C. Nicolau

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Gene therapy: Liposomes and gene delivery–a perspective

D. Papahadjopoulos, C. Nicolau, 1998 .

Enhanced Gene Delivery and Expression in Human Hepatocellular Carcinoma Cells by Cationic Immunoliposomes

J. Wands, L. Mohr, D. Moradpour, 1997 .

In vivo gene electroinjection and expression in rat liver

Darius Moradpour, Richard Heller, Jack Wands, 1996, FEBS letters.

Demetrios Papahadjopoulos and Liposomes: From Art to Science

C. Alving, C. Nicolau, 1995 .

Dextran protection of erythrocytes from low‐pH‐induced hemolysis

C. Nicolau, B. Schulz, A. Cudd, 1989, FEBS letters.

Electro-insertion of xeno-glycophorin into the red blood cell membrane.

C. Nicolau, Y. Mouneimne, P. Tosi, 1989, Biochemical and biophysical research communications.

Full-length CD4 electroinserted in the erythrocyte membrane as a long-lived inhibitor of infection by human immunodeficiency virus.

D. Volsky, C. Nicolau, Y. Mouneimne, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of intravenously injected liposomes with mouse liver mitochondria. A fluorescence and electron microscopy study.

C. Nicolau, A. Cudd, 1986, Biochimica et biophysica acta.

Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries

A. Eliseev, C. Nicolau, Otmar Schaaf, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Ketones as building blocks for dynamic combinatorial libraries: highly active neuraminidase inhibitors generated via selection pressure of the biological target.

A. Eliseev, C. Nicolau, Otmar Schaaf, 2003, Journal of medicinal chemistry.

A liposome-based therapeutic vaccine against β-amyloid plaques on the pancreas of transgenic NORBA mice

T. Balaban, C. Nicolau, J. Lazarte, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Appearance of β-lactamase activity in animal cells upon liposome-mediated gene transfer

P. Hofschneider, C. Nicolau, Wong Tai-Kin, 1980 .

Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system.

M. Cybulsky, G. Gurtner, M. Gimbrone, 1997, Proceedings of the National Academy of Sciences of the United States of America.

In vivo expression of rat insulin after intravenous administration of the liposome-entrapped gene for rat insulin I.

Philippe Soriano, A. le Pape, C. Nicolau, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Protein-mediated fusion of liposomes with microsomal membranes of Aspergillus niger: evidence for a complex mechanism dealing with membranous and cytosolic fusogenic proteins.

C. Nicolau, C. Martinez-Bazenet, C. Audigier-Petit, 1988, Biochimica et biophysica acta.

Low pH fusion of mouse liver nuclei with liposomes bearing covalently bound lysozyme.

P. Wahl, C. Nicolau, T. Arvinte, 1987, Biochimica et biophysica acta.

Stability and immunological reactivity of recombinant membrane CD4 electroinserted into the plasma membrane of erythrocytes

C. Nicolau, J. Hannig, P. Tosi, 1995, FEBS letters.

Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice

D. Riesner, R. Brady, F. van Leuven, 2007, Proceedings of the National Academy of Sciences.

Polyphosphates and Pyrophosphates of Hexopyranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Effect on Oxygen Release

J. Lehn, C. Nicolau, K. Fylaktakidou, 2011, ChemMedChem.

Electroinsertion of full length recombinant CD4 into red blood cell membrane.

C. Nicolau, Y. Mouneimne, P. Tosi, 1990, Biochimica et biophysica acta.

Nucleated cells response to protein electroinsertion.

C. Nicolau, Y. Mouneimne, P. Tosi, 1993, Cytometry.

Electric field‐induced fusion of mitochondria

C. Nicolau, H. Labbé, J. Reynaud, 1989, FEBS letters.

Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene.

Philippe Soriano, J. Dijkstra, A. Legrand, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Liposomes as carriers of DNA.

C. Nicolau, A. Cudd, 1989, Critical reviews in therapeutic drug carrier systems.

Fusion of negatively charged liposomes with clathrin-uncoated vesicles.

P. Nandi, M. Gervais, C. Nicolau, 1987, Biochimica et biophysica acta.

Interaction of negatively charged liposomes with nuclear membranes: adsorption, lipid mixing and lysis of the vesicles.

P. Nandi, C. Nicolau, R. Lawaczeck, 1987, Biochimica et biophysica acta.

Enhanced exercise capacity in mice with severe heart failure treated with an allosteric effector of hemoglobin, myo-inositol trispyrophosphate

J. Lehn, C. Nicolau, W. Colucci, 2009, Proceedings of the National Academy of Sciences.

Hypoxia‐driven Hif2a coordinates mouse liver regeneration by coupling parenchymal growth to vascular expansion

J. Lehn, C. Nicolau, P. Clavien, 2016, Hepatology.

“Endothelial Antibody Factory” at the Blood Brain Barrier: Novel Approach to Therapy of Neurodegenerative Diseases

I. Krizbai, K. Brodaczewska, C. Kieda, 2022, Pharmaceutics.

Nanosecond fluorescence anisotropy decays of 1,6-diphenyl-1,3,5-hexatriene in membranes.

C. Nicolau, K. Hildenbrand, Claude Nicolau, 1979, Biochimica et biophysica acta.

Cell-surface expression and purification of human CD4 produced in baculovirus-infected insect cells.

C. Nicolau, M. Summers, P. Tosi, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Low-pH association of proteins with the membranes of intact red blood cells. I. Exogenous glycophorin and the CD4 molecule.

C. Nicolau, B. Schulz, A. Cudd, 1989, Biochimica et biophysica acta.

Secretion of proteins and antibody fragments from transiently transfected endothelial progenitor cells

L. Heller, R. Heller, C. Nicolau, 2020, Journal of cellular and molecular medicine.

Liposome-Mediated Gene Transfer In Vivo. Uptake and Expression of the Preproinsulin I Gene by Rats and Mice

Philippe Soriano, C. Nicolau, 1983 .

Expression of a beta-lactamase activity in Mycoplasma capricolum transfected with the liposome-encapsulated E.coli pBR 322 plasmid.

C. Nicolau, S. Rottem, 1982, Biochemical and biophysical research communications.

Liposome-mediated DNA transfer in eukaryotic cells. Dependence of the transfer efficiency upon the type of liposomes used and the host cell cycle stage.

C. Nicolau, C. Sené, 1982, Biochimica et biophysica acta.

Liposome-Mediated DNA Transfer in Eukaryotic Cells: Gene Uptake and Expression in the Host Cell

C. Nicolau, C. Sené, 1982 .

Quantitative immunofluorescent assay of full-length, recombinant CD4 in solution and mapping of its epitopes

C. Nicolau, P. Tosi, H. Benoist, 1991, Journal of Fluorescence.

Liposomes as carriers for in vivo gene transfer and expression.

A. Legrand, C. Nicolau, E. Grosse, 1987, Methods in enzymology.

Liposomes as Carriers for in Vivo Transfer and Expression of the Insulin Gene

A. Legrand, C. Nicolau, E. Grosse, 1985 .

Flow cytofluorometric investigation of the uptake by hepatocytes and spleen cells of targeted and untargeted liposomes injected intravenously into mice.

C. Kieda, C. Nicolau, E. Grosse, 1984, Biochimica et biophysica acta.

Molecular events during the interaction of envelopes of myxo- and RNA-tumor viruses with cell membranes. A 270 MHz H nuclear magnetic resonance study.

H. Klenk, C. Nicolau, K. Hildenbrand, 1978, Biochimica et biophysica acta.

Reduced parasitemia observed with erythrocytes containing inositol hexaphosphate

C. Nicolau, D. Struck, G. Ihler, 1988, Antimicrobial Agents and Chemotherapy.

Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release

J. Lehn, C. Nicolau, K. Fylaktakidou, 2011, ChemMedChem.

Subcellular distribution of phospholipids and of polyprenyl phosphate in Aspergillus niger van tieghem

C. Nicolau, J. Frot-Coutaz, R. Got, 1982 .

Human erythrocytes bearing electroinserted CD4 neutralize infection in vitro by primary isolates of human immunodeficiency virus type 1.

C. Flexner, D. Norse, U. Sharma, 1996, Blood.

Immunization with liposome-anchored pegylated peptides modulates doxorubicin sensitivity in P-glycoprotein-expressing P388 cells.

D. Hickman, C. Nicolau, P. Tosi, 2007, Cancer letters.

Biologically active, recombinant DNA in clathrin-coated vesicles isolated from rat livers after in vivo injection of liposome-encapsulated DNA.

P. Nandi, A. Legrand, C. Nicolau, 1986, The Journal of biological chemistry.

Liposomes for gene transfer and expression in vivo.

Philippe Soriano, A. Legrand, C. Nicolau, 1985, Ciba Foundation symposium.

Liposomes for gene transfer and expression in vivo.

C. Nicolau, 1984, Biochemical Society transactions.

Enhancement of the O2 Release Capacity and of the Bohr-Effect of Human Red Blood Cells after Incorporation of Inositol Hexaphosphate by Fusion with Effector-Containing Lipid Vesicles

K. Gersonde, C. Nicolau, 1982 .

Optimization of the production of full‐length rCD4 in baculovirus‐infected Sf9 cells

C. Nicolau, P. Tosi, J. Lazarte, 1992, Biotechnology and bioengineering.

Membrane lipid dynamics and density dependent growth control in normal and transformed avian cells.

A. Vaheri, C. Nicolau, R. Friis, 1978, Experimental cell research.

Spectroscopic evidence for cis‐[PtCl2(NH3)2]‐erythrocyte membrane interaction

C. Nicolau, O. Hörer, 1971, FEBS letters.

Early molecular events in the interaction of enveloped viruses with cells

H. Klenk, C. Nicolau, K. Hildenbrand, 1979, Biophysics of structure and mechanism.

Specific targeting of human hepatocellular carcinoma cells by immunoliposomes in vitro

J. Wands, D. Moradpour, C. Nicolau, 1995, Hepatology.

Inositol tripyrophosphate: a new membrane permeant allosteric effector of haemoglobin.

J. Lehn, C. Nicolau, R. Greferath, 2005, Bioorganic & medicinal chemistry letters.

Density-dependent Growth Control and Lipid Mobilities in Normal and Tumor-Transformed Cell Membranes

A. Vaheri, C. Nicolau, R. Friis, 1977 .

13C-Nuclear Magnetic Resonance Investigations of Xanthine and Some of its N-Methylated Derivatives

C. Nicolau, K. Hildenbrand, 1974, Zeitschrift fur Naturforschung. Section C, Biosciences.

The Allosteric Hemoglobin Effector ITPP Inhibits Metastatic Colon Cancer in Mice

E. Kachaylo, J. Lehn, C. Tschuor, 2017, Annals of surgery.

Antihypoxic Potentiation of Standard Therapy for Experimental Colorectal Liver Metastasis through Myo-Inositol Trispyrophosphate

E. Kachaylo, J. Lehn, C. Tschuor, 2016, Clinical Cancer Research.

The distribution of 1,6 diphenyl hexatriene fluorescence in normal human lymphocytes.

C. Nicolau, S. M. Johnson, 1977, Biochemical and biophysical research communications.

1-H and 13-C nuclear magnetic resonance spectra of the lipids in normal and SV 40 virus-transformed hamster embryo fibroblast membranes.

C. Nicolau, J. Melnick, W. Dietrich, 1975, Biochimica et biophysica acta.

Phase Ib dose-escalation study of the hypoxia-modifier Myo-inositol trispyrophosphate in patients with hepatopancreatobiliary tumors

A. Jetter, J. Lehn, C. Nicolau, 2021, Nature Communications.

Induction of autoantibodies to murine P-glycoprotein: consequences on drug sensitivity in MDR cancer cells and on the expression of mdr genes in organs.

C. Nicolau, P. Tosi, C. Madoulet, 2007, Biochemical and biophysical research communications.

Inhibition of multidrug resistance by immunisation with synthetic P-glycoprotein-derived peptides.

C. Nicolau, P. Tosi, L. Ventéo, 2004, European journal of cancer.

Improved Oxygen Delivery to Tissues and Iron Chelator Transport through the Use of Lysed and Resealed Red Blood Cells: A New Perspective on Cooley's Anemia Therapy a

C. Nicolau, R. Girot, B. Teisseire, 1985, Annals of the New York Academy of Sciences.

Low‐oxygen‐affinity red cells produced in a large‐volume, continuous‐ flow electroporation system

Ulrich Bruggemann, C. Nicolau, J. Hannig, 1995, Transfusion.

Stable rightward shifts of the oxyhemoglobin dissocation curve induced by encapsulation of inositol hexaphosphate in red blood cells using electroporation

C. Nicolau, Y. Mouneimne, S. Slogoff, 1990, FEBS letters.

Incorporation of allosteric effectors of hemoglobin in red blood cells. Physiological effects.

C. Nicolau, B. Teisseire, M. Vallez, 1985, Bibliotheca haematologica.

Resealed red blood cells as a new blood transfusion product.

C. Nicolau, G. Avenard, M. Chassaigne, 1985, Bibliotheca haematologica.

20 – Electroinsertion: An Electrical Method for Protein Implantation into Cell Membranes

C. Nicolau, Y. Mouneimne, P. Tosi, 1991 .

Long-term physiological effects of enhanced O2 release by inositol hexaphosphate-loaded erythrocytes.

C. Nicolau, B. Teisseire, C. Ropars, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Physiological effects of high-P50 erythrocyte transfusion on piglets.

C. Nicolau, B. Teisseire, M. Vallez, 1985, Journal of applied physiology.

Red Blood Cells Exposing CD4, as Competitive Inhibitors of HIV-1 Infection

D. Volsky, C. Nicolau, Y. Mouneimne, 1991 .

Intradermal delivery of interleukin-12 plasmid DNA by in vivo electroporation.

M. Jaroszeski, K. Moelling, L. Heller, 2001, DNA and cell biology.

Myo‐inositol trispyrophosphate‐mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy

J. Lehn, M. Aprahamian, C. Nicolau, 2014, International journal of cancer.

Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial

R. Stupp, A. Jetter, J. Lehn, 2016, BMC Cancer.

Incorporation of Allosteric Effectors of Hemoglobin in Red Blood Cells. Biochemical and Physiological Effects

C. Nicolau, B. Teisseire, Claude Ropars, 1986 .

Intracellular fate of liposome-encapsulated DNA in mouse liver. Analysis using electron microscope autoradiography and subcellular fractionation.

C. Nicolau, A. Cudd, 1985, Biochimica et biophysica acta.

Sequence-independent Control of Peptide Conformation in Liposomal Vaccines for Targeting Protein Misfolding Diseases*

D. Riesner, D. Hickman, C. Nicolau, 2011, The Journal of Biological Chemistry.

Enhancement of P50 by inositol hexa phosphate entrapped in resealed erythrocytes in piglets.

C. Nicolau, B. Teisseire, M. Vallez, 1984, Advances in experimental medicine and biology.

Significance of Low Hemoglobin Oxygen Affinity

C. Nicolau, B. Teisseire, C. Vieilledent, 1986 .

Myo‐InositolTrisPyroPhosphate Treatment Leads to HIF‐1α Suppression and Eradication of Early Hepatoma Tumors in Rats

J. Marescaux, L. Soler, J. Lehn, 2011, Chembiochem : a European journal of chemical biology.

Anti‐angiogenic properties of myo‐inositol trispyrophosphate in ovo and growth reduction of implanted glioma

I. Queguiner, H. Iwao, J. Lehn, 2007, FEBS letters.

Suppression of hypoxia-induced HIF-1α and of angiogenesis in endothelial cells by myo-inositol trispyrophosphate-treated erythrocytes

C. Kieda, J. Lehn, C. Nicolau, 2006, Proceedings of the National Academy of Sciences.

Resonance energy-transfer and fluorescence intensity studies of the transport of liposome-encapsulated molecules into isolated mouse liver nuclei.

P. Wahl, C. Nicolau, T. Arvinte, 1987, Biochemistry.

Improvement of the red blood cell O2 release capacity by lipid vesicle-mediated incorporation of inositol hexaphosphate

K. Gersonde, C. Nicolau, 1979, Blut.

Tetrakisphosphates and Bispyrophosphates of myo‐Inositol Derivatives as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release

J. Lehn, C. Nicolau, A. E. Koumbis, 2011, ChemMedChem.

Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial

R. Stupp, A. Jetter, J. Lehn, 2016, BMC Cancer.

Transport of the highly charged myo-inositol hexakisphosphate molecule across the red blood cell membrane: a phase transfer and biological study.

J. Lehn, C. Nicolau, J. Lazarte, 2002, Bioorganic & medicinal chemistry.

Virus-transformed cell membranes

C. Nicolau, 1978 .

Diagnosis of human immunodeficiency virus infection using citrated whole blood

C. Flexner, H. Farzadegan, U. Sharma, 1997, Clinical and diagnostic laboratory immunology.

Low-pH association of proteins with the membranes of intact red blood cells. II. Studies of the mechanism.

C. Nicolau, B. Schulz, A. Cudd, 1989, Biochimica et biophysica acta.

Stable tumor vessel normalization with pO2 increase and endothelial PTEN activation by inositol trispyrophosphate brings novel tumor treatment

G. Collet, C. Kieda, J. Lehn, 2013, Journal of Molecular Medicine.

Interprofessional and interdisciplinary collaboration for early phase oncological clinical trials in academia - myo-Inositoltrispyrophophate as model.

A. Jetter, J. Lehn, C. Nicolau, 2020, Pharmacological research.

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2

M. Aprahamian, C. Nicolau, J. Freund, 2013, Oncogene.

Electroinsertion of proteins in the plasma membrane of red blood cells.

C. Nicolau, Y. Mouneimne, P. Tosi, 1993, Analytical biochemistry.

Electric-field-induced morphological alterations and fusion of hepatocytes

J. Teissié, C. Nicolau, J. Reynaud, 1987 .

Myo‐inositol trispyrophosphate‐mediated hypoxia reversion controls pancreatic cancer in rodents and enhances gemcitabine efficacy

M. Aprahamian, C. Nicolau, G. Bour, 2014, International journal of cancer.

Immune response against the murine mdri protein induced by vaccination with synthetic lipopeptides in liposomes.

C. Nicolau, P. Tosi, D. Radu, 1995, Biochemical and biophysical research communications.

Myo‐InositolTrisPyroPhosphate Treatment Leads to HIF‐1α Suppression and Eradication of Early Hepatoma Tumors in Rats

J. Marescaux, L. Soler, J. Lehn, 2011, Chembiochem : a European journal of chemical biology.

Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release

J. Lehn, C. Nicolau, K. Fylaktakidou, 2011, ChemMedChem.

Tetrakisphosphates and Bispyrophosphates of myo‐Inositol Derivatives as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release

J. Lehn, C. Nicolau, Alexandros E. Koumbis, 2011, ChemMedChem.

II. Enhancement of gas transport in inositol hexaphosphate-loaded red blood cells

K. Gersonde, C. Nicolau, 1979, Naturwissenschaften.

Red blood cells bearing CD4 bind to gp120 covered plates and aggregate with cells expressing gp120.

C. Nicolau, B. Schulz, T. Arvinte, 1990, Journal of acquired immune deficiency syndromes.

Modification of the oxygen affinity of intracellular haemoglobin by incorporation of polyphosphates into intact red blood cells and enhanced O2 release in the capillary system.

K. Gersonde, C. Nicolau, 1980, Bibliotheca haematologica.