A. Orr

发表

Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures

R. Everett, P. Barlow, P. O’Hare, 1995, Journal of virology.

Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection

C. Boutell, S. McFarlane, T. Alandijany, 2018, PLoS pathogens.

The Replication Defect of ICP0-Null Mutant Herpes Simplex Virus 1 Can Be Largely Complemented by the Combined Activities of Human Cytomegalovirus Proteins IE1 and pp71

R. Everett, A. Orr, A. J. Bell, 2012, Journal of Virology.

Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100

R. Everett, H. Sirma, A. Orr, 2007, Journal of Virology.

Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100

R. Everett, H. Sirma, A. Orr, 2007, Journal of Virology.

Herpes Simplex Virus 1 Ubiquitin Ligase ICP0 Interacts with PML Isoform I and Induces Its SUMO-Independent Degradation

R. Everett, A. Orr, M. Glass, 2012, Journal of Virology.

PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication

R. Everett, H. Sirma, J. Heeren, 2011, Journal of Cell Science.

Cell cycle regulation of PML modification and ND10 composition.

R. van Driel, R. Everett, T. Sternsdorf, 1999, Journal of cell science.

A dynamic connection between centromeres and ND10 proteins.

W. Earnshaw, R. Everett, T. Sternsdorf, 1999, Journal of cell science.

The homeodomain-interacting kinase PKM (HIPK-2) modifies ND10 through both its kinase domain and a SUMO-1 interaction motif and alters the posttranslational modification of PML.

C. Boutell, R. Everett, A. Orr, 2003, Experimental cell research.

STAT-1- and IRF-3-Dependent Pathways Are Not Essential for Repression of ICP0-Null Mutant Herpes Simplex Virus Type 1 in Human Fibroblasts

R. Everett, R. Randall, A. Orr, 2008, Journal of Virology.

Distribution of topoisomerase II cleavage sites in simian virus 40 DNA and the effects of drugs.

K. Kohn, Y. Pommier, G. Capranico, 1991, Journal of molecular biology.

Recruitment of Herpes Simplex Virus Type 1 Transcriptional Regulatory Protein ICP4 into Foci Juxtaposed to ND10 in Live, Infected Cells

G. Sourvinos, R. Everett, A. Orr, 2003, Journal of Virology.

The Disruption of ND10 during Herpes Simplex Virus Infection Correlates with the Vmw110- and Proteasome-Dependent Loss of Several PML Isoforms

P. Freemont, M. Dasso, R. Everett, 1998, Journal of Virology.

The cellular RING finger protein PML is not a functional counterpart of the herpes simplex virus type 1 RING finger protein Vmw110.

R. Everett, M. Elliott, A. Orr, 1995, The Journal of general virology.

A truncated form of herpes simplex virus type 1 immediate-early protein Vmw110 is expressed in a cell type dependent manner.

R. Everett, A. Orr, A. Cross, 1993, Virology.

The Vmw175 binding site in the IE-1 promoter has no apparent role in the expression of Vmw110 during herpes simplex virus type 1 infection.

R. Everett, A. Orr, 1991, Virology.

Herpes simplex virus sequences involved in the initiation of oncogenic morphological transformation of rat cells are not required for maintenance of the transformed state.

I. R. Cameron, A. Orr, B. Dutia, 1985, The Journal of general virology.

The Chicken Adenovirus Gam1 Protein, an Inhibitor of the Sumoylation Pathway, Partially Complements ICP0-Null Mutant Herpes Simplex Virus 1

R. Everett, S. Chiocca, A. Orr, 2014, Journal of Virology.

The Chicken Adenovirus Gam 1 Protein , an Inhibitor of the Sumoylation Pathway , Partially Complements ICP 0-Null Mutant Herpes Simplex Virus 1

R. Everett, S. Chiocca, A. Orr, 2014 .

Cell cycle regulation of PML modification and ND 10 composition

R. Everett, T. Sternsdorf, A. Orr, 1999 .

A Viral Ubiquitin Ligase Has Substrate Preferential SUMO Targeted Ubiquitin Ligase Activity that Counteracts Intrinsic Antiviral Defence

C. Boutell, R. Everett, S. McFarlane, 2011, PLoS pathogens.

PML Residue Lysine 160 Is Required for the Degradation of PML Induced by Herpes Simplex Virus Type 1 Regulatory Protein ICP0

C. Boutell, R. Everett, A. Orr, 2003, Journal of Virology.

Herpes Simplex Virus Type 1 Genomes Are Associated with ND10 Nuclear Substructures in Quiescently Infected Human Fibroblasts

R. Everett, A. Orr, J. Murray, 2007, Journal of Virology.

The UL13 virion protein of herpes simplex virus type 1 is phosphorylated by a novel virus-induced protein kinase.

D. McGeoch, A. Dolan, A. Davison, 1992, The Journal of general virology.

A novel ubiquitin‐specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

R. Everett, A. Orr, A. Cross, 1997, The EMBO journal.

Impact of the Interaction between Herpes Simplex Virus Type 1 Regulatory Protein ICP0 and Ubiquitin-Specific Protease USP7 on Activation of Adeno-Associated Virus Type 2 rep Gene Expression

R. Everett, A. Orr, A. Salvetti, 2006, Journal of Virology.

Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7

C. Boutell, R. Everett, A. Orr, 2005, Journal of Virology.

Phenotype of a Herpes Simplex Virus Type 1 Mutant That Fails To Express Immediate-Early Regulatory Protein ICP0

C. Boutell, R. Everett, A. Orr, 2004, Journal of Virology.

A viral activator of gene expression functions via the ubiquitin–proteasome pathway

R. Everett, A. Orr, C. Preston, 1998, The EMBO journal.

Separation of sequence requirements for HSV-1 Vmw110 multimerisation and interaction with a 135-kDa cellular protein.

R. Everett, M. Elliott, A. Orr, 1995, Virology.

Herpes simplex virus type 1 immediate-early protein Vmw110 binds strongly and specifically to a 135-kDa cellular protein.

R. Everett, A. Orr, M. Meredith, 1994, Virology.

A novel ubiquitin‐specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

R. Everett, A. Orr, A. Cross, 1997, The EMBO journal.

A novel arrangement of zinc-binding residues and secondary structure in the C3HC4 motif of an alpha herpes virus protein family.

B. Luisi, R. Everett, P. Barlow, 1993, Journal of molecular biology.

Cellular proteins expressed in herpes simplex virus transformed cells also accumulate on herpes simplex virus infection.

N. L. La Thangue, A. Orr, J. Macnab, 1985, The EMBO journal.

The 10K virion phosphoprotein encoded by gene US9 from herpes simplex virus type 1.

D. McGeoch, F. Rixon, H. Marsden, 1986, Virology.

Rational design and molecular effects of a new topoisomerase II inhibitor, azatoxin.

Y. Pommier, T. Guzi, T. Macdonald, 1992, Cancer research.

Thiazolothiazepine inhibitors of HIV-1 integrase.

Y. Pommier, N. Neamati, G. Campiani, 1999, Journal of medicinal chemistry.

Arylisothiocyanate-containing esters of caffeic acid designed as affinity ligands for HIV-1 integrase.

Y. Pommier, R. Brown, N. Neamati, 2001, Bioorganic & medicinal chemistry.

Herpes Simplex Virus Type 1 Regulatory Protein ICP0 Aids Infection in Cells with a Preinduced Interferon Response but Does Not Impede Interferon-Induced Gene Induction

R. Everett, A. Orr, 2009, Journal of Virology.

PML Contributes to a Cellular Mechanism of Repression of Herpes Simplex Virus Type 1 Infection That Is Inactivated by ICP0

R. Everett, A. Orr, T. Stamminger, 2006, Journal of Virology.

Formation of Nuclear Foci of the Herpes Simplex Virus Type 1 Regulatory Protein ICP4 at Early Times of Infection: Localization, Dynamics, Recruitment of ICP27, and Evidence for the De Novo Induction of ND10-Like Complexes

G. Sourvinos, R. Everett, A. Orr, 2004, Journal of Virology.

Hypomethylation of host cell DNA synthesized after infection or transformation of cells by herpes simplex virus

A. Orr, R. Adams, J. Macnab, 1988, Molecular and cellular biology.

Hypomethylation ofHostCellDNA Synthesized after Infection or Transformation ofCells byHerpesSimplex Virus

A. Orr, R. Adams, J. Macnab, 1988 .

Metal-dependent inhibition of HIV-1 integrase.

Dirk Strumberg, Marc C Nicklaus, Yves Pommier, 2002, Journal of medicinal chemistry.

Binding to DNA and Its 2 Chemical Synthesis of Radiolabeled Bleomycin A Updated

Samar, George, A. Orr, 2006 .

Identification of the gene encoding the 65-kilodalton DNA-binding protein of herpes simplex virus type 1

D. McGeoch, H. Marsden, D. Parris, 1988, Journal of virology.

Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.

Alexander D. MacKerell, M C Nicklaus, Y. Pommier, 2000, Bioorganic & medicinal chemistry.

The Ability of Herpes Simplex Virus Type 1 Immediate-Early Protein Vmw110 To Bind to a Ubiquitin-Specific Protease Contributes to Its Roles in the Activation of Gene Expression and Stimulation of Virus Replication

R. Everett, A. Orr, M. Meredith, 1999, Journal of Virology.

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

Eui Tae Kim, M. Weitzman, C. Boutell, 2021, Nature Microbiology.

Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site.

R. Everett, M. Elliott, A. Orr, 1991, Nucleic acids research.

The equine herpesvirus 1 gene 63 RING finger protein partially complements Vmw110, its herpes simplex virus type 1 counterpart.

R. Everett, M. Elliott, A. Orr, 1995, The Journal of general virology.

High level expression and purification of herpes simplex virus type 1 immediate early polypeptide Vmw110.

R. Everett, M. Elliott, A. Orr, 1991, Nucleic acids research.

Replacement of the herpes simplex virus type 1 Vmw175 DNA binding domain with its varicella-zoster virus counterpart results in a protein with novel regulatory properties that can support virus growth.

R. Everett, J. Tyler, A. Orr, 1997, The Journal of general virology.

Analysis of the SUMO2 Proteome during HSV-1 Infection

M. Tatham, R. Hay, R. Everett, 2015, PLoS pathogens.

SUMO Pathway Dependent Recruitment of Cellular Repressors to Herpes Simplex Virus Type 1 Genomes

C. Boutell, R. Everett, A. Orr, 2011, PLoS pathogens.

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research

D. Robertson, J. Hughes, D. Alessi, 2021, PLoS biology.

Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide.

K. Kohn, Y. Pommier, G. Capranico, 1991, Nucleic acids research.

Identification of HIV-1 Integrase Inhibitors Based on a Four-Point Pharmacophore

Y. Pommier, N. Neamati, A. Orr, 1998, Antiviral chemistry & chemotherapy.

Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.

K. Kohn, Y. Pommier, A. Orr, 1992, Cancer research.

Rational Design and Molecular Effects of a New Topoisomerase II Inhibitor , Azatoxin 1

Y. Pommier, T. Macdonald, A. Orr, 2006 .

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection

C. Boutell, S. McFarlane, P. Adams, 2019, PLoS pathogens.

Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins

C. Boutell, R. Everett, A. Orr, 2010, Journal of Virology.

MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus

R. Everett, A. Orr, Elizabeth Sloan, 2016, Journal of Virology.

1 MORC 3 , a component of PML Nuclear Bodies , has a role in restricting herpes simplex 2 virus type 1 and human cytomegalovirus 3 4

R. Everett, A. Orr, Elizabeth Sloan, 2016 .

The Viral Ubiquitin Ligase ICP0 Is neither Sufficient nor Necessary for Degradation of the Cellular DNA Sensor IFI16 during Herpes Simplex Virus 1 Infection

R. Everett, A. Orr, Delphine Cuchet-Lourenço, 2013, Journal of Virology.

Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner

C. Boutell, R. Everett, P. Schaffer, 2008, Journal of Virology.

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

Eui Tae Kim, M. Weitzman, B. Garcia, 2021, Nature microbiology.

Stimulation of the Replication of ICP0-Null Mutant Herpes Simplex Virus 1 and pp71-Deficient Human Cytomegalovirus by Epstein-Barr Virus Tegument Protein BNRF1

R. Everett, A. Orr, Yongxu Lu, 2016, Journal of Virology.

C. Boutell, R. Everett, A. Orr, 2013, Journal of Virology.

Analysis of the Functions of Herpes Simplex Virus Type 1 Regulatory Protein ICP0 That Are Critical for Lytic Infection and Derepression of Quiescent Viral Genomes

R. Everett, M. Parsy, A. Orr, 2009, Journal of Virology.

Stimulation of the Replication of ICP0-Null Mutant Herpes Simplex Virus 1 and pp71-Deficient Human Cytomegalovirus by Epstein-Barr Virus Tegument Protein BNRF1

R. Everett, A. Orr, Yongxu Lu, 2016, Journal of Virology.

A transformation-specific polypeptide distinct from heat shock proteins is induced by herpes simplex virus type 2 infection.

A. Orr, J. Macnab, R. Hewitt, 1991, The Journal of general virology.

Comparison of the Biological and Biochemical Activities of Several Members of the Alphaherpesvirus ICP0 Family of Proteins

R. Everett, A. Orr, L. Grant, 2010, Journal of Virology.

Point mutations in the herpes simplex virus type 1 Vmw110 RING finger helix affect activation of gene expression, viral growth, and interaction with PML-containing nuclear structures

R. Everett, A. Orr, Peter O'Hare, 1995, Journal of virology.

An epitope within the DNA-binding domain of the herpes simplex virus immediate early protein Vmw175 is conserved in the varicella-zoster virus gene 62 protein.

R. Everett, J. Tyler, A. Orr, 1993, The Journal of general virology.

Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner

R. Everett, P. Schaffer, A. Orr, 2008, Journal of Virology.