Y. Ioannou

发表

Neural gene therapy for inherited diseases with mental retardation: Principles and prospects

R. Desnick, M. Rattazzi, E. Schuchman, 1995 .

Human acid beta-glucosidase. N-glycosylation site occupancy and the effect of glycosylation on enzymatic activity.

Y. Ioannou, G. Grabowski, M. Grace, 1993, The Journal of biological chemistry.

Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes.

Y. Ioannou, M. E. Higgins, Maureen E. Higgins, 2001, Journal of lipid research.

Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat*

J. Repa, K. Higaki, D. Ory, 2016, The Journal of Biological Chemistry.

Niemann-Pick C1-Like 1 Is Required for an LXR Agonist to Raise Plasma HDL Cholesterol in Mice

L. Jia, Y. Ioannou, Liqing Yu, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Inactivation of NPC1L1 Causes Multiple Lipid Transport Defects and Protects against Diet-induced Hypercholesterolemia*

Y. Ioannou, K. Oishi, C. Scott, 2005, Journal of Biological Chemistry.

The structure and function of the Niemann-Pick C1 protein.

Y. Ioannou, 2000, Molecular genetics and metabolism.

NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein.

R. Gordon, Y. Ioannou, Fannie W. Chen, 2005, The Biochemical journal.

Niemann-Pick C proteins in sterol transport and absorption: flies in the ointment.

Y. Ioannou, 2007, Developmental cell.

Combined transgenic expression of alpha-galactosidase and alpha1,2-fucosyltransferase leads to optimal reduction in the major xenoepitope Galalpha(1,3)Gal.

R. Desnick, Y. Ioannou, M. Sandrin, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Gene therapy for lysosomal storage disorders

Y. Ioannou, C. Benjamin, A. Enriquez, 2003, Expert opinion on biological therapy.

Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice.

P. Howles, P. Tso, Y. Ioannou, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Guilty until proven innocent: the case of NPC1 and cholesterol.

Y. Ioannou, 2005, Trends in biochemical sciences.

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.

P. Howles, Y. Ioannou, D. Hui, 2007, Biochimica et biophysica acta.

Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer.

R. Desnick, H. Romanczuk, S. Cheng, 1999, Human gene therapy.

Human alpha-galactosidase A: glycosylation site 3 is essential for enzyme solubility.

R. Desnick, Y. Ioannou, M. Grace, 1998, The Biochemical journal.

Overexpression of human alpha-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion

R. Desnick, Y. Ioannou, D. Bishop, 1992, The Journal of cell biology.

Quantitative determination of globotriaosylceramide by immunodetection of glycolipid-bound recombinant verotoxin B subunit.

R. Desnick, Y. Ioannou, K. M. Zeidner, 1999, Analytical biochemistry.

Fabry disease: preclinical studies demonstrate the effectiveness of alpha-galactosidase A replacement in enzyme-deficient mice.

R. Desnick, R. Gordon, Y. Ioannou, 2001, American journal of human genetics.

Niemann‐Pick C1 Protein

Y. Ioannou, 2002 .

Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4

T. Yoshimori, Y. Ioannou, Y. Ohsaki, 2006, Journal of Cell Science.

Reduced sensitivity of Niemann-Pick C1-deficient cells to θ-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles

Y. Ioannou, Y. Shimada, Y. Ohsaki, 2004, Histochemistry and Cell Biology.

The role of the Niemann–Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis

Y. Ioannou, J. P. Davies, 2006, Current opinion in lipidology.

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.

H. Hauser, E. Carreira, Y. Ioannou, 2007, Biochimica et biophysica acta.

Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease.

M. Goldberg, R. Desnick, Seng H. Cheng, 2002, Human gene therapy.

NPC 1 late endosomes contain elevated levels of non-esterified ( ‘ free ’ ) fatty acids and an abnormally glycosylated form of the NPC 2 protein

R. Gordon, Y. Ioannou, Fannie W. Chen, 2005 .

Cyclodextrin Induces Calcium-Dependent Lysosomal Exocytosis

Y. Ioannou, Chunlei Li, Fannie W. Chen, 2010, PloS one.

Human α-galactosidase A: characterization of the N-linked oligosaccharides on the intracellular and secreted glycoforms overexpressed by Chinese hamster ovary cells

R. Desnick, Y. Ioannou, M. Ohta, 1998 .

Human α-N-acetylgalactosaminidase: site occupancy and structure of N-linked oligosaccharides

R. Desnick, Y. Ioannou, M. Ohta, 2000 .

In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver.

E. Christensen, Y. Ioannou, T. N. Krogh, 2011, Thrombosis research.

Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann–Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain

Y. Ioannou, Y. Ohsaki, Michitaka Suzuki, 2007, The Journal of Neuroscience.

NPC1 Late Endosomes contain Elevated Levels of Free Fatty Acids and an Abnormally Glycosylated Form of the NPC2 Protein

R. Gordon, Y. Ioannou, Fannie W. Chen, 2005 .

Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

Mercedes K. Taylor, M. Ferrer, Noel Southall, 2022, iScience.

Sequence Analysis

Y. Ioannou, 2000, Science.

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.

M. Willingham, Y. Ioannou, L. Rudel, 2007, The Journal of clinical investigation.

Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells

K. Higaki, Y. Ioannou, Y. Ohsaki, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

K. G. Coleman, M. Polymeropoulos, W. Pavan, 1997, Science.

Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice.

D. Forrest, B. Gelb, H. Vlassara, 2002, Human molecular genetics.

Targeting of NPC1 to Late Endosomes Involves Multiple Signals, Including One Residing within the Putative Sterol-sensing Domain*

Y. Ioannou, C. Scott, M. E. Higgins, 2004, Journal of Biological Chemistry.

Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network.

Y. Ioannou, M. E. Higgins, Fannie W. Chen, 1999, Molecular genetics and metabolism.

MLN64 Transport to the Late Endosome Is Regulated by Binding to 14-3-3 via a Non-canonical Binding Site

Y. Ioannou, Fannie W. Chen, J. P. Davies, 2012, PloS one.

PKC Activation in Niemann Pick C1 Cells Restores Subcellular Cholesterol Transport

Y. Ioannou, Chunlei Li, Fannie W. Chen, 2013, PloS one.

Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment

Y. Ioannou, Fannie W. Chen, F. Tamari, 2009, Biology of the cell.

Defects in transmembrane proteins

Y. Ioannou, 2004 .

Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes Published, JLR Papers in Press, November 4, 2002. DOI 10.1194/jlr.M200230-JLR200

Y. Ioannou, Marc Walter, Joanna P Davies, 2003, Journal of Lipid Research.

Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene.

Y. Ioannou, Y A Ioannou, J P Davies, 1997, Genomics.

Functional variants in the LRRK2 gene confer shared effects on risk for Crohn’s disease and Parkinson’s disease

Judy H. Cho, H. Ostrer, M. Daly, 2018, Science Translational Medicine.

Ribosomal proteins in cell proliferation and apoptosis.

Y. Ioannou, Y A Ioannou, F W Chen, 1999, International reviews of immunology.

Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor.

Y. Ioannou, J. P. Davies, F. W. Chen, 1998, Molecular genetics and metabolism.

Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

E. Chen, A. Borczuk, R. Sears, 2017, The Journal of clinical investigation.

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer.

R. Sears, W. Oh, M. Galsky, 2018, Cancer research.

Transmembrane molecular pump activity of Niemann-Pick C1 protein.

Y. Ioannou, Fannie W. Chen, J. P. Davies, 2000, Science.

Human α-Galactosidase: Characterization and Eukaryotic Expression of the Full-Length cDNA and Structural Organization of the Gene

C. Eng, R. Desnick, R. Kornreich, 1988 .

The NPC1 protein: structure implies function.

Y. Ioannou, C. Scott, 2004, Biochimica et biophysica acta.

An “Exacerbate-reverse” Strategy in Yeast Identifies Histone Deacetylase Inhibition as a Correction for Cholesterol and Sphingolipid Transport Defects in Human Niemann-Pick Type C Disease*♦

Martin Bard, Charles Boone, Katsumi Higaki, 2011, The Journal of Biological Chemistry.

Topological Analysis of Niemann-Pick C1 Protein Reveals That the Membrane Orientation of the Putative Sterol-sensing Domain Is Identical to Those of 3-Hydroxy-3-methylglutaryl-CoA Reductase and Sterol Regulatory Element Binding Protein Cleavage-activating Protein*

Yiannis A. Ioannou, Y. Ioannou, Joanna P. Davies, 2000, The Journal of Biological Chemistry.

Multidrug permeases and subcellular cholesterol transport

Y. Ioannou, 2001, Nature Reviews Molecular Cell Biology.

Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1.

B. Levy, Y. Ioannou, J. P. Davies, 2000, Genomics.

Genetic inactivation of NPC 1 L 1 protects against sitosterolemia in mice lacking ABCG 5 / ABCG 8

L. Jia, Y. Ioannou, Liqing Yu, 2009 .

Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation.

R. Desnick, A. Honda, Y. Ioannou, 1998, Journal of lipid research.

Gene therapy for lysosomal storage disorders with neuropathology.

Y. Ioannou, 2000, Journal of the American Society of Nephrology : JASN.

Quantitation of DNA fragmentation in apoptosis.

Y. Ioannou, Fannie W. Chen, F. W. Chen, 1996, Nucleic acids research.

Sequence Analysis

Y. Ioannou, 2000, Science.

A Frozen Database

Yiannis A. Ioannou, Y. Ioannou, 2000, Science.

In vivo clearance and metabolism of recombinant activated factor VII (rFVIIa) and its complexes with plasma protease inhibitors in the liver.

Y. Ioannou, T. Seested, D. Karpf, 2011, Thrombosis Research.

Sequence Analysis

Y. Ioannou, 2000, Science.

Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment

Y. Ioannou, Fannie W. Chen, F. Tamari, 2009, Biology of the Cell.