B. Herpers

发表

Lentivirus-mediated gene transfer in primary T cells is enhanced by a central DNA flap

N. Taylor, P. Charneau, D. Guétard, 2001, Gene Therapy.

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

B. Herpers, B. Water, S. Ramaiahgari, 2014, Archives of Toxicology.

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

R. Minter, A. Sandercock, L. Jermutus, 2015, Molecular Cancer.

Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases.

C. Ponting, S. Gledhill, B. Herpers, 2003, Biochimica et biophysica acta.

Differential range and activity of various forms of the Hedgehog protein

Rebecca J. Dawber, B. Herpers, F. Docquier, 2005, BMC Developmental Biology.

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

Automated Analysis of NF-κB Nuclear Translocation Kinetics in High-Throughput Screening

Fons J. Verbeek, Bob van de Water, Kuan Yan, 2012, PloS one.

High Content Imaging‐Based Screening for Cellular Toxicity Pathways

Bob van de Water, B. Herpers, B. Water, 2013 .

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells.

Bob van de Water, Lisa Fredriksson, B. van de Water, 2013, Biochemical pharmacology.

Restoration of chemosensitivity for doxorubicin and cisplatin in chondrosarcoma in vitro: BCL-2 family members cause chemoresistance.

A. Cleton-Jansen, B. van de Water, H. Gelderblom, 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

M. Stratton, H. Clevers, J. Tabernero, 2022, Nature Cancer.

Diclofenac inhibits TNFa-induced NF-kB activation causing synergistic hepatocyte apoptosis

B. Herpers, 2012 .

Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility

B. Herpers, L. Price, J. Helin, 2018, Antibodies.

ISH–IEM: a sensitive method to detect endogenous mRNAs at the ultrastructural level

C. Rabouille, B. Herpers, Despina Xanthakis, 2010, Nature Protocols.

Getting the most out of 3D cell based assays with high content image analysis and phenotypic profiling

B. Herpers, L. Price, K. Yan, 2018 .

Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants

B. Herpers, D. Sévin, D. Pritchard, 2022, Archives of Toxicology.

The Nuclear Factor k B Family Member RelB Facilitates Apoptosis of Renal Epithelial Cells Caused by Cisplatin/Tumor Necrosis Factor a Synergy by Suppressing an Epithelial to Mesenchymal Transition – Like Phenotypic Switch s

J. Meerman, B. Herpers, B. Water, 2013 .

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

J. Kleinjans, J. Saez-Rodriguez, Seung-Wook Chung, 2021, Archives of Toxicology.

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

G. Groothuis, E. Danen, B. van de Water, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy

Sylvia E. Le Dévédec, M. Smid, J. Martens, 2021, Scientific Reports.

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Bob van de Water, Harry Vrieling, Giel Hendriks, 2014, Chemical research in toxicology.

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

G. Groothuis, F. Russel, B. Herpers, 2012, Archives of Toxicology.

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies

B. Herpers, B. Water, S. Ramaiahgari, 2014, Archives of Toxicology.

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities

Bob van de Water, Steven Wink, B. van de Water, 2016, Archives of Toxicology.

Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling

R. Minter, A. Sandercock, L. Jermutus, 2015, Molecular Cancer.

Asymmetric localization of Gurken protein and mRNA in the oocyte of Drosophila melanogaster

B. Herpers, 2006 .

The golgi comprises a paired stack that is separated at G2 by modulation of the actin cytoskeleton through Abi and Scar/WAVE.

Florence Friggi-Grelin, C. Rabouille, V. Kondylis, 2007, Developmental cell.

Drosophila patterning is established by differential association of mRNAs with P bodies

Ian M. Dobbie, Ilan Davis, Richard M. Parton, 2012, Nature Cell Biology.

Hherisomes, Hedgehog specialized recycling endosomes, are required for high level Hedgehog signaling and tissue growth.

C. Rabouille, B. Herpers, P. Thérond, 2021, Journal of cell science.

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids

J. Kleinjans, Seung-Wook Chung, B. Herpers, 2022, International journal of molecular sciences.

Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis

Bob van de Water, Sanja Dragovic, Lisa Fredriksson, 2011, Hepatology.

Drosophila Squid/hnRNP helps Dynein switch from a gurken mRNA transport motor to an ultrastructural static anchor in sponge bodies.

C. Rabouille, B. Herpers, R. Delanoue, 2007, Developmental cell.

Src kinases in chondrosarcoma chemoresistance and migration: dasatinib sensitises to doxorubicin in TP53 mutant cells

B. van de Water, H. Gelderblom, B. Herpers, 2013, British Journal of Cancer.

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids

J. Kleinjans, Seung-Wook Chung, B. Herpers, 2022, International journal of molecular sciences.

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity

B. van de Water, G. Hendriks, H. Vrieling, 2015, Archives of Toxicology.

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials

B. van de Water, B. K. Park, B. Herpers, 2012, Molecular medicine.

The Nuclear Factor κB Family Member RelB Facilitates Apoptosis of Renal Epithelial Cells Caused by Cisplatin/Tumor Necrosis Factor α Synergy by Suppressing an Epithelial to Mesenchymal Transition–Like Phenotypic Switch

B. van de Water, J. Meerman, B. Herpers, 2013, Molecular Pharmacology.

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors

T. Dale, K. Ewan, A. Clarke, 2019, bioRxiv.

mRNA localization and ER-based protein sorting mechanisms dictate the use of transitional endoplasmic reticulum-golgi units involved in gurken transport in Drosophila oocytes.

C. Rabouille, B. Herpers, 2004, Molecular biology of the cell.

Abstract 198: Pan-cancer assay-ready organoid drug screening with robust, reproducible and clinically-relevant output

M. Putker, B. Herpers, L. Price, 2023, Cancer Research.

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

B. van de Water, M. de Graauw, B. Herpers, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Bmc Developmental Biology Differential Range and Activity of Various Forms of the Hedgehog Protein

B. Herpers, F. Docquier, Stephen Hebbes, 2022 .