A. Grakoui

A. Grakoui, R. Chinnadurai, V. Velazquez, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Transient CD86 Expression on Hepatitis C Virus-Specific CD8+ T Cells in Acute Infection Is Linked to Sufficient IL-2 Signaling

A. Kirk, K. Workowski, S. Knechtle, 2010, The Journal of Immunology.

Signaling Infection Is Linked to Sufficient IL-2 T Cells in Acute + Virus-Specific CD 8 Transient CD 86 Expression on Hepatitis C Shoukry and

A. Kirk, K. Workowski, S. Knechtle, 2010 .

Acute hepatitis C and HIV coinfection.

K. Workowski, A. Grakoui, H. Radziewicz, 2009, The Lancet. Infectious diseases.

Transcription of infectious yellow fever RNA from full-length cDNA templates produced by in vitro ligation.

C. Rice, A. Grakoui, T. Chambers, 1989, The New biologist.

Pillars article: The immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227.

Mark M. Davis, S. Bromley, Michael Loran Dustin, 2015, Journal of immunology.

CCR2 Signaling Restricts SARS-CoV-2 Infection

Vineet D. Menachery, R. Klein, A. Creanga, 2021, mBio.

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

Vineet D. Menachery, R. Klein, A. Creanga, 2021, bioRxiv.

Inhibition of an in vitro CD4+ T cell alloresponse using altered peptide ligands.

P. Allen, A. Grakoui, C. Daniel, 1998, Journal of immunology.

Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.

J. Bukh, T. Wakita, A. Grakoui, 2008, Virology.

Impaired Hepatitis C Virus (HCV)-Specific Effector CD8+ T Cells Undergo Massive Apoptosis in the Peripheral Blood during Acute HCV Infection and in the Liver during the Chronic Phase of Infection

G. Freeman, K. Workowski, A. Grakoui, 2008, Journal of Virology.

Inhibition of an In Vitro CD 4 1 T Cell Alloresponse Using Altered Peptide Ligands 1

P. Allen, A. Grakoui, C. Daniel, 1998 .

Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity.

B. Pulendran, H. Nakaya, A. Grakoui, 2013, Immunity.

Differential expression of CD26 on virus‐specific CD8+ T cells during active, latent and resolved infection

A. Grakoui, A. Kourtis, C. Ibegbu, 2009, Immunology.

A spatial view of the CD8+ T‐cell response: the case of HCV

A. Grakoui, P. Leone, V. Racanelli, 2011, Reviews in medical virology.

Environmental peer pressure: CD4+ T cell help in tolerance and transplantation

A. Grakoui, Dana Tedesco, 2018, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Deletion and duplication mutations in the C-terminal nonconserved region of Sindbis virus nsP3: effects on phosphorylation and on virus replication in vertebrate and invertebrate cells.

C. Rice, A. Grakoui, M. W. Lastarza, 1994, Virology.

Liver fibrosis occurs through dysregulation of MyD88‐dependent innate B‐cell activity

B. Pulendran, F. Anania, A. Grakoui, 2015, Hepatology.

Variable Patterns of Programmed Death-1 Expression on Fully Functional Memory T Cells after Spontaneous Resolution of Hepatitis C Virus Infection

G. Freeman, M. Houghton, K. Wucherpfennig, 2008, Journal of Virology.

Glucagon‐like peptide‐1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

F. Anania, N. Saxena, A. Grakoui, 2010, Hepatology.

Structural and functional insights into alphavirus polyprotein processing and pathogenesis

J. Marcotrigiano, A. Grakoui, Matthew T. Miller, 2012, Proceedings of the National Academy of Sciences.

IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment.

R. Philip, A. Grakoui, A. Talal, 2015, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

PD-1 tempers Tregs in chronic HCV infection.

A. Grakoui, H. Radziewicz, R. Dunham, 2009, The Journal of clinical investigation.

Turning on the off switch: regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway.

R. Ahmed, A. Grakoui, C. Walker, 2006, Journal of hepatology.

A Neutralization Epitope in the Hepatitis C Virus E2 Glycoprotein Interacts with Host Entry Factor CD81

A. Grakoui, H. Alter, E. Struble, 2014, PloS one.

Rare birds in North America: acute hepatitis C cohorts.

A. Branch, G. Lauer, D. Fierer, 2009, Gastroenterology.

Mapping of RNA- temperature-sensitive mutants of Sindbis virus: complementation group F mutants have lesions in nsP4

J. H. Strauss, E. G. Strauss, C. Rice, 1989, Journal of virology.

Dynamics of Tissue-Specific CD8+ T Cell Responses during West Nile Virus Infection

M. Bevan, A. Grakoui, Y. Seo, 2018, Journal of Virology.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

D. Douek, J. Wrammert, Sucheta Godbole, 2021, bioRxiv.

CD4+ T cell restoration and control of hepatitis C virus replication after childbirth.

G. Lauer, C. Walker, A. Grakoui, 2020, The Journal of clinical investigation.

Building the immunological synapse-toward a quantitative view of T cell activation

Mark M. Davis, S. Bromley, Michael Loran Dustin, 1999, Proceedings of the First Joint BMES/EMBS Conference. 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Annual Fall Meeting of the Biomedical Engineering Society (Cat. N.

The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice

A. Grakoui, E. Morgan, Choon‐myung Lee, 2015, Hepatology.

MappingofRNA- Temperature-Sensitive Mutants ofSindbis Virus: Complementation GroupFMutants HaveLesions innsP4

C. Rice, A. Grakoui, 1989 .

Immune quiescence and hepatitis B virus: tolerance has its limits.

A. Grakoui, V. Velazquez, 2012, Gastroenterology.

Hepatitis C Virus Polyprotein Processing

C. Rice, C. Wychowski, A. Grakoui, 1994 .

Memory in Repetitive Protein–Protein Interaction Series – in Memory of the Late Professor Robert M. Nerem

A. Grakoui, B. Evavold, Cheng-wen Zhu, 2022, bioRxiv.

Prolonged activation of innate antiviral gene signature after childbirth is determined by IFNL3 genotype

K. Workowski, C. Walker, A. Grakoui, 2016, Proceedings of the National Academy of Sciences.

Unraveling the role of PD-1/PD-L interactions in persistent hepatotropic infections: potential for therapeutic application?

R. Ahmed, A. Grakoui, H. Radziewicz, 2008, Gastroenterology.

EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells

A. Grakoui, M. Henkemeyer, Choon‐myung Lee, 2018, Scientific Reports.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant

D. Douek, J. Wrammert, Sucheta Godbole, 2022, Cell Reports Medicine.

Processing oftheYellow FeverVirus Nonstructural Polyprotein: aCatalytically Active NS3Proteinase Domainand NS2BAreRequired forCleavages atDibasic Sites

A. Grakoui, 1991 .

Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus–Specific Memory B Cells

J. Villeneuve, J. Marcotrigiano, A. Grakoui, 2016, The Journal of Immunology.

The immunological synapse: a molecular machine controlling T cell activation.

S. Bromley, Michael Loran Dustin, M. Davis, 1999, Science.

Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics

Charles M. Rice, C. Rice, S. Kotenko, 2006 .

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics

C. Rice, C. Lin, B. Prágai, 1994, Journal of virology.

Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders.

A. Grakoui, Daniel M. Chopyk, Daniel M Chopyk, 2020, Gastroenterology.

A second hepatitis C virus-encoded proteinase.

C. Rice, C. Wychowski, A. Grakoui, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites

C. Rice, C. Wychowski, A. Grakoui, 1993, Journal of virology.

Interferons alpha and lambda inhibit hepatitis C virus replication with distinct signal transduction and gene regulation kinetics.

C. Rice, S. Kotenko, A. Grakoui, 2006, Gastroenterology.

Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules

J. Berzofsky, C. Rice, A. Sette, 1995, Journal of virology.

Liver-Infiltrating Lymphocytes in Chronic Human Hepatitis C Virus Infection Display an Exhausted Phenotype with High Levels of PD-1 and Low Levels of CD127 Expression

G. Freeman, E. Wherry, J. Altman, 2006, Journal of Virology.

Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid

B. Pulendran, T. Denning, A. Grakoui, 2013, The Journal of Immunology.

HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release.

B. Walker, C. Rice, M. Houghton, 1995, The Journal of clinical investigation.

Future landscape of hepatitis C research - Basic, translational and clinical perspectives.

M. Manns, D. Moradpour, A. Grakoui, 2016, Journal of hepatology.

Influence of IFNL3 and HLA-DPB1 genotype on postpartum control of hepatitis C virus replication and T-cell recovery

C. Walker, A. Grakoui, Aryn A. Price, 2016, Proceedings of the National Academy of Sciences.

HCV adaptations to altered CD8+ T-cell immunity during pregnancy.

A. Grakoui, Aryn A. Price, J. Honegger, 2014, Future virology.

Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

S. Lemon, C. Walker, A. Grakoui, 2013, Nature Medicine.

Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs

C. Rice, G. Randall, A. Grakoui, 2002, Proceedings of the National Academy of Sciences of the United States of America.

EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells

A. Grakoui, M. Henkemeyer, Choon‐myung Lee, 2018, Scientific Reports.

Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

C. Rice, F. Palmer-Hill, J. Suzich, 1993, Journal of virology.

Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

Vineet D. Menachery, L. Anderson, P. Shi, 2020, Journal of Virology.

Harnessing the Prokaryotic Adaptive Immune System as a Eukaryotic Antiviral Defense.

A. Grakoui, Aryn A. Price, D. Weiss, 2016, Trends in microbiology.

Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection

L. Anderson, A. Grakoui, M. Suthar, 2021, bioRxiv.

Mechanotransduction in T Cell Development, Differentiation and Function

A. Grakoui, M. Rushdi, S. Travaglino, 2020, Cells.

Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication

N. Heaton, G. Randall, A. Grakoui, 2009, Proceedings of the National Academy of Sciences.

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

C. Rice, C. Walker, A. Grakoui, 2008, PLoS pathogens.

Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV

J. Bukh, A. Kapoor, A. Grakoui, 2022, Hepatology.

Evidence for a functional RNA element in the hepatitis C virus core gene

A. Branch, C. Rice, A. Grakoui, 2007, Proceedings of the National Academy of Sciences.

Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection

J. Ghrayeb, K. Reimann, M. Houghton, 2003, The Journal of experimental medicine.

Hepatitis C virus: why do we need a vaccine to prevent a curable persistent infection?

C. Walker, A. Grakoui, 2015, Current opinion in immunology.

Lack of Phenotypic and Functional Impairment in Dendritic Cells from Chimpanzees Chronically Infected with Hepatitis C Virus

C. Rice, G. Lauer, N. Bhardwaj, 2004, Journal of Virology.

Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage

C. Rice, A. Grakoui, K. Reed, 1995, Journal of virology.

Structure of the Core Ectodomain of the Hepatitis C Virus Envelope Glycoprotein 2

J. Marcotrigiano, A. Grakoui, Joshy Jacob, 2014, Nature.

Structural insights into hepatitis C virus receptor binding and entry

J. Cohen, J. Marcotrigiano, A. Grakoui, 2021, Nature.

TCR-independent pathways mediate the effects of antigen dose and altered peptide ligands on Th cell polarization.

P. Allen, K. Murphy, A. Grakoui, 1999, Journal of immunology.

Molecular basis for the lack of T cell proliferation induced by an altered peptide ligand.

P. Allen, S. Dowdy, A. Grakoui, 1998, International immunology.

Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue1

C. Nelson, D. Fremont, M. Miley, 2001, The Journal of Immunology.

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease.

M. Mohamadzadeh, E. Burd, A. Grakoui, 2018, Gastroenterology.

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic gamma delta T-Cell Receptor-Positive Cells and Pathogenesis of Cholestatic Liver Disease

E. Burd, A. Grakoui, Minghao Gong, 2022 .

CD4+Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T‐cell suppression during chronic liver disease

F. Anania, A. Grakoui, S. Gumber, 2017, Hepatology.

Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease

A. Grakoui, S. Gumber, A. Adams, 2020, The Journal of Immunology.

Systems biological analyses reveal the hepatitis C virus (HCV)‐specific regulation of hematopoietic development

A. Kirk, D. Kalman, S. Knechtle, 2015, Hepatology.

Structural and Functional Consequences of Altering a Peptide MHC Anchor Residue

C. Nelson, D. Fremont, M. Miley, 2001 .

Blocking Hepatitis C Virus Infection with Recombinant Form of Envelope Protein 2 Ectodomain

J. Marcotrigiano, A. Grakoui, G. Mateu, 2009, Journal of Virology.

Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells.

A. Grakoui, Y. Seo, M. Suthar, 2016, Immunity.

Characterization of HCV‐specific Patr class II restricted CD4+ T cell responses in an acutely infected chimpanzee

C. Walker, A. Grakoui, K. Murthy, 2003, Hepatology.

Bad time for Bonzo? Experimental models of hepatitis C virus infection, replication, and pathogenesis

A. Grakoui, A Grakoui, C M Rice, 2001, Hepatology.

Processing of the yellow fever virus nonstructural polyprotein: a catalytically active NS3 proteinase domain and NS2B are required for cleavages at dibasic sites

C. Rice, A. Grakoui, T. Chambers, 1991, Journal of virology.

Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion.

J. Marcotrigiano, Amit A. Upadhyay, A. Grakoui, 2021, The Journal of clinical investigation.

Hepatic enrichment and activation of myeloid dendritic cells during chronic hepatitis C virus infection

A. Kirk, S. Knechtle, A. Grakoui, 2012, Hepatology.

Immune system control of hepatitis C virus infection.

A. Grakoui, J. Stuart, E. Salinas, 2020, Current opinion in virology.

B7‐H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells

A. Grakoui, R. Chinnadurai, 2010, Hepatology.

The Molecular Biology of Hepatitis C Virus

C. Rice, K. Blight, A. Grakoui, 2002 .

Cas9-mediated targeting of viral RNA in eukaryotic cells

David S. Weiss, A. Grakoui, Arash Grakoui, 2015, Proceedings of the National Academy of Sciences.

Resolution of hepatitis E virus infection in CD8+ T cell depleted rhesus macaques.

C. Walker, A. Grakoui, Xin Yin, 2021, Journal of hepatology.

Memory CD8+ T cell differentiation in viral infection: a cell for all seasons.

A. Grakoui, B. Bengsch, H. Radziewicz, 2007, World journal of gastroenterology.

Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C

M. Ghany, Heiyoung Park, B. Rehermann, 2022, Nature Communications.

Memory in repetitive protein–protein interaction series

A. Grakoui, B. Evavold, Yunfeng Chen, 2023, APL Bioengineering.

Altering a Peptide MHC Anchor Residue Structural and Functional Consequences of

C. Nelson, D. Fremont, M. Miley, 2001 .

Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease

A. Singhi, S. Monga, A. Grakoui, 2023, bioRxiv.

Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

L. Anderson, Amit A. Upadhyay, V. Menachery, 2020, bioRxiv.

Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects

Leo Swadling, E. Barnes, A. Grakoui, 2022, PLoS pathogens.

Regions of hepatitis C virus E2 required for membrane association

J. Marcotrigiano, A. Grakoui, A. Dearborn, 2023, Nature Communications.

The immunological synapse: a molecular machine controlling T cell activation.

S. Bromley, Michael Loran Dustin, M. Davis, 1999, Science.

Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.

J. Bukh, T. Wakita, A. Grakoui, 2008, Virology.

Presentation of hepatocellular antigens

A. Grakoui, I. Crispe, 2016, Cellular and Molecular Immunology.

Acute hepatitis C and HIV coinfection.

K. Workowski, A. Grakoui, H. Radziewicz, 2009, The Lancet. Infectious diseases.

Future landscape of hepatitis C research - Basic, translational and clinical perspectives.

M. Manns, D. Moradpour, A. Grakoui, 2016, Journal of hepatology.

Liver fibrosis occurs through dysregulation of MyD88‐dependent innate B‐cell activity

B. Pulendran, F. Anania, A. Grakoui, 2015, Hepatology.

The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice

A. Grakoui, E. Morgan, Choon‐myung Lee, 2015, Hepatology.

IFN-a-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment

R. Philip, A. Grakoui, A. Talal, 2015 .

Soluble ORF2 protein enhances HEV replication and induces long-lasting antibody response and protective immunity in vivo

C. Walker, A. Grakoui, Zongdi Feng, 2023, Hepatology.

Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection

A. Grakoui, N. Abdeltawab, N. Shoukry, 2024, Frontiers in immunology.

Translocation of gut commensal bacteria to the brain

A. Grakoui, Daniel M. Chopyk, Fengzhi Jin, 2023, bioRxiv.

Blocking Hepatitis C Virus Infection with Recombinant Form of Envelope Protein 2 Ectodomain

J. Marcotrigiano, A. Grakoui, G. Mateu, 2009, Journal of Virology.