G. Sen

G. Sen, S. Chattopadhyay, 2014, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

MacrophagesInterferon Induction in Enhanced Encephalitis via Impaired Neurotropic Coronavirus Replication and Deficiency Results in Uncontrolled Ifit2

G. Sen, D. Hinton, S. Stohlman, 2014 .

encephalitis via impaired IFNα/β induction in macrophages 2

G. Sen, D. Hinton, S. Stohlman, 2013 .

Ifit2 Deficiency Results in Uncontrolled Neurotropic Coronavirus Replication and Enhanced Encephalitis via Impaired Alpha/Beta Interferon Induction in Macrophages

G. Sen, D. Hinton, S. Stohlman, 2013, Journal of Virology.

A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity

G. Sen, R. Gilmour, K. Peters, 2007, The Journal of experimental medicine.

Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

J. Nyengaard, C. Thompson, M. Komatsu, 2018, The EMBO journal.

Interferon-mediated inhibition of production of Gazdar murine sarcoma virus, a retrovirus lacking env proteins and containing an uncleaved gag precursor.

G. Sen, A. Pinter, 1983, Virology.

The distal ectodomain of angiotensin-converting enzyme regulates its cleavage-secretion from the cell surface.

G. Sen, I. Sen, R. Ramchandran, 1998, Proceedings of the National Academy of Sciences of the United States of America.

DRBP76, a Double-stranded RNA-binding Nuclear Protein, Is Phosphorylated by the Interferon-induced Protein Kinase, PKR*

W. Guo, G. Sen, Rekha C. Patel, 1999, The Journal of Biological Chemistry.

Interferon-mediated inhibition of retroviral infection: use of a defective retrovirus carrying a drug-resistance gene.

R. Kumar, G. Sen, 1989, Virus research.

The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development

P. Kessler, C. White, G. Sen, 2015, The FEBS journal.

Endoplasmic Reticulum Stress Induces Hyaluronan Deposition and Leukocyte Adhesion*

C. A. de la Motte, R. Pyeritz, V. Hascall, 2003, Journal of Biological Chemistry.

Alpha Interferon Induces Distinct Translational Control Programs To Suppress Hepatitis C Virus RNA Replication

M. Gale, R. Sumpter, G. Sen, 2003, Journal of Virology.

Interferon-stimulated response element and NF kappa B sites cooperate to regulate double-stranded RNA-induced transcription of the IP-10 gene.

Y. Ohmori, G. Sen, T. Hamilton, 1994, Journal of interferon research.

Gene induction by interferons: functional complementation between trans-acting factors induced by alpha interferon and gamma interferon

D. Kalvakolanu, G. Sen, S. Bandyopadhyay, 1990, Molecular and cellular biology.

Select Paramyxoviral V Proteins Inhibit IRF3 Activation by Acting as Alternative Substrates for Inhibitor of κB Kinase ϵ (IKKe)/TBK1*

C. Horvath, G. Sen, Lenette L. Lu, 2008, Journal of Biological Chemistry.

Regulation of synthesis and turnover of an interferon-inducible mRNA

J. Kusari, G. Sen, Ganes Sen, 1986, Molecular and cellular biology.

Caspase-8-mediated Cleavage Inhibits IRF-3 Protein by Facilitating Its Proteasome-mediated Degradation*

G. Stark, G. Sen, S. Chattopadhyay, 2011, The Journal of Biological Chemistry.

Interferon-induced antiviral actions and their regulation.

R. Ransohoff, G. Sen, Ganes C Sen, 1993, Advances in virus research.

CHAPTER 17 - Transcriptional regulation of interferon-inducible genes

G. Sen, 1991 .

Mechanism of interferon action: progress toward its understanding.

G. Sen, Ganes Sen, 1982, Progress in nucleic acid research and molecular biology.

PACT establishes a posttranscriptional brake on mitochondrial biogenesis by promoting the maturation of miR-181c

R. Gottlieb, E. Erbay, G. Sen, 2022, The Journal of biological chemistry.

The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.

D. Lindner, G. Sen, D. Vestal, 2002, The Journal of biological chemistry.

Constitutively Bound EGFR–Mediated Tyrosine Phosphorylation of TLR9 Is Required for Its Ability To Signal

P. Kessler, G. Sen, S. Chattopadhyay, 2018, The Journal of Immunology.

Biochemical pathways in interferon-action.

G. Sen, 1984, Pharmacology & therapeutics.

Increased endonuclease activity in an extract from mouse Ehrlich ascites tumor cells which had been treated with a partially purified interferon preparation: dependence of double-stranded RNA;.

P. Lengyel, B. Lebleu, G. Sen, 1976, Biochemical and biophysical research communications.

Characteristics of Extracts from Interferon-treated HeLa Cells: Presence of a Protein Kinase and Endoribonuclease Activated by Double-stranded RNA and of an Inhibitor of mRNA Methylation

P. Lengyel, B. Lebleu, G. Sen, 1977 .

Interferon, double-stranded RNA and mRNA degradation

P. Lengyel, B. Lebleu, G. Sen, 1976, Nature.

Impairment of reovirus mRNA methylation in extracts of interferon-treated Ehrilich ascites tumor cells: further characteristics of the phenomenon

R. Desrosiers, B. Lebleu, G. Sen, 1977, Journal of virology.

Differential antiviral effects of interferon in three murine cell lines

G. Sen, R. Herz, 1983, Journal of virology.

Regulated cleavage-secretion of the membrane-bound angiotensin-converting enzyme.

K. Misono, G. Sen, I. Sen, 1994, The Journal of biological chemistry.

Cytokine Production Tlr9-mediated Ifn and Proinflammatory Receptor-associated Kinase 2 in the Dual Functions of Il-1

G. Stark, James A. Thomas, G. Sen, 2022 .

Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection.

J. Nyengaard, H. Zetterberg, B. Hansen, 2020, The Journal of clinical investigation.

Phosphatidylinositol 3-Kinase Signaling Delays Sendai Virus-Induced Apoptosis by Preventing XIAP Degradation

C. White, G. Sen, S. Chattopadhyay, 2011, Journal of Virology.

Viral apoptosis is induced by IRF‐3‐mediated activation of Bax

J. Marques, G. Sen, K. Peters, 2010, The EMBO journal.

Stat1 required for interferon-inducible but not constitutive responsiveness to extracellular dsRNA.

G. Sen, C. Elco, 2007, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Hitching RIG to action

G. Sen, Saumendra N. Sarkar, 2005, Nature Immunology.

Biphasic and cardiomyocyte-specific IFIT activity protects cardiomyocytes from enteroviral infection

M. Alirezaei, J. Whitton, G. Sen, 2019, PLoS pathogens.

Missense Mutation in the Second RNA Binding Domain Reveals a Role for Prkra (PACT/RAX) during Skull Development

Y. Hérault, C. Chevalier, C. White, 2011, PloS one.

Organizations and promoter analyses of the human and the mouse genes for PACT, the protein-activator of the interferon-induced protein kinase, PKR.

G. Sen, T. M. Rowe, 2001, Gene.

Phosphorylation of Specific Serine Residues in the PKR Activation Domain of PACT Is Essential for Its Ability to Mediate Apoptosis*

G. Peters, G. Sen, Shoudong Li, 2006, Journal of Biological Chemistry.

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2.

G. Sen, J. McDonald, Benjamin K. Dickerman, 2013, F1000Research.

The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli.

B. Williams, G. Peters, J. Marques, 2008, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Analysis of the negative transcriptional regulatory element in the angiotensin-converting enzyme gene.

G. Sen, S. Kessler, T. Goraya, 1996, Gene expression.

Interferon, double-stranded RNA, and protein phosphorylation.

P. Lengyel, B. Lebleu, G. Sen, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Role of modified nucleosides in tRNA: effect of modification of the 2-thiouridine derivative located at the 5'-end of the anticodon of yeast transfer RNA Lys2.

G. Sen, H. Ghosh, 1976, Nucleic acids research.

Transcriptional repression of interleukin-6 gene by adenoviral E1A proteins.

D. Kalvakolanu, G. Sen, Y. Zhang, 1992, The Journal of biological chemistry.

Requirement of PKR Dimerization Mediated by Specific Hydrophobic Residues for Its Activation by Double-Stranded RNA and Its Antigrowth Effects in Yeast

G. Sen, Rekha C. Patel, 1998, Molecular and Cellular Biology.

Effects of varying lengths of double-stranded RNA on binding and activation of 2'-5'-oligoadenylate synthetase.

G. Sen, S. Desai, 1997, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Effects of Mutating Specific Residues Present Near the Amino Terminus of 2′–5′-Oligoadenylate Synthetase*

S. Ghosh, Abhrajyoti Ghosh, G. Sen, 1997, The Journal of Biological Chemistry.

Antiviral and protein-inducing activities of recombinant human leukocyte interferons and their hybrids

S. Pestka, G. Sen, R. Herz, 1984, Journal of virology.

IRF-3-dependent, NFkappa B- and JNK-independent activation of the 561 and IFN-beta genes in response to double-stranded RNA.

G. Stark, G. Sen, Heather L. Smith, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The non-transcriptional activity of IRF3 modulates hepatic immune cell populations in acute-on-chronic ethanol administration in mice.

G. Sen, S. Chattopadhyay, Xiaoxia Li, 2019, Journal of hepatology.

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

G. Stark, W. Ouyang, C. Tournier, 2015, The Journal of experimental medicine.

Expression of interferon-inducible genes in RD-114 cells

R. Kumar, J. Kusari, G. Sen, 1987, Journal of virology.

Transcriptional analyses of interferon-inducible mRNAs

J. Kusari, G. Sen, 1987, Molecular and cellular biology.

Inhibition of vesicular stomatitis viral mRNA synthesis by interferons

G. Sen, L. Belkowski, Linda S. BELKOWSKIt, 1987, Journal of virology.

Enzymatic Characteristics of Recombinant Medium Isozyme of 2′-5′ Oligoadenylate Synthetase*

Abhrajyoti Ghosh, G. Sen, Saumendra N. Sarkar, 1999, The Journal of Biological Chemistry.

Gene induction by interferons and double-stranded RNA: selective inhibition by 2-aminopurine

R. Kumar, J. Kusari, G. Sen, 1988, Molecular and cellular biology.

Interferon, double-stranded RNA, and protein phosphorylation. Characteristics of a double-stranded RNA-activated protein kinase system partially purified from interferon treated Ehrlich ascites tumor cells.

P. Lengyel, G. Sen, H. Taira, 1978, The Journal of biological chemistry.

The IRF-3/Bax-Mediated Apoptotic Pathway, Activated by Viral Cytoplasmic RNA and DNA, Inhibits Virus Replication

G. Sen, S. Chattopadhyay, M. Yamashita, 2011, Journal of Virology.

Attenuation of cGAS-STING signaling is mediated by a p 62 / SQSTM 1-1 dependent autophagy pathway activated by TBK 1 2 3

J. Nyengaard, C. Thompson, M. Komatsu, 2018 .

Isolation of cDNA clones of rabbit angiotensin converting enzyme: identification of two distinct mRNAs for the pulmonary and the testicular isozymes.

J. Kusari, C. Lai, G. Sen, 1988, Biochemical and biophysical research communications.

Virus Infection in the Brain A Role for Ifit2 in Restricting West Nile

G. Sen, Bimmi Shrestha, Hyelim Cho, 2014 .

A Role for Ifit2 in Restricting West Nile Virus Infection in the Brain

M. Diamond, G. Sen, Hyelim Cho, 2013, Journal of Virology.

Phosphatidylinositol 3-Kinase Signaling Delays Sendai Virus-Induced Apoptosis by Preventing XIAP Degradation (cid:1)

C. White, G. Sen, S. Chattopadhyay, 2011 .

IFN-induced protein with tetratricopeptide repeats 2 (Ifit2) limits autoimmune inflammation by regulating myeloid cell activation and metabolic activity

S. Weinberg, G. Sen, A. Tripathi, 2022, bioRxiv.

Selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme.

G. Sen, C. Colmenares, S. Kessler, 1998, The Journal of clinical investigation.

A Cyclic AMP Response Element in the Angiotensin-converting Enzyme Gene and the Transcription Factor CREM Are Required for Transcription of the mRNA for the Testicular Isozyme*

R. Erickson, J. Blendy, G. Sen, 1998, The Journal of Biological Chemistry.

Nontranscriptional Activity of Interferon Regulatory Factor 3 Protects Mice From High‐Fat Diet‐Induced Liver Injury

G. Sen, S. Chattopadhyay, M. McMullen, 2019, Hepatology communications.

Vascular expression of germinal ACE fails to maintain normal blood pressure in ACE–/– mice

G. Sen, Christina A Gaughan, S. Kessler, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

IRF-3 Activation by Sendai Virus Infection Is Required for Cellular Apoptosis and Avoidance of Persistence

G. Sen, K. Peters, S. Chattopadhyay, 2008, Journal of Virology.

Structure of testicular angiotensin-converting enzyme. A segmental mosaic isozyme.

R. Kumar, J. Kusari, G. Sen, 1989, The Journal of biological chemistry.

Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii

S. Barik, G. Sen, E. Ozhegov, 2015, PLoS pathogens.

EGFR‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions

P. Kessler, G. Sen, S. Chattopadhyay, 2020, The EMBO journal.

Differentiation-dependent activation of interferon-stimulated gene factors and transcription factor NF-kappa B in mouse embryonal carcinoma cells.

D. Kalvakolanu, G. Sen, 1993, Proceedings of the National Academy of Sciences of the United States of America.

PACT-mediated enhancement of reporter gene expression at the translational level.

G. Sen, Shoudong Li, 2003, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Innate Immune Responses to Herpesvirus Infection

G. Sen, C. O’Connor, 2021, Cells.

Coding properties of isoaccepting lysine transfer RNA species from baker's yeast.

G. Sen, H. Ghosh, 1973, Biochimica et biophysica acta.

IRF3 inhibits nuclear translocation of NF-κB to prevent viral inflammation

S. Aras, G. Sen, Ritu Chakravarti, 2022, Proceedings of the National Academy of Sciences of the United States of America.

A Viral On/Off Switch for Interferon

B. Williams, G. Sen, B. Williams, 2003, Science.

The antiviral action of the RIG-I induced pathway of apoptosis (RIPA) is enhanced by its ability to degrade Otulin, which deubiquitinates IRF3

G. Sen, R. Raja, 2021, Cell Death & Differentiation.

A role for Ifit 2 in restricting West Nile virus infection in the brain 1 2 3 4

M. Diamond, G. Sen, Bimmi Shrestha, 2013 .

Establishment of transfected cell lines producing testicular angiotensin-converting enzyme. Structural relationship between its secreted and cellular forms.

G. Sen, I. Sen, H. Samanta, 1991, The Journal of biological chemistry.

Two Tyrosine Residues of Toll-like Receptor 3 Trigger Different Steps of NF-κB Activation*

G. Sen, K. Peters, S. Chattopadhyay, 2006, Journal of Biological Chemistry.

Two tyrosine residues of Toll-like receptor 3 trigger different steps of NF-kappa B activation.

G. Sen, K. Peters, S. Chattopadhyay, 2007, The Journal of biological chemistry.

Intracranial delivery of antisense locked nucleic acids for silencing microRNAs in the mouse brain

G. Sen, Nikhil Sharma, 2022, STAR protocols.

Studies on the role of the 2'-5'-oligoadenylate synthetase-RNase L pathway in beta interferon-mediated inhibition of encephalomyocarditis virus replication

P. Lengyel, R. Kumar, D. Choubey, 1988, Journal of virology.

Ribonuclease activity is associated with subviral particles isolated from interferon-treated vesicular stomatitis virus-infected cells

R. Kumar, G. Sen, A. Banerjee, 1988, Journal of virology.

Clonal derivatives of the RD-114 cell line differ in their antiviral and gene-inducing responses to interferons

R. Kumar, J. Kusari, G. Sen, 1987, Journal of virology.

Effects of interferon on the production of murine mammary tumor virus by mammary tumor cells in culture.

G. Sen, N. Sarkar, 1980, Virology.

A small region in the angiotensin-converting enzyme distal ectodomain is required for cleavage-secretion of the protein at the plasma membrane.

G. Sen, I. Sen, S. Chattopadhyay, 2008, Biochemistry.

Physiological Non-equivalence of the Two Isoforms of Angiotensin-converting Enzyme*

P. Kessler, G. Sen, S. Kessler, 2000, The Journal of Biological Chemistry.

Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis

B. Williams, R. Silverman, E. Borden, 2003, Apoptosis.

Role of Interferon Regulatory Factor 3-Mediated Apoptosis in the Establishment and Maintenance of Persistent Infection by Sendai Virus

G. Sen, S. Chattopadhyay, Manoj Veleeparambil, 2012, Journal of Virology.

Inhibition of RNase L and RNA-dependent Protein Kinase (PKR) by Sunitinib Impairs Antiviral Innate Immunity*

R. Silverman, B. Jha, P. Kessler, 2011, Journal of Biological Chemistry.

Interferons at age 50: past, current and future impact on biomedicine

Graham R. Foster, Gilles Uze, Robert H. Silverman, 2007, Nature Reviews Drug Discovery.

Interferons and viral infections

G. Sen, Volker Fensterl, Ganes C. Sen, 2009, BioFactors.

Viruses and interferons.

G. Sen, G C Sen, 2001, Annual review of microbiology.

The interferon system. A bird's eye view of its biochemistry.

P. Lengyel, G. Sen, G C Sen, 1992, The Journal of biological chemistry.

IRF-3 Activation by Sendai Virus Infection Is Required for Cellular Apoptosis and Avoidance of Persistence

G. Sen, K. Peters, S. Chattopadhyay, 2008, Journal of Virology.

Antiviral, anticellular and enzyme-inducing activities of interferons in RD-114 cells.

G. Sen, B. Rubin, R. Herz, 1983, The Journal of general virology.

Effects of procaine and oxyphenylbutazone on interferon-mediated inhibition of murine leukemia virus production.

G. Sen, R. Herz, 1983, Antiviral research.

Human interferon-alpha-and-gamma-mediated inhibition of retrovirus production in the absence of an inhibitory effect on vesicular stomatitis virus and encephalomyocarditis virus replication in RD-114 cells.

G. Sen, B. Rubin, R. Herz, 1983, Virology.

No Love Lost Between Viruses and Interferons.

G. Sen, S. Chattopadhyay, Volker Fensterl, 2015, Annual review of virology.

HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.

B. Williams, R. Silverman, G. Sen, 1994, Virology.

Novel functions of proteins encoded by viral stress-inducible genes.

G. Sen, Saumendra N. Sarkar, 2004, Pharmacology & therapeutics.

A fast and sensitive method for the analysis of modified nucleosides in tRNA.

G. Sen, H. Ghosh, 1974, Analytical biochemistry.

Cell growth regulatory and antiviral effects of the P69 isozyme of 2-5 (A) synthetase.

Abhrajyoti Ghosh, G. Sen, Saumendra N. Sarkar, 2000, Virology.

Difference in 5' terminal structure between the mRNA and the double-stranded virion RNA of reovirus.

P. Lengyel, R. Desrosiers, G. Sen, 1976, Biochemical and biophysical research communications.

Interferon, double-stranded RNA and RNA degradation. Fractionation of the endonucleaseINT system into two macromolecular components; role of a small molecule in nuclease activation.

P. Lengyel, R. Wiegand, L. Ratner, 1978, Biochemical and biophysical research communications.

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

P. Lengyel, L. Ratner, P. Farrell, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Assays for the interferon-induced enzyme 2',5' oligoadenylate synthetases.

G. Sen, Saumendra N. Sarkar, Mitali Pandey, 2005, Methods in molecular medicine.

A Specific Isozyme of 2′-5′ Oligoadenylate Synthetase Is a Dual Function Proapoptotic Protein of the Bcl-2 Family*

Abhrajyoti Ghosh, G. Sen, Saumendra N. Sarkar, 2001, The Journal of Biological Chemistry.

Interferon, double-stranded RNA and RNA degradation. Characteristics of an endonuclease activity.

P. Lengyel, L. Ratner, B. Lebleu, 1977, European journal of biochemistry.

Interferon-Induced Ifit Proteins: Their Role in Viral Pathogenesis

G. Sen, Volker Fensterl, Volker Fensterl, 2014, Journal of Virology.

Activation of Interferon-inducible 2′5′ Oligoadenylate Synthetase by Adenoviral VAI RNA (*)

G. Ghadge, G. Sen, Shailesh Y. Desai, 1995, The Journal of Biological Chemistry.

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase.

G. Sen, V. Yee, J. Justesen, 2003, Molecular cell.

The Human dsRNA binding protein PACT is unable to functionally substitute for the dsRNA binding protein Drosophila R 2 D 2

G. Sen, J. McDonald, Benjamin K. Dickerman, 2016 .

The Human dsRNA binding protein PACT is unable to functionally substitute for the Drosophila dsRNA binding protein R2D2

G. Sen, J. McDonald, Benjamin K. Dickerman, 2013, F1000Research.

A mutant cell line defective in response to double-stranded RNA and in regulating basal expression of interferon-stimulated genes.

G. Stark, D. Leaman, G. Sen, 1998, Proceedings of the National Academy of Sciences of the United States of America.

p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs

A. Gudkov, E. Komarova, A. Chenchik, 2012, Proceedings of the National Academy of Sciences.

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Hongping Dong, Michael S. Diamond, Pei-Yong Shi, 2010, Nature.

The ISG56/IFIT1 gene family.

G. Sen, Volker Fensterl, 2011, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Transcriptional Profiling of Interferon Regulatory Factor 3 Target Genes: Direct Involvement in the Regulation of Interferon-Stimulated Genes

J. Hiscott, G. Barber, B. tenOever, 2002, Journal of Virology.

The proapoptotic 9-2 isozyme of 2-5 (A) synthetase cannot substitute for the sperm functions of the proapoptotic protein, Bax.

G. Sen, Saumendra N. Sarkar, S. Kessler, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Genes Modulated by Interferons and Double-Stranded RNA

G. Peters, G. Sen, Saumendra N. Sarkar, 2005 .

A Comprehensive View of Regulation of Gene Expression by Double-stranded RNA-mediated Cell Signaling*

Roger E Bumgarner, M. Katze, G. Geiss, 2001, The Journal of Biological Chemistry.

Coordinated Regulation and Widespread Cellular Expression of Interferon-Stimulated Genes (ISG) ISG-49, ISG-54, and ISG-56 in the Central Nervous System after Infection with Distinct Viruses

I. Campbell, G. Sen, S. Ousman, 2006, Journal of Virology.

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

G. Stark, M. Kalady, M. Jackson, 2020, Nature Communications.

Constitutive and ligand-induced EGFR signaling triggers distinct and mutually exclusive downstream signaling networks

T. Pandita, D. Boothman, K. Hatanpaa, 2014, Nature Communications.

A new mechanism of interferon’s antiviral action: Induction of autophagy, essential for paramyxovirus replication, is inhibited by the interferon stimulated gene, TDRD7

Ying Zhang, Saurabh Chattopadhyay, Gayatri Subramanian, 2018, PLoS pathogens.

INHIBITION OF MURINE MAMMARY TUMOR VIRUS PRODUCTION BY INTERFERON TREATMENT OF MAMMARY TUMOR CELLS IN VITRO

G. Sen, N. Sarkar, 1980 .

Herpes simplex virus 1 evades cellular antiviral response by inducing microRNA-24, which attenuates STING synthesis

P. Kessler, G. Sen, Chenyao Wang, 2021, PLoS pathogens.

Gene order of murine mammary tumor virus gag proteins and env proteins.

G. Sen, N. Sarkar, W. Zabłocki, 1980, Virology.

Presence of a proteolytic activity in murine mammary tumor virus.

G. Sen, N. Sarkar, H. Haspel, 1980, The Journal of biological chemistry.

Cloning, sequencing, and expression of two murine 2'-5'-oligoadenylate synthetases. Structure-function relationships.

R. Kumar, J. Kusari, G. Sen, 1991, The Journal of biological chemistry.

Different subcellular localizations for the related interferon-induced GTPases, MuGBP-1 and MuGBP-2: implications for different functions?

G. Sen, D. Vestal, V. Gorbacheva, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis

M. Diamond, G. Sen, S. Stohlman, 2012, PLoS pathogens.

Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

S. Sakamoto, G. Sen, K. Peters, 2004, Nature Structural &Molecular Biology.

Double-stranded RNA Signaling by Toll-like Receptor 3 Requires Specific Tyrosine Residues in Its Cytoplasmic Domain*

G. Sen, Heather L. Smith, Saumendra N. Sarkar, 2003, The Journal of Biological Chemistry.

Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice

B. Williams, C. White, G. Sen, 2007, Journal of Virology.

Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.

G. Sen, F. Terenzi, Srabani Pal, 2005, Virology.

Mouse p56 Blocks a Distinct Function of Eukaryotic Initiation Factor 3 in Translation Initiation*

W. Merrick, G. Sen, F. Terenzi, 2005, Journal of Biological Chemistry.

2′-O Methylation of the Viral mRNA Cap by West Nile Virus Evades Ifit1-Dependent and -Independent Mechanisms of Host Restriction In Vivo

M. Diamond, R. Klein, M. Gale, 2012, PLoS pathogens.

Interferon‐inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1

G. Sen, F. Terenzi, Paramananda Saikia, 2008, The EMBO journal.

PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

M. Hatzoglou, C. Cotton, P. Ramakrishnan, 2020, eLife.

A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis.

R. Krug, G. Sen, J. Min, 2007, Virology.

The IFN-induced GTPase, mGBP-2: Role in IFN-γ induced murine fibroblast proliferation

D. Lindner, G. Sen, D. Vestal, 2001 .

Inhibition of PACT-Mediated Activation of PKR by the Herpes Simplex Virus Type 1 Us11 Protein

I. Mohr, G. Peters, G. Sen, 2002, Journal of Virology.

Novel Characteristics of the Function and Induction of Murine p56 Family Proteins

C. White, G. Sen, Volker Fensterl, 2008, Journal of Virology.

RIG-I-like receptor-induced IRF3 mediated pathway of apoptosis (RIPA): a new antiviral pathway

G. Sen, S. Chattopadhyay, 2016, Protein & Cell.

Ubiquitination of the Transcription Factor IRF-3 Activates RIPA, the Apoptotic Pathway that Protects Mice from Viral Pathogenesis.

G. Sen, T. Kuzmanovic, S. Chattopadhyay, 2016, Immunity.

The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain.

B. Williams, S. Paludan, J. Marques, 2008, The Journal of general virology.

Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity

G. Sen, M. Schnell, Volker Fensterl, 2017, Journal of Virology.

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

B. Williams, G. Sen, R. Patel, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Replication of Hepatitis C Virus (HCV) RNA in Mouse Embryonic Fibroblasts: Protein Kinase R (PKR)-Dependent and PKR-Independent Mechanisms for Controlling HCV RNA Replication and Mediating Interferon Activities

B. Williams, G. Sen, G. Luo, 2006, Journal of Virology.

Viral degradasome hijacks mitochondria to suppress innate immunity

S. Barik, G. Sen, Jayeeta Dhar, 2013, Cell Research.

Antiviral Innate Immunity Disturbs Podocyte Cell Function

G. Sen, S. Chattopadhyay, C. Millward, 2012, Journal of Innate Immunity.

The Cyclic AMP Response Elements of the Genes for Angiotensin-converting Enzyme and Phosphoenolpyruvate Carboxykinase (GTP) Can Mediate Transcriptional Activation by CREMτ and CREMα (*)

G. Sen, R. Hanson, S. Kessler, 1995, The Journal of Biological Chemistry.

Viral stress-inducible genes.

G. Peters, G. Sen, 2007, Advances in virus research.

Crisscross Enzymatic Reaction between the Two Molecules in the Active Dimeric P69 Form of the 2′-5′ Oligodenylate Synthetase*

G. Sen, Saumendra N. Sarkar, Srabani Pal, 2002, The Journal of Biological Chemistry.

The Nature of the Catalytic Domain of 2′-5′-Oligoadenylate Synthetases*

Abhrajyoti Ghosh, G. Sen, S. Sung, 1999, The Journal of Biological Chemistry.

Transcriptional induction of the p69 isoform of 2',5'-oligoadenylate synthetase by interferon-beta and interferon-gamma involves three regulatory elements and interferon-stimulated gene factor 3.

G. Sen, Q. Wang, G. Floyd-Smith, 1999, Experimental cell research.

Production, purification, and characterization of recombinant 2', 5'-oligoadenylate synthetases.

G. Sen, Saumendra N. Sarkar, 1998, Methods.

Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection

P. Rayman, G. Sen, C. Bergmann, 2020, PLoS pathogens.

Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members*

K. Ozato, P. Kessler, C. White, 2016, The Journal of Biological Chemistry.

Sendai Virus Pathogenesis in Mice Is Prevented by Ifit2 and Exacerbated by Interferon

G. Sen, Volker Fensterl, Jaime L. Wetzel, 2014, Journal of Virology.

Interferon-Induced Protein Ifit2 Protects Mice from Infection of the Peripheral Nervous System by Vesicular Stomatitis Virus

G. Sen, Volker Fensterl, Jaime L. Wetzel, 2014, Journal of Virology.

The Inhibitory Action of P56 on Select Functions of E1 Mediates Interferon's Effect on Human Papillomavirus DNA Replication

G. Sen, Volker Fensterl, Paramananda Saikia, 2010, Journal of Virology.

The interferon-stimulated genes: targets of direct signaling by interferons, double-stranded RNA, and viruses.

G. Sen, Saumendra N. Sarkar, G C Sen, 2007, Current topics in microbiology and immunology.

Distinct Induction Patterns and Functions of Two Closely Related Interferon-inducible Human Genes, ISG54 and ISG56*

W. Merrick, G. Sen, F. Terenzi, 2006, Journal of Biological Chemistry.

Analysis of Genes Induced by Sendai Virus Infection of Mutant Cell Lines Reveals Essential Roles of Interferon Regulatory Factor 3, NF-κB, and Interferon but Not Toll-Like Receptor 3

B. Williams, G. Sen, C. Elco, 2005, Journal of Virology.

Identification of the Substrate-binding Sites of 2′-5′-Oligoadenylate Synthetase*

M. Miyagi, G. Sen, J. Crabb, 2002, The Journal of Biological Chemistry.

Interferon-Stimulated Genes Involvement in the Regulation of Regulatory Factor 3 Target Genes : Direct Transcriptional Profiling of Interferon

J. Hiscott, G. Barber, B. tenOever, 2002 .

A new pathway of translational regulation mediated by eukaryotic initiation factor 3

W. Merrick, G. Sen, Daniel J. Hui, 2000, The EMBO journal.

Novel functions of interferon-induced proteins.

G. Sen, Ganes C. Sen, 2000, Seminars in cancer biology.

Characterization of the Interaction between the Interferon-Induced Protein P56 and the Int6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus

G. Sen, Jinjiao Guo, 2000, Journal of Virology.

Induction of the human protein P56 by interferon, double-stranded RNA, or virus infection.

G. Sen, K. Peters, J. Guo, 2000, Virology.

Transcriptional signaling by double-stranded RNA: role of TLR3.

G. Sen, Saumendra N. Sarkar, 2005, Cytokine & growth factor reviews.

Toll-like receptor 3-mediated activation of NF-κB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-β

Tak W. Mak, T. Mak, Zhengfan Jiang, 2004 .

Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

T. Mak, Zhengfan Jiang, G. Sen, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

G. Stark, M. Kalady, M. Jackson, 2020, Nature Communications.

Epidermal Growth Factor Receptor Is Essential for Toll-Like Receptor 3 Signaling

G. Sen, S. Chattopadhyay, Volker Fensterl, 2012, Science Signaling.

Regulation of interferon‐α‐inducible cellular genes in human immunodeficiency virus‐infected monocytes

R. Silverman, M. Meltzer, D. Kalvakolanu, 1994, Journal of leukocyte biology.

A TRIF-Independent Branch of TLR3 Signaling

G. Sen, S. Chattopadhyay, Volker Fensterl, 2012, The Journal of Immunology.

High-Throughput Screening for TLR3–IFN Regulatory Factor 3 Signaling Pathway Modulators Identifies Several Antipsychotic Drugs as TLR Inhibitors

G. Sen, S. Chattopadhyay, Jianzhong Zhu, 2010, The Journal of Immunology.

Replication Suppress Hepatitis C Virus RNA Translational Control Programs To Alpha Interferon Induces Distinct

M. Gale, R. Sumpter, G. Sen, 2003 .

Modular Structure of PACT: Distinct Domains for Binding and Activating PKR

G. Peters, G. Sen, R. Hartmann, 2001, Molecular and Cellular Biology.

Restoration of interferon responses of adenovirus E1A-expressing HT1080 cell lines by overexpression of p48 protein

G. Sen, G. Leonard, 1997, Journal of virology.

Effects of adenovirus E1A protein on interferon-signaling.

G. Sen, G. Leonard, Ganes C. Sen, 1996, Virology.

Transcriptional Induction by Double-stranded RNA Is Mediated by Interferon-stimulated Response Elements without Activation of Interferon-stimulated Gene Factor 3 (*)

G. Stark, G. Sen, S. Bandyopadhyay, 1995, The Journal of Biological Chemistry.

Long-Term Effect of Interferon on Keratinocytes That Maintain Human Papillomavirus Type 31

G. Sen, Jung K. Park, L. Laimins, 2002, Journal of Virology.

Isolation of cDNA Clones for the Interferon-Induced 67,000-Dalton Protein: Direct Induction of a Family of mRNAs by Human Interferon-α and Interferon-β

M. Dizik, G. Sen, R. Lunn, 1990 .

Chromosomal localization of the interferon-inducible human gene encoding mRNA 561.

K. Grzeschik, J. Kusari, G. Sen, 1987, Journal of interferon research.

Molecular basis for PKR activation by PACT or dsRNA.

J. Qin, G. Peters, G. Sen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The Dual Functions of IL-1 Receptor-Associated Kinase 2 in TLR9-Mediated IFN and Proinflammatory Cytokine Production

G. Stark, James A. Thomas, G. Sen, 2011, The Journal of Immunology.

Specific Mutations Near the Amino Terminus of Double-stranded RNA-dependent Protein Kinase (PKR) Differentially Affect Its Double-stranded RNA Binding and Dimerization Properties*

G. Sen, R. Patel, Paul Stanton, 1996, The Journal of Biological Chemistry.

Interferon-inducible gene expression in HL-60 cells: effects of the state of differentiation.

R. Kumar, G. Sen, B. Rubin, 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Inhibition of interferon-inducible gene expression by adenovirus E1A proteins: block in transcriptional complex formation.

M. Harter, D. Kalvakolanu, G. Sen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

G. Sen, R. Patel, 1992, The Journal of biological chemistry.

Interferon Treatment of Ehrlich Ascites Tumor Cells: Effects on Exogenous mRNA Translation and tRNA Inactivation in the Cell Extract

P. Lengyel, B. Lebleu, G. Sen, 1976, Journal of virology.

Inhibition of reovirus messenger RNA methylation in extracts of interferon-treated Ehrlich ascites tumor cells.

P. Lengyel, M. Morgan, A. Shatkin, 1975, Biochemical and biophysical research communications.

Interferons and Antiviral Action

C. White, G. Sen, 2009 .

Characterization of the interactions between double-stranded RNA and the double-stranded RNA binding domain of the interferon induced protein kinase.

G. Sen, R. Patel, 1994, Cellular & molecular biology research.

The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

C. White, G. Sen, C. Subauste, 2013, PLoS pathogens.

Characterization of the Interaction between the Interferon-Induced Protein P 56 and the Int 6 Protein Encoded by a Locus of Insertion of the Mouse Mammary Tumor Virus

G. Sen, Jinjiao Guo, 2000 .

Use of alternative polyadenylation sites for tissue-specific transcription of two angiotensin-converting enzyme mRNAs.

R. Kumar, G. Sen, T. Thekkumkara, 1992, Nucleic acids research.

Crystal structure of IFIT2 (ISG54) predicts functional properties of IFITs

G. Sen, Volker Fensterl, 2012, Cell Research.

Species variation in the testicular angiotensin converting enzyme promoter studied in transgenic mice

R. Erickson, G. Sen, H. Kremling, 1996, Molecular reproduction and development.

Maintenance of normal blood pressure and renal functions are independent effects of angiotensin-converting enzyme.

G. Sen, Ganes C Sen, Sean P Kessler, 2003, The Journal of biological chemistry.

Relative Contributions of the cGAS-STING and TLR3 Signaling Pathways to Attenuation of Herpes Simplex Virus 1 Replication

Muhammad Bilal Latif, P. Kessler, G. Sen, 2020, Journal of Virology.

Nephron function in transgenic mice with selective vascular or tubular expression of Angiotensin-converting enzyme.

G. Sen, J. Schnermann, Christina A Gaughan, 2005, Journal of the American Society of Nephrology : JASN.

STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection.

P. Kessler, S. Barik, G. Sen, 2016, Cell host & microbe.

Angiotensin-converting enzyme: structural relationship of the testicular and the pulmonary forms.

R. Kumar, G. Sen, T. Thekkumkara, 1990, Journal of cardiovascular pharmacology.

Adenovirus E1A represses the cyclic AMP-induced transcription of the gene for phosphoenolpyruvate carboxykinase (GTP) in hepatoma cells.

J. Liu, M. Harter, D. Kalvakolanu, 1992, The Journal of biological chemistry.

PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon.

M. Katze, P. Lengyel, B. Williams, 1993, Journal of interferon research.

The Germinal Isozyme of Angiotensin-converting Enzyme Can Substitute for the Somatic Isozyme in Maintaining Normal Renal Structure and Functions*

G. Sen, Heather L. Smith, Thomas S Scheidemantel, 2002, The Journal of Biological Chemistry.

Tissue-Specific Expression of Transgenic Secreted ACE in Vasculature Can Restore Normal Kidney Functions, but Not Blood Pressure, of Ace-/- Mice

G. Sen, S. Chattopadhyay, P. Senanayake, 2014, PloS one.

Mutations in two specific residues of testicular angiotensin-converting enzyme change its catalytic properties.

S. Kasturi, G. Sen, I. Sen, 1993, The Journal of biological chemistry.

Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology

P. Rayman, G. Sen, C. Bergmann, 2023, Journal of virology.

A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing.

K. Hirose, G. Peters, G. Sen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Viral Stress-inducible Protein p56 Inhibits Translation by Blocking the Interaction of eIF3 with the Ternary Complex eIF2·GTP·Met-tRNAi*

W. Merrick, G. Sen, C. Bhasker, 2003, Journal of Biological Chemistry.

Identification of positive and negative transcriptional regulatory elements of the rabbit angiotensin-converting enzyme gene.

R. Kumar, J. Douglas, G. Sen, 1994, Nucleic acids research.

Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus

G. Sen, W. Hsu, Yeu-Yang Tseng, 2015, Journal of Virology.

Biochemical analysis of PKR activation by PACT.

G. Peters, G. Sen, Benjamin K. Dickerman, 2009, Biochemistry.

The double-stranded RNA-binding protein, PACT, is required for postnatal anterior pituitary proliferation

G. Peters, R. Keri, G. Sen, 2009, Proceedings of the National Academy of Sciences.

The Interferon (IFN)-induced GTPase, mGBP-2

D. Lindner, G. Sen, D. Vestal, 2002, The Journal of Biological Chemistry.

DJ-1-Nrf2 axis is activated upon murine β-coronavirus infection in the CNS

D. Pal, G. Sen, J. D. Sarma, 2021, Brain Disorders.

Inhibition of Viral Pathogenesis and Promotion of the Septic Shock Response to Bacterial Infection by IRF-3 Are Regulated by the Acetylation and Phosphorylation of Its Coactivators

G. Sen, S. Chattopadhyay, Manoj Veleeparambil, 2013, mBio.

Construction and expression of an enzymatically active human-mouse chimeric double-stranded RNA-dependent protein kinase.

G. Sen, R. Patel, 1992, Journal of interferon research.

EGF Receptor-dependent TLR7 Signaling in Macrophages Promotes Glomerular Injury in Crescentic Glomerulonephritis.

G. Sen, M. Arditi, R. Bonegio, 2023, Laboratory investigation; a journal of technical methods and pathology.

Interferon-associated, dsRNA-dependent enzyme activities in a mutant 3T6 cell engaged in the semiconstitutive synthesis of interferon

L. Ratner, G. Sen, A. Ball, 1978, Cell.

Type I interferon signaling facilitates resolution of acute liver injury by priming macrophage polarization

G. Stark, Xue Liang, Peng Han, 2023, Cellular & Molecular Immunology.

Production and purification of recombinant 2'-5' oligoadenylate synthetase and its mutants using the baculovirus system.

Abhrajyoti Ghosh, G. Sen, Saumendra N. Sarkar, 1998, Biochemistry.

Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin.

G. Sen, R. Patel, P. Stanton, 1994, The Journal of biological chemistry.

Identification of the messenger RNAs coding for the gag and env gene products of the murine mammary tumor virus.

G. Sen, S. Marcus, N. Sarkar, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Viral evasion of the interferon system.

M. Gale, G. Sen, 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase.

G. Sen, V. Yee, J. Justesen, 2003, Molecular cell.

Synthesis of interferon-inducible proteins is regulated differently by interferon-α and interferon-γ

G. Sen, B. Rubin, 1984 .

Lnc(ing) interferon production and action

B. Williams, G. Sen, B. Williams, 2019, Cell Research.

Enhancement of expression of exogenous genes by 2-aminopurine. Regulation at the post-transcriptional level.

D. Kalvakolanu, G. Sen, R. Tiwari, 1991, The Journal of biological chemistry.

Sendai Virus Pathogenesis in Mice Is Prevented by Ifit2 and Exacerbated by Interferon

G. Sen, Volker Fensterl, Jaime L. Wetzel, 2014, Journal of Virology.

No Love Lost Between Viruses and Interferons.

G. Sen, S. Chattopadhyay, Volker Fensterl, 2015, Annual review of virology.