D. Schols

G. Verleden, S. Verleden, P. Proost, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Differential activity of candidate microbicides against early steps of HIV-1 infection upon complement virus opsonization

C. Charpentier, G. Vanham, J. Balzarini, 2010, AIDS research and therapy.

Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents

E. Clercq, D. Schols, S. Raghavan, 2015 .

Effect of Particle Carriers for Intraperitoneal Drug Delivery on the Course of Ovarian Cancer and Its Immune Microenvironment in a Mouse Model

I. Vergote, A. Coosemans, J. Ceusters, 2022, Pharmaceutics.

CXCR 4 chemokine receptor antagonists : nickel ( II ) complexes of con fi gurationally restricted macrocycles †

C. Pannecouque, E. Clercq, D. Schols, 2012 .

Potent and selective inhibition of human immunodeficiency virus (HIV)-1 and HIV-2 replication by a class of bicyclams interacting with a viral uncoating event.

E. De Clercq, R. Pauwels, M. Baba, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.

E. De Clercq, R. Pauwels, E. Clercq, 1990, Virology.

Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect.

E. De Clercq, R. Pauwels, M. Baba, 1993, Journal of medicinal chemistry.

Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates

Rafał Gulej, D. Schols, G. Andrei, 2016, Molecules.

Direct arylation of C60Cl6 and C70Cl8 with carboxylic acids: a synthetic avenue to water-soluble fullerene derivatives with promising antiviral activity.

P. Troshin, I. Godovikov, J. Balzarini, 2019, Chemical communications.

Diversion of the Arbuzov reaction: alkylation of C-Cl instead of phosphonic ester formation on the fullerene cage.

P. Troshin, I. Godovikov, S. Troyanov, 2019, Organic & biomolecular chemistry.

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza

G. Opdenakker, P. Proost, A. Wilmer, 2021, JCI insight.

Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum

L. Delang, J. Neyts, D. Schols, 2019, Antiviral Research.

The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications

S. Lebeer, D. Schols, M. Petrova, 2015, PloS one.

Neo-Adjuvant Chemotherapy Reduces, and Surgery Increases Immunosuppression in First-Line Treatment for Ovarian Cancer

D. Timmerman, I. Vergote, A. Coosemans, 2021, Cancers.

Fluorescent CXCL12AF647 as a novel probe for nonradioactive CXCL12/CXCR4 cellular interaction studies

E. De Clercq, D. Schols, S. Liekens, 2004, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation

S. Lebeer, J. Vanderleyden, J. Balzarini, 2016, PloS one.

Membrane permeable, bioreversibly modified Prodrugs of Nucleoside Diphosphate-γ-phosphonates.

D. Schols, C. Meier, Xiao Jia, 2020, Journal of medicinal chemistry.

Synthesis and Antiviral Evaluation of TriPPPro‐AbacavirTP, TriPPPro‐CarbovirTP, and Their 1′,2′‐cis‐Disubstituted Analogues

D. Schols, C. Meier, Simon Weising, 2018, ChemMedChem.

In Vitro Characterization of the Carbohydrate-Binding Agents HHA, GNA, and UDA as Inhibitors of Influenza A and B Virus Replication

L. Naesens, D. Schols, E. Vanderlinden, 2020, Antimicrobial Agents and Chemotherapy.

Pradimicin S, a highly-soluble non-peptidic small-size carbohydrate-binding antibiotic,

J. Balzarini, D. Schols, S. Liekens, 2010 .

Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor.

E. De Clercq, A. Mantovani, P. Proost, 1998, Journal of immunology.

In-Depth Characterization of Zika Virus Inhibitors Using Cell-Based Electrical Impedance

D. Schols, Jordi Doijen, M. Oeyen, 2022, Microbiology Spectrum.

The discovery of Zika virus NS2B-NS3 inhibitors with antiviral activity via an integrated virtual screening approach.

M. U. Mirza, John F. Trant, M. Froeyen, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Humoral immunity in phenotypes of chronic lung allograft dysfunction: A broncho-alveolar lavage fluid analysis.

G. Verleden, S. Verleden, G. Opdenakker, 2016, Transplant immunology.

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

M. Rosenkilde, G. Opdenakker, P. Proost, 2018, Front. Immunol..

2-Chloro-3-pyridin-3-yl-5,6,7,8-tetrahydroindolizine-1-carboxamide (CMV423), a new lead compound for the treatment of human cytomegalovirus infections.

M. Otto, E. De Clercq, L. Naesens, 2002, Antiviral research.

Acetate as a model for aspartate-based CXCR4 chemokine receptor binding of cobalt and nickel complexes of cross-bridged tetraazamacrocycles.

T. Van Loy, D. Schols, S. Archibald, 2019, Dalton transactions.

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity

J. Neyts, D. Schols, E. Tramontano, 2022, ACS medicinal chemistry letters.

Water-soluble fullerene-based nanostructures with promising antiviral and myogenic activity.

P. Troshin, J. Balzarini, D. Schols, 2020, Chemical communications.

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: synthesis, cytotoxic activity and mechanism of action.

E. De Clercq, D. Schols, S. Raghavan, 2014, European journal of medicinal chemistry.

in 1 vitro Zika virus replication and delays disease progression in a robust mouse infection model 2 3 Running Title : Inhibition of Zika virus replication

J. Neyts, E. Verbeken, R. E. Marques, 2016 .

The LD78beta isoform of MIP-1alpha is the most potent CCR5 agonist and HIV-1-inhibiting chemokine.

E. De Clercq, P. Proost, J. Van Damme, 1999, The Journal of clinical investigation.

CD26/dipeptidyl-peptidase IV down-regulates the eosinophil chemotactic potency, but not the anti-HIV activity of human eotaxin by affecting its interaction with CC chemokine receptor 3.

E. De Clercq, M. Parmentier, G. Opdenakker, 1999, Journal of immunology.

CC Chemokine Receptor 3 Human Eotaxin by Affecting Its Interaction Potency , But Not the Anti-HIV Activity of Down-Regulates the Eosinophil Chemotactic CD 26 / Dipeptidyl-Peptidase IV

M. Parmentier, G. Opdenakker, P. Proost, 1999 .

Processing by CD26/dipeptidyl‐peptidase IV reduces the chemotactic and anti‐HIV‐1 activity of stromal‐cell‐derived factor‐1α

E. De Clercq, C. Durinx, P. Proost, 1998, FEBS letters.

Receptor MDCChemokine ( MDC ) Imply an Additional-Terminally Processed Macrophage-Derived 2 and Altered Chemotactic Potency of NH Cutting Edge : Enhanced Anti-HIV-1 Activity

A. Mantovani, P. Proost, S. Sozzani, 1998 .

9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.

E. De Clercq, J. Balzarini, D. Schols, 1999, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The role of CD26/DPP IV in chemokine processing.

P. Proost, I. De Meester, S. Sozzani, 1999, Chemical immunology.

A chimeric yellow fever-Zika virus vaccine candidate fully protects against yellow fever virus infection in mice

J. Neyts, D. Schols, K. Dallmeier, 2020, Emerging microbes & infections.

Inhibition of T-tropic HIV Strains by Selective Antagonization of the Chemokine Receptor CXCR4

E. Clercq, D. Schols, J. Esté, 1997, The Journal of experimental medicine.

Design, antiviral and cytostatic properties of isoxazolidine-containing amonafide analogues

D. Schols, G. Andrei, R. Snoeck, 2015, Bioorganic & Medicinal Chemistry.

Targeting HIV entry through interaction with envelope glycoprotein 120 (gp120): synthesis and antiviral evaluation of 1,3,5-triazines with aromatic amino acids.

J. Balzarini, D. Schols, M. Camarasa, 2011, Journal of medicinal chemistry.

Combination of the CCL5-Derived Peptide R4.0 with Different HIV-1 Blockers Reveals Wide Target Compatibility and Synergic Cobinding to CCR5

S. Morin, D. Schols, L. Vangelista, 2014, Antimicrobial Agents and Chemotherapy.

Cobinding to CCR5 Wide Target Compatibility and Synergic R4.0 with Different HIV-1 Blockers Reveals Combination of the CCL5-Derived Peptide

S. Morin, D. Schols, L. Vangelista, 2014 .

Viral Entry through CXCR4 Is a Pathogenic Factor and Therapeutic Target in Human Immunodeficiency Virus Type 1 Disease

M. L. Penn, E. De Clercq, M. Goldsmith, 2000, Journal of Virology.

Human Ig production and isotype switching in severe combined immunodeficient-human mice.

J. D. de Vries, M. Roncarolo, D. Schols, 1993, Journal of Immunology.

A porcine ex vivo lung perfusion model with maximal argon exposure to attenuate ischemia-reperfusion injury

G. Verleden, S. Verleden, D. Schols, 2017, Medical gas research.

Synthesis, Anti-varicella-zoster virus and Anti-cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles.

D. Schols, G. Andrei, R. Snoeck, 2019, Medicinal chemistry (Shariqah (United Arab Emirates)).

Antiviral agents active against human herpesviruses HHV‐6, HHV‐7 and HHV‐8

E. De Clercq, L. Naesens, J. Neyts, 2001, Reviews in Medical Virology.

Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases

G. Opdenakker, P. Proost, D. Schols, 2021, Frontiers in Immunology.

Presence of class II histocompatibility DR proteins on the envelope of human immunodeficiency virus demonstrated by FACS analysis.

E. De Clercq, R. Pauwels, D. Schols, 1992, Virology.

CXCR7/ACKR3-targeting ligands interfere with X7 HIV-1 and HIV-2 entry and replication in human host cells

T. Van Loy, D. Schols, S. Claes, 2018, Heliyon.

Design of novel CXCR4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

E. De Clercq, D. Schols, G. Bridger, 2011, Bioorganic & medicinal chemistry letters.

Anti-HIV Agents Interfering with the Viral gp120-Cellular CD4 Interaction

E. Clercq, D. Schols, 1992 .

Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.

E. De Clercq, R. Pauwels, M. Baba, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Viral Interactions in Human Lymphoid Tissue: Human Herpesvirus 7 Suppresses the Replication of CCR5-Tropic Human Immunodeficiency Virus Type 1 via CD4 Modulation

J. Grivel, L. Margolis, D. Schols, 2006, Journal of Virology.

Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes

D. Schols, B. Sprangers, M. Waer, 2021, Frontiers in Immunology.

Simultaneous inhibition of human CD4 and 4-1BB biogenesis suppresses cytotoxic T lymphocyte proliferation

D. Schols, B. Sprangers, M. Waer, 2021, bioRxiv.

Differential Cytokine, Chemokine and Growth Factor Expression in Phenotypes of Chronic Lung Allograft Dysfunction

G. Verleden, S. Verleden, P. Proost, 2015, Transplantation.

64Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist

D. Schols, T. Ruest, C. Cawthorne, 2020, The Journal of Nuclear Medicine.

Copper-64 PET imaging of the CXCR4 chemokine receptor using a cross-bridged cyclam bis-tetraazamacrocyclic antagonist

D. Schols, T. Ruest, C. Cawthorne, 2019 .

Differential antiviral activity of derivatized dextrans.

S. Ikeda, J. Neyts, D. Letourneur, 1995, Biochemical pharmacology.

SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells

J. Neyts, D. Schols, S. Claes, 2022, Viruses.

Enhanced autoimmune arthritis in IFN-gamma receptor-deficient mice is conditioned by mycobacteria in Freund's adjuvant and by increased expansion of Mac-1+ myeloid cells.

C. de Wolf‐Peeters, A. Billiau, S. Huang, 1999, Journal of immunology.

Design, synthesis, and cytostatic activity of novel pyrazine sorafenib analogs

Zrinka Rajić Džolić, D. Schols, Nataša Ilić, 2016, Medicinal Chemistry Research.

Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells

J. Bell, E. Clercq, J. Reeves, 2003, Journal of Virology.

No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1

H. Schuitemaker, D. Schols, F. Koning, 2001, Journal of Virology.

CD26-processed RANTES(3-68), but not intact RANTES, has potent anti-HIV-1 activity.

E. De Clercq, P. Proost, I. De Meester, 1998, Antiviral research.

RANTES and MCP-3 inhibit the replication of T-cell-tropic human immunodeficiency virus type 1 strains (SF-2, MN, and HE)

E. De Clercq, P. Proost, J. Van Damme, 1997, Journal of virology.

The antiviral activity of the CXCR4 antagonist AMD3100 is independent of the cytokine-induced CXCR4/HIV coreceptor expression level.

E. De Clercq, D. Schols, G. Bridger, 2003, AIDS research and human retroviruses.

Evaluation of SDF‐1/CXCR4‐induced Ca2+ signaling by fluorometric imaging plate reader (FLIPR) and flow cytometry

E. De Clercq, D. Schols, S. Hatse, 2003, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Switch in Coreceptor Use the Envelope gp120 but Does Not Show a Contains Mutations in α Cell-Derived Factor 1 Virus Type 1 That Is Made Resistant to Stromal T-Cell-Line-Tropic Human Immunodeficiency

D. Schols, J. Esté, C. Cabrera, 2013 .

Coreceptor usage of sequential isolates from cynomolgus monkeys experimentally Infected with simian immunodeficiency virus (SIVsm).

E. De Clercq, E. Fenyö, D. Schols, 2001, Virology.

The simian immunodeficiency virus mnd(GB-1) strain uses CXCR4, not CCR5, as coreceptor for entry in human cells.

E. De Clercq, D. Schols, 1998, The Journal of general virology.

Prone Positioning During Ex Vivo Lung Perfusion Influences Regional Edema Accumulation.

S. Verleden, D. Schols, S. Claes, 2019, The Journal of surgical research.

Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern

Adriano Camps, P. Maes, D. Schols, 2022, bioRxiv.

Steroids can reduce warm ischemic reperfusion injury in a porcine donation after circulatory death model with ex vivo lung perfusion evaluation

G. Verleden, S. Verleden, D. Schols, 2016, Transplant international : official journal of the European Society for Organ Transplantation.

Anti-human immunodeficiency virus effects of cationic metalloporphyrin-ellipticine complexes.

E. De Clercq, J. Balzarini, D. Schols, 1992, Biochemical pharmacology.

Alpha-(1-3)- and alpha-(1-6)-D-mannose-specific plant lectins are markedly inhibitory to human immunodeficiency virus and cytomegalovirus infections in vitro

E. De Clercq, J. Neyts, J. Balzarini, 1991, Antimicrobial Agents and Chemotherapy.

Inhibitory Effects of Polycations on the Replication of Enveloped Viruses (HIV, HSV, CMV, RSV, Influenza A Virus and Togaviruses) in vitro

E. De Clercq, R. Pauwels, M. Hosoya, 1991 .

Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight.

E. De Clercq, E. Clercq, D. Schols, 1991, Journal of medicinal chemistry.

Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compounds.

E. De Clercq, D. Schols, M. Cushman, 1991, Journal of medicinal chemistry.

Selective inhibitory activity of polyhydroxycarboxylates derived from phenolic compounds against human immunodeficiency virus replication.

E. De Clercq, D. Schols, P. Wutzler, 1991, Journal of acquired immune deficiency syndromes.

Flow cytometric method to demonstrate whether anti-HIV-1 agents inhibit virion binding to T4+ cells.

E. De Clercq, R. Pauwels, M. Baba, 1989, Journal of acquired immune deficiency syndromes.

Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

E. De Clercq, C. Pannecouque, B. Clotet, 1998, Molecular pharmacology.

Synthesis of new riboflavin modified ODNs: Effect of riboflavin moiety on the G-quadruplex arrangement and stability.

D. Schols, G. Di Fabio, V. Romanucci, 2020, Bioorganic chemistry.

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeﬁciency Virus Type 1 Activity (cid:1)

L. Vincent, J. Balzarini, D. Schols, 2009 .

Truncation of Macrophage-derived Chemokine by CD26/ Dipeptidyl-Peptidase IV beyond Its Predicted Cleavage Site Affects Chemotactic Activity and CC Chemokine Receptor 4 Interaction*

P. Allavena, G. Opdenakker, P. Proost, 1999, The Journal of Biological Chemistry.

In Vivo Evolution of X4 Human Immunodeficiency Virus Type 1 Variants in the Natural Course of Infection Coincides with Decreasing Sensitivity to CXCR4 Antagonists

H. Schuitemaker, D. Schols, R. V. van Rij, 2004, Journal of Virology.

CADA inhibits human immunodeficiency virus and human herpesvirus 7 replication by down-modulation of the cellular CD4 receptor.

E. De Clercq, D. Schols, G. Andrei, 2002, Virology.

Restricted entry of R5 HIV Type 1 strains into eosinophilic cells.

D. Schols, R. Taylor, D. Wooley, 2004, AIDS research and human retroviruses.

Imbalance in production of cytokines by bone marrow stromal cells following cytomegalovirus infection.

E. Bosmans, D. Schols, R. Snoeck, 1996, The Journal of infectious diseases.

Detection of immediate early, early and late antigens of human cytomegalovirus by flow cytometry.

E. De Clercq, J. Neyts, D. Schols, 1989, Journal of virological methods.

Vascular endothelial growth factor pathway in endometriosis: genetic variants and plasma biomarkers.

D. Lambrechts, A. Fassbender, X. Bossuyt, 2016, Fertility and sterility.

Phosphonylated 8-Azahypoxantines as Acyclic Nucleotide Analogs

D. Schols, G. Andrei, R. Snoeck, 2015 .

The molecular pharmacology of AMD11070: an orally bioavailable CXCR4 HIV entry inhibitor.

D. Schols, R. Wong, S. Fricker, 2012, Biochemical pharmacology.

Modified Cyclodextrin Sulphates(mCDS11) have Potent Inhibitory Activity against HIV and High Oral Bioavailability

E. De Clercq, L. Naesens, D. Schols, 1994 .

The LD78β Isoform of MIP-1α Is the Most Potent CC-Chemokine in Inhibiting CCR5-Dependent Human Immunodeficiency Virus Type 1 Replication in Human Macrophages

E. De Clercq, P. Proost, J. Van Damme, 2001, Journal of Virology.

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2.

R. Schinazi, J. Grivel, L. Margolis, 2010, The Journal of infectious diseases.

Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture

J. D. de Vries, H. Spits, D. Schols, 1994, The Journal of experimental medicine.

Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes.

D. Schols, D. Linder, R. Mewis, 2016, Chemistry.

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities.

D. Schols, C. Cawthorne, S. Archibald, 2015, Dalton transactions.

HIV-1 X4 activities of polycationic "viologen" based dendrimers by interaction with the chemokine receptor CXCR4: study of structure-activity relationship.

D. Schols, D. Huskens, S. Asaftei, 2012, Journal of medicinal chemistry.

Synthesis and Structure−Activity Relationships of Azamacrocyclic C-X-C Chemokine Receptor 4 Antagonists: Analogues Containing a Single Azamacrocyclic Ring are Potent Inhibitors of T-Cell Tropic (X4) HIV-1 Replication

E. De Clercq, D. Schols, G. Bridger, 2010 .

Establishment of a novel CCR5 and CXCR4 expressing CD4+ cell line which is highly sensitive to HIV and suitable for high-throughput evaluation of CCR5 and CXCR4 antagonists

E. De Clercq, D. Schols, S. Hatse, 2004, Retrovirology.

Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine

C. Pannecouque, E. Arnold, P. Herdewijn, 2022, Proceedings of the National Academy of Sciences of the United States of America.

D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy

G. Bormans, T. Van Loy, C. Deroose, 2021, Pharmaceutics.

Early protein expression profile in bronchoalveolar lavage fluid and clinical outcomes in primary graft dysfunction after lung transplantation.

G. Verleden, S. Verleden, D. Schols, 2020, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues

E. De Clercq, J. Neyts, D. Schols, 1996 .

Syncytium formation and destruction of bystander CD4+ cells cocultured with T cells persistently infected with human immunodeficiency virus as demonstrated by flow cytometry.

E. De Clercq, R. Pauwels, M. Baba, 1989, The Journal of general virology.

Sulfated polymers inhibit the interaction of human cytomegalovirus with cell surface heparan sulfate.

A. Van Schepdael, E. De Clercq, J. Esko, 1992, Virology.

Synergistic anti-HIV-1 activity of griffithsin with tenofovir, maraviroc and enfuvirtide

K. Palmer, D. Schols, G. Férir, 2011, Retrovirology.

New Polyacetal Polysulphate Active against Human Immunodeficiency Virus and other Enveloped Viruses

A. Van Schepdael, E. De Clercq, R. Pauwels, 1992 .

Anti-HIV-1 activity of antiviral compounds, as quantitated by a focal immunoassay in CD4+ HeLa cells and a plaque assay in MT-4 cells.

E. De Clercq, R. Pauwels, J. Balzarini, 1990, Journal of virological methods.

Novel sulfated polysaccharides: dissociation of anti-human immunodeficiency virus activity from antithrombin activity.

E. De Clercq, R. Pauwels, M. Baba, 1990, The Journal of infectious diseases.

Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT).

D. Schols, C. Meier, Stefan Weber, 2022, Journal of medicinal chemistry.

Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).

P. Proost, E. Andersson, J. Van Damme, 2004, The international journal of biochemistry & cell biology.

Branched-chain sugar nucleosides: stereocontrolled synthesis and bioevaluation of novel 3'-C-trifluoromethyl and 3'-C-methyl pyranonucleosides.

D. Schols, T. Mavromoustakos, T. Kellici, 2015, Carbohydrate research.

Metal complexes of pyridine-fused macrocyclic polyamines targeting the chemokine receptor CXCR4.

B. Frost, D. Schols, S. Aquaro, 2015, Organic & biomolecular chemistry.

Anti-HIV activity profile of AMD070, an orally bioavailable CXCR4 antagonist

E. Clercq, D. Schols, G. Bridger, 2003 .

Differential in vitro inhibitory activity against HIV-1 of alpha-(1-3)- and alpha-(1-6)-D-mannose specific plant lectins : Implication for microbicide development

M. Lecerf, J. Balzarini, D. Schols, 2007, Journal of Translational Medicine.

Human T-cell development in SCID-hu mice

M. Roncarolo, J. Vries, D. Schols, 1995 .

Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents.

D. Schols, K. Vermeire, T. Bell, 2011, Journal of medicinal chemistry.

IL-4 induces human B cell maturation and IgE synthesis in SCID-hu mice. Inhibition of ongoing IgE production by in vivo treatment with an IL-4/IL-13 receptor antagonist.

J. D. de Vries, M. Roncarolo, D. Schols, 1995, Journal of immunology.

Molecular Mechanism of Action of Monocyclam Versus Bicyclam Non-peptide Antagonists in the CXCR4 Chemokine Receptor*

Dominique Schols, T. Schwartz, M. Rosenkilde, 2007, Journal of Biological Chemistry.

The Anti-HIV potency of cyclotriazadisulfonamide analogs is directly correlated with their ability to down-modulate the CD4 receptor.

E. De Clercq, D. Schols, K. Vermeire, 2003, Molecular pharmacology.

Selective activity of various antiviral compounds against HHV-7 infection.

E. De Clercq, D. Schols, Y. Zhang, 1999, Antiviral research.

Cellular Electrical Impedance as a Method to Decipher CCR7 Signalling and Biased Agonism

T. Van Loy, D. Schols, Jordi Doijen, 2022, International journal of molecular sciences.

Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis

A. Billiau, D. Schols, G. Bridger, 2005, Arthritis research & therapy.

Structure‐activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid

J. Neyts, J. Balzarini, D. Schols, 2017, Antiviral research.

Design and synthesis of pyridin-2-yloxymethylpiperidin-1-ylbutyl amide CCR5 antagonists that are potent inhibitors of M-tropic (R5) HIV-1 replication.

D. Schols, S. Fricker, G. Bridger, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of novel CXCR4 antagonists that are potent inhibitors of T tropic (X4) HIV-1 replication.

E. De Clercq, D. Schols, G. Bridger, 2011, Bioorganic & medicinal chemistry letters.

CXCL12-CXCR4 axis in angiogenesis, metastasis and stem cell mobilization.

D. Schols, S. Liekens, S. Hatse, 2010, Current pharmaceutical design.

A unique class of lignin derivatives displays broad anti-HIV activity by interacting with the viral envelope.

D. Schols, S. Noppen, S. Claes, 2019, Virus research.

Anti-HIV-active Nucleoside Triphosphate Prodrugs.

D. Schols, C. Meier, Xiao Jia, 2020, Journal of medicinal chemistry.

Prodrugs of γ‐Alkyl‐Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase

J. Balzarini, D. Schols, C. Meier, 2020, Angewandte Chemie.

Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro

J. Balzarini, E. Clercq, D. Schols, 1992, European Journal of Clinical Microbiology and Infectious Diseases.

1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide (ribavirin) and 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide (EICAR) markedly potentiate the inhibitory effect of 2′,3′-dideoxyinosine on human immunodeficiency virus in peripheral blood lymphocytes

J. Balzarini, E. Clercq, D. Schols, 1991 .

Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3‐Triazolylbenzyl‐aminophosphonates

D. Schols, G. Andrei, R. Snoeck, 2015, Archiv der Pharmazie.

In-Depth Characterization of Zika Virus Inhibitors Using Cell-Based Electrical Impedance

D. Schols, Jordi Doijen, M. Oeyen, 2022, Microbiology spectrum.

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents.

D. Schols, G. Andrei, S. Manta, 2020, Medicinal chemistry (Shariqah (United Arab Emirates)).

Activity of acyclic nucleoside phosphonate analogues against human immunodeficiency virus in monocyte/macrophages and peripheral blood lymphocytes.

E. De Clercq, C. Perno, J. Balzarini, 1991, Biochemical and biophysical research communications.

γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs as Potential Antivirals.

J. Balzarini, D. Schols, C. Meier, 2020, Journal of medicinal chemistry.

γ‐Non‐Symmetrically Dimasked TriPPPro Prodrugs as Potential Antiviral Agents against HIV

J. Balzarini, D. Schols, C. Meier, 2020, ChemMedChem.

Lipophilic Triphosphate Prodrugs of various Nucleoside Analogues.

D. Schols, C. Meier, Xiao Jia, 2020, Journal of medicinal chemistry.

Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues.

J. Balzarini, D. Schols, I. Hauber, 2016, Angewandte Chemie.

Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-2,6-diaminopurine

E. De Clercq, L. Naesens, J. Balzarini, 1993, Antimicrobial Agents and Chemotherapy.

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker

D. Schols, G. Andrei, R. Snoeck, 2015, Molecules.

Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.

Y. Pommier, M. Kubbutat, M. Preobrazhenskaya, 2016, European journal of medicinal chemistry.

Development of a live biotherapeutic throat spray with lactobacilli targeting respiratory viral infections

S. Lebeer, D. Schols, I. Claes, 2022, Microbial biotechnology.

Cellular electrical impedance to profile SARS-CoV-2 fusion inhibitors and to assess the fusogenic potential of spike mutants

D. Schols, S. Noppen, A. Stevaert, 2022, bioRxiv.

Proﬁle of Resistance of Human Immunodeﬁciency Virus to Mannose-Speciﬁc Plant Lectins

A. Vandamme, J. Balzarini, E. Clercq, 2004 .

Human Immunodeﬁciency Virus Type 1 Escape from Cyclotriazadisulfonamide-Induced CD4-Targeted Entry Inhibition Is Associated with Increased Neutralizing Antibody Susceptibility (cid:1)

D. Schols, K. Vermeire, T. Bell, 2009 .

CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells

E. De Clercq, D. Schols, S. Hatse, 2000, Journal of Virology.

Design, synthesis and antiviral evaluation of novel acyclic phosphonate nucleotide analogs with triazolo[4,5-b]pyridine, imidazo[4,5-b]pyridine and imidazo[4,5-b]pyridin-2(3H)-one systems

D. Schols, G. Andrei, R. Snoeck, 2020, Nucleosides, nucleotides & nucleic acids.

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds.

J Desmyter, E. De Clercq, R. Pauwels, 1988, Journal of virological methods.

Design and synthesis of a new series of hybrids of functionalised N1-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with antiviral activity against Respiratory Syncytial Virus.

Adriano Camps, D. Schols, G. Andrei, 2022, Antiviral research.

Design, Synthesis, Anti-Varicella-Zoster and Antimicrobial Activity of (Isoxazolidin-3-yl)Phosphonate Conjugates of N1-Functionalised Quinazoline-2,4-Diones

D. Schols, G. Andrei, R. Snoeck, 2022, Molecules.

Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High in Vitro Therapeutic Index

W. Luyten, L. Schoofs, D. Schols, 2018, Front. Microbiol..

Anti-HIV Activities of Anionic Metalloporphyrins and Related Compounds

E. De Clercq, J. Balzarini, D. Schols, 1997 .

Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action.

E. De Clercq, C. Pannecouque, J. Balzarini, 2005, The Journal of antimicrobial chemotherapy.

Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones—Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity

D. Schols, G. Andrei, R. Snoeck, 2018, Molecules.

Indolylarylsulfones as HIV-1 non-nucleoside reverse transcriptase inhibitors: new cyclic substituents at indole-2-carboxamide.

E. Novellino, C. Pannecouque, A. Coluccia, 2011, Journal of medicinal chemistry.

New Isoxazolidine-Conjugates of Quinazolinones—Synthesis, Antiviral and Cytostatic Activity

D. Schols, G. Andrei, R. Snoeck, 2016, Molecules.

Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides

D. Schols, Qingshan Zhang, G. Andrei, 2016, Nucleosides, nucleotides & nucleic acids.

Design, synthesis, antiviral and cytostatic activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates as acyclic nucleotide analogues

J. Balzarini, D. Schols, G. Andrei, 2014, Bioorganic & Medicinal Chemistry.

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative.

R T Walker, R. T. Walker, E. De Clercq, 1989, Biochemical and biophysical research communications.

2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase.

E. De Clercq, A. Vandamme, C. Perno, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3‐Triazole Nucleosides

D. Schols, G. Andrei, R. Snoeck, 2017, Archiv der Pharmazie.

Synthesis, anti-varicella-zoster virus and anti-cytomegalovirus activity of quinazoline-2,4-diones containing isoxazolidine and phosphonate substructures

D. Schols, G. Andrei, R. Snoeck, 2016, European Journal of Medicinal Chemistry.

Polysulfonates Derived from Metal Thiolate Complexes as Inhibitors of HIV-1 and Various other Enveloped Viruses In Vitro

E. De Clercq, S. Ikeda, D. Bergstrom, 2002, Antiviral chemistry & chemotherapy.

Discovery of ( ±)-3-(1 H -pyrazol-1-yl)-6,7-dihydro-5 H -[1,2,4]triazolo[3,4- b ][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity

D. Schols, D. Daelemans, L. Persoons, 2021, Molecular Diversity.

Synthesis, molecular docking, and preliminary cytotoxicity study of some novel 2-(naphthalen-1-yl)-methylimidazo[2,1-b][1,3,4]thiadiazoles

D. Schols, Alok Gupta, Sujeet Kumar, 2021 .

Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4‐Methoxybenzyl Derivatives Bearing Imidazo[2,1‐b][1,3,4]thiadiazole

D. Schols, C. Gopi Mohan, R. Aguilera, 2020, Chemistry & biodiversity.

Dengue Virus Entry as Target for Antiviral Therapy

D. Schols, M. Alen, 2012, Journal of tropical medicine.

Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones as Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections

J. Handzlik, D. Schols, G. Andrei, 2021, International journal of molecular sciences.

Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.

Dominique Schols, E. De Clercq, D. Schols, 2010, Journal of medicinal chemistry.

Amides of pyrrole- and thiophene-fused anthraquinone derivatives: A role of the heterocyclic core in antitumor properties.

M. Moisenovich, D. Andreeva, D. Schols, 2020, European journal of medicinal chemistry.

Advantages and shortcomings of cell-based electrical impedance measurements as a GPCR drug discovery tool.

Liliane Schoofs, Walter Luyten, Bart Landuyt, 2019, Biosensors & bioelectronics.

Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[4,5-d]pyrimidine.

W. Dehaen, T. Van Loy, D. Schols, 2022, European journal of medicinal chemistry.

Synthesis of Novel Chiral Sulfonamide-Bearing 1,2,4-Triazole-3-thione Analogs Derived from D- and L-Phenylalanine Esters as Potential Anti-Influenza Agents.

D. Schols, E. E. Oruç-Emre, A. Karaküçük-Iyidoğan, 2016, Chirality.

Antiviral Activity of low-MW Dextran Sulphate (Derived from dextran MW 1000) Compared to Dextran Sulphate Samples of Higher MW

E. De Clercq, R. Pauwels, M. Hosoya, 1991 .

Total synthesis of the antiviral peptide antibiotic feglymycin.

D. Schols, R. Süssmuth, Anne Hänchen, 2009, Angewandte Chemie.

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Antimicrobial agents and chemotherapy.

Interleukin-8 and Growth-Regulated Oncogene Alpha Mediate Angiogenesis in Kaposi's Sarcoma

D. Markovitz, R. Strieter, B. Lane, 2002, Journal of Virology.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

E. De Clercq, D. Schols, M. Witvrouw, 1999, Journal of medicinal chemistry.

Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals

J. Balzarini, D. Schols, C. Meier, 2015, Nature Communications.

Indolylarylsulfones carrying a heterocyclic tail as very potent and broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. Novellino, A. Coluccia, A. Brancale, 2014, Journal of Medicinal Chemistry.

Acyclic nucleoside phosphonates containing the amide bond

D. Schols, G. Andrei, R. Snoeck, 2016, Monatshefte für Chemie - Chemical Monthly.

Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles

D. Schols, D. Daelemans, L. Persoons, 2021, Heliyon.

Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.

C. Pannecouque, D. Schols, M. Witvrouw, 2000, Journal of medicinal chemistry.

Mechanism of anti-human immunodeficiency virus action of polyoxometalates, a class of broad-spectrum antiviral agents.

E. De Clercq, R. Pauwels, M. Hosoya, 1992, Molecular pharmacology.

Tri-armed ligands of G-quadruplex on heteroarene-fused anthraquinone scaffolds: Design, synthesis and pre-screening of biological properties.

D. Schols, V. Tsvetkov, A. Shchekotikhin, 2018, European journal of medicinal chemistry.

An easy microwave-assisted synthesis of C8-alkynyl adenine pyranonucleosides as novel cytotoxic antitumor agents

D. Schols, A. Dimopoulou, S. Manta, 2015, Front. Chem..

The role of N-glycosylation sites on the CXCR4 receptor for CXCL-12 binding and signaling and X4 HIV-1 viral infectivity.

D. Schols, M. Schreiber, D. Huskens, 2007, Virology.

Synthesis and Evaluations of “1,4‐Triazolyl Combretacoumarins” and Desmethoxy Analogs

D. Schols, G. Andrei, R. Snoeck, 2019, European journal of organic chemistry.

Correction: Facile functionalization at the C4 position of pyrimidine nucleosides via amide group activation with (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and biological evaluations of the products.

J. Balzarini, D. Schols, G. Andrei, 2017, Organic & biomolecular chemistry.

Alkylated benzimidazoles: Design, synthesis, docking, DFT analysis, ADMET property, molecular dynamics and activity against HIV and YFV

Ritika Srivastava, Vishal Kumar Singh, Parth Sarthi Sen Gupta, 2020, Computational Biology and Chemistry.

Design, synthesis and biological evaluation of 2-alkoxycarbonyl-3-anilinoindoles as a new class of potent inhibitors of tubulin polymerization.

A. Brancale, G. Viola, Roberta Bortolozzi, 2020, Bioorganic chemistry.

High mannose-specific lectin Msl mediates key interactions of the vaginal Lactobacillus plantarum isolate CMPG5300

S. Lebeer, J. Vanderleyden, J. Balzarini, 2016, Scientific Reports.

Sulfonic acid polymers as a new class of human immunodeficiency virus inhibitors.

E. De Clercq, M. Baba, E. Clercq, 1992, Antiviral research.

Thiophene-2-carboxamide derivatives of anthraquinone: A new potent antitumor chemotype.

M. Moisenovich, D. Andreeva, D. Schols, 2021, European journal of medicinal chemistry.

Active Components from Cassia abbreviata Prevent HIV-1 Entry by Distinct Mechanisms of Action

A. Steinmetz, M. Mori, D. Schols, 2021, International journal of molecular sciences.

Novel In Vivo Model for the Study of Human Immunodeficiency Virus Type 1 Transcription Inhibitors: Evaluation of New 6-Desfluoroquinolone Derivatives

E. De Clercq, C. Pannecouque, E. Verbeken, 2007, Antimicrobial Agents and Chemotherapy.

2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5

C. Pannecouque, E. Verbeken, J. Balzarini, 2007 .

HIV-1 transcription in vivo-1-1 2 A NOVEL IN VIVO MODEL FOR THE STUDY OF HIV-1 3 TRANSCRIPTION INHIBITORS : EVALUATION OF NEW 4 6-DESFLUOROQUINOLONE DERIVATIVES ( 6-DFQs ) 5 6 7

C. Pannecouque, E. Verbeken, J. Balzarini, 2007 .

Asymmetric Primaquine and Halogenaniline Fumardiamides as Novel Biologically Active Michael Acceptors

D. Schols, J. Jampílek, I. Kosalec, 2018, Molecules.

CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells

R. Leurs, M. Smit, K. Chow, 2010, Proceedings of the National Academy of Sciences.

A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.

E. De Clercq, C. Pannecouque, T. Klimkait, 2000, Molecular pharmacology.

Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

E. De Clercq, E. Clercq, D. Schols, 1997, Antiviral research.

Flow cytometric method for the detection of gpI antigens of varicella zoster virus and evaluation of anti-VZV agents.

E. De Clercq, J. Piette, B. Rentier, 1992, Journal of virological methods.

Differential Activity of Polyanionic Compounds and Castanospermine against HIV Replication and HIV-Induced Syncytium Formation Depending on Virus Strain and Cell Type

E. De Clercq, R. Pauwels, D. Schols, 1992 .

Safety, Pharmacokinetics, and Antiviral Activity of AMD3100, a Selective CXCR4 Receptor Inhibitor, in HIV-1 Infection

Dominique Schols, M. Lederman, C. Flexner, 2004, Journal of acquired immune deficiency syndromes.

HIV chemokine receptor inhibitors as novel anti-HIV drugs.

Dominique Schols, D. Schols, Katrien Princen, 2005, Cytokine & growth factor reviews.

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir.

D. Schols, P. Augustijns, J. Brouwers, 2011, Antiviral research.

Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses

E. De Clercq, R. Pauwels, M. Hosoya, 1990 .

Antiviral activity of anti-cytomegalovirus agents (HPMPC, HPMPA) assessed by a flow cytometric method and DNA hybridization technique.

E. De Clercq, J. Neyts, E. Clercq, 1991, Antiviral research.

Sensitive, reproducible and convenient fluorometric assay for the in vitro evaluation of anti-cytomegalovirus agents.

E. De Clercq, J. Neyts, D. Schols, 1991, Journal of virological methods.

Comparative activity of selected antiviral compounds against clinical isolates of human cytomegalovirus

E. Clercq, D. Schols, R. Snoeck, 1991, European Journal of Clinical Microbiology and Infectious Diseases.

Broad Antiviral Activity of Carbohydrate-Binding Agents against the Four Serotypes of Dengue Virus in Monocyte-Derived Dendritic Cells

J. Neyts, J. Balzarini, D. Schols, 2011, PloS one.

New antitumor anthra[2,3-b]furan-3-carboxamides: Synthesis and structure-activity relationship.

P. Kaur, P. Chueh, D. Schols, 2018, European journal of medicinal chemistry.

Novel halogenated 3-deazapurine, 7-deazapurine and alkylated 9-deazapurine derivatives of l-ascorbic or imino-l-ascorbic acid: Synthesis, antitumour and antiviral activity evaluations

K. Pavelić, J. Plavec, D. Schols, 2015, European Journal of Medicinal Chemistry.

Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335

E. De Clercq, R. Pauwels, A. Vandamme, 1992, Antimicrobial Agents and Chemotherapy.

The mannose-specific plant lectins from Cymbidium hybrid and Epipactis helleborine and the (N-acetylglucosamine)n-specific plant lectin from Urtica dioica are potent and selective inhibitors of human immunodeficiency virus and cytomegalovirus replication in vitro.

E. De Clercq, M. Hosoya, J. Neyts, 1992, Antiviral research.

Pentosan polysulfate, a sulfated oligosaccharide, is a potent and selective anti-HIV agent in vitro.

E. De Clercq, R. Pauwels, M. Nakajima, 1988, Antiviral research.

ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS

P Leyssen, E. De Clercq, L. Naesens, 2001 .

Algal Lectins as Potential HIV Microbicide Candidates

D. Schols, D. Huskens, 2012, Marine drugs.

Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate

N. Matoba, K. Palmer, D. Schols, 2011, PloS one.

Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family.

A. Gronenborn, D. Schols, S. Noppen, 2014, The Journal of antimicrobial chemotherapy.

Development of resistance of human immunodeficiency virus type 1 to dextran sulfate associated with the emergence of specific mutations in the envelope gp120 glycoprotein.

E. De Clercq, A. Vandamme, K. Van Laethem, 1997, Molecular pharmacology.

Mannose-Specific Plant Lectins from the Amaryllidaceae Family Qualify as Efficient Microbicides for Prevention of Human Immunodeficiency Virus Infection

E. De Clercq, J. Balzarini, D. Schols, 2004, Antimicrobial Agents and Chemotherapy.

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

E. De Clercq, R. Pauwels, M. Baba, 1988, Antimicrobial Agents and Chemotherapy.

Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV).

D. Schols, Qingshan Zhang, G. Andrei, 2017, Medicinal chemistry.

Diastereoselective Synthesis of (1,3‐Dioxan‐4‐yl)pyrimidine and Purin Nucleoside Analogues

S. Franchini, L. Brasili, L. Jeong, 2015 .

Mechanisms underlying activity of antiretroviral drugs in HIV‐1‐infected macrophages: new therapeutic strategies

A. Antinori, J. Balzarini, D. Schols, 2006, Journal of leukocyte biology.

Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides

S. van Calenbergh, D. Schols, S. Noppen, 2018, European Journal of Medicinal Chemistry.

Synthesis and Anti‐HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives

P. Herdewijn, M. Luo, D. Schols, 2019, Chemistry & biodiversity.

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.

R. Ptak, P. Herdewijn, M. Luo, 2017, Journal of medicinal chemistry.

Novel Isoxazolidine and γ-Lactam Analogues of Homonucleosides

D. Schols, G. Andrei, R. Snoeck, 2019, Molecules.

The Lantibiotic Peptide Labyrinthopeptin A1 Demonstrates Broad Anti-HIV and Anti-HSV Activity with Potential for Microbicidal Applications

J. Vanderleyden, J. Balzarini, D. Schols, 2013, PloS one.

An efficient one-pot conversion of Boc-protected adenines to N-6-ureas

D. Schols, M. A. Peterson, Paulo A. Machicao, 2015 .

A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity

L. Margolis, J. Balzarini, D. Schols, 2013, PLoS pathogens.

Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).

E. De Clercq, J. Neyts, J. Balzarini, 1990, Virology.

5-Halogeno-3'-fluoro-2',3'-dideoxyuridines as inhibitors of human immunodeficiency virus (HIV): potent and selective anti-HIV activity of 3'-fluoro-2',3'-dideoxy-5-chlorouridine.

E. De Clercq, R. Pauwels, P. Herdewijn, 1989, Molecular pharmacology.

Acyclic nucleoside phosphonates containing the amide bond: hydroxy derivatives

D. Schols, G. Andrei, R. Snoeck, 2019, Monatshefte für Chemie - Chemical Monthly.

Novel isoxazolidine analogues of homonucleosides and homonucleotides

J. Balzarini, D. Schols, G. Andrei, 2016, Tetrahedron.

The Viral Polymerase Inhibitor 7-Deaza-2’-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model

J. Neyts, E. Verbeken, R. E. Marques, 2016, bioRxiv.

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs

D. Schols, G. Andrei, R. Snoeck, 2018, Bioorganic & Medicinal Chemistry.

Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.

E. De Clercq, C. Perno, J. Balzarini, 1996, Molecular pharmacology.

Sulphated Cyclodextrins are Potent anti-HIV Agents Acting Synergistically with 2′,3′-dideoxynucleoside Analogues

A. Van Schepdael, E. De Clercq, R. Pauwels, 1991 .

Therapeutic strategies towards HIV-1 infection in macrophages.

J. Balzarini, D. Schols, S. Aquaro, 2006, Antiviral research.

Synthesis of novel N-acyl-β-d-glucopyranosylamines and ureas as potential lead cytostatic agents

D. Schols, A. Dimopoulou, S. Manta, 2016, Medicinal Chemistry Research.

Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

E. De Clercq, C. Pannecouque, E. Clercq, 2000, Molecular pharmacology.

Bicyclams, Selective Antagonists of the Human Chemokine Receptor CXCR4, Potently Inhibit Feline Immunodeficiency Virus Replication

E. De Clercq, Marian C. Horzinek, J. Balzarini, 1999, Journal of Virology.

AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor

J. Moore, T. Sakmar, D. Schols, 1998, Nature Medicine.

Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines.

E. De Clercq, K. Van Laethem, J. Balzarini, 2006, The Journal of antimicrobial chemotherapy.

Microvirin, a Novel α(1,2)-Mannose-specific Lectin Isolated from Microcystis aeruginosa, Has Anti-HIV-1 Activity Comparable with That of Cyanovirin-N but a Much Higher Safety Profile*

E. Dittmann, J. Balzarini, D. Schols, 2010, The Journal of Biological Chemistry.

The candidate sulfonated microbicide, PRO 2000, has potential multiple mechanisms of action against HIV-1.

D. Schols, A. Profy, D. Huskens, 2009, Antiviral research.

The lectin-like protein 1 in Lactobacillus rhamnosus GR-1 mediates tissue-specific adherence to vaginal epithelium and inhibits urogenital pathogens

Jean M. Macklaim, G. Gloor, G. Reid, 2016, Scientific Reports.

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

J. Matthijnssens, B. Weynand, K. Van Laere, 2020, Nature.

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

J. Matthijnssens, B. Weynand, K. Van Laere, 2020, Nature.

Tetrazolium-based plaque assay for HIV-1 and HIV-2, and its use in the evaluation of antiviral compounds.

E. De Clercq, R. Pauwels, M. Baba, 1989, Journal of virological methods.

Griffithsin, Alone and Combined with All Classes of Antiretroviral Drugs, Potently Inhibits HIV Cell-Cell Transmission and Destruction of CD4+ T cells

K. Palmer, D. Schols, G. Férir, 2012 .

SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus

C. Pannecouque, A. Vandamme, J. Balzarini, 1997 .

Synthesis and antiviral properties of new derivatives of 2-(alkylsulfanyl)-6-[1-(2,6-difluorophenyl)cyclopropyl]-5-methylpyrimidin-4(3H)-one

I. A. Kirillov, D. Schols, A. S. Yablokov, 2016, Russian Journal of Organic Chemistry.

Chemokine receptor antagonists as HIV entry inhibitors

E. Clercq, D. Schols, G. Bridger, 2004 .

Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

M. Swanson, D. Markovitz, J. Stuckey, 2021, Scientific Reports.

Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity

M. Swanson, D. Markovitz, J. Stuckey, 2021, Scientific reports.

Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.

T. Nawrot, N. Kaminski, S. Verleden, 2021, American journal of respiratory and critical care medicine.

A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide

E. Hartmann, E. Krause, D. Schols, 2021, Molecular & cellular proteomics : MCP.

A Derivate of the Antibiotic Doxorubicin Is a Selective Inhibitor of Dengue and Yellow Fever Virus Replication In Vitro

P. Herdewijn, A. Gamarnik, M. Froeyen, 2010, Antimicrobial Agents and Chemotherapy.

Antiviral activity of carbohydrate-binding agents and the role of DC-SIGN in dengue virus infection.

J. Neyts, J. Balzarini, D. Schols, 2009, Virology.

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

P. Maes, J. Matthijnssens, M. Van Ranst, 2020, Nature Communications.

A stabilized CXCL9(74-103)-derived peptide selectively inhibits proliferation, adhesion and metastasis of tumor cells that express high levels of heparan sulfate.

P. Proost, D. Schols, S. Noppen, 2022, International journal of biological macromolecules.

Impact of Cytokines on Replication in the Thymus of Primary Human Immunodeficiency Virus Type 1 Isolates from Infants

W. Boscardin, D. Schols, Y. Bryson, 2002, Journal of Virology.

Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach

B. Cacciari, J. Balzarini, D. Schols, 2018, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of Stilbene-Based Resveratrol Analogs as Cytotoxic Agents

E. Clercq, D. Schols, Sujeet Kumar, 2016 .

Safety concerns for the potential use of cyanovirin-N as a microbicidal anti-HIV agent.

J. Balzarini, D. Schols, D. Huskens, 2008, The international journal of biochemistry & cell biology.

Broad Antiviral Activity of Carbohydrate-Binding Agents Against Dengue Virus Infection

D. Schols, M. Alen, 2012 .

Potent in vitro anti-human immunodeficiency virus-1 activity of modified human serum albumins.

E. De Clercq, R. Pauwels, G. Molema, 1991, Molecular pharmacology.

Coreceptor ligand inhibition of fetal brain cell infection by HIV type 1.

E. De Clercq, L. Epstein, P. Gray, 1999, AIDS research and human retroviruses.

CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages

E. De Clercq, G. Simmons, J. Reeves, 1998, Journal of Virology.

Signal Peptide-Binding Drug as a Selective Inhibitor of Co-Translational Protein Translocation

E. Hartmann, K. Kalies, M. Marsh, 2014, PLoS biology.

Evaluation of a panel of 28 biomarkers for the non-invasive diagnosis of endometriosis.

B. De Moor, O. Gevaert, D. Popovic, 2012, Human reproduction.

Crucial role of the N-glycans on the viral E-envelope glycoprotein in DC-SIGN-mediated dengue virus infection.

J. Neyts, J. Balzarini, D. Schols, 2012, Antiviral research.

Coreceptor Phenotype of Natural Human Immunodeficiency Virus with Nef Deleted Evolves In Vivo, Leading to Increased Virulence

E. De Clercq, M. Goldsmith, J. Mills, 2002, Journal of Virology.

Virulence Evolves In Vivo , Leading to Increased Immunodeficiency Virus with Nef Deleted Coreceptor Phenotype of Natural Human

M. Goldsmith, J. Mills, E. Clercq, 2002 .

Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model

G. Verleden, S. Verleden, C. Verfaillie, 2017, Stem Cell Research & Therapy.

IL-2 reverses human T cell unresponsiveness induced by thymic epithelium in SCID-hu mice.

D. Schols, B. Vandekerckhove, D. Jones, 1994, Journal of immunology.

Anti-SCID mouse reactivity shapes the human CD4+ T cell repertoire in hu-PBL-SCID chimeras

M. Roncarolo, P. Lehmann, D. Schols, 1994, The Journal of experimental medicine.

Immunocytochemical demonstration of proopiomelanocortin- and other opioid-related substances and a CRF-like peptide in the gut of the american cockroach, Periplaneta americana L.

H. Vaudry, P. Verhaert, D. Schols, 2004, Histochemistry.

Skeleton binding protein-1-mediated parasite sequestration inhibits spontaneous resolution of malaria-associated acute respiratory distress syndrome

P. E. Van den Steen, D. Schols, Sigrid D'haese, 2021, PLoS pathogens.

Diverging binding capacities of natural LD78β isoforms of macrophage inflammatory protein‐1α to the CC chemokine receptors 1, 3 and 5 affect their anti‐HIV‐1 activity and chemotactic potencies for neutrophils and eosinophils

Dominique Schols, Paul Proost, E. De Clercq, 2001, European journal of immunology.

Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4

E. De Clercq, D. Schols, G. Bridger, 2002, FEBS letters.

Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes

C. Pannecouque, D. Schols, S. Noppen, 2020, Antimicrobial Agents and Chemotherapy.

In Vivo Evolution of Human Immunodeficiency Virus Type 1 toward Increased Pathogenicity through CXCR4-Mediated Killing of Uninfected CD4 T Cells

E. De Clercq, M. Goldsmith, D. Schols, 2003, Journal of Virology.

Structural analogs of umifenovir 2*. The synthesis and antiHIV activity study of new regioisomeric (trans-2-phenylcyclopropyl)-1Н-indole derivatives

S. Lavrenov, D. Schols, V. V. Kachala, 2015, Chemistry of Heterocyclic Compounds.

Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model

S. Seys, B. Steelant, J. Ceuppens, 2022, Frontiers in Immunology.

A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

L. Nguyen, J. Neyts, R. E. Marques, 2018, npj Vaccines.

Productive Infection of Primary Macrophages with Human Herpesvirus 7

E. De Clercq, D. Schols, S. Aquaro, 2001, Journal of Virology.

Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.

F. Gago, J. Neyts, D. Schols, 2022, European journal of medicinal chemistry.

A SCAFFOLD SIMPLIFICATION STRATEGY LEADS TO A NOVEL GENERATION OF DUAL HUMAN IMMUNODEFICIENCY VIRUS AND ENTEROVIRUS-A71 ENTRY INHIBITORS.

F. Gago, S. Hafenstein, L. Delang, 2019, Journal of medicinal chemistry.

Pradimicin A, a Carbohydrate-Binding Nonpeptidic Lead Compound for Treatment of Infections with Viruses with Highly Glycosylated Envelopes, Such as Human Immunodeficiency Virus

Jan Balzarini, Toshikazu Oki, Dominique Schols, 2006, Journal of Virology.

Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates

F. Gago, J. Neyts, D. Schols, 2023, International Journal of Molecular Sciences.

Multivalent Tryptophan‐ and Tyrosine‐Containing [60]Fullerene Hexa‐Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

F. Gago, J. Neyts, N. Martín, 2021, Chemistry.

Exposure of Raji / DC-SIGN cells to HIV-1 and subsequent cocultivation with CD 4 1 C 8166 cells in the presence of OAA and OPA

A. Gronenborn, D. Schols, S. Noppen, 2014 .

Actinohivin, a Broadly Neutralizing Prokaryotic Lectin, Inhibits HIV-1 Infection by Specifically Targeting High-Mannose-Type Glycans on the gp120 Envelope

K. Van Laethem, J. Balzarini, D. Schols, 2010, Antimicrobial Agents and Chemotherapy.

Resistance of HIV-1 to the broadly HIV-1-neutralizing, anti-carbohydrate antibody 2G12.

K. Van Laethem, J. Balzarini, D. Schols, 2007, Virology.

Mutational Pathways, Resistance Profile, and Side Effects of Cyanovirin Relative to Human Immunodeficiency Virus Type 1 Strains with N-Glycan Deletions in Their gp120 Envelopes

F. Gago, K. Van Laethem, J. Balzarini, 2006, Journal of Virology.

Specific CD4 down‐modulating compounds with potent anti‐HIV activity

D. Schols, K. Vermeire, 2003, Journal of leukocyte biology.

Entry of hepatitis C virus and human immunodeficiency virus is selectively inhibited by carbohydrate-binding agents but not by polyanions.

J. Balzarini, D. Schols, D. Daelemans, 2007, Virology.

Carbohydrate-binding Agents Cause Deletions of Highly Conserved Glycosylation Sites in HIV GP120

M. Froeyen, K. Van Laethem, J. Balzarini, 2005, Journal of Biological Chemistry.

A highly reliable, sensitive, flow cytometric/fluorometric assay for the evaluation of the anti-HIV activity of antiviral compounds in MT-4 cells.

E. De Clercq, R. Pauwels, J. Balzarini, 1988, Journal of immunological methods.

Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket – targeting P-pocket by fragment screening

P. Herdewijn, K. Das, D. Schols, 2021, Nature Communications.

Different Evolution of Genotypic Resistance Profiles to Emtricitabine Versus Lamivudine in Tenofovir-Containing Regimens

F. Ceccherini‐Silberstein, P. Narciso, K. Van Laethem, 2010, Journal of acquired immune deficiency syndromes.

Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120.

D. Schols, K. François, R. Süssmuth, 2012, Virology.

Sugar-Binding Proteins Potently Inhibit Dendritic Cell Human Immunodeficiency Virus Type 1 (HIV-1) Infection and Dendritic-Cell-Directed HIV-1 Transfer

J. Balzarini, D. Schols, S. Turville, 2005, Journal of Virology.

Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis

E. De Clercq, M. Froeyen, K. Van Laethem, 2005, Molecular Pharmacology.

Engineering Lactobacillus rhamnosus GG and GR-1 to express HIV-inhibiting griffithsin.

S. Lebeer, J. Vanderleyden, J. Balzarini, 2018, International journal of antimicrobial agents.

Antitumor and antiviral activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic acid derivatives

K. Pavelić, D. Schols, S. Raić-Malić, 2019, European Journal of Medicinal Chemistry.

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.

E. De Clercq, C. Pannecouque, D. Schols, 2012, Dalton transactions.

Pradimicin S, a Highly Soluble Nonpeptidic Small-Size Carbohydrate-Binding Antibiotic, Is an Anti-HIV Drug Lead for both Microbicidal and Systemic Use

K. Van Laethem, J. Balzarini, D. Schols, 2010, Antimicrobial Agents and Chemotherapy.

Citrullination of CXCL12 Differentially Reduces CXCR4 and CXCR7 Binding with Loss of Inflammatory and Anti-HIV-1 Activity via CXCR41

M. Parmentier, P. Proost, J. Van Damme, 2009, The Journal of Immunology.

AMD3100, a CxCR4 antagonist, attenuates allergic lung inflammation and airway hyperreactivity.

Dominique Schols, D. Schols, G. Bridger, 2002, The American journal of pathology.

Role of CXCR4 in Cell-Cell Fusion and Infection of Monocyte-Derived Macrophages by Primary Human Immunodeficiency Virus Type 1 (HIV-1) Strains: Two Distinct Mechanisms of HIV-1 Dual Tropism

E. De Clercq, D. Kolson, I. Frank, 1999, Journal of Virology.

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120.

H. Jörnvall, T. Bergman, J. Balzarini, 2012, The international journal of biochemistry & cell biology.

CXCR4‐targeting nanobodies differentially inhibit CXCR4 function and HIV entry

C. de Graaf, T. Handel, M. Smit, 2018, Biochemical pharmacology.

Potent neutralizing anti-SARS-CoV-2 human antibodies cure infection with SARS-CoV-2 variants in hamster model

J. Lammertyn, N. Callewaert, J. Neyts, 2021, bioRxiv.

Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides.

E. De Clercq, S. Ikeda, J. Neyts, 1996, Journal of medicinal chemistry.

AMD3100, a Potent and Specific Antagonist of the Stromal Cell-Derived Factor-1 Chemokine Receptor CXCR4, Inhibits Autoimmune Joint Inflammation in IFN-γ Receptor-Deficient Mice1

Dominique Schols, E. De Clercq, A. Billiau, 2001, The Journal of Immunology.

In vivo cytokine expression in the thymus. CD3high human thymocytes are activated and already functionally differentiated in helper and cytotoxic cells.

H. Spits, D. Schols, B. Vandekerckhove, 1994, Journal of immunology.

Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies.

Nicholas C. Pflug, D. Schols, K. Vermeire, 2016, Journal of medicinal chemistry.

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

E. De Clercq, C. Pannecouque, D. Schols, 1999, Journal of medicinal chemistry.

Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.

E. De Clercq, C. Pannecouque, J. Neyts, 1998, Journal of medicinal chemistry.

Quantitative evaluation of HIV-1 coreceptor use in the GHOST3 cell assay.

E. De Clercq, E. Fenyö, D. Schols, 2001, Virology.

Inhibition of HIV infection by CXCR4 and CCR5 chemokine receptor antagonists.

E. De Clercq, E. Clercq, D. Schols, 2001, Antiviral chemistry & chemotherapy.

Different contributions of chemokine N‐terminal features attest to a different ligand binding mode and a bias towards activation of ACKR3/CXCR7 compared with CXCR4 and CXCR3

N. Heveker, B. Volkman, Amanda M. Nevins, 2017, British journal of pharmacology.

A Human Immunodeficiency Virus Type 1 Isolate from an Infected Person Homozygous for CCR5Δ32 Exhibits Dual Tropism by Infecting Macrophages and MT2 Cells via CXCR4

G. Stewart, Hassan Mohammad Naif, E. Clercq, 2002, Journal of Virology.

T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use

E. De Clercq, D. Schols, J. Esté, 1998, Journal of Virology.

Development of a cell-based enzyme-linked immunosorbent assay for high-throughput screening of HIV type 1 entry inhibitors targeting the coreceptor CXCR4.

E. De Clercq, Hong-tao Lu, Shibo Jiang, 2003, AIDS research and human retroviruses.

Nucleoside Diphosphate Prodrugs: Nonsymmetric DiPPro-Nucleotides.

J. Balzarini, D. Schols, C. Meier, 2015, Journal of medicinal chemistry.

Cryo-EM structures of Doravirine and Rilpivirine with HIV-1 Reverse Transcriptase/DNA Aptamer – Nonnucleoside Inhibitor Resistance by E138K and M184I Mutations

C. Pannecouque, E. Arnold, P. Herdewijn, 2022, bioRxiv.

Synergistic in vitro anti-HIV type 1 activity of tenofovir with carbohydrate-binding agents (CBAs).

E. Dittmann, M. Swanson, D. Markovitz, 2011, Antiviral research.

Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer

D. Timmerman, L. Boon, P. Agostinis, 2021, Journal for ImmunoTherapy of Cancer.

Palladium-catalyzed cross-coupling reactions on a bromo-naphthalene scaffold in the search for novel human CC chemokine receptor 8 (CCR8) antagonists.

T. T. Nguyen, W. Dehaen, A. Voet, 2020, Bioorganic chemistry.

Novel, negatively charged, human serum albumins display potent and selective in vitro anti-human immunodeficiency virus type 1 activity.

E. De Clercq, R. Pauwels, D. Meijer, 1993, Molecular pharmacology.

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor.

Dominique Schols, E. De Clercq, T. Schwartz, 2005, Biochemical pharmacology.

Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR 5 / CXCR 4 Antagonist

Erik De Clercq, Dominique Schols, T. Schwartz, 2004 .

Mutations at the CXCR4 interaction sites for AMD3100 influence anti‐CXCR4 antibody binding and HIV‐1 entry

Dominique Schols, E. De Clercq, T. Schwartz, 2003, FEBS letters.

Preprotein signature for full susceptibility to the co‐translational translocation inhibitor cyclotriazadisulfonamide

E. Hartmann, K. Kalies, D. Schols, 2020, Traffic.

Nanobody‐Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4‐mediated HIV‐entry and induce antibody effector functions

M. Smit, T. Van Loy, D. Schols, 2018, Biochemical pharmacology.

Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists

W. Dehaen, T. Van Loy, D. Schols, 2021, Molecules.

HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.

R. Doms, E. De Clercq, B. Freedman, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Molecules.

Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.

Y. Pommier, E. De Clercq, C. Pannecouque, 2000, Molecular pharmacology.

Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model

A. Luttun, T. Van Loy, D. Schols, 2022, Cellular and Molecular Life Sciences.

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4.

G. Schoofs, T. Van Loy, D. Schols, 2018, Journal of visualized experiments : JoVE.

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators.

T. Van Loy, D. Schols, S. Claes, 2018, Journal of visualized experiments : JoVE.

Synthesis of 2-[(ω-phthalimidoalkyl)sulfanyl]- pyrimidin-4(3H)-ones, their cytotoxicity and in vitro activity against HIV-1/2

D. Schols, I. Novakov, V. Chapurkin, 2020, Chemistry of Heterocyclic Compounds.

Itaconic acid hybrids as potential anticancer agents

D. Schols, L. Persoons, I. Perković, 2020, Molecular diversity.

Bis(benzoyloxybenzyl)‐DiPPro Nucleoside Diphosphates of Anti‐HIV Active Nucleoside Analogues

J. Balzarini, D. Schols, C. Meier, 2015, ChemMedChem.

Diffusion of Two Potential Anti-HIV Microbicides across Intact and De-Epithelialised, Human Vaginal Mucosa

J. Balzarini, J. V. van Zyl, D. Schols, 2008 .

In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).

C. Charpentier, G. Vanham, J. Balzarini, 2009, The Journal of antimicrobial chemotherapy.

Amino-terminal Truncation of Chemokines by CD26/Dipeptidyl-peptidase IV

Dominique Schols, Paul Proost, E. De Clercq, 1998, The Journal of Biological Chemistry.

Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues.

M. Drew, V. Catalano, D. Schols, 2006, Journal of medicinal chemistry.

Synthesis, characterization and anti-HIV activity of polycarboxylic [60]fullerene derivatives obtained in the reaction of C60Cl6 with a hydroquinone ether

P. Troshin, I. Godovikov, J. Balzarini, 2020 .

STAT2 signaling as double-edged sword restricting viral dissemination but driving severe pneumonia in SARS-CoV-2 infected hamsters

P. Maes, J. Matthijnssens, M. Van Ranst, 2020, bioRxiv.

Synthesis of different types of alkoxy fullerene derivatives from chlorofullerene C60Cl6.

P. Troshin, S. Troyanov, D. Schols, 2017, Organic & biomolecular chemistry.

Biological characterization of ligands targeting the human CC chemokine receptor 8 (CCR8) reveals the biased signaling properties of small molecule agonists.

W. Dehaen, T. Van Loy, D. Schols, 2021, Biochemical pharmacology.

Labyrinthopeptins Exert Broad-Spectrum Antiviral Activity through Lipid-Binding-Mediated Virolysis

A. Meyerhans, T. Schulz, T. Pietschmann, 2019, Journal of Virology.

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

P. Herdewijn, M. Abramov, D. Schols, 2019, Nucleic acids research.

CXCR4 is the primary receptor for feline immunodeficiency virus in astrocytes

T. Tabira, K. Nakagaki, E. Clercq, 2001, Journal of NeuroVirology.

Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.

W. Dehaen, T. Van Loy, D. Schols, 2023, European journal of medicinal chemistry.

A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening

Janez Konc, T. Van Loy, D. Schols, 2022, Frontiers in Pharmacology.

FO‐SPR biosensor calibrated with recombinant extracellular vesicles enables specific and sensitive detection directly in complex matrices

J. Lammertyn, D. Spasic, F. Delport, 2021, Journal of extracellular vesicles.

Water-Promoted Reaction of C60Ar5Cl Compounds with Thiophenes Delivers a Family of Multifunctional Fullerene Derivatives with Selective Antiviral Properties.

P. Troshin, D. Schols, V. Zarubaev, 2021, Organic letters.

Thiophene-based water-soluble fullerene derivatives as highly potent antiherpetic pharmaceuticals.

P. Troshin, I. Godovikov, D. Schols, 2020, Organic & biomolecular chemistry.

A regioselective step-by-step C60Cl6 functionalization approach affords a novel family of C60Ar5Th'Th''H fullerene derivatives with promising antiviral properties.

P. Troshin, D. Schols, A. Shestakov, 2023, Chemical communications.

Labyrinthopeptin A1 inhibits dengue and Zika virus infection by interfering with the viral phospholipid membrane.

D. Schols, S. Noppen, R. Süssmuth, 2021, Virology.

Assessment of protein biomarkers for preoperative differential diagnosis between benign and malignant ovarian tumors.

T. Bourne, B. van Calster, D. Timmerman, 2020, Gynecologic oncology.

Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells.

E. De Clercq, D. Schols, G. Andrei, 2001, Oncology research.

A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA)*

D. Schols, K. Vermeire, T. Bell, 2016, Molecular & Cellular Proteomics.

FLUIDOT: A Modular Microfluidic Platform for Single‐Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining

J. Lammertyn, D. Spasic, D. Schols, 2023, Small methods.

Unique cytokine production profile of anergic human T cells in SCID-hu mice after staphylococcal enterotoxin B administration.

D. Schols, D. Jones, M. Roncarolo, 1995, Journal of immunology.

Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2

W. Dehaen, T. Van Loy, D. Schols, 2023, Molecules.

Development of a Novel SPR Assay to Study CXCR4–Ligand Interactions

K. Das, D. Schols, S. Noppen, 2020, Biosensors.

Immunoregulatory effects of multipotent adult progenitor cells in a porcine ex vivo lung perfusion model

G. Verleden, S. Verleden, C. Verfaillie, 2017, Stem Cell Research & Therapy.

Virus-inhibitory peptide: a natural HIV entry inhibitor in search for a formal target in the viral genome.

M. Quiñones-Mateu, D. Schols, 2011, AIDS.

[Role of chemokines in the HIV infection process].

P. Proost, D. Schols, 2002, Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie.

Circulating Donor-Specific Anti-HLA Antibodies Associate With Immune Activation Independent of Kidney Transplant Histopathological Findings

P. Proost, D. Schols, D. Kuypers, 2022, Frontiers in Immunology.

Carbohydrate-binding agents (CBAs) inhibit HIV-1 infection in human primary monocyte-derived macrophages (MDMs) and efficiently prevent MDM-directed viral capture and subsequent transmission to CD4+ T lymphocytes.

J. Balzarini, D. Schols, E. V. Van Damme, 2008, Virology.

Inhibition of HIV-1-Induced Cytopathogenicity, Syncytium Formation, and Virus-Cell Binding by Naphthalenedisulphonic Acids through Interaction with the Viral Envelope gp120 Glycoprotein

E. De Clercq, M. Baba, D. Schols, 1993 .

Development and Identification of a Novel Anti-HIV-1 Peptide Derived by Modification of the N-Terminal Domain of HIV-1 Integrase

E. Novellino, P. Grieco, A. Bertamino, 2016, Front. Microbiol..

Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents

Adriano Camps, J. Neyts, D. Schols, 2022, Frontiers in Chemistry.

A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present)

D. Schols, S. de Jonghe, Belén Martínez-Gualda, 2021, Expert opinion on therapeutic patents.

Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics

B. de Strooper, Isabelle M S Degors, D. Schols, 2023, Pharmaceutics.

Selective activity of several cholic acid derivatives against human immunodeficiency virus replication in vitro.

E. De Clercq, R. Pauwels, D. Meijer, 1989, Journal of Acquired Immune Deficiency Syndromes.

Fuchsin acid selectively inhibits human immunodeficiency virus (HIV) replication in vitro.

E. De Clercq, R. Pauwels, M. Baba, 1988, Biochemical and biophysical research communications.

Human Immunodeficiency Virus Type 1 Escape from Cyclotriazadisulfonamide-Induced CD4-Targeted Entry Inhibition Is Associated with Increased Neutralizing Antibody Susceptibility

K. Van Laethem, D. Schols, K. Vermeire, 2009, Journal of Virology.

Resistance to raltegravir highlights integrase mutations at codon 148 in conferring cross-resistance to a second-generation HIV-1 integrase inhibitor.

K. Hertogs, M. Cummings, R. Clayton, 2011, Antiviral research.

Design, Synthesis and Biological Evaluation of Novel Primaquine-Cinnamic Acid Conjugates of the Amide and Acylsemicarbazide Type

D. Hadjipavlou-Litina, M. Kralj, D. Schols, 2016, Molecules.

Isolation and identification of naturally modified C-C chemokines MCP-1, MCP-2 and RANTES: effects of posttranslational modifications on receptor usage, chemotactic and anti-HIV-1 activity.

E. De Clercq, P. Proost, A. Lambeir, 1998, European Cytokine Network.

Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1, 2, 3-triazole derivatives

C. Fimognari, E. Catanzaro, D. Schols, 2022, Comput. Biol. Chem..

Structural investigation and anti-HIV activities of high molecular weight ATA polymers

E. Clercq, D. Schols, M. Cushman, 1992 .

A novel experimental porcine model to assess the impact of differential pulmonary blood flow on ischemia–reperfusion injury after unilateral lung transplantation

G. Verleden, S. Verleden, D. Schols, 2020, Intensive Care Medicine Experimental.

A Novel Series of Indole Alkaloid Derivatives Inhibit Dengue and Zika Virus Infection by Interference with the Viral Replication Complex

P. Lemey, C. Pannecouque, D. Schols, 2021, Antimicrobial agents and chemotherapy.

A Novel Experimental Porcine Model to Assess the Impact of Differential Pulmonary Blood Flow on Primary Graft Dysfunction After Unilateral Lung Transplantation

G. Verleden, S. Verleden, D. Schols, 2020 .

Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100.

E. De Clercq, T. Schwartz, E. Clercq, 2001, Molecular pharmacology.

Synthesis of novel thioalkylated triazolothiazoles and their promising in-vitro antiviral activity

D. Schols, S. Claes, L. Persoons, 2023, Journal of Molecular Structure.

Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles.

Dominique Schols, Kurt Hertogs, K. Hertogs, 2010, Virology.

Differences in the mannose oligomer specificities of the closely related lectins from Galanthus nivalis and Zea mays strongly determine their eventual anti-HIV activity

K. Van Laethem, P. Rougé, J. Balzarini, 2011, Retrovirology.

Capture and transmission of HIV-1 by the C-type lectin L-SIGN (DC-SIGNR) is inhibited by carbohydrate-binding agents and polyanions.

E. Vanstreels, K. Van Laethem, J. Balzarini, 2009, Antiviral research.

Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells.

E. De Clercq, R. Pauwels, D. Schols, 1990, Cytometry.

Acyclic/Carbocyclic Guanosine Analogues as Anti‐Herpesvirus Agents

L. Naesens, B. Degrève, J. Balzarini, 2001 .

Exploring the purine core of 3′-C-ethynyladenosine (EAdo) in search of novel nucleoside therapeutics

S. van Calenbergh, J. Balzarini, D. Schols, 2016, Bioorganic & Medicinal Chemistry Letters.

Inhibitors of HIV infection via the cellular CD4 receptor.

D. Schols, K. Vermeire, T. Bell, 2006, Current medicinal chemistry.

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor.

G. Vanham, D. Schols, P. Augustijns, 2008, Current HIV research.

Cyclotriazadisulfonamides: promising new CD4-targeted anti-HIV drugs.

D. Schols, K. Vermeire, 2005, The Journal of antimicrobial chemotherapy.

New nitrogen containing substituents at the indole-2-carboxamide yield high potent and broad spectrum indolylarylsulfone HIV-1 non-nucleoside reverse transcriptase inhibitors.

E. Novellino, B. Clotet, A. Coluccia, 2012, Journal of medicinal chemistry.

BAL neutrophilia in azithromycin-treated lung transplant recipients: Clinical significance.

G. Verleden, S. Verleden, P. Proost, 2015, Transplant immunology.

Combination of antiretroviral drugs as microbicides.

J. Balzarini, D. Schols, 2012, Current HIV research.

Novel Recombinant Virus Assay for Measuring Susceptibility of Human Immunodeficiency Virus Type 1 Group M Subtypes To Clinically Approved Drugs

A. Vandamme, K. Van Laethem, M. Quiñones-Mateu, 2009, Journal of Clinical Microbiology.

Profile of Resistance of Human Immunodeficiency Virus to Mannose-Specific Plant Lectins

E. De Clercq, A. Vandamme, K. Van Laethem, 2004, Journal of Virology.

Spermine and spermidine bind CXCR4 and inhibit CXCR4- but not CCR5-tropic HIV-1 infection

Yasser B. Ruiz-Blanco, J. Münch, S. Wiese, 2023, Science advances.

Agonist-Induced Internalization of CC Chemokine Receptor 5 as a Mechanism to Inhibit HIV Replication

D. Schols, F. Ooms, T. Ferain, 2011, Journal of Pharmacology and Experimental Therapeutics.

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

L. Vincent, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

Improving potencies and properties of CD4 down-modulating CADA analogs

D. Schols, K. Vermeire, T. Bell, 2012, Expert opinion on drug discovery.

CD4 down-modulating compounds with potent anti-HIV activity.

D. Schols, K. Vermeire, T. Bell, 2004, Current pharmaceutical design.

Synthesis and cancer cell cytotoxicity of 2-aryl-4-(4-aryl-2-oxobut-3-en-1-ylidene)-substituted benzothiazepanes

J. Van Camp, D. Schols, C. Grootaert, 2023, Phytochemistry Letters.

Prospective CCR5 small molecule antagonist compound design using a combined mutagenesis/modeling approach.

D. Schols, S. Fricker, G. Bridger, 2011, Journal of the American Chemical Society.

Synthesis and Structure−Activity Relationship Studies of CD4 Down-Modulating Cyclotriazadisulfonamide (CADA) Analogues

M. Drew, V. Catalano, D. Schols, 2006 .

PRO-2000 exhibits SARS-CoV-2 antiviral activity by interfering with spike-heparin binding.

L. Naesens, G. Schoofs, D. Schols, 2023, Antiviral research.

Synthesis of CADA Analog Prodrugs Designed as Novel Down-modulators of the CD4 Receptor

D. Schols, K. Vermeire, E. Scarbrough, 2009 .

Synthesis of Novel CADA Analog Prodrugs Designed as Down-Modulators of the CD4 Receptor

D. Schols, K. Vermeire, E. Scarbrough, 2010 .

Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines as highly potent inhibitors of cyclin G-associated kinase.

P. Herdewijn, M. Froeyen, D. Schols, 2021, European journal of medicinal chemistry.

Synthesis of Enantiomerically Pure 1′,2′-cis-dideoxy, -dideoxydidehydro, -ribo and -deoxy Carbocyclic Nucleoside Analogues

J. Neyts, D. Schols, C. Meier, 2018, Synthesis.

The Phthalocyanine Prototype Derivative Alcian Blue Is the First Synthetic Agent with Selective Anti-Human Immunodeficiency Virus Activity Due to Its gp120 Glycan-Binding Potential

C. Pannecouque, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

Inhibition of human IgE synthesis in vitro and in SCID-hu mice by an interleukin-4 receptor antagonist.

G. Aversa, J. D. de Vries, D. Schols, 1995, International archives of allergy and immunology.

Mitigating hERG Inhibition: Design of Orally Bioavailable CCR5 Antagonists as Potent Inhibitors of R5 HIV-1 Replication.

D. Schols, R. Wong, S. Fricker, 2012, ACS medicinal chemistry letters.

HIV-1 gp 120 and chemokines activate ion channels in primary macrophages through CCR 5 and CXCR 4 stimulation

R. Doms, B. Freedman, C. Mcmanus, 2000 .

Lymphoid and myeloid differentiation of fetal liver CD34+lineage- cells in human thymic organ culture

J. D. de Vries, H. Spits, D. Schols, 1994, The Journal of experimental medicine.

A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

L. Nguyen, J. Neyts, R. E. Marques, 2018, npj Vaccines.

C-terminal truncation of CXCL10 attenuates inflammatory activity but retains angiostatic properties

P. Proost, D. Schols, S. Struyf, 2023, bioRxiv.

CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.

E. De Clercq, C. Pannecouque, D. Schols, 2012, Dalton transactions.

Chemotherapy of human immunodeficiency virus by pradimicin A: a novel therapeutic concept for treatment of glycosylated enveloped viruses

C. Perno, J. Balzarini, D. Schols, 2006 .

Long-Lasting Enfuvirtide Carrier Pentasaccharide Conjugates with Potent Anti-Human Immunodeficiency Virus Type 1 Activity

L. Vincent, J. Balzarini, D. Schols, 2009, Antimicrobial Agents and Chemotherapy.

In silico design, synthesis and anti-HIV activity of quinoline derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs)

D. Schols, P. Kumari, Richa Mishra, 2022, Comput. Biol. Chem..

Exploring antiviral potency of N-1 substituted pyrimidines against HIV-1 and other DNA/RNA viruses: Design, synthesis, characterization, ADMET analysis, docking, molecular dynamics and biological activity

Parth Sarthi Sen Gupta, S. Gupta, D. Schols, 2023, Comput. Biol. Chem..

Total synthesis of the antiviral peptide antibiotic feglymycin.

D. Schols, R. Süssmuth, Anne Hänchen, 2009, Angewandte Chemie.

ACYCLIC/CARBOCYCLIC GUANOSINE ANALOGUES AS ANTI-HERPESVIRUS AGENTS

L. Naesens, J. Neyts, B. Degrève, 2001 .

Cell-Based Electrical Impedance Platform to Evaluate Zika Virus Inhibitors in Real Time.

D. Schols, M. Oeyen, Eef Meyen, 2023, Journal of visualized experiments : JoVE.

The role of cytokines in transplantation tolerance

M. Roncarolo, D. Schols, R. Bacchetta, 1995 .