L. Taupenot

发表

Stimulus-transcription Coupling in Pheochromocytoma Cells

D. O'Connor, K. Tang, S. Mahata, 1996, The Journal of Biological Chemistry.

Tyrosine Hydroxylase, the Rate-Limiting Enzyme in Catecholamine Biosynthesis: Discovery of Common Human Genetic Variants Governing Transcription, Autonomic Activity, and Blood Pressure In Vivo

Douglas W. Smith, N. Schork, D. O'Connor, 2007, Circulation.

Granulogenesis in Non-neuroendocrine COS-7 Cells Induced by EGFP-tagged Chromogranin A Gene Transfection: Identical and Distinct Distribution of CgA and EGFP

D. O'Connor, J. Itoh, S. Takekoshi, 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

JPET # 157271 1 Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15 q 24 : Influence on heritable autonomic traits in twin pairs

Smith, E. Eskin, N. Schork, 2009 .

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure

N. Schork, D. O'Connor, B. Tayo, 2010, Journal of hypertension.

The neuroendocrine peptide catestatin is a cutaneous antimicrobial and induced in the skin after injury.

D. O'Connor, P. Elias, S. Mahata, 2008, The Journal of investigative dermatology.

MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension.

N. Schork, D. O'Connor, G. Schmid-Schönbein, 2013, Human molecular genetics.

Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis.

C. Nievergelt, D. O'Connor, S. Mahata, 2009, Journal of the American Society of Nephrology : JASN.

A Common Genetic Variant in the 3′-UTR of Vacuolar H+-ATPase ATP6V0A1 Creates a Micro-RNA Motif to Alter Chromogranin A Processing and Hypertension Risk

D. O'Connor, L. Taupenot, Lei Wang, 2011, Circulation. Cardiovascular genetics.

JPET # 157271 1 Natural variation within the neuronal nicotinic acetylcholine receptor cluster on human chromosome 15 q 24 : Influence on heritable autonomic traits in twin pairs

E. Eskin, N. Schork, D. O'Connor, 2009 .

The Protein Architecture of Human Secretory Vesicles Reveals Differential Regulation of Signaling Molecule Secretion by Protein Kinases

D. O'Connor, T. Ideker, M. Smoot, 2012, PloS one.

Human Tyrosine Hydroxylase Natural Genetic Variation: Delineation of Functional Transcriptional Control Motifs Disrupted in the Proximal Promoter

D. O'Connor, J. Rodriguez-Flores, B. Brar, 2010, Circulation. Cardiovascular genetics.

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

N. Schork, D. O'Connor, R. Salem, 2008, Journal of the American College of Cardiology.

Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism.

D. O'Connor, R. Salem, R. Henry, 2005, The Journal of clinical endocrinology and metabolism.

Genome-wide linkage analysis of chromogranin B expression in the CEPH pedigrees: implications for exocytotic sympathochromaffin secretion in humans.

N. Schork, D. O'Connor, M. Stridsberg, 2004, Physiological genomics.

Peptidergic activation of transcription and secretion in chromaffin cells. Cis and trans signaling determinants of pituitary adenylyl cyclase-activating polypeptide (PACAP).

D. O'Connor, H. Wu, S. Mahata, 1998, The Journal of clinical investigation.

The Local Chromaffin Cell Plasminogen/Plasmin System and the Regulation of Catecholamine Secretion

S. Yasothornsrikul, L. Taupenot, L. Miles, 2002, Annals of the New York Academy of Sciences.

Tissue plasminogen activator and chromaffin cell function.

D. O'Connor, S. Mahata, M. Mahata, 2000, Advances in experimental medicine and biology.

Autonomic Function in Hypertension: Role of Genetic Variation at the Catecholamine Storage Vesicle Protein Chromogranin B

Douglas W. Smith, N. Schork, D. O'Connor, 2009, Circulation. Cardiovascular genetics.

Human Cathepsin V Protease Participates in Production of Enkephalin and NPY Neuropeptide Neurotransmitters*

D. O'Connor, C. Peters, T. Reinheckel, 2012, The Journal of Biological Chemistry.

Human pheochromocytoma: different patterns of catecholamines and chromogranins in the intact tumour, urine and serum in clinically unsuspected cases.

R. Angeletti, K. Helle, D. Aunis, 1996, Scandinavian journal of clinical and laboratory investigation.

Determinants for chromogranin A sorting into the regulated secretory pathway are also sufficient to generate granule-like structures in non-endocrine cells.

L. Taupenot, M. Spiess, C. Prescianotto-Baschong, 2009, The Biochemical journal.

Identification of a novel sorting determinant for the regulated pathway in the secretory protein chromogranin A

D. O'Connor, S. Mahata, L. Taupenot, 2002, Journal of Cell Science.

Role of H+-ATPase-mediated Acidification in Sorting and Release of the Regulated Secretory Protein Chromogranin A

D. O'Connor, L. Taupenot, K. L. Harper, 2005, Journal of Biological Chemistry.

Chapter 72 – Catecholamines, Pheochromocytoma, and Hypertension: Genomic Insights

N. Schork, D. O'Connor, S. Mahata, 2007 .

Transfection: Identical and Distinct Distribution of CgA and EGFP Granulogenesis in Non-neuroendocrine COS-7 Cells Induced by EGFP-tagged Chromogranin A Gene

D. O'Connor, S. Takekoshi, L. Taupenot, 2013 .

Secretory Granule Biogenesis in Sympathoadrenal Cells

D. O'Connor, L. Taupenot, A. Jackson, 2006, Journal of Biological Chemistry.

Catecholamine storage vesicles and the metabolic syndrome: the role of the chromogranin A fragment pancreastatin

D. O'Connor, R. Salem, S. Mahata, 2006, Diabetes, obesity & metabolism.

Intracellular Protein Trafficking into Catecholamine Storage Vesicles

D. O'Connor, L. Taupenot, N. Mahapatra, 2002 .

Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation.

N. Schork, D. O'Connor, N. Olson, 2007, Biochemistry.

Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells.

D. O'Connor, William Arbuthnot Sir Lane, B. Gibson, 2003, Biochemistry.

Proteolytic Cleavage of Chromogranin A (CgA) by Plasmin

D. O'Connor, S. Mahata, M. Mahata, 2001, The Journal of Biological Chemistry.

A novel, catecholamine release-inhibitory peptide from chromogranin A: autocrine control of nicotinic cholinergic-stimulated exocytosis.

D. O'Connor, S. Yoo, H. Wu, 1998, Advances in pharmacology.

Chromogranin A in human disease.

S. Mahata, M. Mahata, L. Taupenot, 2000, Advances in experimental medicine and biology.

Bacterial endotoxin induces [Ca2+]i transients and changes the organization of actin in microglia

D. Aunis, L. Taupenot, J. Ciesielski-Treska, 1994, Glia.

Chromogranin A Induces a Neurotoxic Phenotype in Brain Microglial Cells*

D. Aunis, S. Chasserot-Golaz, A. Corti, 1998, The Journal of Biological Chemistry.

The novel catecholamine release-inhibitory peptide catestatin (chromogranin A344-364). Properties and function.

D. O'Connor, S. Mahata, M. Mahata, 2000, Advances in experimental medicine and biology.

Human Tyrosine Hydroxylase Natural Allelic Variation: Influence on Autonomic Function and Hypertension

D. O'Connor, J. Rodriguez-Flores, J. Wessel, 2010, Cellular and Molecular Neurobiology.

Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin.

D. O'Connor, S. Mahata, M. Mahata, 2008, Endocrinology.

Chromogranin A induces a neurotoxic phenotype in brain microglial cells.

D. Aunis, S. Chasserot-Golaz, A. Corti, 1998, The Journal of biological chemistry.

Fast‐Breaking Results on the PACAP/VIP/Secretin Peptide Family in Chromaffin Cells

L. Taupenot, D. Vaudry, 2002, Annals of the New York Academy of Sciences.

The chromogranin-secretogranin family.

D. O'Connor, L. Taupenot, K. L. Harper, 2003, The New England journal of medicine.

mechanisms of disease The Chromogranin – Secretogranin Family

D. O'Connor, L. Taupenot, K. L. Harper, 2003 .

Chromogranin A alters ductal morphogenesis and increases deposition of basement membrane components by mammary epithelial cells in vitro.

L. Orci, M. Bader, R. Montesano, 1999, Biochemical and biophysical research communications.

Novel autocrine feedback control of catecholamine release. A discrete chromogranin a fragment is a noncompetitive nicotinic cholinergic antagonist.

D. O'Connor, S. Yoo, H. Wu, 1997, The Journal of clinical investigation.

Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides.

D. O'Connor, J. Rodriguez-Flores, S. Mahata, 2009, Endocrinology.

Nerve growth factor‐stimulated neuronal differentiation induces changes in P2 receptor expression and nucleotide‐stimulated catecholamine release

P. Insel, L. Taupenot, David B. Arthur, 2007, Journal of neurochemistry.

Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.

D. O'Connor, B. Tayo, R. Salem, 2010, Journal of the American College of Cardiology.

Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin

D. O'Connor, B. Brar, S. Mahata, 2011, Cell and Tissue Research.

Genetic regulation of catecholamine synthesis, storage and secretion in the spontaneously hypertensive rat.

N. Schork, D. O'Connor, T. Aitman, 2010, Human molecular genetics.

Long‐term induction of an aldose reductase protein by basic fibroblast growth factor in rat astrocytes in vitro

G. Labourdette, P. Bouillon, L. Taupenot, 1995, Electrophoresis.

Chromogranin a triggers a phenotypic transformation and the generation of nitric oxide in brain microglial cells

D. Aunis, S. Chasserot-Golaz, M. Bader, 1996, Neuroscience.

Genetic variation at the delta‐sarcoglycan (SGCD) locus elevates heritable sympathetic nerve activity in human twin pairs

C. Nievergelt, A. Schork, D. O'Connor, 2013, Journal of neurochemistry.

Pro-hormone Secretogranin II Regulates Dense Core Secretory Granule Biogenesis in Catecholaminergic Cells*

D. O'Connor, R. Giuly, J. Rodriguez-Flores, 2010, The Journal of Biological Chemistry.

Interaction of the catecholamine release-inhibitory peptide catestatin (human chromogranin A352-372) with the chromaffin cell surface and Torpedo electroplax: implications for nicotinic cholinergic antagonism

D. O'Connor, S. Mahata, M. Mahata, 2000, Regulatory Peptides.

Pleiotropic effects of novel trans-acting loci influencing human sympathochromaffin secretion.

N. Schork, D. O'Connor, S. Mahata, 2006, Physiological genomics.

Natural Variation within the Neuronal Nicotinic Acetylcholine Receptor Cluster on Human Chromosome 15q24: Influence on Heritable Autonomic Traits in Twin Pairs

Douglas W. Smith, E. Eskin, N. Schork, 2009, Journal of Pharmacology and Experimental Therapeutics.

Processing of chromogranin B in bovine adrenal medulla. Identification of secretolytin, the endogenous C-terminal fragment of residues 614-626 with antibacterial activity.

D. Aunis, A. van Dorsselaer, L. Taupenot, 1995, European journal of biochemistry.

The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.

D. O'Connor, S. Mahata, L. Taupenot, 2008, Biochemistry.

Primary culture of bovine chromaffin cells

D. O'Connor, S. Mahata, M. Mahata, 2007, Nature Protocols.

Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing.

Nitin Gupta, Pavel Pevzner, P. Pevzner, 2010, Journal of proteome research.

Secretoneurin and chemoattractant receptor interactions

D. O'Connor, D. Kelvin, S. Mahata, 1998, Journal of Neuroimmunology.

Neuroendocrine nicotinic receptor activation increases susceptibility to bacterial infections by suppressing antimicrobial peptide production.

D. O'Connor, P. Elias, S. Mahata, 2010, Cell host & microbe.

Recombinant human chromogranin A: expression, purification and characterization of the N-terminal derived peptides

K. Helle, D. Aunis, M. Bader, 1995, Regulatory Peptides.

Analysis of Regulated Secretion Using PC12 Cells

L. Taupenot, 2007, Current protocols in cell biology.

Heritability and Genome-Wide Linkage in US and Australian Twins Identify Novel Genomic Regions Controlling Chromogranin A: Implications for Secretion and Blood Pressure

D. O'Connor, N. Martin, J. Whitfield, 2008, Circulation.

Cox-2 promotes chromogranin A expression and bioactivity: evidence for a prostaglandin E2-dependent mechanism and the involvement of a proximal cyclic adenosine 5'-monophosphate-responsive element.

D. O'Connor, N. Loh, R. Thakker, 2007, Endocrinology.

Time-dependent effects of the neuropeptide PACAP on catecholamine secretion : stimulation and desensitization.

D. O'Connor, S. Mahata, M. Mahata, 1999, Hypertension.

Heredity of Endothelin Secretion: Human Twin Studies Reveal the Influence of Polymorphism at the Chromogranin A Locus, a Novel Determinant of Endothelial Function

Douglas W. Smith, N. Schork, D. O'Connor, 2007, Circulation.

Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a β-strand/loop/β-strand structure secured by hydrophobic interactions and predictive of activity

Igor Tsigelny, D. O'Connor, I. Tsigelny, 1998, Regulatory Peptides.

Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway

S. Mahata, L. Taupenot, V. Hook, 2008, Journal of Biological Chemistry.

Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension.

D. O'Connor, B. Tayo, R. Salem, 2010, Journal of the American College of Cardiology.

Functional allelic heterogeneity and pleiotropy of a repeat polymorphism in tyrosine hydroxylase: prediction of catecholamines and response to stress in twins.

N. Schork, J. Wessel, M. Ziegler, 2004, Physiological genomics.

Regulation of chromogranin A transcription and catecholamine secretion by the neuropeptide PACAP. Stimulation and desensitization.

D. O'Connor, H. Wu, S. Mahata, 2000, Advances in experimental medicine and biology.

National Academy of Clinical Biochemistry Guidelines for the Use of Tumor Markers in Neoplasms of the Dispersed Neuroendocrine System

L. Taupenot, Shereen Ezzat, Sylvia L. Asa, 2022 .

Autonomic Function in Hypertension: Role of Genetic Variation at the Catecholamine Storage Vesicle Protein Chromogranin B

Douglas W. Smith, N. Schork, D. O'Connor, 2009, Circulation. Cardiovascular genetics.