A. Karaplis

发表

Regulation of parathyroid hormone-like peptide in cultured normal human keratinocytes. Effect of growth factors and 1,25 dihydroxyvitamin D3 on gene expression and secretion.

D. Banville, G. Hendy, W. Gulliver, 1991, The Journal of clinical investigation.

Parathyroid hormone regulates fetal‐placental mineral homeostasis

G. Karsenty, C. Kovacs, A. Karaplis, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone.

M. Hediger, K. Mohammad, T. Guise, 2003, The Journal of clinical investigation.

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression.

M. McKee, D. Miao, D. Goltzman, 2002, Molecular endocrinology.

Morphological Approach to Biological Action of PTHrP and Vitamin D3 on Endochondral Ossification

John H. White, Kimimitsu Oda, N. Amizuka, 2004 .

Parathyroid hormone is essential for normal fetal bone formation.

D. Miao, D. Goltzman, A. Karaplis, 2002, The Journal of clinical investigation.

TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation.

H. Jüppner, D. Goltzman, A. Karaplis, 2009, American journal of physiology. Endocrinology and metabolism.

Genetics and animal models of hypoparathyroidism

A. Karaplis, N. Garfield, 2001, Trends in Endocrinology & Metabolism.

Osteoblast-Derived PTHRP and Breast Cancer Bone Metastasis

A. Karaplis, 2004 .

The p27 Pathway Modulates the Regulation of Skeletal Growth and Osteoblastic Bone Formation by Parathyroid Hormone–Related Peptide

Rong Wang, D. Miao, D. Goltzman, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Defects in mesenchymal stem cell self‐renewal and cell fate determination lead to an osteopenic phenotype in Bmi‐1 null mice

D. Miao, D. Goltzman, A. Karaplis, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target.

W. Muller, P. Siegel, R. Kremer, 2011, The Journal of clinical investigation.

Bisphosphonates for treatment of osteoporosis: expected benefits, potential harms, and drug holidays.

Jacques P. Brown, W. Leslie, J. Adachi, 2014, Canadian family physician Medecin de famille canadien.

Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone.

D. Miao, D. Goltzman, A. Karaplis, 2007, Endocrinology.

Physiological roles for parathyroid hormone-related protein: lessons from gene knockout mice.

H. Kronenberg, A. Karaplis, H. Kronenberg, 1996, Vitamins and hormones.

Defective interplay between mTORC1 activity and endoplasmic reticulum stress-unfolded protein response in uremic vascular calcification.

A. Koromilas, M. Lipman, A. Karaplis, 2018, American journal of physiology. Renal physiology.

Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34.

H. Genant, D. Miao, H. Kronenberg, 2005, The Journal of clinical investigation.

Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein

D. Miao, D. Goltzman, A. Karaplis, 2008, Proceedings of the National Academy of Sciences.

DNA damage checkpoint pathway modulates the regulation of skeletal growth and osteoblastic bone formation by parathyroid hormone-related peptide

D. Miao, D. Goltzman, A. Karaplis, 2018, International journal of biological sciences.

Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation.

C. Watson, A. F. Stewart, J. Wysolmerski, 2003, The Journal of clinical investigation.

The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus, and PTH

E. Brown, G. Ding, D. Miao, 2011, PLoS genetics.

Skeletal Recovery After Weaning Does Not Require PTHrP

J. Wysolmerski, C. Kovacs, N. Sims, 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice.

D. Miao, D. Goltzman, A. Karaplis, 2004, Endocrinology.

Tumor‐Induced Osteomalacia: Clinical and Basic Studies

T. Clemens, D. Dempster, E. Shane, 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Vitamin D Status and Response to Daily 400 IU Vitamin D3 and Weekly Alendronate 70 mg in Men and Women with Osteoporosis

J. Sampalis, A. Karaplis, D. Hanley, 2011, The Annals of pharmacotherapy.

The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice.

E. Brown, D. Miao, D. Goltzman, 2012, American journal of physiology. Endocrinology and metabolism.

The Calcium-Sensing Receptor Mediates Bone Turnover Induced by Dietary Calcium and Parathyroid Hormone in Neonates

E. Brown, D. Miao, D. Goltzman, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Endogenous PTH Deficiency Impairs Fracture Healing and Impedes the Fracture-Healing Efficacy of Exogenous PTH(1-34)

D. Miao, D. Goltzman, A. Karaplis, 2011, PloS one.

Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium.

D. Miao, D. Goltzman, A. Karaplis, 2009, Endocrinology.

Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles.

D. Miao, G. Hendy, D. Goltzman, 2006, Endocrinology.

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype.

D. Miao, D. Goltzman, A. Karaplis, 2009, American journal of physiology. Endocrinology and metabolism.

FGF23 Is Not Required to Regulate Fetal Phosphorus Metabolism but Exerts Effects Within 12 Hours After Birth

B. Lanske, C. Kovacs, Yue Ma, 2016, Endocrinology.

CHAPTER 6 – Nuclear Actions of PTHrP

A. Karaplis, M. Nguyen, 2001 .

Parathyroid hormone‐related peptide and the parathyroid hormone/parathyroid hormone‐related peptide receptor in skeletal development

A. Karaplis, L. Vautour, 1997, Current opinion in nephrology and hypertension.

Molecular basis of the spectrum of skeletal complications of neoplasia

S. Rabbani, R. Kremer, D. Goltzman, 2000, Cancer.

PTH and PTHrP Effects on the Skeleton

D. Goltzman, A. Karaplis, 2000, Reviews in Endocrine and Metabolic Disorders.

Parathyroid hormone-related peptide (PTHrP) regulates fetal-placental calcium transport through a receptor distinct from the PTH/PTHrP receptor.

B. Lanske, C. Kovacs, H. Kronenberg, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Knockdown of parathyroid hormone related protein in smooth muscle cells alters renal hemodynamics but not blood pressure.

P. Chambon, D. Metzger, T. Massfelder, 2013, American journal of physiology. Renal physiology.

Parathyroid hormone‐related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets

P. A. Friedman, T. Clemens, A. F. Stewart, 2001, British journal of pharmacology.

Role of PTHrP nuclear localization and carboxyl terminus sequences in postnatal spinal cord development

Rong Wang, D. Miao, A. Karaplis, 2020, Developmental neurobiology.

Absence of PTHrP Nuclear Localization and Carboxyl Terminus Sequences Leads to Abnormal Brain Development and Function

Qi Chen, D. Miao, D. Goltzman, 2012, PloS one.

Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles.

D. Goltzman, A. Karaplis, M. Pollak, 2001, Endocrinology.

Molecular Regulation of Osteoblast Differentiation

M. McKee, A. Karaplis, Prasanna L Bukka, 2004 .

Programmed cell death of chondrocytes and aberrant chondrogenesis in mice homozygous for parathyroid hormone-related peptide gene deletion.

N. Amizuka, D. Goltzman, A. Karaplis, 1996, Endocrinology.

Distinctive anabolic roles of 1,25-dihydroxyvitamin D(3) and parathyroid hormone in teeth and mandible versus long bones.

D. Miao, D. Goltzman, A. Karaplis, 2009, The Journal of endocrinology.

Metabolic bone disease: Lessons from knockout mice

A. Karaplis, 2000 .

Nuclear forms of parathyroid hormone-related peptide are translated from non-AUG start sites downstream from the initiator methionine.

A. Karaplis, B. He, M. Nguyen, 2001, Endocrinology.

CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders.

D. Miao, D. Goltzman, A. Karaplis, 2016, The Journal of clinical investigation.

Targeted ablation of the chromogranin a (Chga) gene: normal neuroendocrine dense-core secretory granules and increased expression of other granins.

M. Tremblay, G. Hendy, R. Day, 2006, Molecular endocrinology.

Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue.

D. Banville, G. Hendy, D. Goltzman, 1990, Molecular endocrinology.

Endogenous Parathyroid Hormone–Related Protein Compensates for the Absence of Parathyroid Hormone in Promoting Bone Accrual In Vivo in a Model of Bone Marrow Ablation

D. Miao, D. Goltzman, A. Karaplis, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The Role of Parathyroid Hormone-Related Protein (PTHrP) in Osteoblast Response to Microgravity: Mechanistic Implications for Osteoporosis Development

D. Goltzman, A. Karaplis, A. Camirand, 2016, PloS one.

Haploinsufficiency of endogenous parathyroid hormone‐related peptide impairs bone fracture healing

A. Karaplis, Y. Qiu, Hong-fei Shi, 2013, Clinical and experimental pharmacology & physiology.

Endogenous parathyroid hormone–related protein compensates for the absence of parathyroid hormone in promoting bone accrual in vivo in a model of bone marrow ablation

D. Miao, D. Goltzman, A. Karaplis, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Hypercalcaemia with lymphoedema

L. Bégin, A. Karaplis, M. Trifiro, 1996, The Lancet.

Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization.

B. Lanske, C. Kovacs, Yue Ma, 2014, Endocrinology.

Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice.

M. McKee, D. Miao, D. Goltzman, 2004, Bone.

Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders.

D. Miao, D. Goltzman, A. Karaplis, 2004, Endocrinology.

Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone

C. Kovacs, Yue Ma, A. Karaplis, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Variable number of tandem repeats polymorphism in parathyroid hormone-related protein as predictor of peak bone mass in young healthy Finnish males.

D. Goltzman, A. Karaplis, E. Löyttyniemi, 2008, European journal of endocrinology.

Mineralizing enthesopathy is a common feature of renal phosphate-wasting disorders attributed to FGF23 and is exacerbated by standard therapy in hyp mice.

Jean-Pierre R. Falet, C. Macica, A. Karaplis, 2012, Endocrinology.

Renal Phosphate-Wasting Disorders Attributed to FGF 23 and Is Exacerbated by Standard Therapy in Hyp Mice

Jean-Pierre R. Falet, C. Macica, A. Karaplis, 2012 .

Deficiency of the parathyroid hormone‐related peptide nuclear localization and carboxyl terminal sequences leads to premature skin ageing partially mediated by the upregulation of p27

D. Miao, D. Goltzman, A. Karaplis, 2015, Experimental dermatology.

Exogenous PTH‐Related Protein and PTH Improve Mineral and Skeletal Status in 25‐Hydroxyvitamin D‐1α‐Hydroxylase and PTH Double Knockout Mice

D. Miao, G. Hendy, D. Goltzman, 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development.

D. Miao, G. Hendy, D. Goltzman, 2005, Human molecular genetics.

Role of PTHrP and PTH-1 receptor in endochondral bone development.

A. Karaplis, R. Deckelbaum, 1998, Frontiers in bioscience : a journal and virtual library.

Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in mice

D. Miao, Ling Chen, D. Goltzman, 2011, Clinical and experimental pharmacology & physiology.

Early lethality in Hyp mice with targeted deletion of Pth gene.

D. Miao, D. Goltzman, A. Karaplis, 2007, Endocrinology.

The Autosomal Dominant Hypophosphatemic Rickets R176Q Mutation in Fibroblast Growth Factor 23 Resists Proteolytic Cleavage and Enhances in Vivo Biological Potency*

D. Miao, D. Goltzman, A. Karaplis, 2003, The Journal of Biological Chemistry.

Skeletal abnormalities in Pth-null mice are influenced by dietary calcium.

B. Lanske, D. Miao, G. Hendy, 2004, Endocrinology.

PTHrP Inhibits Adipocyte Differentiation by Down-Regulating PPARγ Activity via a MAPK-Dependent Pathway.

D. Goltzman, A. Karaplis, I. Bolivar, 2001, Endocrinology.

Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development.

M. Tanaka, M. Lipman, N. Amizuka, 1996, Developmental biology.

Calcitriol increases during pregnancy and bone formation upregulates post-lactation without parathyroid hormone

C. Kovacs, A. Karaplis, B. J. Kirby, 2011 .

Constitutive expression of parathyroid hormone‐related peptide PTHnP stimulates growth and inhibits differentiation of CFK2 chondrocytes

D. Goltzman, A. Karaplis, J. Henderson, 1996, Journal of cellular physiology.

Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D.

D. Goltzman, A. Karaplis, L. Nguyen-Yamamoto, 2017, Journal of the American Society of Nephrology : JASN.

PTHrP Nuclear Localization and Carboxyl Terminus Sequences Modulate Dental and Mandibular Development in Part via the Action of p27.

Rong Wang, D. Miao, D. Goltzman, 2016, Endocrinology.

Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23.

D. Miao, D. Goltzman, A. Karaplis, 2009, American journal of physiology. Heart and circulatory physiology.

Skeletal and Reproductive Abnormalities in Pth-Null Mice

B. Lanske, D. Miao, G. Hendy, 2005 .

Parathyroid hormone-related protein is required for tooth eruption.

W. Philbrick, A. Karaplis, I. Nakchbandi, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The nucleus: A target site for parathyroid hormone‐related peptide (PTHrP) action

A. Karaplis, M. Nguyen, 1998, Journal of cellular biochemistry.

Role of Parathyroid Hormone‐Related Protein in Skeletal Development

B. Lanske, H. Kronenberg, A. Karaplis, 1996, Annals of the New York Academy of Sciences.

Amplification of the parathyroid hormone-related peptide gene in a colonic carcinoma.

N. Amizuka, D. Goltzman, A. Karaplis, 1996, The Journal of clinical endocrinology and metabolism.

Subcellular localization of prostaglandin E2 binding sites in bovine adrenal medulla.

W. Powell, A. Karaplis, 1984, Biochimica et biophysica acta.

Calcium Sensing Receptor Absence Delays Postnatal Brain Development via Direct and Indirect Mechanisms

D. Miao, D. Goltzman, A. Karaplis, 2013, Molecular Neurobiology.

Interaction of nascent preproparathyroid hormone molecules with microsomal membranes

H. Kronenberg, A. Karaplis, H. Keutmann, 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Deletion of the Nuclear Localization Sequences and C-Terminus of PTHrP Impairs Embryonic Mammary Development but also Inhibits PTHrP Production

J. Wysolmerski, A. Karaplis, P. Dann, 2014, PloS one.

Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene.

J Glowacki, J. Glowacki, R. Bronson, 1994, Genes & development.

Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities.

N. Amizuka, A. Karaplis, H. Ozawa, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.

B. Lanske, H. Kronenberg, R. Nissenson, 1996, Endocrinology.

Parathyroid hormone-related peptide-depleted mice show abnormal epiphyseal cartilage development and altered endochondral bone formation

N. Amizuka, D. Goltzman, A. Karaplis, 1994, The Journal of cell biology.

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.

M. Rudnicki, Zhoutao Chen, I. Pogribny, 2001, Human molecular genetics.

Inefficient Membrane Targeting, Translocation, and Proteolytic Processing by Signal Peptidase of a Mutant Preproparathyroid Hormone Protein (*)

Henry M. Kronenberg, A. Arnold, H. Kronenberg, 1995, The Journal of Biological Chemistry.

Stromal cells are critical targets in the regulation of mammary ductal morphogenesis by parathyroid hormone-related protein.

J. Orloff, B. Lanske, J. Wysolmerski, 1998, Developmental biology.

Embryonic Development of Bone and Regulation of Intramembranous and Endochondral Bone Formation

A. Karaplis, 2008 .

Embryonic Development of Bone and the Molecular Regulation of Intramembranous and Endochondral Bone Formation

A. Karaplis, 2002 .

Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor.

H. Jüppner, H. Kronenberg, A. Abou-Samra, 1993, Endocrinology.

PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth

B. Lanske, R. Mulligan, H. Jüppner, 1996, Science.

Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro.

R. Baron, D. Miao, H. Kronenberg, 2004, Endocrinology.

Parathyroid hormone-related peptide interacts with bone morphogenetic protein 2 to increase osteoblastogenesis and decrease adipogenesis in pluripotent C3H10T 1/2 mesenchymal cells.

D. Miao, D. Goltzman, A. Karaplis, 2003, Endocrinology.

The parathyroid hormone regulates skin tumour susceptibility in mice

S. Wakana, E. Isogai, H. Shitara, 2017, Scientific Reports.

The PTH/Vitamin D/FGF23 Axis

D. Goltzman, A. Karaplis, 2015 .

Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis.

R. Kremer, A. Karaplis, Gloria Assaker, 2019, Advances in experimental medicine and biology.

Parathyroid hormone related protein (PTHrP) in tumor progression.

R. Kremer, A. Karaplis, A. Camirand, 2011, Advances in experimental medicine and biology.

Expression and characterization of recombinant rat parathyroid hormone-related peptide (1–141) and an amino-terminally-truncated analogue (38–141)

R. Sauvé, G. Hendy, S. Rabbani, 1997, Molecular and Cellular Endocrinology.

Nucleolar localization of parathyroid hormone-related peptide enhances survival of chondrocytes under conditions that promote apoptotic cell death

B. Lanske, N. Amizuka, D. Goltzman, 1995, Molecular and cellular biology.

Mice Lacking the UBC4-testis Gene Have a Delay in Postnatal Testis Development but Normal Spermatogenesis and Fertility

P. Hingamp, D. Cyr, S. Wing, 2005, Molecular and Cellular Biology.

Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment

D. Miao, D. Goltzman, A. Karaplis, 2016, Scientific Reports.

Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis.

H. Kronenberg, D. Goltzman, A. Karaplis, 2015, Endocrinology.

The murine gene encoding parathyroid hormone: genomic organization, nucleotide sequence and transcriptional regulation.

H. Kronenberg, A. Karaplis, B. He, 2002, Journal of molecular endocrinology.

Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA.

D. Miao, D. Goltzman, A. Karaplis, 2002, Journal of cell science.

Recent studies on the biological action of parathyroid hormone (PTH)-related peptide (PTHrP) and PTH/PTHrP receptor in cartilage and bone.

N. Amizuka, D. Goltzman, A. Karaplis, 2000, Histology and histopathology.

Parathyroid Hormone–related Peptide (pthrp)-dependent and -independent Effects of Transforming Growth Factor ␤ (tgf-␤ ) on Endochondral Bone Formation

R. Serra, A. Karaplis, P. Sohn, 1999 .

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

A. Grauer, M. Brandi, M. Lorentzon, 2017, The New England journal of medicine.

Parathyroid hormone ablation alters erythrocyte parameters that are rescued by calcium‐sensing receptor gene deletion

E. Brown, N. Chattopadhyay, D. Goltzman, 2013, European journal of haematology.

Understanding Vitamin D From Mouse Knockout Models

G. Hendy, R. Kremer, D. Goltzman, 2018 .

Inactivating mutation in the human parathyroid hormone receptor type 1 gene in Blomstrand chondrodysplasia.

N. Amizuka, A. Karaplis, D. Semeraro, 1998, Endocrinology.

M. Mckee, D. Goltzman, A. Karaplis, 2000 .

Cloning of Human PEX cDNA

M. Lipman, D. Goltzman, A. Karaplis, 1998, The Journal of Biological Chemistry.

Specific binding of prostaglandins E1 and E2 to adrenal medulla.

W. Powell, A. Karaplis, 1981, The Journal of biological chemistry.

Rosiglitazone impacts negatively on bone by promoting osteoblast/osteocyte apoptosis.

D. Miao, D. Goltzman, A. Karaplis, 2004, The Journal of endocrinology.

Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice

Edward Brown, Weiwei Sun, D. Miao, 2010, Development.

Defective postnatal endochondral bone development by chondrocyte-specific targeted expression of parathyroid hormone type 2 receptor.

D. Goltzman, A. Karaplis, D. Panda, 2012, American journal of physiology. Endocrinology and metabolism.

Impairment of spatial learning and memory in transgenic mice overexpressing human fibroblast growth factor-23

N. Gu, D. Miao, Ling Chen, 2011, Brain Research.

A Case of Male Osteoporosis: A 37-Year-Old Man with Multiple Vertebral Compression Fractures

A. Karaplis, S. Radi, 2017, Case reports in endocrinology.

SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis

Yan Zhang, A. Koromilas, M. Lipman, 2022, The Journal of clinical investigation.

Binding of prostaglandin E2 to cultured bovine adrenal chromaffin cells and its effect on catecholamine secretion.

W. Powell, C. Funk, A. Karaplis, 1989, Biochimica et Biophysica Acta.

Calcium Sensing Receptor Absence Delays Postnatal Brain Development via Direct and Indirect Mechanisms

D. Miao, D. Goltzman, A. Karaplis, 2013, Molecular Neurobiology.

Femur geometrical parameters in the pathogenesis of atypical femur fractures

Jacques P. Brown, B. Godbout, A. Karaplis, 2013 .

PTHrP: novel roles in skeletal biology.

A. Karaplis, 2001, Current pharmaceutical design.

PTHrP Regulates Fatty Acid Metabolism via Novel lncRNA in Breast Cancer Initiation and Progression Models

J. Ragoussis, R. Kremer, A. Karaplis, 2023, Cancers.

Nuclear Forms of Parathyroid Hormone-Related Peptide Are Translated from Non-AUG Start Sites Downstream from the Initiator Methionine**This work was supported by the Canadian Arthritis Network and the Medical Research Council (MRC) of Canada.

A. Karaplis, B. He, M. T. Audrey Nguyen, 2001, Endocrinology.

Upregulation of calcitriol during pregnancy and skeletal recovery after lactation do not require parathyroid hormone

C. Kovacs, Yue Ma, A. Karaplis, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target.

W. Muller, P. Siegel, R. Kremer, 2011, The Journal of clinical investigation.

Neither absence nor excess of FGF23 disturbs murine fetal-placental phosphorus homeostasis or prenatal skeletal development and mineralization.

B. Lanske, C. Kovacs, Yue Ma, 2014, Endocrinology.

Parathyroid hormone regulates fetal‐placental mineral homeostasis

G. Karsenty, C. Kovacs, A. Karaplis, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Parathyroid Hormone–related Peptide (PTHrP)-dependent and -independent Effects of Transforming Growth Factor β (TGF-β) on Endochondral Bone Formation

R. Serra, A. Karaplis, P. Sohn, 1999, The Journal of cell biology.

Prostaglandin E-binding sites in the fetal adrenal.

W. Powell, A. Karaplis, 1981, Endocrinology.

Haploinsufficiency of parathyroid hormone-related peptide (PTHrP) results in abnormal postnatal bone development.

M. Lipman, N. Amizuka, A. Karaplis, 1996, Developmental biology.