I. Charo

发表

"Mirror image" antagonists of thrombin-induced platelet activation based on thrombin receptor structure.

V. Wheaton, C. Esmon, S. Coughlin, 1992, The Journal of clinical investigation.

Decreased lesion formation in CCR2−/− mice reveals a role for chemokines in the initiation of atherosclerosis

I. Charo, L. Boring, J. Gosling, 1998, Nature.

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells

S. Lira, A. Luster, I. Charo, 2011, Nature Immunology.

Thrombin receptor expression in normal and atherosclerotic human arteries.

Thiennu H. Vu, S. Coughlin, T. Vu, 1992, The Journal of clinical investigation.

CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation

D. Hume, A. Cumano, F. Geissmann, 2009, The Journal of experimental medicine.

Chemokine receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

A. Mantovani, K. Matsushima, M. Thelen, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Chemokine receptors (version 2019.5) in the IUPHAR/BPS Guide to Pharmacology Database

A. Mantovani, M. Rosenkilde, K. Matsushima, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

International union of pharmacology. XXII. Nomenclature for chemokine receptors.

K. Matsushima, M. Baggiolini, I. Charo, 2000, Pharmacological reviews.

Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2.

S. Kunkel, A. Matsukawa, C. Hogaboam, 2000, The American journal of pathology.

The Amino-terminal Extracellular Domain of the MCP-1 Receptor, but Not the RANTES/MIP-1α Receptor, Confers Chemokine Selectivity

I. Charo, F. Monteclaro, 1996, The Journal of Biological Chemistry.

Selective employment of chemokine receptors as human immunodeficiency virus type 1 coreceptors determined by individual amino acids within the envelope V3 loop

B. Chesebro, M. Goldsmith, R. Atchison, 1997, Journal of virology.

MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B.

B. Rollins, S. Young, I. Charo, 1999, The Journal of clinical investigation.

Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis

J. Flynn, J. Ernst, I. Charo, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Involvement of chemokine receptor 2 and its ligand, monocyte chemoattractant protein-1, in the development of atherosclerosis: lessons from knockout mice

I. Charo, W. Peters, 2001, Current opinion in lipidology.

CCR2-Dependent Trafficking of F4/80dim Macrophages and CD11cdim/intermediate Dendritic Cells Is Crucial for T Cell Recruitment to Lungs Infected with Mycobacterium tuberculosis1

M. Mack, J. Cyster, J. Ernst, 2004, The Journal of Immunology.

A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury

R. Ransohoff, P. Kubes, E. Kolaczkowska, 2015, The Journal of experimental medicine.

The Amino-terminal Domain of CCR2 Is Both Necessary and Sufficient for High Affinity Binding of Monocyte Chemoattractant Protein 1

I. Charo, F. Monteclaro, 1997, The Journal of Biological Chemistry.

LA Fitzgerald The platelet membrane glycoprotein IIb-IIIa complex

L. Parise, I. Charo, D. Phillips, 1988 .

CCL7 Is a Negative Regulator of Cutaneous Inflammation Following Leishmania major Infection

Wuyuan Lu, I. Charo, Jean K. Lim, 2019, Front. Immunol..

Domains specifying thrombin–receptor interaction

V. Wheaton, S. Coughlin, D. T. Hung, 1991, Nature.

Targeted Disruption of the Scavenger Receptor and Chemokine CXCL16 Accelerates Atherosclerosis

I. Charo, A. Aslanian, 2006, Circulation.

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice.

T. Schall, I. Charo, T. Sullivan, 2013, American journal of physiology. Renal physiology.

Macrophage Polarization and Insulin Resistance: PPARγ in Control

I. Charo, 2007 .

Angiotensin II infusion promotes ascending aortic aneurysms: attenuation by CCR2 deficiency in apoE−/− mice

A. Daugherty, I. Charo, A. P. Owens, 2010, Clinical science.

Tumor Necrosis Factor- (cid:1) -converting Enzyme Mediates the Inducible Cleavage of Fractalkine*

I. Charo, C. Tsou, C. Haskell, 2022 .

The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood

R. Ransohoff, I. Charo, A. Cardona, 2012, The Journal of Immunology.

Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome.

M. Burdick, R. Strieter, S. Kunkel, 2001, The Journal of clinical investigation.

Resistance to Experimental Autoimmune Encephalomyelitis in Mice Lacking the Cc Chemokine Receptor (Ccr2)

H. Weiner, R. Klein, A. Luster, 2000, The Journal of experimental medicine.

CC Chemokine Receptor 2 is Protective Against Noise-Induced Hair Cell Death: Studies in CX3CR1+/GFP Mice

R. Ransohoff, I. Charo, K. Hirose, 2006, Journal of the Association for Research in Otolaryngology.

Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis.

I. Charo, P. Lesnik, C. Haskell, 2003, The Journal of clinical investigation.

CCR2-/- knockout mice revascularize normally in response to severe hindlimb ischemia.

I. Charo, G. Tang, L. Messina, 2004, Journal of vascular surgery.

CCR2 Deficiency Decreases Intimal Hyperplasia After Arterial Injury

J. Badimón, J. Fallon, M. Roqué, 2002, Arteriosclerosis, thrombosis, and vascular biology.

MCP‐1‐dependent signaling in CCR2−/− aortic smooth muscle cells

B. Rollins, Harry Ma, K. Soejima, 2004, Journal of leukocyte biology.

Increased Expression of CCL2 in Insulin-Producing Cells of Transgenic Mice Promotes Mobilization of Myeloid Cells From the Bone Marrow, Marked Insulitis, and Diabetes

S. Lira, S. Rankin, I. Charo, 2008, Diabetes.

Prostaglandin I2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels.

S. Shak, I. Charo, I. Goldstein, 1984, The Journal of clinical investigation.

Chemokine Receptor 2 (CCR2) in Atherosclerosis, Infectious Diseases, and Regulation of T‐Cell Polarization

I. Charo, W. Peters, 2003, Microcirculation.

Neutrophil‐dominant experimental autoimmune uveitis in CC‐chemokine receptor 2 knockout mice

Takeru Yoshimura, K. Sonoda, I. Charo, 2011, Acta ophthalmologica.

Inhibition of MCP-1/CCR2 Signaling Does Not Inhibit Intimal Proliferation in a Mouse Aortic Transplant Model

B. Rollins, I. Charo, J. Alexis, 2008, Journal of Vascular Research.

Murine Monocyte Chemoattractant Protein (MCP)-5: A Novel CC Chemokine That Is a Structural and Functional Homologue of Human MCP-1

A. Luster, I. Charo, E. García-Zepeda, 1997, The Journal of experimental medicine.

CC chemokine receptor 2 promotes recruitment of myeloid cells associated with insulin resistance in nonalcoholic fatty liver disease.

James J. Campbell, C. Weston, D. Adams, 2018, American journal of physiology. Gastrointestinal and liver physiology.

Interrelations of platelet aggregation and secretion.

R. Feinman, I. Charo, T. Detwiler, 1977, The Journal of clinical investigation.

Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells.

B. Rollins, I. Charo, B. Blazar, 2004, American journal of physiology. Lung cellular and molecular physiology.

Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2.

A. Ritchie, H. Broxmeyer, I. Charo, 1999, Blood.

Critical Role of Monocyte Chemoattractant Protein-1 Receptor CCR2 on Monocytes in Hypertension-Induced Vascular Inflammation and Remodeling

A. Takeshita, T. Tsuzuki, T. Sugaya, 2004, Circulation research.

CCR 2 antagonist CCX 140-B provides renal and glycemic benefits in diabetic transgenic human CCR 2 knockin mice

T. Schall, I. Charo, T. Sullivan, 2013 .

Characterization of CCX140-B, an orally bioavailable antagonist of the CCR2 chemokine receptor, for the treatment of type 2 diabetes and associated complications.

T. Schall, I. Charo, Daniel M. Johnson, 2012, The Journal of pharmacology and experimental therapeutics.

CX 3 CR1 + CD115 + CD135 + common macrophage/DC precursors and the role of CX 3 CR1 in their response to infl ammation

D. Hume, A. Cumano, F. Geissmann, 2009 .

Inhibition of fibrinogen binding to GP IIb-IIIa by a GP IIIa peptide.

I. Charo, D. Phillips, R. Scarborough, 1991, The Journal of biological chemistry.

Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa.

I. Charo, D. Phillips, A. Arfsten, 1993, The Journal of biological chemistry.

Alkylsulfone-containing trisubstituted cyclohexanes as potent and bioavailable chemokine receptor 2 (CCR2) antagonists.

Michael G. Yang, J. Barrish, S. Mandlekar, 2014, Bioorganic & medicinal chemistry letters.

Importance of Monocyte Chemoattractant Protein-1 Pathway in Neointimal Hyperplasia After Periarterial Injury in Mice and Monkeys

A. Takeshita, T. Ichiki, I. Charo, 2002, Circulation research.

Transient Role for CD1d-Restricted Natural Killer T Cells in the Formation of Atherosclerotic Lesions

H. Chapman, I. Charo, A. Aslanian, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Chemokine receptors (version 2020.5) in the IUPHAR/BPS Guide to Pharmacology Database

A. Mantovani, M. Rosenkilde, K. Matsushima, 2020 .

Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

Steffen Jung, M. Merad, J. Gommerman, 2011, Immunity.

Zmynd15 Encodes a Histone Deacetylase-dependent Transcriptional Repressor Essential for Spermiogenesis and Male Fertility*

David L. Young, Wei Yan, E. Verdin, 2010, The Journal of Biological Chemistry.

Molecular Cloning and Functional Characterization of a Novel Human CC Chemokine Receptor (CCR5) for RANTES, MIP-1β, and MIP-1α*

P. Gray, I. Charo, J. Gosling, 1996, The Journal of Biological Chemistry.

Molecular cloning and functional expression of two monocyte chemoattractant protein 1 receptors reveals alternative splicing of the carboxyl-terminal tails.

S. Coughlin, A. Connolly, I. Charo, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Enhanced Pulmonary Allergic Responses to Aspergillus in CCR2−/− Mice1

T. Standiford, S. Kunkel, C. Hogaboam, 2000, The Journal of Immunology.

Impaired lung dendritic cell activation in CCR2 knockout mice.

S. Lira, S. Chensue, I. Charo, 2004, The American journal of pathology.

Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2-/- mice: the role of mast cells.

R. Strieter, S. Kunkel, I. Charo, 1999, Journal of immunology.

Monocyte recruitment in venous thrombus resolution.

Alberto Smith, B. Rollins, D. Greaves, 2006, Journal of vascular surgery.

Bone Marrow–Derived Monocyte Chemoattractant Protein-1 Receptor CCR2 Is Critical in Angiotensin II–Induced Acceleration of Atherosclerosis and Aneurysm Formation in Hypercholesterolemic Mice

K. Sunagawa, A. Takeshita, T. Tsuzuki, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Characterization of Pharmacologic and Pharmacokinetic Properties of CCX168, a Potent and Selective Orally Administered Complement 5a Receptor Inhibitor, Based on Preclinical Evaluation and Randomized Phase 1 Clinical Study

T. Schall, I. Charo, Daniel M. Johnson, 2016, PloS one.

Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri.

V. Fried, I. Charo, D. Phillips, 1991, The Journal of biological chemistry.

Platelet glycoprotein IIb-IIIa-like proteins mediate endothelial cell attachment to adhesive proteins and the extracellular matrix.

I. Charo, D. Phillips, L. Bekeart, 1987, The Journal of biological chemistry.

IL-13-Induced Inflammation and Remodeling Lung : Role of CCR 2 in the Pathogenesis of IL-13-Induced Chemokine Responses in the

B. Ma, R. Homer, I. Charo, 2002 .

CCR2: from cloning to the creation of knockout mice.

I. Charo, 1999, Chemical immunology.

Mice: The Role of Mast Cells - / - CCR2Bronchial Hyperreactivity in Normal But Not Mediates Cockroach Allergen-Induced Monocyte Chemoattractant Protein-1

R. Strieter, S. Kunkel, I. Charo, 1999 .

Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo1

H. Auchincloss, R. Abdi, M. Jurewicz, 2004, The Journal of Immunology.

Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen.

B. Rollins, I. Charo, L. Boring, 2002, Cytokine.

IL-17–Secreting γδ T Cells Are Completely Dependent upon CCR6 for Homing to Inflamed Skin

James J. Campbell, T. Schall, I. Charo, 2017, The Journal of Immunology.

Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms.

I. Charo, D. Phillips, A. Arfsten, 1993, The Journal of biological chemistry.

CC Chemokine Receptor 2 Promotes 1 Recruitment of Myeloid Cells Associated with 2 Insulin Resistance in Non-Alcoholic Fatty Liver 3 Disease 4

James J. Campbell, C. Weston, D. Adams, 2018 .

Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection.

D. Salant, I. Charo, W. Hancock, 2001, The Journal of clinical investigation.

Analysis of corneal inflammation induced by cauterisation in CCR2 and MCP-1 knockout mice

T. Hisatomi, K. Sonoda, I. Charo, 2006, British Journal of Ophthalmology.

CCR2 regulates development of Theiler's murine encephalomyelitis virus-induced demyelinating disease.

S. Miller, W. Karpus, I. Charo, 2007, Viral immunology.

Immunopathology and Infectious Disease Impaired Lung Dendritic Cell Activation in CCR 2 Knockout Mice

S. Lira, S. Chensue, I. Charo, 2004 .

Mycobacterium tuberculosis Recruitment to Lungs Infected with Dendritic Cells Is Crucial for T Cell dim / intermediateMacrophages and CD 11 c dimCCR 2-Dependent Trafficking of F 4 / 80

M. Mack, J. Cyster, J. Ernst, 2004 .

Adulthood Present on Microglia from Embryonic The Fractalkine Receptor but Not CCR 2

R. Ransohoff, I. Charo, A. Cardona, 2011 .

B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction

D. Tsiantoulas, P. Bruneval, N. Danchin, 2013, Nature Medicine.

Differential Roles of Chemokines CCL2 and CCL7 in Monocytosis and Leukocyte Migration during West Nile Virus Infection

Christopher J. Obara, Wuyuan Lu, I. Charo, 2015, The Journal of Immunology.

Migration during West Nile Virus Infection Ccl7 in Monocytosis and Leukocyte Differential Roles of Chemokines Ccl2 And

Christopher J. Obara, Wuyuan Lu, I. Charo, 2022 .

Evidence that Calcium Regulates Platelet Function

R. Feinman, I. Charo, T. Detwiler, 1978, Thrombosis and Haemostasis.

Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa.

I. Charo, D. Phillips, L. Fitzgerald, 1985, The Journal of biological chemistry.

Molecular Uncoupling of Fractalkine-mediated Cell Adhesion

I. Charo, Michael D. Cleary, C. Haskell, 1999 .

CC-chemokine receptor 2 required for bleomycin-induced pulmonary fibrosis.

S. Kunkel, R. Mccullumsmith, S. Phan, 2003, Cytokine.

Monocyte chemoattractant protein-3, but not monocyte chemoattractant protein-2, is a functional ligand of the human monocyte chemoattractant protein-1 receptor.

P. Proost, J. Van Damme, I. Charo, 1995, Journal of immunology.

Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function.

S. Coughlin, I. Charo, J. Gosling, 1996, Journal of immunology.

Macrophage polarization and insulin resistance: PPARgamma in control.

I. Charo, 2007, Cell metabolism.

Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.

I. Charo, D. Phillips, S. C. Rall, 1986, Proceedings of the National Academy of Sciences of the United States of America.

The lumi-aggregometer: a new instrument for simultaneous measurement of secretion and aggregation by platelets.

J. Lubowsky, M. Zabinski, R. Feinman, 1977, The Journal of laboratory and clinical medicine.

Tumor necrosis factor-alpha-converting enzyme mediates the inducible cleavage of fractalkine.

I. Charo, C. Tsou, C. Haskell, 2001, The Journal of biological chemistry.

Chronic expression of monocyte chemoattractant protein‐1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice

B. Rollins, R. Ransohoff, G. Kidd, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Abstract 5655: Inhibition of CCR2 potentiates checkpoint inhibitor immunotherapy in murine model of pancreatic cancer

T. Schall, I. Charo, Rajinder Singh, 2017 .

Prostaglandin endoperoxides and thromboxane A2 can induce platelet aggregation in the absence of secretion

R. Feinman, I. Charo, T. Detwiler, 1977, Nature.

CCR 2 + monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx 3 cr 1 deficient mice

J. Sahel, X. Guillonneau, F. Behar-Cohen, 2013 .

MCP-1 in Human Disease

B. Rollins, I. Charo, L. Boring, 1999 .

CCR2 antagonism leads to marked reduction in proteinuria and glomerular injury in murine models of focal segmental glomerulosclerosis (FSGS)

James J. Campbell, T. Schall, I. Charo, 2018, PloS one.

of Platelet Aggregation and Secretion

R. Feinman, I. Charo, T. Detwiler, 1977 .

Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated by betagamma dimers released by activation of Galphai-coupled receptors.

I. Charo, H. Arai, C. Tsou, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Identification of C-C chemokine receptor 1 (CCR1) as the hemofiltrate C-C chemokine (HCC)-1 receptor.

I. Charo, T. Paradis, R. Gladue, 1998 .

Synthesis and expression of the fibroblast fibronectin receptor in human monocytes.

C. Damsky, I. Charo, D. Brown, 1989, The Journal of clinical investigation.

A Mechanism for the Impaired IFN-γ Production in C-C Chemokine Receptor 2 (CCR2) Knockout Mice: Role of CCR2 in Linking the Innate and Adaptive Immune Responses1

I. Charo, W. Peters, M. Dupuis, 2000, The Journal of Immunology.

Chemokine Fractalkine/CX3CL1 Negatively Modulates Active Glutamatergic Synapses in Rat Hippocampal Neurons

F. Eusebi, C. Limatola, C. Gross, 2006, The Journal of Neuroscience.

Differential Regulation of G-protein-mediated Signaling by Chemokine Receptors*

I. Charo, H. Arai, 1996, The Journal of Biological Chemistry.

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Sara G. Murray, H. Lassmann, J. Ryu, 2015, Nature Communications.

The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation.

I. Charo, F. Monteclaro, Israel F. Charo, 1996, The Journal of biological chemistry.

Role of CCR8 and Other Chemokine Pathways in the Migration of Monocyte-derived Dendritic Cells to Lymph Nodes

F. Tacke, Steffen Jung, S. Lira, 2004, The Journal of experimental medicine.

In CCR2-/- mice monocyte recruitment and egress of LDL cholesterol in vivo is impaired.

I. Charo, O. Stein, Y. Stein, 2003, Biochemical and biophysical research communications.

Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion

R. Ransohoff, I. Charo, L. Jakeman, 2002, Journal of neuroscience research.

Organization and Differential Expression of the Human Monocyte Chemoattractant Protein 1 Receptor Gene

S. J. Myers, I. Charo, J. Gosling, 1997, The Journal of Biological Chemistry.

Targeted deletion of CX3CR1 reveals a role for fractalkine in cardiac allograft rejection

D. Salant, I. Charo, W. Hancock, 2001 .

The critical role of ocular‐infiltrating macrophages in the development of choroidal neovascularization

T. Hisatomi, K. Sonoda, T. Sakamoto, 2003, Journal of leukocyte biology.

Human Placental Cytotrophoblasts Attract Monocytes and Cd56bright Natural Killer Cells via the Actions of Monocyte Inflammatory Protein 1α

S. Fisher, Yan Zhou, I. Charo, 2001, The Journal of experimental medicine.

Chemokines in the pathogenesis of vascular disease.

I. Charo, Israel F Charo, Mark B Taubman, 2004, Circulation research.

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

Robert V Farese, H. Broxmeyer, S. Kunkel, 1997, The Journal of clinical investigation.

Additive Roles for MCP-1 and MCP-3 in CCR2-Mediated Recruitment of Inflammatory Monocytes during Listeria monocytogenes Infection1

E. Pamer, N. Serbina, I. Charo, 2008, The Journal of Immunology.

Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.

M. Mack, I. Charo, S. Weisberg, 2007, The Journal of clinical investigation.

Inhibition of platelet secretion by an antagonist of intracellular calcium.

R. Feinman, I. Charo, T. Detwiler, 1976, Biochemical and biophysical research communications.

Research on the Biochemical Basis of Platelet Function

I. Charo, T. Detwiler, 1977 .

CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

José-Alain Sahel, Jean-Louis Bourges, Francine Behar-Cohen, 2013, EMBO molecular medicine.

Inhibition of Chemokine-Glycosaminoglycan Interactions in Donor Tissue Reduces Mouse Allograft Vasculopathy and Transplant Rejection

G. McFadden, J. Esko, I. Charo, 2010, PloS one.

Progress Toward a Human CD4/CCR5 Transgenic Rat Model for De Novo Infection by Human Immunodeficiency Virus Type 1

M. Goldsmith, R. Grant, D. Littman, 2002, The Journal of experimental medicine.

The many roles of chemokines and chemokine receptors in inflammation.

R. Ransohoff, I. Charo, Israel F Charo, 2006, The New England journal of medicine.

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin

Jeffrey W. Smith, D. Cheresh, I. Charo, 1990, The Journal of cell biology.

CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

R. Leibel, I. Charo, S. Weisberg, 2006, The Journal of clinical investigation.

CCR2 deficiency impairs macrophage infiltration and improves cognitive function after traumatic brain injury.

E. Huang, Jialing Liu, I. Charo, 2014, Journal of neurotrauma.

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

R. Jain, T. Schall, Meenal Datta, 2019, Proceedings of the National Academy of Sciences.

Differential roles of microglia and monocytes in the inflamed central nervous system

H. Weiner, R. Ransohoff, G. Kidd, 2014, The Journal of experimental medicine.

Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells

O. Garaschuk, F. Heppner, A. Aguzzi, 2012, Proceedings of the National Academy of Sciences.

CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice.

I. Charo, Y. Si, C. Tsou, 2010, The Journal of clinical investigation.

Selective Chemokine Receptor Usage by Central Nervous System Myeloid Cells in CCR2-Red Fluorescent Protein Knock-In Mice

R. Ransohoff, I. Charo, A. Cardona, 2010, PloS one.

GPIIb-IIIa: The responsive integrin

David R. Phillips, I. Charo, D. Phillips, 1991, Cell.

Pertussis Toxin-Induced Reversible Encephalopathy Dependent on Monocyte Chemoattractant Protein-1 Overexpression in Mice

B. Rollins, R. Ransohoff, V. Tuohy, 2002, The Journal of Neuroscience.

Efficacy of Chemokine Receptor Inhibition in Treating IL-36α–Induced Psoriasiform Inflammation

T. Schall, I. Charo, Rajinder Singh, 2019, The Journal of Immunology.

Molecular Uncoupling of Fractalkine-mediated Cell Adhesion and Signal Transduction

I. Charo, Michael D. Cleary, C. Haskell, 1999, The Journal of Biological Chemistry.

Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis

Marc Dupuis, Wendy Peters, D. McDonald, 2001, European journal of immunology.

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2−/− Mice: Evidence for Independent Chemokine Functions in Atherogenesis

S. Lira, I. Charo, N. Saederup, 2008, Circulation.

Edinburgh Research Explorer common macrophage/DC precursors and the role of CX(3)CR1 in their response to inflammation

D. Hume, A. Cumano, F. Geissmann, 2009 .

Resolving postoperative neuroinflammation and cognitive decline

M. Maze, K. Akassoglou, M. Feldmann, 2011, Annals of neurology.

Unique Role of the Chemokine Domain of Fractalkine in Cell Capture

I. Charo, Michael D. Cleary, C. Haskell, 2000, The Journal of Biological Chemistry.

Aspergillus antigen induces robust Th2 cytokine production, inflammation, airway hyperreactivity and fibrosis in the absence of MCP-1 or CCR2

B. Rollins, D. Erle, Madeleine W Rodriguez, 2004, Respiratory research.

CC Chemokine Receptor-2 Is Not Essential for the Development of Antigen-Induced Pulmonary Eosinophilia and Airway Hyperresponsiveness1

J. Drazen, K. Ackerman, A. Luster, 2000, The Journal of Immunology.

HyperresponsivenessPulmonary Eosinophilia and Airway for the Development of Antigen-Induced CC Chemokine Receptor-2 Is Not Essential

J. Drazen, G. T. Sanctis, A. Luster, 2000 .

Tissue Factor Is Induced by Monocyte Chemoattractant Protein-1 in Human Aortic Smooth Muscle and THP-1 Cells*

B. Rollins, J. Fallon, Y. Nemerson, 1997, The Journal of Biological Chemistry.

Dual effect of chemokine CCL7/MCP-3 in the development of renal tubulointerstitial fibrosis.

J. Schanstra, P. Heeringa, J. Pradère, 2013, Biochemical and biophysical research communications.

Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.

I. Charo, L. Boring, J. Gosling, 1996, The Journal of biological chemistry.

Macrophages recruited via CCR2 produce insulin‐like growth factor‐1 to repair acute skeletal muscle injury

R. Ransohoff, I. Charo, Haiyan Lu, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Dissociation of Chemotaxis from Agonist-induced Receptor Internalization in a Lymphocyte Cell Line Transfected with CCR2B

I. Charo, H. Arai, C. Franci, 1997, The Journal of Biological Chemistry.

Signal Transduction and Ligand Specificity of the Human Monocyte Chemoattractant Protein-1 Receptor in Transfected Embryonic Kidney Cells (*)

S. J. Myers, I. Charo, L. Wong, 1995, The Journal of Biological Chemistry.

IL-13-Induced Chemokine Responses in the Lung: Role of CCR2 in the Pathogenesis of IL-13-Induced Inflammation and Remodeling1

B. Ma, R. Homer, I. Charo, 2002, The Journal of Immunology.

The CC Chemokine MCP-1 Stimulates Surface Expression of CX3CR1 and Enhances the Adhesion of Monocytes to Fractalkine/CX3CL1 via p38 MAPK1

O. Quehenberger, I. Charo, Yury I. Miller, 2006, The Journal of Immunology.

CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood

T. Schall, T. Handel, I. Kufareva, 2019, The Journal of Immunology.

Molecular cloning and functional expression of two monocyte

A. Herman, I. Charo, C. Franci, 2022 .

Blinding the monocytes to protect the heart.

I. Charo, 2013, Circulation.

Running title: Charo; CCR2 Knockdown Reduces Myocardial Inflammation

I. Charo, F. Charo, 2013 .

521 Chemokine receptor inhibition as a novel therapeutic approach for psoriasis

T. Schall, I. Charo, J. McMahon, 2016 .

Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of Gαi-coupled receptors

I. Charo, H. Arai, C. Tsou, 1997 .

The Transcriptional Repressor BLIMP1 Curbs Host Defenses by Suppressing Expression of the Chemokine CCL8

Daniel R. Caffrey, M. Severa, E. Kurt-Jones, 2014, The Journal of Immunology.

Identification of C-C Chemokine Receptor 1 (CCR1) as the Monocyte Hemofiltrate C-C Chemokine (HCC)-1 Receptor

J. Boyd, I. Charo, T. Paradis, 1998, The Journal of experimental medicine.

Differential Influence of Chemokine Receptors CCR2 and CXCR3 in Development of Atherosclerosis In Vivo

F. Mach, S. Steffens, I. Charo, 2005, Circulation.

from Human Foreskin Microvessels

S. Shak, I. Charo, I. Goldstein, 1984 .

The Vitronectin Receptor vfl3 Binds Fibronectin and Acts in Concert with asfll in Promoting Cellular Attachment and Spreading on Fibronectin

J W Smith, David A. Cheresh, I. F. Charo, 1990 .

CurrentsModulation of NMDA-Mediated Synaptic μ Involvement of cAMP-Dependent Protein Kinase in

F. Eusebi, C. Limatola, C. Gross, 2015 .

Anti-inflammatory therapeutics for the treatment of atherosclerosis

R. Taub, I. Charo, 2011, Nature Reviews Drug Discovery.

Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines

M. Goldsmith, R. Atchison, I. Charo, 1996, Science.

Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation

R. Ransohoff, I. Charo, A. Cardona, 2013, The Journal of Immunology.

Orally administered CCR2 selective inhibitor CCX872-b clinical trial in pancreatic cancer.

S. Sleijfer, A. Hezel, T. Schall, 2017 .

Chemokine receptors in GtoPdb v.2023.1 Chemokine receptors in GtoPdb v.2023.1

A. Mantovani, K. Matsushima, M. Thelen, 2023 .

The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation

K. Sonoda, I. Charo, K. Egashira, 2004, British Journal of Ophthalmology.

Rac1 and CDC42Hs play a critical role in MCP-1-induced chemotaxis

I. Charo, H. Arai, 2000 .

Interrelations ofPlatelet Aggregation andSecretion

I. Charo, 1977 .

The platelet membrane glycoprotein IIb-IIIa complex.

L. Parise, I. Charo, L. Fitzgerald, 1988, Blood.

Identification of C-c Chemokine Receptor 1 (ccr1) as the Monocyte Hemofiltrate C-c Chemokine (hcc)-1 Receptor

J. Boyd, I. Charo, T. Paradis, 1998 .