F. Christ

发表

N-terminal half of transportin SR2 interacts with HIV integrase

Z. Debyser, V. G. Tsirkone, J. Blokken, 2017, The Journal of Biological Chemistry.

Cellular Cofactors of Lentiviral Integrase: From Target Validation to Drug Discovery

Z. Debyser, B. Desimmie, F. Christ, 2012, Molecular biology international.

Transportin-SR2 Imports HIV into the Nucleus

Zeger Debyser, Rik Gijsbers, Richard Benarous, 2008, Current Biology.

Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication*

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2005, Journal of Biological Chemistry.

The Interaction of LEDGF/p75 with Integrase Is Lentivirus-specific and Promotes DNA Binding*

R. Benarous, J. Vercammen, Z. Debyser, 2005, Journal of Biological Chemistry.

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

A. Marchand, A. Voet, M. de Maeyer, 2010, Nature chemical biology.

Track A Basic Science

S. Sugden, D. Hazuda, F. Pereyra, 2012, Journal of the International AIDS Society.

Identification of the LEDGF/p75 binding site in HIV-1 integrase.

J. Rain, R. Benarous, A. Voet, 2007, Journal of molecular biology.

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Journal of medicinal chemistry.

Phage display-directed discovery of LEDGF/p75 binding cyclic peptide inhibitors of HIV replication.

M. Humbert, U. Dietrich, Jelle Hendrix, 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeting integration beyond strand transfer: development of second-generation HIV integrase inhibitors

A. Voet, Z. Debyser, F. Christ, 2011 .

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer.

A. Voet, Z. Debyser, F. Christ, 2009, Future medicinal chemistry.

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein‐protein Interaction Inhibitors

Z. Debyser, F. Christ, S. Ferro, 2016, Molecular informatics.

Pharmacophore‐Based Discovery of Small‐Molecule Inhibitors of Protein–Protein Interactions between HIV‐1 Integrase and Cellular Cofactor LEDGF/p75

Z. Debyser, F. Christ, S. Ferro, 2009, ChemMedChem.

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors.

Z. Debyser, F. Christ, S. Ferro, 2015, Bioorganic & medicinal chemistry.

Cellular Cofactors of HIV as Drug Targets

B. Desimmie, F. Christ, 2014 .

Diketoacid chelating ligands as dual inhibitors of HIV-1 integration process.

N. Neamati, Z. Debyser, F. Christ, 2014, European journal of medicinal chemistry.

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition.

Z. Debyser, F. Christ, S. Ferro, 2014, Bioorganic & medicinal chemistry.

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

Z. Debyser, F. Christ, S. Ferro, 2013, Journal of enzyme inhibition and medicinal chemistry.

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays.

Z. Debyser, F. Christ, S. Ferro, 2013, European journal of medicinal chemistry.

Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.

T. Sanchez, N. Neamati, Z. Debyser, 2013, Bioorganic & medicinal chemistry.

A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication

Erik Serrao, N. Neamati, Laith Q. Al‐Mawsawi, 2012, PloS one.

Small molecules targeting protein-protein interactions: A promising anti-HIV strategy

Z. Debyser, F. Christ, S. Ferro, 2010 .

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor.

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2010, Bioorganic & medicinal chemistry.

Inhibitory profile of a LEDGF/p75 peptide against HIV‐1 integrase: Insight into integrase–DNA complex formation and catalysis

Zeger Debyser, Nouri Neamati, Frauke Christ, 2008, FEBS letters.

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.

Z. Debyser, F. Christ, M. Witvrouw, 2009, Journal of medicinal chemistry.

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

V. Veverka, M. Hubálek, K. Cermakova, 2018, Proceedings of the National Academy of Sciences.

Integrase as a Novel Target for the Inhibition of Human Immunodeficiency Virus Type 1 Infection: Current Status and Future Perspectives

J. Schapiro, A. Voet, Z. Debyser, 2009 .

Overexpression of the Lens Epithelium-Derived Growth Factor/p75 Integrase Binding Domain Inhibits Human Immunodeficiency Virus Replication

Jelle Hendrix, J. Vercammen, R. Gijsbers, 2006, Journal of Virology.

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

R. Gijsbers, Z. Debyser, Irena Zurnić, 2019, Retrovirology.

Interaction of the HIV-1 Intasome with Transportin 3 Protein (TNPO3 or TRN-SR2)*

Zeger Debyser, Mark P Foster, Frauke Christ, 2012, The Journal of Biological Chemistry.

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

C. Weydert, N. Bannert, J. Hofkens, 2013, Retrovirology.

HIV-1 integrase inhibition: looking at cofactor interactions.

Z. Debyser, F. Christ, 2015, Future medicinal chemistry.

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.

F. Bailly, Z. Debyser, C. Calmels, 2014, Journal of medicinal chemistry.

Differential interaction of HIV-1 integrase and JPO2 with the C terminus of LEDGF/p75.

R. Benarous, R. Gijsbers, Z. Debyser, 2007, Journal of molecular biology.

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ*

J. Rain, R. Benarous, Jelle Hendrix, 2009, Journal of Biological Chemistry.

The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity

Sandy S. Tungteakkhun, Z. Debyser, F. Christ, 2012, Molecular Cancer Research.

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75)

K. Cermakova, R. Gijsbers, Z. Debyser, 2013, Leukemia.

Assays for evaluation of HIV-1 integrase enzymatic activity, DNA binding, and cofactor interaction

Jelle Hendrix, Z. Debyser, Y. Engelborghs, 2011 .

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia.

C. Weydert, K. Cermakova, Z. Debyser, 2016, Trends in pharmacological sciences.

Photocross-linking of the Homing Endonuclease PI-SceI to Its Recognition Sequence*

A. Pingoud, V. Pingoud, F. Christ, 1999, The Journal of Biological Chemistry.

Binding, bending and cleavage of DNA substrates by the homing endonuclease Pl-SceI.

A. Pingoud, V. Pingoud, F. Christ, 1996, Nucleic acids research.

The monomeric homing endonuclease PI‐SceI has two catalytic centres for cleavage of the two strands of its DNA substrate

A. Pingoud, V. Pingoud, F. Christ, 1999, The EMBO journal.

A Mutational Analysis of DNA Binding and Cleavage by the Homing Endonuclease PI-SceI

A. Pingoud, V. Pingoud, F. Christ, 2000, Molecular Biology.

LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators

G. Nigita, A. Canella, M. Carlon, 2021, Cancer Gene Therapy.

A model for the PI-SceIxDNA complex based on multiple base and phosphate backbone-specific photocross-links.

A. Pingoud, V. Pingoud, F. Christ, 2000, Journal of molecular biology.

Magnesium chelating 2-hydroxyisoquinoline-1,3(2H,4H)-diones, as inhibitors of HIV-1 integrase and/or the HIV-1 reverse transcriptase ribonuclease H domain: discovery of a novel selective inhibitor of the ribonuclease H function.

F. Bailly, H. Vezin, Z. Debyser, 2011, Journal of medicinal chemistry.

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

F. Bailly, Z. Debyser, C. Calmels, 2011, European journal of medicinal chemistry.

BET-Independent Murine Leukemia Virus Integration Is Retargeted In Vivo and Selects Distinct Genomic Elements for Lymphomagenesis

R. Gijsbers, Z. Debyser, F. Christ, 2022, Microbiology spectrum.

Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach

A. Fassihi, L. Saghaie, Simone Brogi, 2019, Front. Chem..

The Stress Oncoprotein LEDGF/p75 Interacts with the Methyl CpG Binding Protein MeCP2 and Influences Its Transcriptional Activity

Sandy S. Tungteakkhun, Z. Debyser, F. Christ, 2012, Molecular Cancer Research.

[Analysis of binding and cleavage of DNA by the gene conversion PI-SCEI endonuclease using site-directed mutagenesis].

A. Pingoud, V. Pingoud, F. Christ, 2000, Молекулярная биология.

A Versatile and Practical Synthesis toward the Development of Novel HIV‐1 Integrase Inhibitors

C. Tintori, G. Vignaroli, M. Botta, 2011, ChemMedChem.

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2008, Journal of medicinal chemistry.

Synthesis of new pyridazine derivatives as potential anti‐HIV‐1 agents

F. Christ, S. Ferro, R. Gitto, 2009 .

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors.

F. Bailly, Z. Debyser, C. Calmels, 2013, ACS medicinal chemistry letters.

Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

J. Vercammen, Z. Debyser, Y. Engelborghs, 2007, The Journal of antimicrobial chemotherapy.

Synthesis of New Pyridazine Derivatives as Potential anti-HIV-1 Agents.

F. Christ, S. Ferro, R. Gitto, 2010 .

Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors

L. Vrang, Z. Debyser, F. Christ, 2008, Antimicrobial Agents and Chemotherapy.

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.

Myriam Witvrouw, Zeger Debyser, Alba Chimirri, 2008, Bioorganic & medicinal chemistry letters.

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2009, Bioorganic & medicinal chemistry letters.

New chloro,fluorobenzylindole derivatives as integrase strand-transfer inhibitors (INSTIs) and their mode of action.

Z. Debyser, F. Christ, S. Ferro, 2010, Bioorganic & medicinal chemistry.

Synthesis, anti-HIV-1 and antiproliferative evaluation of novel 4-nitroimidazole derivatives combined with 5-hydroxy-4-pyridinone moiety

A. Fassihi, L. Saghaie, Z. Debyser, 2020 .

Synthesis and biological evaluation of novel antiviral agents as protein–protein interaction inhibitors

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2014, Journal of enzyme inhibition and medicinal chemistry.

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process.

Zeger Debyser, Alba Chimirri, Rosaria Gitto, 2011, Antiviral research.

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors.

Zeger Debyser, Afshin Fassihi, Simone Brogi, 2019, Medicinal chemistry (Shariqah (United Arab Emirates)).

Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV—Based Vectors and for a Cure for HIV-1 Infection

Z. Debyser, F. Christ, Anayat Bhat, 2022, Viruses.

Host factors for retroviral integration site selection.

R. Gijsbers, Z. Debyser, F. Christ, 2015, Trends in biochemical sciences.

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Z. Debyser, F. Christ, Gerlinde Vansant, 2018, Viruses.

2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.

F. Bailly, Z. Debyser, B. Desimmie, 2013, ACS chemical biology.

Proceedings of the Frontiers of Retrovirology Conference 2016

R. König, D. Elleder, R. Sachidanandam, 2016, Retrovirology.

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment.

A. Fassihi, L. Saghaie, Z. Debyser, 2022, Bioorganic & medicinal chemistry letters.

Discovery of a novel 5-carbonyl-1H-imidazole-4-carboxamide class of inhibitors of the HIV-1 integrase-LEDGF/p75 interaction.

Erik Serrao, N. Neamati, Z. Debyser, 2013, Bioorganic & medicinal chemistry.

Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase-LEDGF/p75 Interaction

Erik Serrao, N. Neamati, F. Christ, 2018 .

Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.

Zeger Debyser, Nouri Neamati, Frauke Christ, 2013, Journal of medicinal chemistry.

Design and discovery of 5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxamide inhibitors of HIV-1 integrase.

N. Neamati, Yang Liu, Daoguang Zhang, 2014, Bioorganic & medicinal chemistry.

Development of an AlphaScreen-Based HIV-1 Integrase Dimerization Assay for Discovery of Novel Allosteric Inhibitors

C. Tintori, M. Botta, Z. Debyser, 2012, Journal of biomolecular screening.

Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

Stephen M. Shaw, A. Marchand, S. Butler, 2012, Antimicrobial Agents and Chemotherapy.

Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection

Suha M. Saleh, R. Gijsbers, Z. Debyser, 2017, Journal of virus eradication.

BET-independent MLV integration is retargeted in vivo and selects distinct genomic elements for lymphomagenesis

R. Gijsbers, Z. Debyser, F. Christ, 2022, bioRxiv.

Lentiviral nuclear import: a complex interplay between virus and host

Z. Debyser, F. Christ, L. Vandekerckhove, 2007, BioEssays : news and reviews in molecular, cellular and developmental biology.

RNAi-based treatment of HIV/AIDS: Current status and perspectives

R. Gijsbers, Z. Debyser, F. Christ, 2006 .

The HIV-1 Integrase Mutant R263A/K264A Is 2-fold Defective for TRN-SR2 Binding and Viral Nuclear Import*

Susana Rocha, R. Gijsbers, Z. Debyser, 2014, The Journal of Biological Chemistry.

Binding and Viral Nuclear R 263 A / K 264 A Is 2-fold Defective for The HIV-1 Integrase Mutant Microbiology :

Susana Rocha, R. Gijsbers, Z. Debyser, 2014 .

LEDGIN-mediated Inhibition of Integrase–LEDGF/p75 Interaction Reduces Reactivation of Residual Latent HIV

Suha M. Saleh, C. Weydert, E. Verdin, 2016, EBioMedicine.

LEDGF/p75-Independent HIV-1 Replication Demonstrates a Role for HRP-2 and Remains Sensitive to Inhibition by LEDGINs

F. Bushman, R. Gijsbers, Z. Debyser, 2012, PLoS pathogens.

Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects

A. Ramalho, R. Farré, M. Ensinck, 2020, Cells.

Targeting Virus-host Interactions of HIV Replication.

C. Weydert, Z. Debyser, F. Christ, 2015, Current topics in medicinal chemistry.

Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets.

Z. Debyser, J. Blokken, F. Christ, 2017, Drug discovery today. Technologies.

Design of cell-permeable stapled peptides as HIV-1 integrase inhibitors.

N. Neamati, Z. Debyser, Stéphanie De Houwer, 2013, Journal of medicinal chemistry.

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 – 2014)

A. Marchand, M. de Maeyer, Z. Debyser, 2014, Expert opinion on therapeutic patents.

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

R. Gijsbers, Z. Debyser, J. Blokken, 2021, Microbiology spectrum.

LEDGF/p75 and transportin-SR2 are cellular cofactors of HIV integrase and novel targets for antiviral therapy

A. Voet, Z. Debyser, F. Christ, 2009 .

In search of small molecules blocking interactions between HIV proteins and intracellular cofactors.

Z. Debyser, F. Christ, K. Busschots, 2009, Molecular bioSystems.

Towards a Functional Cure of HIV-1: Insight Into the Chromatin Landscape of the Provirus

Z. Debyser, F. Christ, Anne Bruggemans, 2021, Frontiers in Microbiology.

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

C. Weydert, N. Bannert, J. Hofkens, 2013, Retrovirology.

LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection.

Z. Debyser, F. Christ, S. van Belle, 2021, Advances in experimental medicine and biology.

Dynamic Oligomerization of Integrase Orchestrates HIV Nuclear Entry

J. Hofkens, Jelle Hendrix, Susana Rocha, 2016, Scientific Reports.

The LEDGF/p75 integrase interaction, a novel target for anti-HIV therapy.

Z. Debyser, F. Christ, 2013, Virology.

In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75.

Jelle Hendrix, Z. Debyser, F. Christ, 2011, Journal of molecular biology.

Structure of transportin SR2, a karyopherin involved in human disease, in complex with Ran.

Z. Debyser, V. G. Tsirkone, F. Christ, 2014, Acta crystallographica. Section F, Structural biology communications.

Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression

T. Ndung’u, C. Winkler, P. An, 2011, AIDS.

Targeting Cellular Cofactors in HIV Therapy

U. Dietrich, E. Crespan, G. Maga, 2014 .

GS-9822, a Preclinical LEDGIN Candidate, Displays a Block-and-Lock Phenotype in Cell Culture

Z. Debyser, F. Christ, Ruby Z Cai, 2021, Antimicrobial Agents and Chemotherapy.

Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity.

N. Neamati, Z. Debyser, F. Christ, 2012, Journal of medicinal chemistry.

Role of Transportin-SR2 in HIV-1 Nuclear Import

Z. Debyser, F. Christ, Iván Nombela, 2021, Viruses.

On the Substrate Specificity of DNA Methyltransferases

A. Jeltsch, F. Christ, M. Fatemi, 1999, The Journal of Biological Chemistry.

Validation of host factors of HIV integration as novel drug targets for anti-HIV therapy

Z. Debyser, B. Desimmie, F. Christ, 2014 .

Interplay between HIV Entry and Transportin-SR2 Dependency

R. Gijsbers, Z. Debyser, Stéphanie De Houwer, 2011, Retrovirology.

Single-Cell Imaging of HIV-1 Provirus (SCIP)

A. Cereseto, D. Arosio, R. Gijsbers, 2013, Proceedings of the National Academy of Sciences.

Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids

A. Ramalho, L. Dupont, M. Ensinck, 2022, ERJ Open Research.

Cellular co-factors of HIV-1 integration.

Z. Debyser, F. Christ, K. Busschots, 2006, Trends in biochemical sciences.

The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection

Susana Rocha, Z. Debyser, F. De Wit, 2019, PLoS pathogens.

Identification of Residues in the C-terminal Domain of HIV-1 Integrase That Mediate Binding to the Transportin-SR2 Protein*

Z. Debyser, Stéphanie De Houwer, F. Christ, 2012, The Journal of Biological Chemistry.

Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival

P. Van Vlierberghe, V. Veverka, A. Canella, 2021, Cells.

Molecular Mechanism of LEDGF/p75 Dimerization.

J. Brynda, V. Veverka, K. Cermakova, 2020, Structure.

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis.

A. Engelman, P. Van Vlierberghe, Z. Debyser, 2018, Blood.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

V. Veverka, K. Cermakova, K. Procházková, 2015, Nature Communications.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

C. Weydert, I. Paron, N. Bannert, 2015, Retrovirology.

"...the unique multimodal mode of action (of LEDGINs) and the lack of cross-resistance with any known class of ARVs make them excellent candidates for future cART, in particular for patients failing on current therapy."

F. Christ, 2015 .

Identification of small peptides inhibiting the integrase‐LEDGF/p75 interaction through targeting the cellular co‐factor

Kam Y. J. Zhang, A. Voet, M. de Maeyer, 2013, Journal of peptide science : an official publication of the European Peptide Society.

De novo design of small molecule inhibitors targeting the LEDGF/p75-HIV integrase interaction

A. Voet, E. V. D. Eycken, Z. Debyser, 2012 .

TheStressOncoproteinLEDGF/p75InteractswiththeMethyl CpG Binding Protein MeCP2 and Influences Its

Sandy S. Tungteakkhun, Z. Debyser, F. Christ, 2012 .

Discovery of N-aryl-naphthylamines as in vitro inhibitors of the interaction between HIV integrase and the cofactor LEDGF/p75.

E. Novellino, R. Di Santo, R. Costi, 2015, European journal of medicinal chemistry.

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus

C. Van den Haute, R. Gijsbers, Z. Debyser, 2006, Journal of Virology.

Nitrogen-containing polyhydroxylated aromatics as HIV-1 integrase inhibitors: synthesis, structure-activity relationship analysis, and biological activity

N. Neamati, Z. Debyser, F. Christ, 2012, Journal of enzyme inhibition and medicinal chemistry.

Kuwanon‐L as a New Allosteric HIV‐1 Integrase Inhibitor: Molecular Modeling and Biological Evaluation

C. Tintori, M. Botta, Z. Debyser, 2015, Chembiochem : a European journal of chemical biology.

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection.

Z. Debyser, B. Desimmie, F. Christ, 2013, Drug discovery today. Technologies.

Cryopreservation of reduced cytochrome C for determination of N-formyl-methionyl-leucyl-phenylalanine-stimulated superoxide anion production in human whole blood

M. Thiel, A. Martignoni, F. Christ, 2002, European Journal of Applied Physiology.

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

C. Weydert, I. Paron, N. Bannert, 2015, Retrovirology.

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2007, PLoS pathogens.

Article Transportin-SR2 Imports HIV into the Nucleus

J. Rain, R. Benarous, A. Cereseto, 2008 .

Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeﬁciency Virus Integrase Strand Transfer Inhibitors (cid:1)

L. Vrang, Z. Debyser, F. Christ, 2008 .

Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

C. Weydert, I. Paron, N. Bannert, 2020, Retrovirology.

Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration

J. Hofkens, Jelle Hendrix, Susana Rocha, 2020, Journal of Virology.

Discovery of small molecule HIV-1 integrase dimerization inhibitors.

Cristina Tintori, Silvio Massa, Zeger Debyser, 2012, Bioorganic & medicinal chemistry letters.

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

R. Gijsbers, Z. Debyser, Irena Zurnić, 2019, Retrovirology.

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation.

Z. Debyser, F. Christ, S. Ferro, 2011, European journal of medicinal chemistry.

Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry

A. Scala, Z. Debyser, F. Christ, 2018, ACS medicinal chemistry letters.

Proceedings of the Frontiers of Retrovirology Conference 2016

Sebastian A. Wagner, R. König, D. Elleder, 2016, Retrovirology.

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

A. Marchand, Z. Debyser, Lieve Dirix, 2018, Retrovirology.

Interaction of Transportin-SR2 with Ras-related Nuclear Protein (Ran) GTPase*

Z. Debyser, V. G. Tsirkone, Stéphanie De Houwer, 2013, The Journal of Biological Chemistry.

Role of Transportin-SR2 (Transportin-3, TRN-SR2, TNPO3) in HIV replication

Z. Debyser, F. Christ, 2015 .

Interaction of TRN-SR 2 with Ran 1 Interaction of Transportin-SR 2 with Ras-related nuclear protein ( Ran ) GTPase *

Z. Debyser, V. G. Tsirkone, F. Christ, 2013 .

LEDGINs reveal a role for LEDGF/p75 in late stage HIV replication

C. Weydert, N. Bannert, Jelle Hendrix, 2013 .

2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.

F. Bailly, Z. Debyser, M. Andreola, 2016, European journal of medicinal chemistry.

Interaction of the HIV-1 intasome with Transportin 3 ( TNPO 3 or TRN-SR 2 )

G. Duyne, M. Foster, Kushol Gupta, 2012 .

Inhibitors of the integrase–transportin-SR2 interaction block HIV nuclear import

A. Marchand, Z. Debyser, Lieve Dirix, 2018, Retrovirology.

Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors

R. Gijsbers, Z. Debyser, F. Christ, 2013, AIDS.

CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import

K. Steel, A. Forge, N. Ingham, 2014, Stem Cell Research & Therapy.

Development of a series of 3-hydroxyquinolin-2(1H)-ones as selective inhibitors of HIV-1 reverse transcriptase associated RNase H activity.

F. Bailly, Z. Debyser, F. Christ, 2012, Bioorganic & medicinal chemistry letters.

Transportin-SR2 Imports HIV into the Nucleus

J. Rain, R. Benarous, A. Cereseto, 2008, Current Biology.

Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection

Z. Debyser, F. Christ, Gerlinde Vansant, 2018, Viruses.

Pharmacological advances in anti‐retroviral therapy for human immunodeficiency virus‐1 infection: A comprehensive review

Z. Debyser, F. Christ, N. Ahemad, 2024, Reviews in medical virology.

Protein-protein and protein-chromatin interactions of LEDGF/p75 as novel drug targets.

Z. Debyser, F. Christ, J. De Rijck, 2017, Drug discovery today. Technologies.

Lens Epithelium-derived Growth Factor/p75 Interacts with the Transposase-derived DDE Domain of PogZ*

J. Rain, R. Benarous, Jelle Hendrix, 2009, Journal of Biological Chemistry.

Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.

F. Bailly, Z. Debyser, C. Calmels, 2014, Journal of Medicinal Chemistry.

Insights into the functions of a molecular Swiss army knife: the intasome structure reveals inhibitor action

F. Christ, 2010 .

Abolished clustering of MeCP2T158M can be partially reverted with small molecules

Z. Debyser, F. Christ, M. Nijs, 2024, Translational Medicine Communications.

HDAC inhibitors rescue MeCP2T158M speckles in a high content screen

Z. Debyser, F. Christ, M. Nijs, 2023, bioRxiv.