J. Lemm

发表

Assembly of functional Sindbis virus RNA replication complexes: requirement for coexpression of P123 and P34

C. Rice, J. Lemm, 1993, Journal of virology.

Roles of nonstructural polyproteins and cleavage products in regulating Sindbis virus RNA replication and transcription

C. Rice, J. Lemm, Charles M. Rice, 1993, Journal of virology.

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

Min Gao, Nicholas A. Meanwell, Lawrence G. Hamann, 2010, Nature.

Characterizations of HCV NS5A replication complex inhibitors.

N. Meanwell, D. Langley, J. Lemm, 2013, Virology.

HCV NS5A replication complex inhibitors. Part 5: discovery of potent and pan-genotypic glycinamide cap derivatives.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

Carl T. Bergstrom, Chong-Hwan Chang, M. Witmer, 2011, Bioorganic & medicinal chemistry letters.

Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.

A. Mathur, J. Cutrone, N. Meanwell, 2017, Bioorganic & medicinal chemistry letters.

Discovery and development of hepatitis C virus NS5A replication complex inhibitors.

N. Meanwell, D. Langley, J. Lemm, 2014, Journal of medicinal chemistry.

Combinations of Lambda Interferon with Direct-Acting Antiviral Agents Are Highly Efficient in Suppressing Hepatitis C Virus Replication

J. Lemm, Chaoqun Chen, A. Sheaffer, 2012, Antimicrobial Agents and Chemotherapy.

Hepatitis C virus NS5A replication complex inhibitors: the discovery of daclatasvir.

L. Hamann, A. Fura, N. Meanwell, 2014, Journal of medicinal chemistry.

Template-Dependent Initiation of Sindbis Virus RNA Replication In Vitro

C. Rice, A. Bergqvist, J. Lemm, 1998, Journal of Virology.

Replication-Competent Chimeric Hepatitis C Virus Subgenomic Replicons

J. Lemm, R. Colonno, M. Gao, 2005, Intervirology.

Mutations which alter the level or structure of nsP4 can affect the efficiency of Sindbis virus replication in a host-dependent manner

V. Stollar, C. Rice, J. Lemm, 1990, Journal of virology.

Immunization with nonstructural proteins promotes functional recovery of alphavirus-infected neurons

C. Rice, D. Griffin, J. Lemm, 1997, Journal of virology.

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.

N. Meanwell, J. Lemm, K. Yeung, 2017, ACS medicinal chemistry letters.

The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.

B. Beno, K. Kish, S. Sheriff, 2017, MedChemComm.

HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.

N. Meanwell, J. Lemm, B. Pearce, 2014, Journal of medicinal chemistry.

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes.

N. Meanwell, M. Deshpande, Scott W. Martin, 2011, ACS medicinal chemistry letters.

Development of a Cell-Based High-Throughput Specificity Screen Using a Hepatitis C Virus-Bovine Viral Diarrhea Virus Dual Replicon Assay

J. Lemm, R. Colonno, M. Gao, 2005, Antimicrobial Agents and Chemotherapy.

Discovery and preclinical characterization of the cyclopropylindolobenzazepine BMS-791325, a potent allosteric inhibitor of the hepatitis C virus NS5B polymerase.

Chong-Hwan Chang, M. Witmer, B. Beno, 2014, Journal of medicinal chemistry.

Identification of a novel series of potent HCV NS5B Site I inhibitors.

N. Meanwell, J. Lemm, J. Kadow, 2014, Bioorganic & medicinal chemistry letters.

Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: potent allosteric inhibitors of the hepatitis C virus NS5B polymerase.

B. Beno, M. Poss, J. Lemm, 2012, Bioorganic & medicinal chemistry letters.

HCV NS5A replication complex inhibitors. Part 3: discovery of potent analogs with distinct core topologies.

A. Good, N. Meanwell, J. Lemm, 2013, Bioorganic & medicinal chemistry letters.

Hepatitis C virus NS5A replication complex inhibitors. Part 6: Discovery of a novel and highly potent biarylimidazole chemotype with inhibitory activity toward genotypes 1a and 1b replicons.

A. Good, N. Meanwell, J. Lemm, 2014, Journal of medicinal chemistry.

Polypeptide requirements for assembly of functional Sindbis virus replication complexes: a model for the temporal regulation of minus‐ and plus‐strand RNA synthesis.

J. H. Strauss, E. G. Strauss, C. Rice, 1994, The EMBO journal.

Preclinical Characterization of BMS-791325, an Allosteric Inhibitor of Hepatitis C Virus NS5B Polymerase

N. Meanwell, J. Lemm, R. Colonno, 2014, Antimicrobial Agents and Chemotherapy.

Randomized, Placebo-Controlled, Single-Ascending-Dose Study of BMS-791325, a Hepatitis C Virus (HCV) NS5B Polymerase Inhibitor, in HCV Genotype 1 Infection

P. Tebas, J. Lemm, D. Grasela, 2014, Antimicrobial Agents and Chemotherapy.

Effect on Hepatitis C Virus Replication of Combinations of Direct-Acting Antivirals, Including NS5A Inhibitor Daclatasvir

J. Lemm, M. Gao, Mengping Liu, 2012, Antimicrobial Agents and Chemotherapy.

Effect on HCV Replication by Combinations of Direct Acting Antivirals 5 Including NS 5 A Inhibitor Daclatasvir 6 7 8

J. Lemm, M. Gao, Mengping Liu, 2012 .

De Novo Initiation of RNA Synthesis by the RNA-Dependent RNA Polymerase (NS5B) of Hepatitis C Virus

R. Hamatake, J. Lemm, G. Luo, 2000, Journal of Virology.

Genetic analysis of the nsP3 region of Sindbis virus: evidence for roles in minus-strand and subgenomic RNA synthesis

C. Rice, J. Lemm, M. W. Lastarza, 1994, Journal of virology.

1194 CHARACTERIZATION OF VIRAL ESCAPE IN HCV GENOTYPE 1-INFECTED PATIENTS TREATED WITH BMS-791325 AND PEGYLATED INTERFERON-ALFA AND RIBAVIRIN

P. Fracasso, J. Lemm, D. McPhee, 2012 .

Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.

M. Witmer, B. Beno, K. Kish, 2018, ACS medicinal chemistry letters.

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.

Qi Gao, Min Gao, Steven Sheriff, 2017, Journal of medicinal chemistry.

Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.

N. Meanwell, J. Lemm, J. Kadow, 2016, Bioorganic & medicinal chemistry letters.

Potency and Resistance Analysis of Hepatitis C Virus NS5B Polymerase Inhibitor BMS-791325 on All Major Genotypes

J. Lemm, M. Gao, Mengping Liu, 2014, Antimicrobial Agents and Chemotherapy.

Identification of Hepatitis C Virus NS5A Inhibitors

N. Meanwell, M. Deshpande, Scott W. Martin, 2009, Journal of Virology.

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization.

L. Hamann, N. Meanwell, J. Lemm, 2011, The Journal of general virology.

Replicationin Suppressing Hepatitis C Virus Direct-Acting Antiviral Agents Are Highly Combinations of Lambda Interferon with

J. Lemm, Chaoqun Chen, J. Friborg, 2014 .

Specific Inhibition of Bovine Viral Diarrhea Virus Replicase

J. Lemm, R. Colonno, M. Gao, 2003, Journal of Virology.

SAR studies on a series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides: potent inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.

B. Beno, M. Poss, J. Lemm, 2011, Bioorganic & medicinal chemistry letters.

Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.

M. Witmer, B. Beno, K. Kish, 2011, Bioorganic & medicinal chemistry letters.

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

Min Gao, Nicholas A. Meanwell, Yong Tu, 2015, Nature.

HCV NS5A replication complex inhibitors. Part 2: investigation of stilbene prolinamides.

N. Meanwell, J. Lemm, M. Gao, 2012, Bioorganic & medicinal chemistry letters.

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

N. Meanwell, Scott W. Martin, Joseph L. Cantone, 2011, Antimicrobial Agents and Chemotherapy.

Resensitizing daclatasvir-resistant hepatitis C variants by allosteric modulation of NS5A

N. Meanwell, D. Langley, J. Lemm, 2015, Nature.