D. Kahne

发表

Design of compounds that increase the absorption of polar molecules.

S. Choe, G. Amidon, P. Venkatesan, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Advances in understanding bacterial outer-membrane biogenesis

T. Silhavy, D. Kahne, N. Ruiz, 2006, Nature Reviews Microbiology.

Reconstitution of Outer Membrane Protein Assembly from Purified Components

D. Kahne, Christine L Hagan, Seokhee Kim, 2010, Science.

Assembly and Maintenance of Lipids at the Bacterial Outer Membrane.

D. Kahne, N. Ruiz, Emily A Lundstedt, 2020, Chemical reviews.

The bacterial cell envelope.

T. Silhavy, S. Walker, D. Kahne, 2010, Cold Spring Harbor perspectives in biology.

Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring.

C. Walsh, D. Kahne, L. Heide, 2004, Angewandte Chemie.

Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli.

Daniel Kahne, T. Silhavy, D. Kahne, 2007, Genes & development.

Lipoprotein Cofactors Located in the Outer Membrane Activate Bacterial Cell Wall Polymerases

S. Walker, D. Kahne, T. Bernhardt, 2010, Cell.

Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms.

S. Walker, D. Kahne, T. Bernhardt, 2014, Journal of the American Chemical Society.

Regulation of cell size in response to nutrient availability by fatty acid biosynthesis in Escherichia coli

Roy Kishony, Daniel Kahne, R. Kishony, 2012, Proceedings of the National Academy of Sciences.

Distinct single-cell morphological dynamics under beta-lactam antibiotics.

Roy Kishony, Daniel Kahne, R. Kishony, 2012, Molecular cell.

Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides.

Jon S Thorson, Jiqing Jiang, Daniel Kahne, 2002, Chemistry & biology.

Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli

Daniel Kahne, T. Silhavy, D. Kahne, 2005, Cell.

A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases.

C. Walsh, R. Kruger, D. Kahne, 2005, Journal of the American Chemical Society.

AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.

C. Walsh, R. Kruger, G. Gatto, 2005, Chemistry & biology.

A unifying nitrososynthase involved in nitrosugar biosynthesis.

D. Kahne, B. Bachmann, Yunfeng Hu, 2008, Journal of the American Chemical Society.

Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics.

S. Walker, D. Kahne, Christian Gampe, 2011, Tetrahedron.

Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design.

P. Sliż, S. Walker, D. Kahne, 2008, ACS chemical biology.

Hybrid glycopeptide antibiotics.

D. Kahne, U. Eggert, S. J. Shaw, 2001, Journal of the American Chemical Society.

Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics.

S. Walker, D. Kahne, S. Donadio, 2005, Journal of the American Chemical Society.

Glycopeptide and lipoglycopeptide antibiotics.

C. Walsh, W. Lu, D. Kahne, 2005, Chemical reviews.

Membrane integration of an essential β-barrel protein prerequires burial of an extracellular loop

D. Kahne, Christine L Hagan, J. Wzorek, 2017, Proceedings of the National Academy of Sciences.

Nonconsecutive disulfide bond formation in an essential integral outer membrane protein

T. Silhavy, D. Kahne, N. Ruiz, 2010, Proceedings of the National Academy of Sciences.

Chemical Conditionality A GeneticStrategy to Probe Organelle Assembly

T. Silhavy, D. Kahne, N. Ruiz, 2005, Cell.

Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II.

S. Walker, Janine M. May, D. Kahne, 2013, Journal of the American Chemical Society.

Chromomycin A3 as a Blueprint for Designed Metal Complexes

D. Kahne, C. Kraml, Domingos J. Silva, 1994 .

Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli.

David J. Sherman, W. Denny, D. Kahne, 2013, Bioorganic & medicinal chemistry.

Genetic Basis for Activity Differences Between Vancomycin and Glycolipid Derivatives of Vancomycin

T. Silhavy, D. Kahne, N. Ruiz, 2001, Science.

Combinatorial approaches to carbohydrates.

D. Kahne, Daniel Kahne, 1997, Current opinion in chemical biology.

Calicheamicin−DNA Recognition: An Analysis of Seven Different Drug−DNA Complexes

A. Andreotti, S. Walker, D. Kahne, 2000 .

Structural characterization of a calicheamicin-DNA complex by NMR

S. Walker, J. Murnick, D. Kahne, 1993 .

NMR characterization of calicheamicin γ1I bound to DNA

A. Andreotti, S. Walker, D. Kahne, 1994 .

The Molecular Basis for Pyrimidine-Selective DNA Binding: Analysis of Calicheamicin Oligosaccharide Derivatives by Capillary Electrophoresis

D. Kahne, Kaustav Biswas, S. Pal, 2000 .

Antibiotic Combinations That Enable One-Step, Targeted Mutagenesis of Chromosomal Genes.

Wonsik Lee, Timothy C. Meredith, S. Walker, 2018, ACS infectious diseases.

The direction of chain growth and substrate preferences of SEDS-family peptidoglycan glycosyltransferases.

S. Walker, D. Kahne, A. Taguchi, 2019, Journal of the American Chemical Society.

The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel

D. Kahne, Elizaveta Freinkman, Shu-Sin Chng, 2011, Proceedings of the National Academy of Sciences.

The effects of glycosylation on peptide backbone conformation

A. Andreotti, D. Kahne, 1993 .

Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division.

D. Hooper, S. Walker, D. Kahne, 2014, ACS chemical biology.

Cationic facial amphiphiles: a promising class of transfection agents.

S. Midha, S. Babu, H. Axelrod, 1996, Proceedings of the National Academy of Sciences of the United States of America.

LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface

T. Silhavy, Dorothee Andres, D. Kahne, 2014, Proceedings of the National Academy of Sciences.

Glycopeptide and lipoglycopeptide antibiotics.

C. Walsh, W. Lu, D. Kahne, 2005, Chemical reviews.

The Mechanism of Action of Lysobactin.

R. Müller, Wonsik Lee, S. Walker, 2016, Journal of the American Chemical Society.

Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams

S. Walker, D. Kahne, N. Ruiz, 2017, Nature chemical biology.

Identification of a Functionally Unique Family of Penicillin-Binding Proteins.

M. Gilmore, S. Walker, D. Van Tyne, 2017, Journal of the American Chemical Society.

N-methylimidazolium chloride-catalyzed pyrophosphate formation: application to the synthesis of Lipid I and NDP-sugar donors.

D. Kahne, H. Tsukamoto, 2011, Bioorganic & medicinal chemistry letters.

Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

C. Walsh, D. Kahne, C. F. Freel Meyers, 2003, Biochemistry.

The assembly of β-barrel outer membrane proteins.

D. Kahne, D. Tomasek, 2021, Current opinion in microbiology.

Formation of a β-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA

D. Kahne, James Lee, D. Tomasek, 2019, eLife.

Characterization of a stalled complex on the β-barrel assembly machine

T. Silhavy, D. Kahne, N. Ruiz, 2016, Proceedings of the National Academy of Sciences.

Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model

David J. Sherman, T. Silhavy, D. Kahne, 2016, Nature Reviews Microbiology.

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli

T. Silhavy, D. Kahne, N. Ruiz, 2008, Proceedings of the National Academy of Sciences.

Analysis of Glycan Polymers Produced by Peptidoglycan Glycosyltransferases*

S. Walker, D. Kahne, T. Wang, 2007, Journal of Biological Chemistry.

Studying a cell division amidase using defined peptidoglycan substrates.

S. Walker, D. Kahne, D. Perlstein, 2009, Journal of the American Chemical Society.

Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn

D. Kahne, H. Clausen, S. Danishefsky, 2005, Cancer Immunology, Immunotherapy.

Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane

David J. Sherman, Janine M. May, D. Kahne, 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates.

D. Kahne, M. Oberthür, Catherine Leimkuhler, 2004, Organic letters.

Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7.

C. Walsh, S. Garneau‐Tsodikova, D. Kahne, 2007, Biochemistry.

In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides.

C. Walsh, S. Walker, D. Kahne, 2005, Journal of the American Chemical Society.

Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.

Ho Young Lee, C. Walsh, C. Khosla, 2004, Journal of the American Chemical Society.

Structural basis for unidirectional export of lipopolysaccharide to the cell surface

A. Kruse, D. Kahne, N. Ruiz, 2019, Nature.

Lipoprotein LptE is required for the assembly of LptD by the β-barrel assembly machine in the outer membrane of Escherichia coli

T. Silhavy, D. Kahne, N. Ruiz, 2011, Proceedings of the National Academy of Sciences.

AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.

Wei Lu, Daniel Kahne, Christopher T Walsh, 2004, Biochemistry.

Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.

C. Walsh, S. Walker, D. Kahne, 2007, Journal of the American Chemical Society.

Scavenging Byproducts in the Sulfoxide Glycosylation Reaction: Application to the Synthesis of Ciclamycin 0

D. Kahne, K. Sakurai, J. Gildersleeve, 1999 .

The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases.

S. Walker, D. Kahne, D. Perlstein, 2010, Journal of the American Chemical Society.

Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths.

S. Walker, D. Kahne, T. Wang, 2008, Journal of the American Chemical Society.

The direction of glycan chain elongation by peptidoglycan glycosyltransferases.

S. Walker, D. Kahne, D. Perlstein, 2007, Journal of the American Chemical Society.

Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases.

S. Walker, D. Kahne, Eric J. Fechter, 2007, Journal of the American Chemical Society.

Better substrates for bacterial transglycosylases.

S. Walker, D. Kahne, X. Ye, 2001, Journal of the American Chemical Society.

Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors

P. Schultz, Timothy C. Meredith, D. Kahne, 2018, Proceedings of the National Academy of Sciences.

Development of an activity assay for discovery of inhibitors of lipopolysaccharide transport.

D. Kahne, Luisa S. Gronenberg, 2010, Journal of the American Chemical Society.

Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway.

C. Walsh, D. Kahne, C. F. Freel Meyers, 2005, Biochemistry.

Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN.

C. Walsh, D. Kahne, L. Heide, 2004, Biochemistry.

The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.

David J. Sherman, Janine M. May, D. Kahne, 2017, Journal of the American Chemical Society.

Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin.

C. Walsh, D. Kahne, Wei Lu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Concise synthesis of the calicheamicin oligosaccharide using the sulfoxide glycosylation method

D. Augeri, Soong-Hoon Kim, Dan Yang, 1994 .

Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex.

D. Kahne, Luisa S. Gronenberg, Shu-Sin Chng, 2010, Biochemistry.

Studies of the 2:1 chromomycin A3-Mg2+ complex in methanol: role of the carbohydrates in complex formation

D. Kahne, Domingos J. Silva, 1993 .

Substituent effects on the stereochemistry of substituted cyclohexanone dimethylhydrazone alkylations. An x-ray crystal structure of lithiated cyclohexanone dimethylhydrazone

J. Clardy, G. Duyne, F. Mohamadi, 1984 .

Synthesis of Vancomycin from the Aglycon

D. Kahne, M. Ge, C. Thompson, 1999 .

Glycosylation of unreactive substrates

Yuan Cheng, S. Walker, D. Kahne, 1989 .

Stereocontrol in homogeneous catalytic hydrogenation via hydroxyl group coordination

D. Kahne, G. Stork, 1983 .

The use of alkoxy-substituted anomeric radicals for the construction of β-glycosides

Dan Yang, D. Kahne, J. Lim, 1988 .

A one-step synthesis of the ciclamycin trisaccharide

D. Kahne, Subharekha Raghavan, 1993 .

SmI2 cleavage of chromomycin A3 sugars

D. Kahne, G. Molander, C. Harris, 1999 .

The sugars in chromomycin A3 stabilize the Mg(2+)-dimer complex.

D. Kahne, D. J. Silva, R. Goodnow, 1993, Biochemistry.

Sugars as DNA binders: a comment on the calicheamicin oligosaccharide

K. Valentine, S. Walker, D. Kahne, 1990 .

Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics.

Steven J. Malcolmson, N. Kelleher, C. Walsh, 2011, Journal of the American Chemical Society.

Direct introduction of CH2OH by intermolecular trapping of CO

D. Kahne, Varsha Gupta, 1993 .

Kinetic cyanations of ketone enolates

D. Kahne, D. B. Collum, D. Collum, 1982 .

Construction of glycosidic N-O linkages in oligosaccharides

Soong-Hoon Kim, Dan Yang, D. Kahne, 1991 .

Reconstruction of Vancomycin by Chemical Glycosylation of the Pseudoaglycon

D. Kahne, M. Ge, C. Thompson, 1998 .

Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate

S. Walker, D. Kahne, Yanan Hu, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides.

C. Walsh, Zhong Chen, M. Peczuh, 2001, Biochemistry.

Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala.

Zhong Chen, M. Ge, D. Kahne, 1999, Science.

Glycosylation of glycopeptides: a comparison of chemoenzymatic and chemical methods

C. Walsh, Zhong Chen, R. Kruger, 2005 .

Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library

W. C. Still, D. Kahne, Y. Uozumi, 1996, Science.

The Role of Hydrophobic Substituents in the Biological Activityof Glycopeptide Antibiotics

J. Carbeck, D. Kahne, S. Fukuzawa, 2000 .

Preparation of the 4-ethylamino sugar of calicheamicin: Assignment of absolute configuration.

Dan Yang, D. Kahne, M. Lee, 1990 .

Generalizing Glycosylation: Synthesis of the Blood Group Antigens Lea, Leb, and Lex Using a Standard Set of Reaction Conditions

D. Kahne, Lin Yan, 1996 .

Design of an Oligosaccharide Scaffold That Binds in the Minor Groove of DNA

D. Kahne, M. Maletic, J. Gildersleeve, 2000 .

A One-Step Synthesis of the Ciclamycin Trisaccharide.

D. Kahne, Subharekha Raghavan, 1993 .

Sulfenate Intermediates in the Sulfoxide Glycosylation Reaction

D. Kahne, J. Gildersleeve, R. A. Pascal, 1998 .

Efficient Regio- and Stereocontrolled Synthesis of Highly Functionalized Polycyclic Systems Using the Diels-Alder Addition of Stannyl-Substituted Vinylketeneacetals

D. Kahne, G. Stork, 1989 .

p-Methoxybenzyl Ethers as Acid-Labile Protecting Groups in Oligosaccharide Synthesis

D. Kahne, Lin Yan, 1995 .

A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis.

C. Walsh, D. Kahne, Wenjun Zhang, 2010, Journal of the American Chemical Society.

Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli.

T. Silhavy, D. Kahne, Tao Wu, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Hydrogen Bonding in Micelle Formation

Yuan Cheng, D. Kahne, P. Venkatesan, 1994 .

The total synthesis of moenomycin A.

D. Kahne, Xuechen Li, Wenjiang Zhu, 2006, Journal of the American Chemical Society.

Glycosylation on the Merrifield Resin Using Anomeric Sulfoxides

D. Kahne, Carol M. Taylor, Lin Yan, 1994 .

Analysis of Hydroxylamine Glycosidic Linkages: Structural Consequences of the NO Bond in Calicheamicin

S. Walker, D. Kahne, D. Gange, 1994 .

Determining absolute configuration in flexible molecules: a case study.

P. Wipf, N. Berova, D. Beratan, 2001, Journal of the American Chemical Society.

On the essentiality of lipopolysaccharide to Gram-negative bacteria.

Timothy C. Meredith, D. Kahne, Ge Zhang, 2013, Current opinion in microbiology.

FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein

A. Kruse, Wonsik Lee, S. Walker, 2018, Nature Microbiology.

A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery

A. Kruse, E. Garner, S. Walker, 2018, PLoS genetics.

An activation pathway governs cell wall polymerization by a bacterial morphogenic machine

A. Kruse, E. Garner, S. Walker, 2018, bioRxiv.

FtsW is a peptidoglycan polymerase that is activated by its cognate penicillin-binding protein

Wonsik Lee, S. Walker, D. Kahne, 2018, bioRxiv.

SEDS proteins are a widespread family of bacterial cell wall polymerases

A. Kruse, W. Robins, D. Rudner, 2016, Nature.

Outer Membrane Biogenesis.

T. Silhavy, D. Kahne, Anna Konovalova, 2017, Annual review of microbiology.

Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane

David J. Sherman, Janine M. May, D. Kahne, 2015, Philosophical Transactions of the Royal Society B: Biological Sciences.

Haloduracin α Binds the Peptidoglycan Precursor Lipid II with 2:1 Stoichiometry

S. Walker, D. Kahne, W. A. van der Donk, 2011, Journal of the American Chemical Society.

Polyvalent binding to carbohydrates immobilized on an insoluble resin.

M. Ge, D. Kahne, L. Yan, 1997, Proceedings of the National Academy of Sciences of the United States of America.

YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli

T. Silhavy, R. Misra, John N. Werner, 2006, Molecular microbiology.

β-Barrel membrane protein assembly by the Bam complex.

T. Silhavy, D. Kahne, Christine L Hagan, 2011, Annual review of biochemistry.

Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane

T. Silhavy, D. Kahne, N. Ruiz, 2010, Proceedings of the National Academy of Sciences.

Nonstatistical binding of a protein to clustered carbohydrates.

G. Whitesides, D. Kahne, L. Yan, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface

T. Silhavy, Dorothee Andres, D. Kahne, 2014, eLife.

Cytoplasmic ATP Hydrolysis Powers Transport of Lipopolysaccharide Across the Periplasm in E. coli

D. Kahne, Elizaveta Freinkman, Suguru Okuda, 2012, Science.

Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export.

D. Kahne, N. Ruiz, Elizaveta Freinkman, 2012, Biochemistry.

Transport of lipopolysaccharide across the cell envelope: the long road of discovery

T. Silhavy, D. Kahne, N. Ruiz, 2009, Nature Reviews Microbiology.

Functional and structural analysis of a key region of the cell wall inhibitor moenomycin.

S. Walker, D. Kahne, Shinichiro Fuse, 2010, ACS chemical biology.

Complete characterization of the seventeen step moenomycin biosynthetic pathway.

S. Walker, D. Kahne, B. Ostash, 2009, Biochemistry.

d-Amino Acids Indirectly Inhibit Biofilm Formation in Bacillus subtilis by Interfering with Protein Synthesis

Daniel Kahne, Roberto Kolter, R. Losick, 2013, Journal of bacteriology.

SENSITIVITY OF GLYCOPEPTIDE CONFORMATION TO CARBOHYDRATE CHAIN LENGTH

A. Andreotti, D. Kahne, R. Liang, 1995 .

Reconstitution of Peptidoglycan Cross-Linking Leads to Improved Fluorescent Probes of Cell Wall Synthesis

R. Losick, D. Rudner, S. Walker, 2014, Journal of the American Chemical Society.

Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan.

S. Walker, D. Kahne, T. Wang, 2011, Journal of the American Chemical Society.

Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis

Debora S. Marks, Thomas A. Hopf, Anna G. Green, 2018, Nature.

Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors

T. Silhavy, D. Kahne, Christine L Hagan, 2017 .

Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2.

C. Schubert, D. Kahne, K. Sakurai, 2006, Journal of the American Chemical Society.

Use of a retroinverso p53 peptide as an inhibitor of MDM2.

D. Kahne, Hak Suk Chung, K. Sakurai, 2004, Journal of the American Chemical Society.

A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane

D. Kahne, N. Ruiz, B. Bertani, 2018, Molecular microbiology.

MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis

Lok-To Sham, D. Kahne, T. Bernhardt, 2014, Science.

Disulfide Rearrangement Triggered by Translocon Assembly Controls Lipopolysaccharide Export

J. Beckwith, D. Boyd, D. Kahne, 2012, Science.

Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli

Daniel Kahne, T. Silhavy, D. Kahne, 2007, Proceedings of the National Academy of Sciences.

Structural basis for unidirectional export of lipopolysaccharide to the cell surface

A. Kruse, D. Kahne, N. Ruiz, 2019, Nature.

Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge

David J. Sherman, D. Needleman, D. Kahne, 2018, Science.

Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex

Anna G. Green, D. Marks, A. Kruse, 2020, Nature Microbiology.

Hydrolysis of a peptide bond in neutral water

W. C. Still, D. Kahne, W. Still, 1988 .

Structure and Function of an Essential Component of the Outer Membrane Protein Assembly Machine

Piotr Sliz, Daniel Kahne, S. Harrison, 2007, Science.

Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization

Marina Santiago, S. Walker, D. Kahne, 2020, Nature microbiology.

Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization

Marina Santiago, S. Walker, D. Kahne, 2020, Nature Microbiology.

Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan

S. Walker, M. G. Pinho, D. Kahne, 2019, Nature Microbiology.

The cell cycle in Staphylococcus aureus is regulated by an amidase that controls peptidoglycan synthesis

S. Walker, M. G. Pinho, D. Kahne, 2019, bioRxiv.

Robust Suppression of Lipopolysaccharide Deficiency in Acinetobacter baumannii by Growth in Minimal Medium

R. Losick, D. Kahne, E. Nagy, 2019, Journal of bacteriology.

Outer Membrane Translocon Communicates with Inner Membrane ATPase To Stop Lipopolysaccharide Transport.

D. Kahne, Ran Xie, Rebecca J. Taylor, 2018, Journal of the American Chemical Society.

Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport

David J. Sherman, S. Walker, D. Kahne, 2014, Proceedings of the National Academy of Sciences.

The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

M. Nardini, M. Bolognesi, L. Gourlay, 2013, Journal of bacteriology.

Inhibition of the β-barrel assembly machine by a peptide that binds BamD

D. Kahne, Christine L Hagan, J. Wzorek, 2015, Proceedings of the National Academy of Sciences.

β-Barrel Membrane Protein Assembly by the

T. Silhavy, D. Kahne, Christine L Hagan, 2011 .

Using biological performance similarity to inform disaccharide library design.

Paul A. Clemons, Daniel Kahne, P. Clemons, 2009, Journal of the American Chemical Society.

The Bacterial Cell Wall: From Lipid II Flipping to Polymerization.

D. Kahne, N. Ruiz, Sujeet Kumar, 2022, Chemical reviews.

Probing the barrier function of the outer membrane with chemical conditionality.

T. Silhavy, D. Kahne, N. Ruiz, 2006, ACS chemical biology.

Fine-Tuning of σE Activation Suppresses Multiple Assembly-Defective Mutations in Escherichia coli

T. Silhavy, D. Kahne, J. Wzorek, 2019, Journal of bacteriology.

Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics.

D. Kahne, K. Sakurai, 2010, Tetrahedron letters.

Strategies for the design of minor groove binders: a re-evaluation based on the emergence of site-selective carbohydrate binders.

D. Kahne, 1995, Chemistry & biology.

Cleavage behavior of calicheamicin gamma 1 and calicheamicin T.

S. Walker, D. Kahne, G. Ellestad, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Structure of a nascent membrane protein as it folds on the Bam complex

S. Harrison, S. Rawson, D. Kahne, 2020, Nature.

Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion

T. Silhavy, D. Kahne, Christine L Hagan, 2018, Proceedings of the National Academy of Sciences.

In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins.

S. Walker, D. Kahne, Yuan Qiao, 2017, Nature chemical biology.

Structurally Homologous Domains Export Is Assembled via Conserved Protein Complex for Lipopolysaccharide The Escherichia coli Lpt Transenvelope

M. Nardini, M. Bolognesi, L. Gourlay, 2013 .

Activation of the Escherichia coli β-barrel assembly machine (Bam) is required for essential components to interact properly with substrate

T. Silhavy, D. Kahne, Christine L Hagan, 2012, Proceedings of the National Academy of Sciences.

Pathway-Directed Screen for Inhibitors of the Bacterial Cell Elongation Machinery

S. Walker, D. Kahne, T. Bernhardt, 2018, Antimicrobial Agents and Chemotherapy.

Hydrogen abstraction on photolysis of a naphthocarborane

D. Kahne, A. J. Link, Zhendong Zhu, 2000 .

Rapid β-lactam-induced lysis requires successful assembly of the cell division machinery

R. Kishony, J. Beckwith, D. Kahne, 2009, Proceedings of the National Academy of Sciences.

Membrane Potential Is Required for MurJ Function.

S. Walker, D. Kahne, N. Ruiz, 2018, Journal of the American Chemical Society.

Overcoming degeneracy in carbohydrate recognition.

A. Basu, D. Kahne, 2003, Angewandte Chemie.

Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1.

C. Walsh, S. Garneau‐Tsodikova, D. Kahne, 2006, Biochemistry.

Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections.

S. Walker, D. Kahne, Yuan Qiao, 2017, Journal of the American Chemical Society.

Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain.

D. Kahne, Catherine Leimkuhler, Yi Zhang, 2006, Journal of the American Chemical Society.

Suppressor Mutations in LptF Bypass Essentiality of LptC by Forming a Six-Protein Transenvelope Bridge That Efficiently Transports Lipopolysaccharide

J. Simorre, D. Kahne, E. C. M. Moura, 2022, mBio.

The structural basis for induction of VanB resistance.

C. Walsh, M. Peczuh, D. Kahne, 2002, Journal of the American Chemical Society.

Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons.

C. Walsh, R. Kruger, D. Kahne, 2005, Chemistry & biology.

Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity

S. Walker, D. Kahne, T. Bernhardt, 2016, Proceedings of the National Academy of Sciences.

Detection of transport intermediates in the peptidoglycan flippase MurJ identifies residues essential for conformational cycling.

S. Walker, D. Kahne, N. Ruiz, 2020, Journal of the American Chemical Society.

Stochastic detection of monovalent and bivalent protein-ligand interactions.

Stefan Howorka, Daniel Kahne, S. Howorka, 2004, Angewandte Chemie.

Design of an Oligosaccharide Scaffold that Binds in the Minor Groove of DNA.

I. Pelczer, D. Kahne, M. Maletic, 2000 .

Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis

S. Walker, D. Kahne, Dianah Barrett, 2007, Proceedings of the National Academy of Sciences.

Crystal structure of the outer membrane lipopolysaccharide transport protein LptE (RlpB) from Escherichia coli in the tetragonal crystal form

D. Kahne, G. Malojcic, 2015 .

Crystal structure of the lipopolysaccharide assembly complex LptD-LptE from the Escherichia coli outer membrane

D. Kahne, R. Garner, G. Malojcic, 2015 .

A Fluorescent Probe Distinguishes between Inhibition of Early and Late Steps of Lipopolysaccharide Biogenesis in Whole Cells.

Timothy C. Meredith, D. Kahne, M. Lebar, 2017, ACS chemical biology.

Kinetic Characterization of the Glycosyltransferase Module of Staphylococcus aureus PBP2

S. Walker, D. Kahne, Catherine Leimkuhler, 2005, Journal of bacteriology.

Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus.

S. Walker, D. Kahne, K. Schaefer, 2018, Journal of the American Chemical Society.

Detection of Lipid-Linked Peptidoglycan Precursors by Exploiting an Unexpected Transpeptidase Reaction

S. Walker, D. Kahne, Yuan Qiao, 2014, Journal of the American Chemical Society.

Chemical tools to characterize peptidoglycan synthases.

S. Walker, D. Kahne, A. Taguchi, 2019, Current opinion in chemical biology.

Outer Membrane Biogenesis.

T. Silhavy, D. Kahne, Anna Konovalova, 2017, Annual review of microbiology.

Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge

David J. Sherman, D. Needleman, D. Kahne, 2018, Science.

Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II.

S. Walker, Janine M. May, D. Kahne, 2013, Journal of the American Chemical Society.

Structural requirements for VanA activity of vancomycin analogues

Zhong Chen, D. Kahne, U. Eggert, 2002 .

The Mechanism of Action of Lysobactin.

R. Müller, Wonsik Lee, S. Walker, 2016, Journal of the American Chemical Society.

The Escherichia coli Lpt Transenvelope Protein Complex for Lipopolysaccharide Export Is Assembled via Conserved Structurally Homologous Domains

M. Nardini, M. Bolognesi, L. Gourlay, 2013, Journal of bacteriology.

Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors.

S. Walker, D. Kahne, H. Tsukamoto, 2013, Journal of the American Chemical Society.

Primer preactivation of peptidoglycan polymerases.

S. Walker, D. Kahne, Yihui Wu, 2011, Journal of the American Chemical Society.

LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface

T. Silhavy, Dorothee Andres, D. Kahne, 2014, Proceedings of the National Academy of Sciences.

Nonconsecutive disulfide bond formation in an essential integral outer membrane protein

T. Silhavy, D. Kahne, N. Ruiz, 2010, Proceedings of the National Academy of Sciences.

Structure and Function of an Essential Component of the Outer Membrane Protein Assembly Machine

S. Harrison, T. Silhavy, D. Kahne, 2007, Science.

Use of triethylene glycol to mimic oligosaccharides: design and synthesis of a ligand based on chromomycin A3.

D. Kahne, C. Kraml, D. J. Silva, 1994, Bioorganic & medicinal chemistry.