacology.

β-Lactam antibiotics and transport via the dipeptide carrier system across the intestinal brush-border membrane

T. Terasaki, I. Tamai, A. Tsuji, 1987 .

Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer.

I. Tamai, A. Tsuji, D. Kobayashi, 2003, Journal of pharmaceutical sciences.

Intestinal absorption mechanism of amphoteric beta-lactam antibiotics I: Comparative absorption and evidence for saturable transport of amino-beta-lactam antibiotics by in situ rat small intestine.

A. Tsuji, E. Nakashima, T. Yamana, 1981, Journal of pharmaceutical sciences.

Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.

T. Terasaki, I. Tamai, A. Tsuji, 1993, Biochemical pharmacology.

Sodium- and chloride-dependent transport of taurine at the blood-brain barrier.

I. Tamai, A. Tsuji, 1996, Advances in experimental medicine and biology.

In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier.

I. Tamai, A. Tsuji, K Kawazu, 1994, Biochemical pharmacology.

Blood‐brain‐barrier Transport of Lipid Microspheres Containing Clinprost, a Prostaglandin I2 Analogue

Y. Sai, K. Sakanaka, I. Tamai, 1996, The Journal of pharmacy and pharmacology.

Muscle microdialysis as a model study to relate the drug concentration in tissue interstitial fluid and dialysate.

T. Terasaki, A. Tsuji, Y. Deguchi, 1991, Journal of pharmacobio-dynamics.

Kinetics of Michaelis‐Menten absorption of amino‐penicillins in rats

A. Tsuji, E. Nakashima, T. Asano, 1978, The Journal of pharmacy and pharmacology.

Effect of γ‐butyrobetaine on fatty liver in juvenile visceral steatosis mice

M. Nomura, I. Tamai, A. Tsuji, 2001 .

Title Involvement of multidrug resistance-associated protein 1 in intestinaltoxicity of methotrexate

Y. Kato, A. Tsuji, Y. Kubo, 2017 .

Gene Knockout and Metabolome Analysis of SLC22A4

M. Tomita, M. Sugimoto, T. Soga, 2010 .

PDZK 1 Directly Regulates the Function of Organic Cation / Carnitine Transporter OCTN 2

Y. Kato, Y. Sai, A. Tsuji, 2004 .

L-type fatty acid binding protein transgenic mouse as a novel tool to explore cytotoxicity to renal proximal tubules.

Kimihiro Ito, T. Sugaya, Y. Kato, 2008, Drug metabolism and pharmacokinetics.

Small molecular drug transfer across the blood-brain barrier via carrier-mediated transport systems

A. Tsuji, 2011, NeuroRX.

Functional Clarification of MCT1-Mediated Transport of Monocarboxylic Acids at the Blood-Brain Barrier Using In Vitro Cultured Cells and In Vivo BUI Studies

I. Tamai, A. Tsuji, F. Suzuki, 2004, Pharmaceutical Research.

Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids.

H. Takanaga, Y. Sai, H. Higashida, 1995, Biochemical and biophysical research communications.

Comparative stability of cephalosporins in aqueous solution: kinetics and mechanisms of degradation.

A. Tsuji, T. Yamana, A Tsuji, 1976, Journal of pharmaceutical sciences.

Degradation kinetics and mechanism of aminocephalosporins in aqueous solution: cefadroxil.

A. Tsuji, S. Horiuchi, E. Nakashima, 1981, Journal of pharmaceutical sciences.

Inhibitory effect of supramolecular polyrotaxane-dipeptide conjugates on digested peptide uptake via intestinal human peptide transporter.

Y. Sai, N. Yui, T. Ooya, 2002, Bioconjugate chemistry.

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

J. Nezu, I. Tamai, A. Tsuji, 2004, Journal of Pharmacology and Experimental Therapeutics.

P-glycoprotein (Abcb1) is involved in absorptive drug transport in skin.

Yukio Kato, Akira Tsuji, Yoshiyuki Kubo, 2008, Journal of controlled release : official journal of the Controlled Release Society.

Kinetic analysis and characterization of the bacterial regrowth after treatment of Escherichia coli with beta-lactam antibiotics.

S. Mitsuhashi, I. Tamai, A. Tsuji, 1984, Journal of pharmaceutical sciences.

Hydrolysis and epimerization kinetics of hetacillin in aqueous solution.

A. Tsuji, T. Yamana, Y. Itatani, 1977, Journal of pharmaceutical sciences.

Novel method for determination of partition coefficients of penicillins and cephalosporins by high-pressure liquid chromatography.

A. Tsuji, E. Miyamoto, T. Yamana, 1977, Journal of pharmaceutical sciences.

Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency.

T. Matsuishi, S. Kibira, J. Nezu, 1999, Human molecular genetics.

Involvement of Human Organic Anion Transporting Polypeptide OATP-B (SLC21A9) in pH-Dependent Transport across Intestinal Apical Membrane

J. Nezu, I. Tamai, A. Tsuji, 2003, Journal of Pharmacology and Experimental Therapeutics.

Introduction to the Blood–Brain Barrier: Blood–brain barrier transport of drugs

I. Tamai, A. Tsuji, 1998 .

Kinetic approach to the development in beta-lactam antibiotics. I. Comparative stability of semisynthetic penicllins and 6-aminopenicillanic acid in aqueous solution.

A. Tsuji, T. Yamana, A Tsuji, 1974, Chemical & pharmaceutical bulletin.

Selective analysis of mutual displacement effects at the primary binding sites of phenoxymethylpenicillin and cephalothin bindings to human serum albumin.

T. Terasaki, A. Tsuji, H. Nouda, 1992, Journal of pharmacobio-dynamics.

Relationship between lipophilicity and binding affinity with human serum albumin for penicillin and cephem antibiotics.

T. Terasaki, A. Tsuji, H. Nouda, 1992, Journal of pharmacobio-dynamics.

Evidence for the existence of a common transport system of beta-lactam antibiotics in isolated rat hepatocytes.

T. Terasaki, I. Tamai, A. Tsuji, 1985, The Journal of antibiotics.

ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate.

Yukio Kato, Akira Tsuji, Tomoko Sugiura, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Improved nasal bioavailability of elcatonin by insoluble powder formulation.

I. Tamai, A. Tsuji, F. Ishikawa, 2001, International journal of pharmaceutics.

pH‐Dependent and Carrier‐mediated Transport of Salicylic Acid Across Caco‐2 Cells

H. Takanaga, I. Tamai, A. Tsuji, 1994, The Journal of pharmacy and pharmacology.

pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H(+)-cotransport mechanism versus pH-partition hypothesis.

T. Terasaki, I. Tamai, A. Tsuji, 1990, Journal of Pharmacy and Science.

Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.

A. Guo, T. Nakanishi, I. Tamai, 1998, Biochemical and biophysical research communications.

pH-Dependent and Carrier-mediated Acid Across Caco-2 Transport of Salicylic Cells

H. Takanaga, I. Tamai, A. Tsuji, 2010 .

Application of Fractal Kinetics for Carrier-Mediated Transport of Drugs Across Intestinal Epithelial Membrane

Akira Tsuji, Takuo Ogihara, I. Tamai, 1998, Pharmaceutical Research.

Possible Role of Anion Exchanger AE2 as the Intestinal Monocarboxylic Acid/Anion Antiporter

Y. Sai, I. Tamai, A. Tsuji, 1998, Pharmaceutical Research.

Carrier-Mediated Intestinal Transport of Drugs

Akira Tsuji, I. Tamai, A. Tsuji, 1996, Pharmaceutical Research.

Transcellular Transport of Benzole Acid Across Caco-2 Cells by a pH-Dependent and Carrier-Mediated Transport Mechanism

H. Takanaga, T. Terasaki, I. Tamai, 2004, Pharmaceutical Research.

Structural characterization of substrates for the anion exchange transporter in Caco-2 cells.

I. Tamai, A. Tsuji, T. Ogihara, 1999, Journal of pharmaceutical sciences.

Organic anion transporters.

I. Tamai, A. Tsuji, 1999, Pharmaceutical biotechnology.

Carrier-mediated approaches for oral drug delivery

I. Tamai, A. Tsuji, 1996 .

Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles.

T. Terasaki, I. Tamai, A. Tsuji, 1991, Journal of pharmacobio-dynamics.

Effects of surfactants on the aqueous stability and solubility of beta-lactam antibiotics.

A. Tsuji, E. Miyamoto, T. Yamana, 1982, Journal of pharmaceutical sciences.

GI absorption of beta-lactam antibiotics II: deviation from pH--partition hypothesis in penicillin absorption through in situ and in vitro lipoidal barriers.

A. Tsuji, E. Miyamoto, T. Yamana, 1978, Journal of pharmaceutical sciences.

Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes

I. Tamai, A. Tsuji, H. Kato, 1988, Antimicrobial Agents and Chemotherapy.

Prediction of the Distribution Volumes of Cefazolin and Tobramycin in Obese Children Based on Physiological Pharmacokinetic Concepts

L. Benet, A. Tsuji, E. Nakashima, 1989, Pharmaceutical Research.

Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.

J. Nezu, A. Oku, M. Shimane, 1999, The Journal of pharmacology and experimental therapeutics.

Physicochemical properties of beta-lactam antibacterials: deuterium solvent isotope effect on penicillin G degradation rate.

A. Tsuji, E. Miyamoto, T. Yamana, 1977, Journal of pharmaceutical sciences.

A Time- and Cost-Saving Method of Producing Rat Polyclonal Antibodies

Y. Kato, A. Tsuji, T. Wakayama, 2006, Acta histochemica et cytochemica.

A new fluorometric method for simultaneous determination of penicillins and penicilloic acids

A. Tsuji, Etsuko Miyamoto, Tsukinaka Yamana, 1978, The Journal of pharmacy and pharmacology.

Kinetics of benzylpenicillin metabolism in isolated rat hepatocytes.

I. Tamai, A. Tsuji, 1987, The Journal of antibiotics.

Carbenicillin Prodrugs: Stability Kinetics of α-phenyl and α-indanyl Esters in Aqueous Solution

T. Terasaki, A. Tsuji, E. Miyamoto, 1979 .

Chemical reactions in cephalosporin allergy: high-pressure liquid chromatographic analysis of cephalosporin aminolysis kinetics.

A. Tsuji, E. Miyamoto, T. Yamana, 1979, Journal of pharmaceutical sciences.

Chemical reactions involved in penicillin allergy: kinetics and mechanism of penicillin aminolysis

A. Tsuji, E. Miyamoto, T. Yamana, 1975, The Journal of pharmacy and pharmacology.

Chemical aspects of penicillin allergy: imidazole‐catalysed penicilloylation

A. Tsuji, E. Miyamoto, T. Yamana, 1975, The Journal of pharmacy and pharmacology.

P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells.

T. Tsuruo, T. Yamashima, T. Terasaki, 1992, Life sciences.

Determination of Protein Binding of a Highly Lipophilic Drug, Isocarbacyclin Methyl Ester (TEI‐9090), Using a Polydimethylsiloxane‐coated Glass Beads Assay

A. Tsuji, T. Suwa, Y. Kohno, 1994, The Journal of pharmacy and pharmacology.

Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells.

Y. Sai, K. Naruhashi, I. Tamai, 2003, Journal of pharmaceutical sciences.

Effect of dose‐concentration on the absorption of amoxicillin and ampicillin from the rat intestine

A. Tsuji, T. Yamana, N. Honjo, 1977, The Journal of pharmacy and pharmacology.

Transporter-mediated drug delivery: recent progress and experimental approaches.

Akira Tsuji, Y. Sai, A. Tsuji, 2004, Drug discovery today.

Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin.

H. Kusuhara, Y. Sugiyama, K. Miyamoto, 2013, Journal of pharmaceutical sciences.

p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1.

Y. Minemoto, Y. Sai, E. Takeda, 2000, Biochemical and biophysical research communications.

Molecular and Functional Identification of Sodium Ion-dependent, High Affinity Human Carnitine Transporter OCTN2*

J. Nezu, A. Oku, M. Shimane, 1998, The Journal of Biological Chemistry.

Serum protein binding of lomefloxacin, a new antimicrobial agent, and its related quinolones.

T. Terasaki, A. Tsuji, E. Okezaki, 1989, Journal of pharmaceutical sciences.

Molecular and cytogenetic characterization of the mouse ATP-binding cassette transporter Abcg4.

T. Ishikawa, Y. Matsuda, Y. Sai, 2002, Gene.

Studies on Functional Sites of Organic Cation/Carnitine Transporter OCTN2 (SLC22A5) Using a Ser467Cys Mutant Protein

J. Nezu, Y. Sai, I. Tamai, 2002, Journal of Pharmacology and Experimental Therapeutics.

Molecular and Functional Characterization of Carnitine/Organic Cation Transporter OCTN Family in Human and Mouse.

J. Nezu, A. Oku, M. Shimane, 2000 .

Effects of fasting on biperiden pharmacokinetics in the rat.

A. Tsuji, T. Hashimoto, E. Nakashima, 1987, Journal of Pharmacy and Science.

Transporter-mediated Drug Interactions.

A. Tsuji, 2002, Drug metabolism and pharmacokinetics.

Blood-brain barrier function of P-glycoprotein

I. Tamai, A. Tsuji, 1997 .

Drug delivery through the blood-brain barrier

Akira Tsuji, I. Tamai, A. Tsuji, 1996 .

GI absorption of beta-lactam antibiotics I: kinetic assessment of competing absorption and degradation in GI tract.

A. Tsuji, E. Miyamoto, T. Yamana, 1978, Journal of pharmaceutical sciences.

Comparative stabilities of cephalosporins in aqueous solution.

A. Tsuji, T. Yamana, O. Nakano, 1974, The Journal of antibiotics.

Saturable absorption of amino‐cephalosporins by the rat intestine

A. Tsuji, E. Nakashima, T. Yamana, 1979, The Journal of pharmacy and pharmacology.

ROLE OF ORGANIC ANION TRANSPORTER OATP1B1 (OATP-C) IN HEPATIC UPTAKE OF IRINOTECAN AND ITS ACTIVE METABOLITE, 7-ETHYL-10-HYDROXYCAMPTOTHECIN: IN VITRO EVIDENCE AND EFFECT OF SINGLE NUCLEOTIDE POLYMORPHISMS

Shigeki Sugiura, Akira Tsuji, I. Tamai, 2005, Drug Metabolism and Disposition.

Contribution of organic anion transporting polypeptide OATP‐C to hepatic elimination of the opioid pentapeptide analogue [d‐Ala 2 , d‐Leu5]‐enkephalin

Akira Tsuji, J. Nezu, Y. Sai, 2003, The Journal of pharmacy and pharmacology.

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.

J. Nezu, Y. Sai, I. Tamai, 2002, The Journal of pharmacology and experimental therapeutics.

Characteristics of L‐Carnitine Transport in Cultured Human Hepatoma HLF Cells

K. Miyamoto, M. Nomura, I. Tamai, 1999, The Journal of pharmacy and pharmacology.

Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice.

M. Nomura, I. Tamai, A. Tsuji, 1999, The Journal of pharmacology and experimental therapeutics.

Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter

G. Tsujimoto, T. Matsuishi, J. Nezu, 1999, Nature Genetics.

Influx transporters and drug targeting: Application of peptide and cation transporters

A. Tsuji, 2005 .

Application of Muscle Microdialysis to Evaluate the Concentrations of the Fluoroquinolones Pazufloxacin and Ofloxacin in the Tissue Interstitial Fluids of Rats

I. Tamai, A. Tsuji, H. Narita, 1997, The Journal of pharmacy and pharmacology.

Transporter-mediated permeation of drugs across the blood-brain barrier.

I. Tamai, A. Tsuji, I Tamai, 2000, Journal of pharmaceutical sciences.

Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats.

Y. Sugiyama, A. Tsuji, Q. Meng, 2010, Drug metabolism and pharmacokinetics.

In Vivo and in Vitro Blood–Brain Barrier Transport of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors

T. Terasaki, I. Tamai, A. Tsuji, 1994, Pharmaceutical Research.

Involvement of Multidrug Resistance-Associated Protein 2 in Intestinal Secretion of Grepafloxacin in Rats

Y. Sai, K. Naruhashi, I. Tamai, 2002, Antimicrobial Agents and Chemotherapy.

Effect of surfactants on degradation of penicillins and cephalosporins in acidic medium

A. Tsuji, E. Miyamoto, T. Yamana, 1978, The Journal of pharmacy and pharmacology.

Physicochemical Properties of β-Lactam Antibiotics: Oil-Water Distribution

A. Tsuji, E. Miyamoto, T. Yamana, 1977 .

Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.

J. Nezu, A. Oku, M. Shimane, 1999, The Journal of pharmacology and experimental therapeutics.

In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier.

T. Yamashima, K. Sakanaka, I. Tamai, 1995, Biochemical pharmacology.

Involvement of organic anion transport system in transdermal absorption of flurbiprofen.

Y. Kato, A. Tsuji, Y. Kubo, 2007, Journal of controlled release : official journal of the Controlled Release Society.

Mutual effects of amino-beta-lactam antibiotics and glycylglycine on the transmural potential difference in the small intestinal epithelium of rats.

A. Tsuji, E. Nakashima, 1985, Journal of pharmacobio-dynamics.

Kinetics and mechanism of in vitro uptake of amino-beta-lactam antibiotics by rat small intestine and relation to the intact-peptide transport system.

A. Tsuji, H. Mizuo, E. Nakashima, 1984, Biochemical pharmacology.

Active Secretion of Drugs from the Small Intestinal Epithelium in Rats by P‐Glycoprotein Functioning as an Absorption Barrier

Y. Sai, I. Tamai, A. Tsuji, 1996, The Journal of pharmacy and pharmacology.

Carnitine/xenobiotics transporters in the human mammary gland epithelia, MCF12A.

J. Nezu, P. Harper, I. Tamai, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Application of HPLC in Disposition Study of A14-125I-Labeled Insulin in Mice

A. Tsuji, Y. Kang, Young-Sook Kang, 1990, Diabetes.

Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): roles in carnitine recognition.

Y. Kato, Y. Sai, M. Ishiguro, 2004, Drug metabolism and pharmacokinetics.

Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency.

I. Tamai, A. Tsuji, F. Suzuki, 1998, Biochemical pharmacology.

Intestinal absorption mechanism of amphoteric beta-lactam antibiotics II: Michaelis-Menten kinetics of cyclacillin absorption and its pharmacokinetic analysis in rats.

A. Tsuji, E. Nakashima, T. Yamana, 1981, Journal of pharmaceutical sciences.

GI absorption of beta-lactam antibiotics. III: Kinetic evidence for in situ absorption of ionized species of monobasic penicillins and cefazolin from the rat small intestine and structure-absorption rate relationships.

A. Tsuji, E. Miyamoto, T. Yamana, 1979, Journal of pharmaceutical sciences.

Intraocular penetration kinetics of prednisolone after subconjunctival injection in rabbits.

I. Tamai, A. Tsuji, K. Sasaki, 1988, Ophthalmic research.

PEPT (SLC15A) Family

Y. Kato, A. Tsuji, T. Sugiura, 2013 .

Insoluble Powder Formulation as an Effective Nasal Drug Delivery System

Toshikazu Yamaguchi, I. Tamai, A. Tsuji, 2002, Pharmaceutical Research.

Evaluation of predictability for vancomycin dosage regimens by the Bayesian method with Japanese population pharmacokinetic parameters.

K. Miyamoto, A. Tsuji, H. Teramachi, 2002, Biological & pharmaceutical bulletin.

Acetyl‐L‐carnitine permeability across the blood–brain barrier and involvement of carnitine transporter OCTN2

Y. Sai, I. Tamai, A. Tsuji, 2003, Biopharmaceutics & drug disposition.

Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport.

T. Terasaki, I. Tamai, A. Tsuji, 1990, Journal of pharmacobio-dynamics.

Stability kinetics of ginsenosides in aqueous solution.

A. Tsuji, E. Miyamoto, I. Kitagawa, 1984, Journal of pharmaceutical sciences.

Mechanisms of intestinal absorption of the antibiotic, fosfomycin, in brush-border membrane vesicles in rabbits and humans.

T. Terasaki, I. Tamai, A. Tsuji, 1992, Journal of pharmacobio-dynamics.

Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane.

T. Terasaki, I. Tamai, A. Tsuji, 1990, Journal of pharmacobio-dynamics.

Hepatic Uptake of Octreotide, a Long-Acting Somatostatin Analogue, via a Bile Acid Transport System

T. Terasaki, I. Tamai, A. Tsuji, 2004, Pharmaceutical Research.

Na+/H+ exchanger 3 affects transport property of H+/oligopeptide transporter 1.

Yukio Kato, Akira Tsuji, Yoshiyuki Kubo, 2005, Drug metabolism and pharmacokinetics.

Carrier-mediated transport of cefixime, a new cephalosporin antibiotic, via an organic anion transport system in the rat renal brush-border membrane.

I. Tamai, A. Tsuji, Y. Kin, 1988, The Journal of pharmacology and experimental therapeutics.

Saturable uptake of cefixime, a new oral cephalosporin without an α‐amino group, by the rat intestine

T. Terasaki, I. Tamai, A. Tsuji, 1987, The Journal of pharmacy and pharmacology.

Physicochemical properties of amphoteric beta-lactam antibiotics. II: Solubility and dissolution behavior of aminocephalosporins as a function of pH.

A. Tsuji, E. Nakashima, T. Yamana, 1979, Journal of pharmaceutical sciences.

Pharmacokinetic behaviour in polymorphonuclear leucocytes of N,N‐dimethylcarbamoylmethyl α,2‐dimethyl‐5H‐[1]benzopyrano[2,3‐b]‐pyridine‐7‐acetate (Y‐23023), a new prodrug type of antiinflammatory agent, and indomethacin after oral administrations in rats

A. Tsuji, I. Yamada, Y. Nagamatsu, 1994, The Journal of pharmacy and pharmacology.

Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.

I. Tamai, A. Tsuji, M Kawahara, 1999, Journal of pharmaceutical sciences.

Tissue selective drug delivery utilizing carrier-mediated transport systems.

A. Tsuji, 1999, Journal of controlled release : official journal of the Controlled Release Society.

Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique.

T. Terasaki, A. Tsuji, O. Nagata, 1994, Biological and Pharmaceutical Bulletin.

Functional Expression of Stereoselective Metabolism of Cephalexin by Exogenous Transfection of Oligopeptide Transporter PEPT1

Y. Kato, A. Tsuji, Y. Kubo, 2007, Drug Metabolism and Disposition.

Carrier-Mediated Transport of H1-Antagonist at the Blood-Brain Barrier: A Common Transport System of H1-Antagonists and Lipophilic Basic Drugs

T. Terasaki, A. Tsuji, Yasuo Ito, 1994, Pharmaceutical Research.

Carrier-Mediated Transport of H1-Antagonist at the Blood–Brain Barrier: Mepyramine Uptake into Bovine Brain Capillary Endothelial Cells in Primary Monolayer Cultures

T. Terasaki, A. Tsuji, Yasuo Ito, 1994, Pharmaceutical Research.

Carrier-mediated lung distribution of HSR-903, a new quinolone antibacterial agent.

Y. Sai, I. Tamai, A. Tsuji, 1999, The Journal of pharmacology and experimental therapeutics.

Racemization kinetics of meluadrine tartrate in aqueous solution.

A. Tsuji, O. Nagata, H. Kato, 2001, Chemical & pharmaceutical bulletin.

Dysfunction of choline transport system through blood-brain barrier in stroke-prone spontaneously hypertensive rats.

T. Terasaki, A. Tsuji, Y. Kang, 1990, Journal of pharmacobio-dynamics.

Kinetics and mechanism of penicillin aminolysis involved in penicillin allergy

A. Tsuji, E. Miyamoto, T. Yamana, 1975, The Journal of pharmacy and pharmacology.

The reaction of benzylpenicillin with amines containing hydroxyl groups

A. Tsuji, E. Miyamoto, T. Yamana, 1975, The Journal of pharmacy and pharmacology.

Asymmetric Intestinal First-Pass Metabolism Causes Minimal Oral Bioavailability of Midazolam in Cynomolgus Monkey

Y. Kato, A. Tsuji, N. Amano, 2007, Drug Metabolism and Disposition.

Role of MRP family proteins in the export of organic anion compounds from liver and intestine

Y. Sugiyama, X. Chu, Takao Shimizu, 1997 .

Application of Cell Culture Systems to the Study of Drug Transport and Metabolism

K. Audus, B. Hirst, R. Borchardt, 1995 .

Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug.

I. Tamai, A. Tsuji, K. Ueno, 2003, Journal of pharmaceutical sciences.

Interindividual changes in volume of distribution of cefazolin in newborn infants and its prediction based on physiological pharmacokinetic concepts.

A. Tsuji, E. Nakashima, F. Ichimura, 1988, Journal of pharmaceutical sciences.

T. Terasaki, A. Tsuji, K. Nishide, 1986, Journal of pharmacobio-dynamics.

Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol.

Y. Kato, A. Tsuji, T. Sugiura, 2009, Journal of pharmaceutical sciences.

A carrier‐mediated transport system for benzylpenicillin in isolated hepatocytes

T. Terasaki, I. Tamai, A. Tsuji, 1985, The Journal of pharmacy and pharmacology.

Hepatobiliary transport kinetics of HSR-903, a new quinolone antibacterial agent.

Y. Sugiyama, Y. Sai, I. Tamai, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Species Difference in Intestinal Absorption Mechanism of Etoposide and Digoxin between Cynomolgus Monkey and Rat

Y. Kato, A. Tsuji, N. Amano, 2008, Pharmaceutical Research.

Stabilization of Drugs. I. The Quantitative Prediction of the pH-Dependency of Amide and Anilide Hydrolyses by Neighboring Hydroxyl Groups

A. Tsuji, T. Yamana, Y. Mizukami, 1973 .

Studies on the Stability of Amides. IV. Intramolecular Hydroxyl Group Participation in the Acidic Hydrolysis of Aliphatic Amides

A. Tsuji, T. Yamana, Y. Mizukami, 1972 .

The Predominant Contribution of Oligopeptide Transporter PepT1 to Intestinal Absorption of β‐Lactam Antibiotics in the Rat Small Intestine

T. Nakanishi, Y. Sai, H. Higashida, 1997, The Journal of pharmacy and pharmacology.

Decalcification of calcium polycarbophil in rats.

I. Tamai, A. Tsuji, T. Saito, 1997, Biological & pharmaceutical bulletin.

Physicochemical Properties of Calcium Polycarbophil, a Water‐absorbing Polymer

I. Tamai, A. Tsuji, O. Nagata, 1996, The Journal of pharmacy and pharmacology.

[Tissue distribution of the multidrug-resistance gene product P-glycoprotein and its physiological function].

I. Tamai, A. Tsuji, A. Sakata, 1997, Nihon rinsho. Japanese journal of clinical medicine.

Comparative Examination of the Initial Dosage Setting of Vancomycin Therapy in the Adult MRSA Patients.

K. Miyamoto, A. Tsuji, H. Teramachi, 2002 .

Specific binding and clearance of [3H]dynorphin (1–13) in the perfused rat lung: an application of the multiple‐indicator dilution method

T. Terasaki, A. Tsuji, H. Sato, 1990, The Journal of pharmacy and pharmacology.

Adsorptive-Mediated Transcytosis of a Synthetic Basic Peptide, 001-C8 in Caco-2 Cells

Y. Sai, I. Tamai, A. Tsuji, 1998, Pharmaceutical Research.

Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis.

Y. Sai, I. Tamai, A. Tsuji, 1998, Bioorganic & medicinal chemistry.

Metabolism and disposition of novel des-fluoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters.

A. Tsuji, H. Kato, Hiroyuki Fukumoto, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Acidic drug transport in vivo through the blood-brain barrier. A role of the transport carrier for monocarboxylic acids.

T. Terasaki, A. Tsuji, Y. Kang, 1990, Journal of pharmacobio-dynamics.

Carrier-mediated or specialized transport of drugs across the blood-brain barrier.

I. Tamai, A. Tsuji, Tsuji, 1999, Advanced drug delivery reviews.

Entrapping Efficiency of an Oil-in-Water Emulsion Containing Isocarbacyclin Methyl Ester (TEI-9090) in Dog and Human Sera

A. Tsuji, T. Suwa, Y. Kohno, 1994, Pharmaceutical Research.

Quantitative relationship between structure and peritoneal membrane transport based on physiological pharmacokinetic concepts for acidic drugs.

A. Tsuji, E. Nakashima, F. Ichimura, 1995, Drug metabolism and disposition: the biological fate of chemicals.

[The pharmacogenomics of drug transporters: functional analysis approaches].

T. Ishikawa, H. Endou, A. Tsuji, 2004, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats.

J. Terao, K. Miyamoto, A. Tsuji, 2011, Free radical biology & medicine.

Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice

A. Harada, Y. Kato, A. Tsuji, 2009, Drug Metabolism and Disposition.

Physiologically based pharmacokinetic prediction of p ‐phenylbenzoic acid disposition in the pregnant rat

A. Tsuji, T. Nanbo, M. Kawahara, 1998, Biopharmaceutics & drug disposition.

Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse.

Y. Kato, Y. Sai, I. Tamai, 2006 .