K. Miyake

J. Millán, K. Miyake, B. Foster, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl

N. Miyake, T. Shimada, K. Miyake, 2005, Gene Therapy.

HIV-mediated expression of Btk in hematopoietic stem cells is not sufficient to restore B cell function in X-linked immunodeficient mice.

T. Shimada, K. Miyake, H. Tanabe, 2005, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

Selective Transduction of HIV-1-Infected Cells by the Combination of HIV and MMLV Vectors

T. Shimada, K. Miyake, N. Suzuki, 2001, International journal of hematology.

Adeno-Associated Viral Vector-Mediated Expression of Endostatin Inhibits Tumor Growth and Metastasis in an Orthotropic Pancreatic Cancer Model in Hamsters

T. Misawa, E. Uchida, T. Shimada, 2004, Cancer Research.

Orthotropic Pancreatic Cancer Model in Hamsters Endostatin Inhibits Tumor Growth and Metastasis in an Adeno-Associated Viral Vector-Mediated Expression of Updated

T. Misawa, E. Uchida, T. Shimada, 2004 .

Gene Delivery and Expression Series Viral Vector Mediated Gene Delivery and Expression ( 5 )

T. Shimada, K. Miyake, 2012 .

Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells

J. Bell, E. Clercq, J. Reeves, 2003, Journal of Virology.

TERT and TERC mutations detected in cryptic dyskeratosis congenita suppress telomerase activity

E. Ito, N. Miyake, S. Kojima, 2020, International journal of laboratory hematology.

Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection

J. Millán, N. Miyake, T. Shimada, 2021, Molecular therapy. Methods & clinical development.

Enzyme replacement in the CSF to treat metachromatic leukodystrophy in mouse model using single intracerebroventricular injection of self-complementary AAV1 vector

T. Shimada, Yoshiyuki Yamazaki, A. Morita, 2015, Scientific Reports.

Global gene transfer into the CNS across the BBB after neonatal systemic delivery of single-stranded AAV vectors

N. Miyake, T. Shimada, K. Miyake, 2011, Brain Research.

Treatment of adult metachromatic leukodystrophy model mice using intrathecal administration of type 9 AAV vector encoding arylsulfatase A

Hidenori Suzuki, N. Miyake, T. Shimada, 2021, Scientific Reports.

New innovations for ocular gene therapy

K. Miyake, Hiroshi Takahashi, K. Nakamoto, 2017 .

Human herpesvirus 7 infection of lymphoid and myeloid cell lines transduced with an adenovirus vector containing the CD4 gene

S. Fujita, T. Shimada, K. Miyake, 1997, Journal of virology.

Human immunodeficiency virus vector-mediated intra-articular expression of angiostatin inhibits progression of collagen-induced arthritis in mice

T. Shimada, K. Miyake, S. Yoshino, 2005, Rheumatology International.

Two-step gene transfer using an adenoviral vector carrying the CD4 gene and human immunodeficiency viral vectors.

T. Shimada, K. Miyake, T. Tohyama, 1996, Human gene therapy.

Targeted Gene Transfer into CD4 Positive Cells by HIV-Based Retroviral Vectors

T. Shimada, K. Miyake, 1996 .

miR-15 b mediates oxaliplatin-induced chronic neuropathic pain through BACE 1 downregulation Running title : miR-15 b mediates oxaliplatin-induced chronic pain

A. Sakamoto, Hidenori Suzuki, N. Miyake, 2016 .

Chemotherapy for minimally differentiated acute myeloid leukemia (AML-M0)

T. Kuwabara, T. Yamada, K. Miyake, 1993, Annals of Hematology.

siRNA knockdown of tissue inhibitor of metalloproteinase-1 in keloid fibroblasts leads to degradation of collagen type I.

T. Shimada, K. Miyake, R. Ogawa, 2014, The Journal of investigative dermatology.

Improved Intravitreal AAV-Mediated Inner Retinal Gene Transduction after Surgical Internal Limiting Membrane Peeling in Cynomolgus Monkeys.

Yoshiyuki Yamazaki, Y. Katakai, N. Miyake, 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia

N. Miyake, T. Shimada, K. Miyake, 2007, Gene Therapy.

Ribosomal Protein S19 Deficiency Leads to Reduced Proliferation and Increased Apoptosis but Does Not Affect Terminal Erythroid Differentiation in a Cell Line Model of Diamond‐Blackfan Anemia

S. Karlsson, J. Richter, K. Miyake, 2008, Stem cells.

Successful treatment of metachromatic leukodystrophy using bone marrow transplantation of HoxB4 overexpressing cells.

S. Karlsson, N. Miyake, T. Shimada, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Development and Application of HIV Vectors Pseudotyped with HIV Envelopes

T. Shimada, K. Miyake, 2011 .

Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector.

T. Shimada, K. Miyake, N. Suzuki, 2001, Human gene therapy.

Cyclical mechanical stretch enhances degranulation and IL‐4 secretion in RBL‐2H3 mast cells

H. Komiyama, K. Asai, T. Shimada, 2014, Cell Biochemistry and Function.

The Activated K-RAS Protein Accelerates Human Derived-MLL/AF4 Induced Leukemo-Lymphomogenicity In Transgenic Mice Model

N. Miyake, T. Shimada, K. Miyake, 2010 .

A possible correlation between the type of bcr-abl hybrid messenger RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia.

K. Ozawa, T. Yamada, K. Miyake, 1991, Blood.

Direct Comparison of Four Adeno-Associated Virus Serotypes in Mediating the Production of Antiangiogenic Proteins in Mouse Muscle

N. Miyake, T. Shimada, K. Miyake, 2011, Cancer investigation.

Systemic cancer gene therapy using adeno-associated virus type 1 vector expressing MDA-7/IL24.

T. Tajiri, M. Ishizaki, E. Uchida, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia.

N. Miyake, K. Miyake, K. Inokuchi, 2017, Experimental hematology.

Amlexanox Downregulates S100A6 to Sensitize KMT2A/AFF1-Positive Acute Lymphoblastic Leukemia to TNFα Treatment.

K. Miyake, K. Inokuchi, K. Nakayama, 2017, Cancer research.

Amount of Green Fluorescent Protein in the Anterior Chamber after Intravitreal Injection of Triple-Mutated Self-Complementary AAV2 Vectors is Not Affected by Previous Vitrectomy Surgery.

Y. Katakai, K. Miyake, S. Kameya, 2021, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

Relationship of the type of bcr-abl hybrid mRNA to clinical course and transforming activity in Philadelphia-positive chronic myelogenous leukemia.

K. Miyake, H. Matsuoka, K. Inokuchi, 1992, Leukemia research.

Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice

T. Shimada, K. Miyake, K. Inokuchi, 2014, Bone Marrow Transplantation.

In vivo gene transfer into corneal epithelial progenitor cells by viral vectors.

T. Shimada, K. Miyake, N. Suzuki, 2000, Advances in experimental medicine and biology.

Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.

J. Millán, N. Miyake, T. Shimada, 2015, Human gene therapy.

Long-term correction of biochemical and neurological abnormalities in MLD mice model by neonatal systemic injection of an AAV serotype 9 vector

N. Miyake, T. Shimada, K. Miyake, 2014, Gene Therapy.

Tissue Inhibitor of Metalloproteinase-2 Suppresses Collagen Synthesis in Cultured Keloid Fibroblasts

T. Shimada, K. Miyake, R. Ogawa, 2015, Plastic and reconstructive surgery. Global open.

New strategy for in vivo transgene expression in corneal epithelial progenitor cells

T. Shimada, K. Miyake, N. Suzuki, 2002, Current eye research.

Erythropoiesis in the Rps19 disrupted mouse: Analysis of erythropoietin response and biochemical markers for Diamond-Blackfan anemia.

S. Karlsson, G. Ronquist, K. Miyake, 2006, Blood cells, molecules & diseases.

Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase.

T. Kanda, T. Shimada, K. Yoshiike, 1999, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Loss of DCC gene expression is of prognostic importance in acute myelogenous leukemia.

Kayo Nakamura, S. Tanosaki, T. Shimada, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

MicroRNA cluster miR-17-92 regulates multiple functionally related voltage-gated potassium channels in chronic neuropathic pain

Takashi Okada, Koichi Miyake, Takashi Shimada, 2017, Nature Communications.

Role of survivin in acute lung injury: epithelial cells of mice and humans

S. Kunugi, Y. Fukuda, K. Miyake, 2013, Laboratory Investigation.

Development of cellular models for ribosomal protein S19 (RPS19)-deficient diamond-blackfan anemia using inducible expression of siRNA against RPS19.

Koichi Miyake, Johan Richter, S. Karlsson, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits.

S. Karlsson, A. Aspesi, S. Ellis, 2007, Blood.

Deficiency of ribosomal protein S19 in CD34+ cells generated by siRNA blocks erythroid development and mimics defects seen in Diamond-Blackfan anemia.

Koichi Miyake, Johan Richter, Hans Matsson, 2005, Blood.

HOXB4‐Induced Self‐Renewal of Hematopoietic Stem Cells Is Significantly Enhanced by p21 Deficiency

Koichi Miyake, S. Karlsson, N. Miyake, 2006, Stem cells.

Ex vivo cell-mediated gene therapy for metachromatic leukodystrophy using neurospheres

M. Migita, T. Shimada, Y. Fukunaga, 2006, Brain Research.

miR‐15b mediates oxaliplatin‐induced chronic neuropathic pain through BACE1 down‐regulation

A. Sakamoto, Hidenori Suzuki, N. Miyake, 2017, British journal of pharmacology.

miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability.

F. Saitow, Hidenori Suzuki, N. Miyake, 2013, Brain : a journal of neurology.

Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5

Keiichi Fukuda, Masaki Ieda, Koji Nakade, 2012, Circulation research.

Apoptotic Cell Death and Regeneration in the Newborn Retina After Irradiation Prior to Bone Marrow Transplantation

M. Ishizaki, J. Hayakawa, T. Shimada, 2007, Current eye research.

Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia

K. Miyake, K. Inokuchi, K. Dan, 2011, Leukemia.

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

J. Millán, C. Farquharson, K. Miyake, 2022, JBMR plus.

Adeno-associated virus type 8 vector–mediated expression of siRNA targeting vascular endothelial growth factor efficiently inhibits neovascularization in a murine choroidal neovascularization model

N. Miyake, T. Shimada, K. Miyake, 2014, Molecular vision.

Adeno-associated vector (type 8)-mediated expression of soluble Flt-1 efficiently inhibits neovascularization in a murine choroidal neovascularization model.

T. Shimada, I. Masuda, K. Miyake, 2010, Human gene therapy.

Human RPS 19 , the gene mutated in Diamond-Blackfan anemia , encodes a ribosomal protein required for the maturation of 40 S ribosomal subunits

S. Karlsson, A. Aspesi, S. Ellis, 2007 .

Basic and clinical studies on functional RNA molecules for advanced medical technologies.

A. Gemma, M. Seike, K. Ui-Tei, 2010, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

subunits a ribosomal protein required for the maturation of 40S ribosomal , the gene mutated in Diamond-Blackfan anemia, encodes RPS19 Human

A. Aspesi, K. Miyake, J. Flygare, 2010 .

Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector

J. Millán, N. Miyake, T. Shimada, 2016, Molecular therapy. Methods & clinical development.

Serotype-independent method of recombinant adeno-associated virus (AAV) vector production and purification.

Yoshiyuki Yamazaki, N. Miyake, T. Shimada, 2012, Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.

Rescue of severe infantile hypophosphatasia mice by AAV-mediated sustained expression of soluble alkaline phosphatase.

J. Millán, N. Miyake, T. Shimada, 2011, Human gene therapy.

Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice.

T. Shimada, K. Miyake, H. Takahashi, 2005, Clinical and experimental rheumatology.

Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells

H. Hirai, S. Yanagi, N. Miyake, 2014, The Cerebellum.

Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration

S. Honda, S. Torii, S. Shimizu, 2020, Nature Communications.

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

K. Kataoka, H. Mizusawa, K. Miyata, 2015, Nature Communications.

Direct Comparison of Administration Routes for AAV8-mediated Ocular Gene Therapy

N. Miyake, T. Shimada, K. Miyake, 2013, Current eye research.

Targeted gene transfer into ependymal cells through intraventricular injection of AAV1 vector and long-term enzyme replacement via the CSF

Yoshiyuki Yamazaki, T. Shimada, K. Miyake, 2014, Scientific Reports.

Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.

K. Fukuda, N. Miyake, K. Miyake, 2019, Biochemical and biophysical research communications.

Neonatal Gene Therapy for Inherited Disorders

N. Miyake, T. Shimada, K. Miyake, 2017, Selected Topics in Neonatal Care.

Neonatal Gene Therapy for Inherited Disorders Neonatal Gene Therapy for Inherited Disorders

N. Miyake, T. Shimada, K. Miyake, 2018 .

Expression of the DCC gene in myelodysplastic syndromes and overt leukemia.

K. Miyake, K. Inokuchi, K. Dan, 1993, Leukemia research.

A possible correlation between the type of bcr-abl hybrid messenger RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia [see comments]

K. Ozawa, T. Yamada, K. Miyake, 1991 .

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis.

H. Hirai, T. Shimada, K. Miyake, 2003, Blood.

DCC protein expression in hematopoietic cell populations and its relation to leukemogenesis.

K. Miyake, K. Inokuchi, K. Dan, 1996, The Journal of clinical investigation.

Mutations in p53 cDNA sequence introduced by retroviral vector.

T. Shimada, K. Miyake, A. Watanabe, 2006, Biochemical and biophysical research communications.

Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model

H. Hirai, T. Shimada, K. Miyake, 2014, Molecular therapy. Methods & clinical development.

Gene Delivery into the Central Nervous System (CNS) Using AAV Vectors

N. Miyake, T. Shimada, K. Miyake, 2015 .

Mutant Ataxin-3 with an Abnormally Expanded Polyglutamine Chain Disrupts Dendritic Development and Metabotropic Glutamate Receptor Signaling in Mouse Cerebellar Purkinje Cells

H. Hirai, S. Yanagi, N. Miyake, 2013, The Cerebellum.

Development of Muscle-Directed Systemic Cancer Gene Therapy

T. Shimada, K. Miyake, 2013 .

Lentivirus-mediated expression of angiostatin efficiently inhibits neovascularization in a murine proliferative retinopathy model

M. Ishizaki, T. Shimada, K. Miyake, 2003, Gene Therapy.

Tyrosine triple mutated AAV2-BDNF gene therapy in a rat model of transient IOP elevation

T. Igarashi, N. Miyake, T. Shimada, 2016, Molecular vision.

Resistance of MLL–AFF1-positive acute lymphoblastic leukemia to tumor necrosis factor-alpha is mediated by S100A6 upregulation

T. Shimada, K. Miyake, K. Inokuchi, 2011, Blood cancer journal.

D816V mutation in the KIT gene activation loop has greater cell-proliferative and anti-apoptotic ability than N822K mutation in core-binding factor acute myeloid leukemia.

N. Miyake, K. Miyake, K. Inokuchi, 2017, Experimental hematology.

Report on Experiments and Clinical Cases ― Team-based Learning Using an Audience Response System : A Possible New Strategy for Interactive Medical Education

M. Kudo, K. Miyake, T. Fujikura, 2013 .