D. Clarke

发表

Human cloned α1A-adrenoceptor isoforms display α1L-adrenoceptor pharmacology in functional studies

J. Gever, A. Ford, D. V. Daniels, 1999 .

Molecular cloning, genomic characterization and expression of novel human α1A‐adrenoceptor isoforms

A. Ford, D. V. Daniels, R. Eglen, 1998 .

Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons

K. Bley, D. Clarke, J. Hunter, 1997, PAIN.

Pre-synaptic 5-HT Receptors Mediating Inhibition of Transmitter Release from Peripheral Cholinergic and Noradrenergic Nerves

D. Clarke, R. Bond, D. Blue, 1989 .

Partial agonistic activity of GR43175 at the inhibitory prejunctional 5-HT1-like receptor in rat kidney.

D. Clarke, D. Craig, R. Bond, 1989, Journal of autonomic pharmacology.

Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the α‐ and β‐subtypes

D. Clarke, R. Bond, 1988 .

SDZ NVI 085, an alpha 1A-adrenoceptor agonist with 5-HT2A receptor antagonist properties.

A. Ford, D. Clarke, W. Lachnit, 1996, European journal of pharmacology.

RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for functional alpha 1-adrenoceptors in human prostate: implications for adrenoceptor classification.

T. Stamey, A. Ford, J. McNeal, 1996, Molecular pharmacology.

α1-Adrenoceptor classification: sharpening Occam's razor

A. Ford, T. Williams, D. Clarke, 1994 .

In vivo monoamine oxidase inhibition by d-amphetamine.

D. Clarke, P. A. Shore, H. H. Miller, 1980, Biochemical pharmacology.

The 5-HT4 receptor: a place in the sun.

J. Fozard, J. Bockaert, D. Clarke, 1992, Trends in pharmacological sciences.

Semicarbazide-sensitive amine oxidase activity in streptozotocin diabetic rats.

D. Clarke, B. E. Hayes, 1990, Research communications in chemical pathology and pharmacology.

A comparison of cardiac and vascular clorgyline-resistant amine oxidase and monoamine oxidase. Inhibition by amphetamine, mexiletine and other drugs.

D. Clarke, B. Callingham, G. A. Lyles, 1982, Biochemical pharmacology.

Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluoromethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder.

D. Clarke, A. Leonardi, R. Testa, 2001, The Journal of urology.

Characterization of α1‐adrenoceptors mediating vasoconstriction to noradrenaline and nerve stimulation in the isolated perfused mesentery of rat

T. Williams, D. Clarke, 1995, British journal of pharmacology.

The 5-HT4 receptor: naughty, but nice.

J. Fozard, D. Clarke, D. Craig, 1989, Trends in pharmacological sciences.

Unsurmountable antagonism to 5-hydroxytryptamine in rat kidney results from pseudoirreversible inhibition rather than multiple receptors or allosteric receptor modulation.

D. Clarke, R. Bond, A. Ornstein, 1989, The Journal of pharmacology and experimental therapeutics.

Effect of cyclooxygenase inhibitors on the micturition reflex in rats: correlation with inhibition of cyclooxygenase isozymes

D. Clarke, A. Leonardi, R. Testa, 2006, BJU international.

Subchronic Toxicity of Atorvastatin, a Hydroxymethylglutaryl-Coenzyme A Reductase Inhibitor, in Beagle Dogs

M. Albassam, D. Clarke, K. Walsh, 1996, Toxicologic pathology.

A response to isoprenaline unrelated to α‐and β‐adrenoceptor agonism

D. Clarke, R. Bond, 1987 .

In vitroα1‐adrenoceptor pharmacology of Ro 70–0004 and RS‐100329, novel α1A‐adrenoceptor selective antagonists

J. Gever, A. Ford, D. V. Daniels, 1999 .

Pharmacological characterization of a neuronal receptor for 5-hydroxytryptamine in guinea pig ileum with properties similar to the 5-hydroxytryptamine receptor.

D. Clarke, D. Craig, 1990, The Journal of pharmacology and experimental therapeutics.

Peristalsis evoked by 5‐HT and renzapride: evidence for putative 5‐HT4 receptor activation

D. Clarke, D. Craig, 1991, British journal of pharmacology.

Histochemical fluorescence studies on noradrenaline accumulation by Uptake2 in the isolated rat heart

C. J. Jones, D. Clarke, P. Linley, 1969, British journal of pharmacology.

5-Hydroxytryptamine4 receptors mediate relaxation of the rat oesophageal tunica muscularis mucosae

D. Clarke, D. Craig, G. Baxter, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Benzimidazolone derivatives act as 5-HT4 receptor ligands in rat oesophagus.

D. Clarke, G. Baxter, 1992, European journal of pharmacology.

Therapeutic Possibilities with Serotonergic Drugs

A. Ford, D. Hoyer, D. Clarke, 1995 .

Cardiac norepinephrine releasing action of kynuramine, an endogenous diamine derived from L-tryptophan.

D. Clarke, T. Johnson, K. Charlton, 1984, Life sciences.

Effects of prolonged administration of certain antihypertensive agents.

D. Clarke, J. Buckley, B. Jandhyala, 1974, Journal of pharmaceutical sciences.

Benzylamine oxidase in normal and atherosclerotic human aortae.

D. Clarke, P. Ostrow, B. E. Hayes, 1983, Experimental and molecular pathology.

Evidence for a noradrenergic innervation to "atypical" beta adrenoceptors (or putative beta-3 adrenoceptors) in the ileum of guinea pig.

D. Clarke, D. T. Taneja, D. Taneja, 1992, The Journal of pharmacology and experimental therapeutics.

Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors

D. Clarke, R. Bond, K. Charlton, 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

Neurogenic influences of bilateral adrenalectomy on monoamine oxidase.

D. Clarke, S. S. Sampath, 1976, Journal of pharmaceutical sciences.

A specific increase in intraneuronal monoamine oxidase activity in the rat vas deferens following adrenalectomy

D. Clarke, S. S. Sampath, 1972 .

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

P P Humphrey, P R Saxena, G. Martin, 1994, Pharmacological reviews.

Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.

Ming Huang, Hong Sun, Eileen Johnson, 2007, Journal of medicinal chemistry.

Pharmacological analyses of endo-6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl-2,3-dihydro-2-oxo-1 H- benzimidazole-1-carboxylate hydrochloride (DAU 6285) at the 5-hydroxytryptamine4 receptor in the tunica muscularis mucosae of rat esophagus and ileum of guinea pig: role of endogenous 5-hydroxytryp

A. Ford, D. Clarke, S. Hegde, 1993, The Journal of pharmacology and experimental therapeutics.

Synthesis, pharmacology and pharmacokinetics of 3-(4-aryl-piperazin-1-ylalkyl)-uracils as uroselective alpha1A-antagonists.

A. Ford, T. Williams, J. Jasper, 2003, Bioorganic & medicinal chemistry letters.

An explanation for deamination of phenylethylamine by multiple types of monoamine oxidase.

D. Clarke, E. Dial, 1979, Pharmacological research communications.

Characteristics and specificity of phenelzine and benserazide as inhibitors of benzylamine oxidase and monoamine oxidase.

D. Clarke, T. Andree, 1982, Biochemical pharmacology.

Rat and human cardiac monoamine oxidase: a comparison with other tissues.

D. Clarke, E. Dial, 1979, European journal of pharmacology.

Persistent neuronal blockade with guanethidine in dog mesenteric arteries

D. Clarke, J. Buckley, 1978, The Journal of pharmacy and pharmacology.

BLOOD PRESSURE RESPONSES TO ADRENAL FIELD STIMULATION AS A MEASURE OF ADRENAL CATECHOLAMINE RELEASE

D. Clarke, W. M. Romanyshyn, W.M. ROMANYSHYN, 1976, British journal of pharmacology.

Restoration of tyramine responses by bretylium, BW392C60, bethanidine and monoamine oxidase inhibitors in reserpine‐treated rats

D. Clarke, 1970, British journal of pharmacology.

Characterization of angiotensin receptors mediating the neuromodulatory effects of angiotensin in the vas deferens of the rabbit.

D. Clarke, S. Hegde, 1993, The Journal of pharmacology and experimental therapeutics.

Sympathetic nerve function and DOCA-NaCl induced hypertension.

D. Clarke, H. Barry, H. Smookler, 1970, Life sciences. Pt. 1: Physiology and pharmacology.

Monoamine oxidase inhibition and bretylium on adrenergic neuronal transmission

D. Clarke, 1969, The Journal of pharmacy and pharmacology.

Chronic guanethidine and adrenal medullary function in the rat

D. Clarke, W. M. Romanyshyn, W. M. Romanyshyn, 1976, The Journal of pharmacy and pharmacology.

Clinicopathologic effects of chronic reserpine administration in mongrel dogs.

D. Clarke, H. Adams, J. Buckley, 1971, Journal of pharmaceutical sciences.

Studies on the biochemical aspects of the 'disulfiram-like' reaction induced by oral hypoglycemics.

D. Clarke, M. Asaad, 1976, European journal of pharmacology.

Acute effects of 6-hydroxyDOPA and its interaction with DOPA on brain amine levels.

C. Chi, D. Clarke, H. Barry, 1972, Life sciences. Pt. 1: Physiology and pharmacology.

A study of amine oxidases in bleomycin-induced pulmonary fibrosis.

D. Clarke, D. F. Counts, J. Kelley, 1983, Biochemical pharmacology.

Synthesis and Pharmacology of 3-(4-Arylpiperazin-1-ylalkyl)-Uracils as Uroselective α 1A -Antagonists

A. Ford, T. Williams, J. Jasper, 2003 .

A comparison of the action of mexiletine and morphine in rodent models of acute and chronic pain.

D. Clarke, J. Hunter, L. Waterbury, 1995, Proceedings of the Western Pharmacology Society.

Modulation in vitro of monoamine oxidase activity by thyroid hormones.

D. Clarke, M. Asaad, 1978, Biochemical pharmacology.

Autonomic receptor mechanisms in embryonic chick myocardial cell cultures.

D. Clarke, R. Ertel, J. C. Chao, 1971, The Journal of pharmacology and experimental therapeutics.

Evidence for an inhibitory 5‐HT4 receptor in urinary bladder of Rhesus and Cynomolgus monkeys

A. Ford, D. Clarke, M. Waikar, 1994, British journal of pharmacology.

The 5‐HT4 Receptor

D. Clarke, A. Ford, 1993, Medicinal research reviews.

5-HT4 Receptor: Current Status

J. Bockaert, D. Clarke, 1993 .

International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update.

R. Lefkowitz, J. Hieble, D. Bylund, 1995, Pharmacological reviews.

An inhibitory prejunctional 5-HT1-like receptor in the isolated perfused rat kidney

D. Clarke, R. Bond, K. Charlton, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Responses to norepinephrine resistant to inhibition by alpha and beta adrenoceptor antagonists.

D. Clarke, R. Bond, K. Charlton, 1986, The Journal of pharmacology and experimental therapeutics.

Vasoconstrictor and norepinephrine potentiating action of 5-hydroxykynuramine in the isolated perfused rat kidney: involvement of serotonin receptors and alpha1-adrenoceptors

D. Clarke, T. Johnson, K. Charlton, 1984, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of methoxamine on maximum urethral pressure in women with genuine stress incontinence: A placebo‐controlled, double‐blind crossover study

D. Clarke, D. Craig, N. Bryan, 2001, Neurourology and urodynamics.

Pharmacological Properties of the Putative 5-HT4 Receptor in Guinea-Pig Ileum and Rat Oesophagus: Role in Peristalsis

D. Clarke, D. Craig, G. Baxter, 1991 .

Effects of hypophysectomy, bilateral adrenalectomy and hormone replacement therapy upon organ monoamine oxidase activity

D. Clarke, S. S. Sampath, 1975, Experientia.

243 – L-THYROXINE (T4) AND ORGAN MONOAMINE OXIDASE (MAO) ACTIVITY

D. Clarke, Lata S. Moonat, 1977 .

Studies on the functional role of intraneuronal monamine oxidase.

D. Clarke, S. S. Sampath, 1973, The Journal of pharmacology and experimental therapeutics.

Choline uptake in myocardial cell cultures.

D. Clarke, R. Ertel, F. R. Franke, 1972, Life sciences. Pt. 1: Physiology and pharmacology.

α1L‐Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man

A. Ford, D. Clarke, D. Blue, 1998, British journal of pharmacology.

Alpha 1-adrenoceptor subtypes in the human cardiovascular and urogenital systems.

A. Ford, T. Williams, D. Clarke, 1998, Advances in pharmacology.

Pharmacological pleiotropism of the human recombinant α1A‐adrenoceptor: implications for α1‐adrenoceptor classification

J. Gever, A. Ford, D. V. Daniels, 1997 .

Rectal absorption of homatropine [14C]methylbromide in the rat

D. Clarke, M. Cramer, L. A. Cates, 1978, The Journal of pharmacy and pharmacology.

Functional evidence equating the pharmacologically‐defined α1A‐ and cloned α1C‐adrenoceptor: studies in the isolated perfused kidney of rat

A. Ford, N. Sharif, D. Clarke, 1995 .

Pharmacological characterization of an α1A‐adrenoceptor mediating contractile responses to noradrenaline in isolated caudal artery of rat

A. Ford, D. Clarke, W. Lachnit, 1997, British journal of pharmacology.

Functional evidence equating the pharmacologically-defined alpha 1A- and cloned alpha 1C-adrenoceptor: studies in the isolated perfused kidney of rat.

A. Ford, N. Sharif, T. Williams, 1995, British Journal of Pharmacology.

Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification.

J. Gever, A. Ford, D. V. Daniels, 1997, British journal of pharmacology.

Evidence for a noradrenergic innervation to α1A‐adrenoceptors in rat kidney

D. Clarke, D. Blue, R. Vimont, 1992 .

PHARMACOLOGICAL CHARACTERIZATION OF α-ADRENORECEPTOR SUBTYPES IN RAT ISOLATED THORACIC AORTA

D. Clarke, T. Johnson, A. Hamed, 1983 .

Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies.

J. Gever, A. Ford, D. V. Daniels, 1999, European journal of pharmacology.

In vitro alpha1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel alpha1A-adrenoceptor selective antagonists.

J. Gever, A. Ford, R. Chess-Williams, 1999, British Journal of Pharmacology.

Alpha 1-adrenoceptor classification: sharpening Occam's razor.

A. Ford, T. Williams, D. Clarke, 1994, TIPS - Trends in Pharmacological Sciences.

Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the alpha- and beta-subtypes.

D. Clarke, R. Bond, 1988, British journal of pharmacology.

Vascular alpha1-adrenoceptors in rat kidney: agonist and antagonist [prazosin, idazoxan, WB 4101, (+)-niguldipine] characterization☆

D. Clarke, D. Blue, R. Vimont, 1990 .

An analysis of unsurmountable antagonism to 5-hydroxytryptamine in the isolated perfused rat kidney: evidence for pseudoirreversible inhibition

D. Clarke, D. Craig, A. Ornstein, 1990 .

5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum

R. Eglen, D. Clarke, D. Craig, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Slow off-rate of prazosin accounts for deviations from competitive antagonism in the isolated perfused kidney of rat.

D. Clarke, D. Blue, 1992, General pharmacology.

5-Hydroxytryptamine stimulates cyclic AMP formation in the tunica muscularis mucosae of the rat oesophagus via 5-HT4 receptors.

A. Ford, R. Eglen, D. Clarke, 1992, European journal of pharmacology.

Amine oxidase activity in commercial preparations of bovine serum albumin.

D. Clarke, A. Al-Naji, 1983, Life sciences.

Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity.

L. Arik, E. Laird, V. Viswanadhan, 2007, Journal of medicinal chemistry.

Phenylethylamine--deamination by multiple types of monoamine oxidase.

D. Clarke, E. Dial, 1978, Biochemical pharmacology.

Characteristics of Rat Skull Benzylamine Oxidase

D. Clarke, Terrance H. Andree, 1982, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Antagonist characterization of atypical beta adrenoceptors in guinea pig ileum: blockade by alprenolol and dihydroalprenolol.

R. Eglen, D. Clarke, R. Bond, 1990, The Journal of pharmacology and experimental therapeutics.

The isolated perfused rat brain preparation in the study of monoamine oxidase and benzylamine oxidase. Lack of selective brain perfusion.

D. Clarke, T. Andree, 1981, Biochemical pharmacology.

A differential effect of chronically administered guanethidine on sympathetic neurotransmission to the dog heart and mesenteric arterial blood vessels.

D. Clarke, I. Cavero, J. Buckley, 1974, Canadian journal of physiology and pharmacology.

Blood pressure and heart rate effects of kynuramine in pithed rats.

D. Clarke, T. Johnson, 1983, European Journal of Pharmacology.

Kynuramine: high affinity for [3H]tryptamine binding sites.

D. Clarke, T. Johnson, K. Charlton, 1984, European journal of pharmacology.

Cardiovascular actions of kynuramine and 5-hydroxykynuramine in pithed rats

D. Clarke, T. Johnson, A. Hamed, 2005, Journal of Neural Transmission.

An α-adrenoceptor inhibitory action of kynuramine

D. Clarke, T. Johnson, 1981 .

N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists.

A. Ford, T. Williams, M. S. Kava, 1997, Journal of medicinal chemistry.

Amphetamine and monoamine oxidase inhibition: an old idea gains new acceptance

D. Clarke, 1980 .

Effect of selective antagonists of group I metabotropic glutamate receptors on the micturition reflex in rats

D. Clarke, E. Poggesi, A. Leonardi, 2008, BJU international.

Autonomic receptors and choline uptake in embryonic chick myocardial cell cultures.

D. Clarke, R. Ertel, F. R. Franke, 1971, British journal of pharmacology.

The influence of bretylium on the interactions of infused sympathomi- metic amines and tyramine in the reserpine-treated pithed rat.

D. Clarke, G. Leach, 1968, British journal of pharmacology and chemotherapy.

Restoration of blood pressure and heart rate responses to tyramine by infusion of 5‐hydroxytryptamine in reserpine‐treated pithed rats

J. Fozard, D. Clarke, 1970, The Journal of pharmacy and pharmacology.

A transistorised impulse generator for recording the heart rate from intact and isolated preparations

L. N. Hulley, D. Clarke, G. Leach, 1966, The Journal of pharmacy and pharmacology.

The effect of differing reserpine pretreatments on the cardiovascular response to tyramine

D. Clarke, 1967, The Journal of pharmacy and pharmacology.

Characterization of the alpha-1 adrenoceptor subtype mediating [3H]-arachidonic acid release and calcium mobilization in Madin-Darby canine kidney cells.

P. Insel, D. Clarke, D. Craig, 1994, Journal of Pharmacology and Experimental Therapeutics.

5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.

E. Laird, D. Clarke, Jonas Boström, 2013, Future medicinal chemistry.

EFFECT OF ETHANOL ON THE OXIDATIVE METABOLISM OF TRYPTAMINE BY RAT LIVER HOMOGENATE

D. Clarke, H. Barry, B. N. Dixit, 1974, British Journal of Pharmacology.

Are adrenergic nerves required for uptake in the isolated perfused rat heart?

D. Clarke, C. J. Jones, 1969, European journal of pharmacology.