J. Carpenter

发表

Stability of lipid/DNA complexes during agitation and freeze-thawing.

T. Anchordoquy, L. G. Girouard, J. Carpenter, 1998, Journal of pharmaceutical sciences.

Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation

John F. Carpenter, Theodore W. Randolph, J. Carpenter, 2003, Pharmaceutical Research.

Effects of drying methods and additives on the structure, function, and storage stability of subtilisin: role of protein conformation and molecular mobility

A. Gaertner, J. Carpenter, T. Randolph, 2002 .

Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry.

K. Menard, P. Setlow, M. Manning, 2008, Journal of pharmaceutical sciences.

Infrared and circular dichroism spectroscopic characterization of structural differences between beta-lactoglobulin A and B.

M. Manning, S. Allison, J. Carpenter, 1996, Biochemistry.

Dehydration-induced conformational transitions in proteins and their inhibition by stabilizers.

T. Arakawa, J. Carpenter, S. Prestrelski, 1993, Biophysical journal.

Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.

Theodore W Randolph, Donn Sederstrom, Erwin Freund, 2015, Journal of pharmaceutical sciences.

Potential inaccurate quantitation and sizing of protein aggregates by size exclusion chromatography: essential need to use orthogonal methods to assure the quality of therapeutic protein products.

W. Jiskoot, G. Winter, C. R. Middaugh, 2010, Journal of pharmaceutical sciences.

Congo Red Populates Partially Unfolded States of an Amyloidogenic Protein to Enhance Aggregation and Amyloid Fibril Formation*

M. Manning, J. Carpenter, T. Randolph, 2003, The Journal of Biological Chemistry.

Stabilization of phosphofructokinase with sugars during freeze-drying: characterization of enhanced protection in the presence of divalent cations.

J. Carpenter, J. Crowe, L. Crowe, 1987, Biochimica et biophysica acta.

Stabilization of phosphofructokinase during air-drying with sugars and sugar/transition metal mixtures.

J. Carpenter, J. Crowe, L. Crowe, 1987, Cryobiology.

Transmission electron microscopy as an orthogonal method to characterize protein aggregates.

Anke M. Mulder, J. Quispe, B. Carragher, 2015, Journal of pharmaceutical sciences.

Effect of Tween 20 on freeze-thawing- and agitation-induced aggregation of recombinant human factor XIII.

M. Manning, S. Frokjaer, J. Flink, 1998, Journal of pharmaceutical sciences.

Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges.

W. Jiskoot, M. Joubert, L. Narhi, 2016, Journal of pharmaceutical sciences.

Preparation of Active Proteins, Vaccines and Pharmaceuticals as Fine Powders using Supercritical or Near-Critical Fluids

J. Carpenter, R. Sievers, J. A. Villa, 2008, Pharmaceutical Research.

Rational Design of Stable Protein Formulations

M. Manning, J. Carpenter, 2002, Pharmaceutical Biotechnology.

Using X-Ray Crystallography to Simplify and Accelerate Biologics Drug Development.

E. Baker, T. Laue, J. Carpenter, 2017, Journal of pharmaceutical sciences.

Aggregation of recombinant human interferon gamma: kinetics and structural transitions.

M. Manning, J. Carpenter, T. Randolph, 1998, Journal of pharmaceutical sciences.

Stabilization of dry phospholipid bilayers and proteins by sugars.

J. Carpenter, J. Crowe, L. Crowe, 1987, The Biochemical journal.

Protein–Solvent Interactions in Pharmaceutical Formulations

T. Arakawa, J. Carpenter, Y. Kita, 1991, Pharmaceutical Research.

Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation.

M. Manning, J. Carpenter, E. Chi, 2005, Journal of pharmaceutical sciences.

A new mechanism for decreasing aggregation of recombinant human interferon-gamma by a surfactant: slowed dissolution of lyophilized formulations in a solution containing 0.03% polysorbate 20.

J. Carpenter, T. Randolph, J. Cleland, 2002, Journal of pharmaceutical sciences.

A transient expansion of the native state precedes aggregation of recombinant human interferon-gamma.

J. Carpenter, T. Randolph, J. Cleland, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Real-Time in Situ Monitoring of Lysozyme During Lyophilization Using Infrared Spectroscopy: Dehydration Stress in the Presence of Sucrose

J. Carpenter, C. Stushnoff, R. Remmele, 1997, Pharmaceutical Research.

Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry.

J. Carpenter, R. Nayar, T. Randolph, 2009, Journal of pharmaceutical sciences.

Maintenance of transfection rates and physical characterization of lipid/DNA complexes after freeze-drying and rehydration.

T. Anchordoquy, J. Carpenter, D. Kroll, 1997, Archives of biochemistry and biophysics.

Understanding and modulating opalescence and viscosity in a monoclonal antibody formulation.

Theodore W Randolph, Hasige A Sathish, John F Carpenter, 2010, Journal of pharmaceutical sciences.

Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2016, Journal of pharmaceutical sciences.

Formation of an active dimer during storage of interleukin-1 receptor antagonist in aqueous solution.

T. Arakawa, L. Narhi, B. Chang, 1996, Biophysical journal.

Calcium-induced changes to the molecular conformation and aggregate structure of beta-casein at the air-water interface.

D. K. Schwartz, J. Carpenter, C. Vessely, 2005, Biomacromolecules.

Characterization and quantitation of aggregates and particles in interferon-β products: potential links between product quality attributes and immunogenicity.

J. Carpenter, James G Barnard, Ken Babcock, 2013, Journal of pharmaceutical sciences.

Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose.

J. Carpenter, T. Randolph, W. Qi, 2016, Journal of pharmaceutical sciences.

Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2016, Journal of pharmaceutical sciences.

Polymers protect lactate dehydrogenase during freeze-drying by inhibiting dissociation in the frozen state.

T. Anchordoquy, J. Carpenter, 1996, Archives of biochemistry and biophysics.

Lyophilization-induced protein denaturation in phosphate buffer systems: monomeric and tetrameric beta-galactosidase.

J. Carpenter, K. Pikal-Cleland, Katherine A. Pikal‐Cleland, 2001, Journal of pharmaceutical sciences.

Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples.

M. Pikal, J. Carpenter, T. Randolph, 2014, Journal of pharmaceutical sciences.

Storage stability of keratinocyte growth factor-2 in lyophilized formulations: effects of formulation physical properties and protein fraction at the solid-air interface.

J. Carpenter, T. Randolph, M. Cicerone, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

An infrared spectroscopic study of the interactions of carbohydrates with dried proteins.

J. Carpenter, J. Crowe, 1989, Biochemistry.

Infrared spectroscopic studies of lyophilization- and temperature-induced protein aggregation.

S. Allison, J. Carpenter, A. Dong, 1995, Journal of pharmaceutical sciences.

Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation.

Jared S. Bee, J. Carpenter, T. Randolph, 2015, Journal of pharmaceutical sciences.

Effects of transportation of IV bags containing protein formulations via hospital pneumatic tube system: Particle characterization by multiple methods.

J. Carpenter, L. Crawford, P. Kolhe, 2022, Journal of pharmaceutical sciences.

Effects of tubing type, operating parameters and surfactants on particle formation during peristaltic filling pump processing of a monoclonal antibody formulation.

Krishna M. G. Mallela, Yannick Elias, J. Carpenter, 2020, Journal of pharmaceutical sciences.

Effects of Tubing Type, Formulation, and Postpumping Agitation on Nanoparticle and Microparticle Formation in Intravenous Immunoglobulin Solutions Processed With a Peristaltic Filling Pump.

J. Carpenter, Cheng Her, 2019, Journal of pharmaceutical sciences.

Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues.

W. Jiskoot, D. Volkin, D. Crommelin, 2018, Journal of pharmaceutical sciences.

The mechanism of cryoprotection of proteins by solutes.

J. Carpenter, J. Crowe, 1988, Cryobiology.

Albinterferon α2b adsorption to silicone oil-water interfaces: effects on protein conformation, aggregation, and subvisible particle formation.

J. Carpenter, T. Randolph, PINAKI BASU, 2014, Journal of pharmaceutical sciences.

Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models.

R. Torres, J. Carpenter, T. Randolph, 2017, Journal of pharmaceutical sciences.

Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone in Mice.

R. Torres, J. Carpenter, T. Randolph, 2016, Journal of pharmaceutical sciences.

In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations.

R. Torres, J. Carpenter, T. Randolph, 2015, Journal of pharmaceutical sciences.

Noninvasive determination of protein conformation in the solid state using near infrared (NIR) spectroscopy.

M. Manning, J. Carpenter, R. Nayar, 2005, Journal of pharmaceutical sciences.

Freezing- and Drying-Induced Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives

J. Carpenter, T. Randolph, K. Izutsu, 1999 .

Perturbations of Protein Structure and Mechanisms of Protein Protection by Stabilizing Additives

J. Carpenter, T. Randolph, K. Izutsu, 2004 .

Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations.

B. Kerwin, J. Carpenter, T. Randolph, 2005, Journal of pharmaceutical sciences.

Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation.

B. Chang, J. Carpenter, A. Dong, 1996, Archives of biochemistry and biophysics.

Real-Time Infrared Spectroscopic Analysis of Lysozyme During Lyophilization. Structure-Hydration Behavior and Influence of Sucrose.

J. Carpenter, C. Stushnoff, R. Remmele, 1995 .

Are freezing and dehydration similar stress vectors? A comparison of modes of interaction of stabilizing solutes with biomolecules

J. Carpenter, J. Crowe, L. Crowe, 1990 .

Conformational properties of nine purified cystathionine β-synthase mutants.

J. Carpenter, T. Majtan, A. Pey, 2012, Biochemistry.

Intermolecular beta-sheet results from trifluoroethanol-induced nonnative alpha-helical structure in beta-sheet predominant proteins: infrared and circular dichroism spectroscopic study.

M. Manning, J. Carpenter, A. Dong, 1998, Archives of biochemistry and biophysics.

High particle variability across siliconized and oil-free syringes and needles from the same lots

M. Maia, J. Carpenter, M. Farah, 2021, Scientific Reports.

Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes.

J. Carpenter, T. Majtan, J. Kraus, 2010, The Journal of biological chemistry.

The Role of Protein Excipient in Driving Antibody Responses to Erythropoietin.

R. Torres, J. Carpenter, T. Randolph, 2015, Journal of pharmaceutical sciences.

Silicone oil microdroplets and protein aggregates in repackaged bevacizumab and ranibizumab: effects of long-term storage and product mishandling.

M. Kahook, J. Carpenter, N. Mandava, 2011, Investigative ophthalmology & visual science.

Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development

J. Carpenter, A. Hawe, Sarah Zölls, 2020 .

Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations.

J. Carpenter, T. Randolph, W. Qi, 2018, Journal of pharmaceutical sciences.

In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice

W. Jiskoot, J. Carpenter, C. Löwik, 2013, Pharmaceutical Research.

Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice

M. Biel, G. Winter, S. Michalakis, 2014, Pharmaceutical Research.

Impact of Sterilization Method on Protein Aggregation and Particle Formation in Polymer-Based Syringes.

Y. Abe, J. Carpenter, Aaron B. Krueger, 2017, Journal of pharmaceutical sciences.

Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics.

D. Brems, P. Bondarenko, J. Carpenter, 2007, Biochemistry.

Cryoprotection of antibody by organic solutes and organic solute/divalent cation mixtures.

J. Carpenter, L. Bourgeois, K. Hazen, 1988, Archives of biochemistry and biophysics.

Stability of Subtilisin and Lysozyme under High Hydrostatic Pressure

J. Carpenter, T. Randolph, J. N. Webb, 2000, Biotechnology progress.

Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates.

J. Carpenter, S. Owen, A. Gandhi, 2018, Journal of pharmaceutical sciences.

Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature.

J. Carpenter, T. Randolph, R. Pettis, 2014, Journal of pharmaceutical sciences.

Infrared spectroscopic studies of protein formulations containing glycine.

R. Suryanarayanan, M. Manning, J. Carpenter, 2004, Journal of pharmaceutical sciences.

Application of infrared spectroscopy to development of stable lyophilized protein formulations.

J. Carpenter, A. Dong, S. Prestrelski, 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations.

J. Carpenter, R. Nayar, T. Randolph, 2008, Journal of pharmaceutical sciences.

Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions.

J. Carpenter, T. Randolph, A. Gandhi, 2019, Journal of pharmaceutical sciences.

In-Depth Comparison of Lysine-Based Antibody-Drug Conjugates Prepared on Solid Support Versus in Solution

J. Carpenter, S. Owen, A. Gandhi, 2018, Antibodies.

Spectroscopic Evidence of Tertiary Structural Differences Between Insulin Molecules in Fibrils.

T. Rades, M. Groenning, J. Carpenter, 2019, Journal of pharmaceutical sciences.

Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid.

S. Frokjaer, J. Flink, J. Carpenter, 1998, Archives of biochemistry and biophysics.

Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution.

J. Carpenter, R. Nayar, T. Randolph, 2009, Journal of pharmaceutical sciences.

Comparative fourier transform infrared and circular dichroism spectroscopic analysis of alpha1-proteinase inhibitor and ovalbumin in aqueous solution.

M. Manning, J. Carpenter, A. Dong, 2000, Archives of biochemistry and biophysics.

Protein Aggregation during Ultrasonic Nebulization

C. Lengsfeld, J. Carpenter, J. A. Giarratano, 2012 .

Engineering challenges of protein formulations

J. Carpenter, T. Randolph, 2007 .

Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition.

K. Middleton, M. Manning, S. Allison, 1998, Archives of biochemistry and biophysics.

Investigations into the fouling mechanism of parvovirus filters during filtration of freeze-thawed mAb drug substance solutions.

J. Carpenter, T. Randolph, James G Barnard, 2014, Journal of pharmaceutical sciences.

Studies of the structure of insulin fibrils by Fourier transform infrared (FTIR) spectroscopy and electron microscopy.

S. Frokjaer, J. Carpenter, J. Brange, 2001, Journal of pharmaceutical sciences.

Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran.

K. Middleton, M. Manning, S. Allison, 2000, Journal of pharmaceutical sciences.

Identification of strombine and taurine as cryoprotectants in the intertidal bivalve Mytilus edulis

J. Carpenter, J. Crowe, S. Loomis, 1988 .

Long-term preservation of dried phosphofructokinase by sugars and sugar/zinc mixtures.

J. Carpenter, J. Crowe, S. Loomis, 1988, Cryobiology.

Cryoprotection of phosphofructokinase with organic solutes: characterization of enhanced protection in the presence of divalent cations.

J. Carpenter, J. Crowe, L. Crowe, 1986, Archives of biochemistry and biophysics.

Comparison of pH-dependent allostery and dissociation for phosphofructokinases from Artemia embryos and rabbit muscle: nature of the enzymes acylated with diethylpyrocarbonate.

J. Carpenter, S. Hand, 1986, Archives of biochemistry and biophysics.

Mechanism for benzyl alcohol-induced aggregation of recombinant human interleukin-1 receptor antagonist in aqueous solution.

B. Chang, M. Manning, B. Kerwin, 2004, Journal of Pharmacy and Science.

Thermal stability of low molecular weight urokinase during heat treatment. III. Effect of salts, sugars and Tween 80

M. Vrkljan, J. Henkin, M. Manning, 1996 .

Subvisible Particles in Solutions of Remicade in Intravenous Saline Activate Immune System Pathways in In Vitro Human Cell Systems.

J. Carpenter, M. Fogg, M. Baker, 2021, Journal of pharmaceutical sciences.

Antibody responses in mice to particles formed from adsorption of a murine monoclonal antibody onto glass microparticles.

G. Winter, J. Carpenter, T. Randolph, 2014, Journal of pharmaceutical sciences.

Effects of Excipients on the Chemical and Physical Stability of Glucagon during Freeze-Drying and Storage in Dried Formulations

J. Carpenter, W. Qi, S. Prestrelski, 2012, Pharmaceutical Research.

Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins.

Amber Haynes Fradkin, J. Carpenter, T. Randolph, 2011, Journal of pharmaceutical sciences.

Evidence of partial unfolding of proteins at the ice/freeze-concentrate interface by infrared microscopy.

J. Carpenter, S. Nail, J. J. Schwegman, 2009, Journal of pharmaceutical sciences.

Infrared microscopy for in situ measurement of protein secondary structure during freezing and freeze-drying.

J. Carpenter, S. Nail, J. J. Schwegman, 2007, Journal of pharmaceutical sciences.

Secondary structures of proteins adsorbed onto aluminum hydroxide: infrared spectroscopic analysis of proteins from low solution concentrations.

B. Kerwin, J. Carpenter, S. Krishnan, 2006, Analytical biochemistry.

Effects of potassium bromide disk formation on the infrared spectra of dried model proteins.

M. Manning, J. Carpenter, Jeffrey D. Meyer, 2004, Journal of pharmaceutical sciences.

The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution.

G. Winter, M. Manning, J. Carpenter, 2001, Journal of pharmaceutical sciences.

Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid.

S. Frokjaer, J. Flink, J. Carpenter, 1999, Journal of pharmaceutical sciences.

Conformational stability of lyophilized PEGylated proteins in a phase-separating system.

J. Carpenter, T. Randolph, M. C. Heller, 1999, Journal of pharmaceutical sciences.

Secondary structure of antifreeze proteins from overwintering larvae of the beetle Dendroides canadensis.

M. Manning, J. Carpenter, J. Duman, 1998, Archives of biochemistry and biophysics.

Spectroscopic study of secondary structure and thermal denaturation of recombinant human factor XIII in aqueous solution.

M. Manning, J. Carpenter, A. Dong, 1997, Archives of biochemistry and biophysics.

Hydrophobic ion pairing as a method for enhancing structure and activity of lyophilized subtilisin BPN' suspended in isooctane.

M. Manning, J. Carpenter, J. Matsuura, 1997, Archives of Biochemistry and Biophysics.

Counteracting effects of thiocyanate and sucrose on chymotrypsinogen secondary structure and aggregation during freezing, drying, and rehydration.

S. Allison, J. Carpenter, A. Dong, 1996, Biophysical journal.

Quantitation of the area of overlap between second-derivative amide I infrared spectra to determine the structural similarity of a protein in different states.

M. Manning, S. Allison, J. Carpenter, 1996, Journal of pharmaceutical sciences.

Solid state chemistry of proteins: II. The correlation of storage stability of freeze-dried human growth hormone (hGH) with structure and dynamics in the glassy solid.

M. Pikal, J. Carpenter, M. Cicerone, 2008, Journal of pharmaceutical sciences.

Effects of phase separating systems on lyophilized hemoglobin.

J. Carpenter, T. Randolph, M. C. Heller, 1996, Journal of pharmaceutical sciences.

Structure of Proteins in Lyophilized Formulations Using Fourier Transform Infrared Spectroscopy.

T. Arakawa, J. Carpenter, S. Prestrelski, 1995 .

Ligand-induced conformational and structural dynamics changes in Escherichia coli cyclic AMP receptor protein.

J. Lee, J. Carpenter, A. Dong, 2002, Biochemistry.

Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres.

J. Carpenter, J. Cleland, A. Dong, 1999, Journal of pharmaceutical sciences.

Drug delivery matrix containing native protein precipitates suspended in a poloxamer gel.

M. Manning, J. Carpenter, A. Dong, 1997, Journal of pharmaceutical sciences.

Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures.

N. Warne, J. Carpenter, S. Krishnan, 2004, Journal of pharmaceutical sciences.

Stability of Human Serum Albumin During Bioprocessing: Denaturation and Aggregation During Processing of Albumin Paste

M. Manning, J. Carpenter, Jeffrey D. Meyer, 2000, Pharmaceutical Research.

Effect of zinc binding and precipitation on structures of recombinant human growth hormone and nerve growth factor.

M. Manning, J. Carpenter, T. Randolph, 2000, Journal of pharmaceutical sciences.

Development of a Stable Freeze-dried Formulation of Recombinant Human Interleukin-1 Receptor Antagonist

G. Reeder, B. Chang, J. Carpenter, 1996, Pharmaceutical Research.

The effect of mutations on the structure of insulin fibrils studied by Fourier transform infrared (FTIR) spectroscopy and electron microscopy.

S. Frokjaer, J. Carpenter, J. Brange, 2002, Journal of pharmaceutical sciences.

Exploring the protein stabilizing capability of surfactants against agitation stress and the underlying mechanisms.

J. Carpenter, A. Marx, G. Fricker, 2022, Journal of pharmaceutical sciences.

Effect of secondary structure on the activity of enzymes suspended in organic solvents.

M. Manning, J. Carpenter, A. Dong, 1996, Archives of biochemistry and biophysics.

Factors affecting short-term and long-term stabilities of proteins.

S J Prestrelski, T. Arakawa, W. Kenney, 2001, Advanced drug delivery reviews.

Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine.

A. Morin, J. Carpenter, T. Randolph, 2009, Journal of pharmaceutical sciences.

Interactions of stabilizing additives with proteins during freeze-thawing and freeze-drying.

T. Arakawa, J. Carpenter, J. Crowe, 1992, Developments in biological standardization.

Comparison of Solute-Induced Protein Stabilization in Aqueous Solution and in the Frozen and Dried States

T. Arakawa, J. Carpenter, J. Crowe, 1990 .

Cryoprotective capacity of end products of anaerobic metabolism

J. Carpenter, J. Crowe, S. Loomis, 1989 .

Antifreeze protein modulates cell survival during cryopreservation: mediation through influence on ice crystal growth.

T. N. Hansen, J. Carpenter, 1992, Proceedings of the National Academy of Sciences of the United States of America.

HIGH-MOLECULAR-WEIGHT AGGREGATES IN REPACKAGED BEVACIZUMAB

M. Kahook, J. Carpenter, J. M. Petrash, 2010, Retina.

Functional analysis of cryopreserved veins

P. Hagen, J. Carpenter, K. Brockbank, 1990 .

Lyophilization of Protein Pharmaceuticals

B. Chang, J. Carpenter, 2020 .

Preformulation study of highly purified inactivated polio vaccine, serotype 3.

J. Carpenter, T. Randolph, W. Qi, 2014, Journal of pharmaceutical sciences.

Effects of sucrose on rFVIIa aggregation and methionine oxidation.

S. Frokjaer, J. Flink, M. van de Weert, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

The role of vitrification in anhydrobiosis.

J. Carpenter, J. Crowe, L. Crowe, 1998, Annual review of physiology.

The basis for toxicity of certain cryoprotectants: A hypothesis

John F. Carpenter, T. Arakawa, J. Carpenter, 1990 .

Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange.

D. Wuttke, R. F. Latypov, B. Kerwin, 2011, Journal of pharmaceutical sciences.

Effects of pH, temperature, and sucrose on benzyl alcohol-induced aggregation of recombinant human granulocyte colony stimulating factor.

D. Brems, J. Carpenter, S. Krishnan, 2006, Journal of pharmaceutical sciences.

Effects of Tween 20 and Tween 80 on the stability of Albutropin during agitation.

M. Manning, Danny K. Chou, J. Carpenter, 2005, Journal of pharmaceutical sciences.

Aggregation and Particle Formation of Therapeutic Proteins in Contact With a Novel Fluoropolymer Surface Versus Siliconized Surfaces: Effects of Agitation in Vials and in Prefilled Syringes.

John F Carpenter, J. Carpenter, J. Brake, 2016, Journal of pharmaceutical sciences.

Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions.

Theodore W Randolph, Hanns-Christian Mahler, Christine Wurth, 2012, Journal of pharmaceutical sciences.

Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2010, Journal of pharmaceutical sciences.

Contributions of local mobility and degree of retention of native secondary structure to the stability of recombinant human growth hormone (rhGH) in glassy lyophilized formulations

John F. Carpenter, Marcus T. Cicerone, Theodore W. Randolph, 2013 .

Temperature-dependent perturbation of phospholipid bilayers by dimethylsulfoxide.

J H Crowe, J. Carpenter, J. Crowe, 1992, Biochimica et biophysica acta.

Interactions of sugars with membranes.

B. Spargo, J. Carpenter, J. Crowe, 1988, Biochimica et biophysica acta.

Modes of interaction of cryoprotectants with membrane phospholipids during freezing.

A S Rudolph, J H Crowe, J. Carpenter, 1987, Cryobiology.

Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilization.

J. Carpenter, T. Randolph, J A Searles, 2001, Journal of pharmaceutical sciences.

The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf.

J. Carpenter, T. Randolph, J A Searles, 2001, Journal of pharmaceutical sciences.

Light-induced aggregation of type I soluble tumor necrosis factor receptor.

T. Boone, B. Kerwin, J. Carpenter, 2009, Journal of pharmaceutical sciences.

Effect of glycine on pH changes and protein stability during freeze-thawing in phosphate buffer systems.

T. Anchordoquy, J. Carpenter, J. Cleland, 2002, Journal of pharmaceutical sciences.

Substandard Quality of the Antimicrobials Sold in the Street Markets in Haiti

J. Carpenter, A. Figueras, K. Dahl, 2020, Antibiotics.

Particles shed from syringe filters and their effects on agitation-induced protein aggregation.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding.

B. Chang, S. Allison, J. Carpenter, 1999, Archives of biochemistry and biophysics.

Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state.

B. Chang, M. Manning, J. Carpenter, 1997, Proceedings of the National Academy of Sciences of the United States of America.

High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2002, Biochimica et biophysica acta.

Modes of stabilization of a protein by organic solutes during desiccation

J. Carpenter, J. Crowe, 1988 .

Effects of antifreeze proteins on red blood cell survival during cryopreservation.

P. Davies, J. Carpenter, H. Chao, 1996, The Journal of experimental biology.

Functional analysis of cryopreserved veins. Preliminary report.

P. Hagen, J. Carpenter, K. Brockbank, 1990, Journal of Vascular Surgery.

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. I. Enzyme activity and calorimetric studies.

S J Prestrelski, J. Carpenter, S. Prestrelski, 1993, Archives of biochemistry and biophysics.

Preservation of Differentiation and Clonogenic Potential of Human Hematopoietic Stem and Progenitor Cells during Lyophilization and Ambient Storage

D. Pyatt, J. Carpenter, Sandhya S. Buchanan, 2010, PloS one.

Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation.

J. Carpenter, T. Randolph, J F Carpenter, 1999, Biotechnology and bioengineering.

Effects of storage temperature on viable bioprosthetic heart valves.

J. Carpenter, J F Carpenter, K. Brockbank, 1992, Cryobiology.

Cryopreservation of stem cells using trehalose: evaluation of the method using a human hematopoietic cell line.

Mehmet Toner, John F Carpenter, Jason P Acker, 2004, Stem cells and development.

BSA degradation under acidic conditions: a model for protein instability during release from PLGA delivery systems.

Steven P Schwendeman, John F Carpenter, J. Carpenter, 2006, Journal of pharmaceutical sciences.

Surface-induced denaturation of proteins during freezing and its inhibition by surfactants.

B. Chang, J. Carpenter, J F Carpenter, 1996, Journal of pharmaceutical sciences.

Rational design of stable lyophilized protein formulations: theory and practice.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2002, Pharmaceutical biotechnology.

Effects of Sugars and Polymers on Crystallization of Poly(ethylene glycol) in Frozen Solutions: Phase Separation Between Incompatible Polymers

J. Carpenter, T. Randolph, S. Yoshioka, 1996, Pharmaceutical Research.

pH-Induced Metabolic Transitions in Artemia Embryos Mediated by a Novel Hysteretic Trehalase

J. Carpenter, S. Hand, JOHN F. CARPENTER, 1986, Science.

Structural and Functional Modifications of Corneal Crystallin ALDH3A1 by UVB Light

Ying Chen, V. Vasiliou, J. Carpenter, 2010, PloS one.

Arrestment of carbohydrate metabolism during anaerobic dormancy and aerobic acidosis inArtemia embryos: determination of pH-sensitive control points

J. Carpenter, S. Hand, 1986, Journal of Comparative Physiology B.

Intermolecular β-Sheet Results from Trifluoroethanol-Induced Nonnative α-Helical Structure in β-Sheet Predominant Proteins: Infrared and Circular Dichroism Spectroscopic Study

M. Manning, J. Carpenter, A. Dong, 1998 .

A specific molar ratio of stabilizer to protein is required for storage stability of a lyophilized monoclonal antibody.

J L Cleland, Chung C. Hsu, J. Carpenter, 2001, Journal of pharmaceutical sciences.

Anhydrobiosis: cellular adaptations to extreme dehydration.

J. Carpenter, J. Crowe, L. Crowe, 1997 .

Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations.

Theodore W Randolph, John F Carpenter, S. Golledge, 2002, Journal of pharmaceutical sciences.

Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.

Theodore W Randolph, C Russell Middaugh, Wim Jiskoot, 2012, Journal of pharmaceutical sciences.

Mechanisms of interaction of amino acids with phospholipid bilayers during freezing.

J. Carpenter, J. Crowe, S. Loomis, 1988, Biochimica et biophysica acta.

Temperature dependence of benzyl alcohol- and 8-anilinonaphthalene-1-sulfonate-induced aggregation of recombinant human interleukin-1 receptor antagonist.

D. Katayama, B. Kerwin, J. Carpenter, 2006, Biochemistry.

Potential induction of anti-PEG antibodies and complement activation toward PEGylated therapeutics.

T. Anchordoquy, J. Carpenter, H. Schellekens, 2014, Drug discovery today.

The Role of Platelets in Chilling‐Induced Injury a

T. N. Hansen, J. Carpenter, 1994, Annals of the New York Academy of Sciences.

Effect of salts and sugars on phase separation of polyvinylpyrrolidone[ndash ]dextran solutions induced by freeze-concentration

J. Carpenter, T. Randolph, K. Izutsu, 1998 .

Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants.

Theodore W Randolph, C Russell Middaugh, Lilia A. Rabia, 2015, Journal of pharmaceutical sciences.

Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying.

J. Carpenter, T. Randolph, Scott A. Merkley, 2008, Journal of pharmaceutical sciences.

Effects of solution conditions, processing parameters, and container materials on aggregation of a monoclonal antibody during freeze-thawing.

J. Carpenter, L. Kueltzo, T. Randolph, 2008, Journal of pharmaceutical sciences.

Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice

Michael J. Pikal, John F. Carpenter, Theodore W. Randolph, 1997, Pharmaceutical Research.

Chemical-gas sterilization of external surface of polymer-based prefilled syringes and its effect on stability of model therapeutic protein.

Y. Abe, J. Carpenter, Takaaki Kurinomaru, 2021, Journal of pharmaceutical sciences.

Effects of surfaces and leachables on the stability of biopharmaceuticals.

Jared S. Bee, S. Bishop, J. Carpenter, 2011, Journal of pharmaceutical sciences.

Quantitation of aggregate levels in a recombinant humanized monoclonal antibody formulation by size-exclusion chromatography, asymmetrical flow field flow fractionation, and sedimentation velocity.

John P. Gabrielson, G. Winter, J. Carpenter, 2007, Journal of pharmaceutical sciences.

Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study.

John F Carpenter, J. Carpenter, W. Qi, 2016, Journal of pharmaceutical sciences.

Analytical approaches to assess the degradation of therapeutic proteins

John F. Carpenter, Vasco Filipe, Andrea Hawe, 2013 .

Secondary structure of recombinant human cystathionine beta-synthase in aqueous solution: effect of ligand binding and proteolytic truncation.

M. Manning, J. Carpenter, J. Kraus, 1997, Archives of biochemistry and biophysics.

Survival of water stress in annual fish embryos: dehydration avoidance and egg envelope amyloid fibers.

J. Carpenter, S. Hand, J. Podrabsky, 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

Quaternary conformational stability: The effect of reversible self‐association on the fibrillation of two insulin analogs

J. Carpenter, T. Randolph, C. Fernández, 2011, Biotechnology and bioengineering.

Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony‐stimulating factor

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2003, Protein science : a publication of the Protein Society.

Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes.

Theodore W Randolph, John F Carpenter, D. K. Schwartz, 2015, Journal of pharmaceutical sciences.

Quantitation of dimethyl sulfoxide in solutions and tissues by high-performance liquid chromatography.

J. Carpenter, P. Dawson, 1991, Cryobiology.

Selective domain stabilization as a strategy to reduce fusion protein aggregation.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Calorimetric determination of inhibition of ice crystal growth by antifreeze protein in hydroxyethyl starch solutions.

T. N. Hansen, J. Carpenter, 1993, Biophysical Journal.

Calorimetric determination of inhibition of ice

T. N. Hansen, J. Carpenter, 2005 .

alphaT244M mutation affects the redox, kinetic, and in vitro folding properties of Paracoccus denitrificans electron transfer flavoprotein.

M. Manning, J. Carpenter, F. Frerman, 1997, Biochemistry.

Buffer-dependent fragmentation of a humanized full-length monoclonal antibody.

Theodore W Randolph, Hasige A Sathish, John F Carpenter, 2010, Journal of pharmaceutical sciences.

Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation.

Theodore W Randolph, John F Carpenter, Danny K Chou, 2012, Journal of pharmaceutical sciences.

Tween protects recombinant human growth hormone against agitation-induced damage via hydrophobic interactions.

J L Cleland, M C Manning, R. Kelley, 1998, Journal of pharmaceutical sciences.

Microparticles and Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product.

John F Carpenter, L. Caplan, J. Carpenter, 2017, Journal of pharmaceutical sciences.

Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice

M. Biel, G. Winter, S. Michalakis, 2015, Pharmaceutical Research.

Mechanisms Involved in the Protection of UV-induced Protein Inactivation by the Corneal Crystallin ALDH3A1*

V. Vasiliou, J. Carpenter, Tia Estey, 2007, Journal of Biological Chemistry.

Immunogenicity of aggregates of recombinant human growth hormone in mouse models.

Amber Haynes Fradkin, Theodore W Randolph, John F Carpenter, 2009, Journal of pharmaceutical sciences.

High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization.

D. Wuttke, J. Carpenter, T. Randolph, 2008, Journal of pharmaceutical sciences.

Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2008, Journal of pharmaceutical sciences.

Effects of solution conditions and surface chemistry on the adsorption of three recombinant botulinum neurotoxin antigens to aluminum salt adjuvants.

J. Carpenter, R. Nayar, T. Randolph, 2007, Journal of pharmaceutical sciences.

Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.

Lilia A. Rabia, Kimberly J. Hassett, N. Mantis, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Inhibition of stress-induced aggregation of protein therapeutics.

M C Manning, B. Chang, M. Manning, 1999, Methods in enzymology.

Counteracting Effects of Renal Solutes on Amyloid Fibril Formation by Immunoglobulin Light Chains*

M. Manning, J. Carpenter, E. Chi, 2001, The Journal of Biological Chemistry.

Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2009, Biochemistry.

Some Lessons Learned From a Comparison Between Sedimentation Velocity Analytical Ultracentrifugation and Size Exclusion Chromatography to Characterize and Quantify Protein Aggregates.

John F. Carpenter, J. Carpenter, Aditya V. Gandhi, 2017, Journal of pharmaceutical sciences.

Cryopreservation of Human Hematopoietic Stem and Progenitor Cells Loaded with Trehalose: Transient Permeabilization via the Adenosine Triphosphate-Dependent P2Z Receptor Channel

D. Pyatt, J. Carpenter, S. Hand, 2005 .

Physical Compatibility of Y-site Pediatric Drug Administration: A Call for Question of US Pharmacopeia Standards.

J. Carpenter, Cheng Her, J. Bremmer, 2023, The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG.

Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying.

T. Anchordoquy, J. Carpenter, T. Randolph, 2001, Archives of biochemistry and biophysics.

Separation of freezing- and drying-induced denaturation of lyophilized proteins using stress-specific stabilization. II. Structural studies using infrared spectroscopy.

S J Prestrelski, J. Carpenter, S. Prestrelski, 1993, Archives of biochemistry and biophysics.

Inhibition of agitation-induced aggregation of an IgG-antibody by hydroxypropyl-beta-cyclodextrin.

Theodore W Randolph, Gerhard Winter, John F Carpenter, 2010, Journal of pharmaceutical sciences.

Precipitation of a monoclonal antibody by soluble tungsten.

Theodore W Randolph, Erwin Freund, John F Carpenter, 2009, Journal of pharmaceutical sciences.

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.

Steven Kozlowski, Theodore W Randolph, C Russell Middaugh, 2009, Journal of pharmaceutical sciences.

Reversible dissociation and inactivation of phosphofructokinase in the ischemic rat heart.

J. Carpenter, S. Hand, 1986, The American journal of physiology.

Freezing-induced perturbation of tertiary structure of a monoclonal antibody.

Theodore W Randolph, Wei Wang, John F Carpenter, 2014, Journal of pharmaceutical sciences.

Application of the preferential exclusion mechanism to preservation of proteins and phospholipid bilayers

J. Carpenter, J. Crowe, L. Crowe, 1989 .

Protein aggregation and particle formation in prefilled glass syringes.

Theodore W Randolph, John F Carpenter, Jared S. Bee, 2014, Journal of pharmaceutical sciences.

IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.

Theodore W Randolph, John F Carpenter, A. Tyagi, 2009, Journal of pharmaceutical sciences.

Recombinant murine growth hormone particles are more immunogenic with intravenous than subcutaneous administration.

R. Torres, J. Carpenter, T. Randolph, 2014, Journal of pharmaceutical sciences.

Protein denaturation during freezing and thawing in phosphate buffer systems: monomeric and tetrameric beta-galactosidase.

G. Amidon, N. Rodríguez-Hornedo, J. Carpenter, 2000, Archives of biochemistry and biophysics.

DEHP Nanodroplets Leached from Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum.

J. Carpenter, T. Randolph, A. Frazer-Abel, 2020, Journal of pharmaceutical sciences.

High Pressure Refolding of Recombinant Human Growth Hormone from Insoluble Aggregates

J. Carpenter, T. Randolph, C. Balny, 2001, The Journal of Biological Chemistry.

High pressure fosters protein refolding from aggregates at high concentrations.

J. Carpenter, T. Randolph, J F Carpenter, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Optimization of Infrared Microscopy to Assess Secondary Structure of Insulin Molecules Within Individual Subvisible Particles in Aqueous Formulations.

T. Rades, M. Groenning, J. Carpenter, 2019, Journal of pharmaceutical sciences.

Characterization of Factors Affecting Nanoparticle Tracking Analysis Results With Synthetic and Protein Nanoparticles.

Aaron B Krueger, John F Carpenter, P. Carnell, 2016, Journal of pharmaceutical sciences.

Characterization of Nanoparticle Tracking Analysis for Quantification and Sizing of Submicron Particles of Therapeutic Proteins.

J. Carpenter, W. Qi, James G Barnard, 2015, Journal of pharmaceutical sciences.

Subvisible and Visible Particle Analysis in Biopharmaceutical Research and Development

John F. Carpenter, Andrea Hawe, J. Carpenter, 2015 .

Interactions of Stabilizers with Proteins During Freezing and Drying.

T. Arakawa, J. Carpenter, T. Anchordoguy, 1995 .

Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations.

J. Carpenter, W. Qi, E. Lewis, 2015, Analytical biochemistry.

Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization.

J. Carpenter, T. Randolph, J F Carpenter, 1999, Archives of biochemistry and biophysics.

Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution.

Theodore W Randolph, John F Carpenter, D. Brems, 2009, Journal of pharmaceutical sciences.

Protein Aggregation and Particle Formation: Effects of Formulation, Interfaces, and Drug Product Manufacturing Operations

Stefan Fischer, J. Carpenter, T. Randolph, 2010 .

Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study.

K. Menard, M. Manning, D. Katayama, 2009, Journal of pharmaceutical sciences.

Thermal Stability of Low Molecular Weight Urokinase During Heat Treatment. II. Effect of Polymeric Additives

John F. Carpenter, M. Vrkljan, J. Henkin, 1994, Pharmaceutical Research.

Aggregation of granulocyte colony stimulating factor under physiological conditions: characterization and thermodynamic inhibition.

Theodore W Randolph, Mark C Manning, Eva Y Chi, 2002, Biochemistry.

Effects of sucrose on conformational equilibria and fluctuations within the native‐state ensemble of proteins

B. Chang, M. Manning, J. Carpenter, 2003, Protein science : a publication of the Protein Society.

Controlling deamidation rates in a model peptide: effects of temperature, peptide concentration, and additives.

M C Manning, M. Manning, J. Shively, 2001, Journal of pharmaceutical sciences.

Protease autolysis in heavy-duty liquid detergent formulations: effects of thermodynamic stabilizers and protease inhibitors

M. Manning, J. Carpenter, T. Randolph, 2004 .

Response of a concentrated monoclonal antibody formulation to high shear

Joey Pollastrini, Erwin Freund, Bhavya Mehta, 2009, Biotechnology and bioengineering.

The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin.

A. Gaertner, J. Carpenter, T. Randolph, 2000, Archives of biochemistry and biophysics.

Manipulation of Lyophilization‐Induced Phase Separation: Implications For Pharmaceutical Proteins

J. Carpenter, T. Randolph, J F Carpenter, 1997, Biotechnology progress.

Thermodynamic Modulation of Light Chain Amyloid Fibril Formation*

M. Manning, J. Carpenter, T. Randolph, 2000, The Journal of Biological Chemistry.

Analyzing insulin samples by size-exclusion chromatography: a column degradation study.

M. Wempe, J. Carpenter, Brandon M Teska, 2015, Journal of pharmaceutical sciences.

Two decades of publishing excellence in pharmaceutical biotechnology.

G. Winter, D. Volkin, S. Uchiyama, 2015, Journal of pharmaceutical sciences.

Effects of protein perturbants on phospholipid bilayers.

J. Carpenter, J. Crowe, L. Crowe, 1990, Archives of biochemistry and biophysics.

Monoclonal antibody interactions with micro- and nanoparticles: adsorption, aggregation, and accelerated stress studies.

Jared S. Bee, J. Carpenter, T. Randolph, 2009, Journal of pharmaceutical sciences.

Production of particles of therapeutic proteins at the air–water interface during compression/dilation cycles

Jared S. Bee, D. K. Schwartz, J. Carpenter, 2012 .

Immunogenicity of Isogenic IgG in Aggregates and Immune Complexes

L. Wysocki, J. Carpenter, G. Kirchenbaum, 2017, PloS one.

Dose levels in particulate-containing formulations impact anti-drug antibody responses to murine monoclonal antibody in mice.

G. Winter, J. Carpenter, T. Randolph, 2015, Journal of pharmaceutical sciences.

IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2013, Journal of pharmaceutical sciences.

Phase-Appropriate Application of Analytical Methods to Monitor Subvisible Particles Across the Biotherapeutic Drug Product Life Cycle

Dean Ripple, Roman Mathaes, Linda Narhi, 2019, The AAPS Journal.

Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces.

Jared S. Bee, J. Carpenter, T. Randolph, 2013, Journal of pharmaceutical sciences.

Critical evaluation and guidance for using the Coulter method for counting subvisible particles in protein solutions.

John F Carpenter, J. Carpenter, Matthew N. Rhyner, 2012, Journal of pharmaceutical sciences.

Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway.

Theodore W Randolph, John F Carpenter, S. Singh, 2011, Journal of pharmaceutical sciences.

Flow cytometry: a promising technique for the study of silicone oil-induced particulate formation in protein formulations.

Theodore W Randolph, John P. Gabrielson, John F Carpenter, 2011, Analytical biochemistry.

UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences.

Amber Haynes Fradkin, Theodore W Randolph, John F Carpenter, 2014, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Pressure effect on subtilisin crystallization and solubility

C. Glatz, J. Carpenter, T. Randolph, 1999 .

Ultraviolet radiation decreases expression and induces aggregation of corneal ALDH3A1.

V. Vasiliou, J. Carpenter, Aglaia Pappa, 2003, Chemico-biological interactions.

Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2003, Biochemistry.

Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2015, Journal of pharmaceutical sciences.

Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2016, Journal of pharmaceutical sciences.

Measurement of the second osmotic virial coefficient for protein solutions exhibiting monomer-dimer equilibrium.

J. Carpenter, T. Randolph, B. Kendrick, 2008, Analytical biochemistry.

Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2018, Journal of pharmaceutical sciences.

Micro- And Nanoparticles Delivered in Intravenous Saline and in an Intravenous Solution of a Therapeutic Antibody Product

L. Caplan, J. Carpenter, W. Qi, 2017 .

A Platform for Preparing Homogeneous Proteinaceous Subvisible Particles With Distinct Morphologies.

Thomas Rades, John F Carpenter, T. Rades, 2018, Journal of pharmaceutical sciences.

Application of a Best Practice Approach Using Resonant Mass Measurement for Biotherapeutic Product Characterization.

Amber Haynes Fradkin, Natalia Markova, Aaron B Krueger, 2019, Journal of pharmaceutical sciences.

In Vivo Fluorescence Imaging of IgG1 Aggregates After Subcutaneous and Intravenous Injection in Mice

W. Jiskoot, J. Carpenter, C. Löwik, 2013, Pharmaceutical Research.

Effects of Product Handling Parameters on Particle Levels in a Commercial Factor VIII Product: Impacts and Mitigation.

Yoshihiko Abe, John F Carpenter, Y. Abe, 2019, Journal of pharmaceutical sciences.

Silicone oil‐free syringes, siliconized syringes and needles: quantitative assessment of silicone oil release with drugs used for intravitreal injection

M. Maia, C. Probst, J. Carpenter, 2021, Acta ophthalmologica.

Mechanical Shock During Shipping of Medications: The Roles of Packaging and Transportation Vendors.

L. Caplan, J. Carpenter, Elizabeth Cheng, 2020 .

High‐Pressure Refolding of Disulfide‐Cross‐Linked Lysozyme Aggregates: Thermodynamics and Optimization

J. Carpenter, T. Randolph, Richard J. St. John, 2002, Biotechnology progress.

Aggregation of a monoclonal antibody induced by adsorption to stainless steel

Theodore W Randolph, Erwin Freund, John F Carpenter, 2010, Biotechnology and bioengineering.

High‐pressure studies of aggregation of recombinant human interleukin‐1 receptor antagonist: Thermodynamics, kinetics, and application to accelerated formulation studies

J. Carpenter, T. Randolph, J. Seely, 2005, Protein science : a publication of the Protein Society.

Partial molar volume, surface area, and hydration changes for equilibrium unfolding and formation of aggregation transition state: High-pressure and cosolute studies on recombinant human IFN-γ

J. Carpenter, T. Randolph, J. Cleland, 2001, Proceedings of the National Academy of Sciences of the United States of America.

High-pressure studies on protein aggregates and amyloid fibrils.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2006, Methods in Enzymology.

Measurement of Tg in lyophilized protein and protein excipient mixtures by dynamic mechanical analysis

K. Menard, D. Katayama, J. Carpenter, 2009 .

Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation.

M. Manning, Danny K. Chou, J. Carpenter, 2013, Journal of pharmaceutical sciences.

The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study.

Theodore W Randolph, John F Carpenter, D. K. Schwartz, 2013, Journal of pharmaceutical sciences.

Aggregation of human serum albumin during a thermal viral inactivation step.

M. Manning, J. Carpenter, Jeffrey D. Meyer, 2009, International journal of biological macromolecules.

Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure

B. Chang, J. Carpenter, T. Randolph, 2006, Protein science : a publication of the Protein Society.

Entrapping intermediates of thermal aggregation in alpha-helical proteins with low concentration of guanidine hydrochloride.

J. Carpenter, T. Randolph, A. Dong, 2000, The Journal of biological chemistry.

Kinetics and Energetics of Assembly, Nucleation, and Growth of Aggregates and Fibrils for an Amyloidogenic Protein

J. Carpenter, T. Randolph, F. Stevens, 2002, The Journal of Biological Chemistry.

Impact of Ethylene Oxide Sterilization of Polymer-Based Prefilled Syringes on Chemical Degradation of a Model Therapeutic Protein During Storage.

Yoshihiko Abe, John F Carpenter, Y. Abe, 2019, Journal of pharmaceutical sciences.

Effects of Excipients on the Chemical and Physical Stability of Glucagon during Freeze-Drying and Storage in Dried Formulations

J. Carpenter, W. Qi, S. Prestrelski, 2012, Pharmaceutical Research.

Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO(2)-assisted aerosolization.

J. Carpenter, J F Carpenter, R. Sievers, 2001, Journal of pharmaceutical sciences.

Compatibility of medications with intravenous lipid emulsions: Effects of simulated Y-site mixing.

J. Carpenter, Cheng Her, Emma L Ross, 2020, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

Purification and characterization of two polymorphic variants of short chain acyl-CoA dehydrogenase reveal reduction of catalytic activity and stability of the Gly185Ser enzyme.

J. Vockley, D. Babovic‐Vuksanovic, N. Gregersen, 2002, Biochemistry.

Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics.

Theodore W Randolph, John F Carpenter, Shujun Bai, 2011, Journal of pharmaceutical sciences.

Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2003, Journal of pharmaceutical sciences.

High‐pressure refolding of bikunin: Efficacy and thermodynamics

J. Ouyang, J. Carpenter, T. Randolph, 2004, Protein science : a publication of the Protein Society.

Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation.

Jared S. Bee, J. Carpenter, T. Randolph, 2014, Biochemistry.

Selective domain stabilization as a strategy to reduce human serum albumin-human granulocyte colony stimulating factor aggregation rate.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions.

Chikako Yomota, Theodore W Randolph, John F Carpenter, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Role of electrostatic repulsion on colloidal stability of Bacillus halmapalus alpha-amylase.

Peter Westh, John F Carpenter, P. Westh, 2009, Biochimica et biophysica acta.

Long‐Term Storage of Proteins

Theodore W Randolph, John F Carpenter, Mark C Manning, 2002, Current protocols in protein science.

The Impact Of Formulation Composition And Process Settings Of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation.

T. De Beer, B. Vanbillemont, C. Probst, 2020, Journal of pharmaceutical sciences.

Quantification of glycine crystallinity by near-infrared (NIR) spectroscopy.

R. Suryanarayanan, M. Manning, J. Carpenter, 2004, Journal of pharmaceutical sciences.

Population balance modeling of aggregation kinetics of recombinant human interleukin-1 receptor antagonist.

Theodore W Randolph, Brent S Kendrick, Eva Y Chi, 2005, Journal of pharmaceutical sciences.

Adsorption of monoclonal antibodies to glass microparticles.

Theodore W Randolph, Hanns-Christian Mahler, Christine Wurth, 2011, Journal of pharmaceutical sciences.

Use of Analytical Ultracentrifugation as an Orthogonal Method for Size Exclusion Chromatography: Assuring Quality for Therapeutic Protein Products and Meeting Regulatory Expectations

J. Carpenter, G. Johnson, D. L. Bain, 2016 .

Approaches for increasing the solution stability of proteins.

M C Manning, M. Vrkljan, M. Manning, 1995, Biotechnology and bioengineering.

High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics.

Theodore W Randolph, Brent S Kendrick, John F Carpenter, 2008, Journal of pharmaceutical sciences.

In-vitro assessment of release of silicone oil droplets with the use of variety of syringes and needles used in intravitreal injections

M. Maia, C. Probst, J. Carpenter, 2021, European journal of ophthalmology.

Working to improve healthcare for people in developing countries.

J. Carpenter, 2008, Journal of pharmaceutical sciences.

Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses.

Theodore W Randolph, John F Carpenter, J. Carpenter, 2012, Journal of pharmaceutical sciences.

Temperature adaptation in Gillichthys (Teleost: Gobiidae) A(4)-lactate dehydrogenases: identical primary structures produce subtly different conformations.

G. Somero, P. A. Fields, J. Carpenter, 2002, The Journal of experimental biology.

Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions.

J. Carpenter, T. Randolph, Jared R. Snell, 2016, Journal of pharmaceutical sciences.

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.

Patrick G. Swann, W. Jiskoot, G. Winter, 2009, Journal of pharmaceutical sciences.

Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces.

J. Carpenter, T. Randolph, Shyam B. Mehta, 2016, Journal of pharmaceutical sciences.

Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation.

Donn R. Sederstrom, J. Carpenter, T. Randolph, 2015, Journal of pharmaceutical sciences.

Rescue of Cystathionine β-Synthase (CBS) Mutants with Chemical Chaperones

J. Carpenter, T. Majtan, J. Kraus, 2010, The Journal of Biological Chemistry.

IgG particle formation during filling pump operation: a case study of heterogeneous nucleation on stainless steel nanoparticles.

A. Tyagi, K. Maloney, J. Carpenter, 2009, Journal of pharmaceutical sciences.

Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation.

M. Manning, Danny K. Chou, J. Carpenter, 2013, Journal of pharmaceutical sciences.

Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study.

J. Carpenter, W. Qi, E. Lewis, 2016, Journal of pharmaceutical sciences.

Mimicking Low pH Virus Inactivation Used in Antibody Manufacturing Processes - Effect of Processing Conditions and Biophysical Properties on Antibody Aggregation and Particle Formation.

Z. Li, J. Carpenter, N. Kim, 2021, Journal of pharmaceutical sciences.

Fundamental differences in the interactions of stabilizing solutes with proteins during freeze-thawing versus during freeze-drying☆

J. Carpenter, J. Crowe, 1988 .

pH-induced hysteretic properties of phosphofructokinase purified from rat myocardium.

J. Carpenter, S. Hand, 1986, The American journal of physiology.