M. Witvrouw

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Integrase Mutants Defective for Interaction with LEDGF/p75 Are Impaired in Chromosome Tethering and HIV-1 Replication*

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2005, Journal of Biological Chemistry.

Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Journal of medicinal chemistry.

Evaluation of the anti-HIV activity of statins

B. Clotet, E. Negredo, M. Witvrouw, 2005, AIDS.

Synthesis and anti-HIV-1 and anti-HCMV activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil derivatives.

E. De Clercq, C. Pannecouque, J. Balzarini, 2006, Chemical & pharmaceutical bulletin.

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

J. Duan, M. Garneau, P. Bonneau, 2014, Antimicrobial Agents and Chemotherapy.

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions.

Z. Debyser, F. Christ, M. Witvrouw, 2009, Journal of medicinal chemistry.

In Search of Authentic Inhibitors of HIV-1 Integration

E. De Clercq, P. Cherepanov, Z. Debyser, 2002, Antiviral chemistry & chemotherapy.

Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations.

E. De Clercq, T. Harrer, M. Van Ranst, 1999, Journal of Acquired Immune Deficiency Syndromes.

Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides: The search for linked π-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase

E. Clercq, M. Witvrouw, J. Marco, 1997 .

Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain.

E. De Clercq, A. Vandamme, J. Balzarini, 1996, The Journal of infectious diseases.

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors

E. De Clercq, C. Pannecouque, A. Vandamme, 2002, Antimicrobial Agents and Chemotherapy.

Synthesis and Antiviral Activities of 3-Aralkyl-Thiomethylimidazo[1,2-b]Pyridazine Derivatives

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

Synthesis and antiviral properties of some polyphenols related to Salvia genus.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Bioorganic & medicinal chemistry letters.

Antiviral resistance to diketo acids is associated with the mutations T66I, L74M and S230R in the HIV-1 integrase gene

C. Pannecouque, N. Neamati, T. Burke, 2002 .

Discovery of 2,3-diaryl-1,3-thiazolidin-4-ones as potent anti-HIV-1 agents.

E. De Clercq, C. Pannecouque, J. Balzarini, 2001, Bioorganic & medicinal chemistry letters.

Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect.

E. De Clercq, R. Pauwels, M. Baba, 1993, Journal of medicinal chemistry.

Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro.

G. Georgsson, M. Witvrouw, H. Thormar, 1999, Sexually transmitted infections.

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

E. De Clercq, R. Pauwels, B. Rosenwirth, 1994, Antimicrobial Agents and Chemotherapy.

Differential antiviral activity of derivatized dextrans.

S. Ikeda, J. Neyts, D. Letourneur, 1995, Biochemical pharmacology.

Antiviral Portrait Series: 4. Polysuifates as Inhibitors of HIV and Other Enveloped Viruses

E. De Clercq, M. Witvrouw, J. Desmyter, 1994 .

Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).

E. De Clercq, C. Pannecouque, B. Clotet, 1998, Molecular pharmacology.

Mutations in Both env and gag genes are required for HIV-1 resistance to the polysulfonic dendrimer SPL2923, as corroborated by chimeric virus technology

E. De Clercq, A. Vandamme, Z. Debyser, 2005, Antiviral chemistry & chemotherapy.

env Chimeric Virus Technology for Evaluating Human Immunodeficiency Virus Susceptibility to Entry Inhibitors

C. Pannecouque, A. Vandamme, K. Van Laethem, 2003, Antimicrobial Agents and Chemotherapy.

Resistance of the human immunodeficiency virus to the inhibitory action of negatively charged albumins on virus binding to CD4.

E. De Clercq, B. Clotet, D. Meijer, 1999, AIDS research and human retroviruses.

Synthesis and anti-HIV activity of 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazines (TTDs): a new family of HIV-1 specific non-nucleoside reverse transcriptase inhibitors.

E. De Clercq, J. Balzarini, M. Witvrouw, 1999, Bioorganic & medicinal chemistry.

New arylpyrido-diazepine and -thiodiazepine derivatives are potent and highly selective HIV-1 inhibitors targeted at the reverse transcriptase.

E. De Clercq, R. Pauwels, G. Antonelli, 1996, Antiviral research.

In vitro evaluation of the effect of temporary removal of HIV drug pressure.

C. Pannecouque, M. Witvrouw, K. Andries, 2000, Antiviral research.

Sulfated polysaccharides extracted from sea algae as potential antiviral drugs.

E. Clercq, M. Witvrouw, E. De Clercq, 1997, General pharmacology.

Modified Cyclodextrin Sulphates(mCDS11) have Potent Inhibitory Activity against HIV and High Oral Bioavailability

E. De Clercq, L. Naesens, D. Schols, 1994 .

SYNTHESIS AND BIOLOGICAL ACTIVITY OF 4-SUBSTITUTED 1-[1-(2-HYDROXYETHOXY)- METHYL-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1H-PYRAZOLO[3,4-d]PYRIMIDINES

E. De Clercq, C. Pannecouque, M. Witvrouw, 2001, Nucleosides, nucleotides & nucleic acids.

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 4-SUBSTITUTED 1-[1-(4-HYDROXYBUTYL)-1,2,3-TRIAZOL-(4 & 5)-YLMETHYL]-1H-PYRAZOLO-[3,4-d]PYRIMIDINES

E. De Clercq, C. Pannecouque, M. Witvrouw, 2001, Nucleosides, nucleotides & nucleic acids.

Synthesis and Structure−Activity Relationships of Phenylenebis(methylene)- Linked Bis-tetraazamacrocycles That Inhibit Human Immunodeficiency Virus Replication. 2. Effect of Heteroaromatic Linkers on the Activity of Bicyclams

E. De Clercq, R. Pauwels, M. Witvrouw, 1996 .

2-hydroxyisoquinoline-1,3(2H,4H)-diones as inhibitors of HIV-1 integrase and reverse transcriptase RNase H domain: influence of the alkylation of position 4.

F. Bailly, Z. Debyser, C. Calmels, 2011, European journal of medicinal chemistry.

Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137

A. Voet, M. de Maeyer, Z. Debyser, 2008, Antimicrobial Agents and Chemotherapy.

Mechanism of the Antiviral Activity of New Aurintricarboxylic Acid Analogues

E. De Clercq, J. Neyts, D. Schols, 1996 .

Antiviral activity of a sulphated polysaccharide from the red seaweed Nothogenia fastigiata.

E. Damonte, S. Ikeda, J. Neyts, 1994, Biochemical pharmacology.

New Polyacetal Polysulphate Active against Human Immunodeficiency Virus and other Enveloped Viruses

A. Van Schepdael, E. De Clercq, R. Pauwels, 1992 .

Toward novel HIV-1 integrase binding inhibitors: molecular modeling, synthesis, and biological studies.

C. Tintori, M. Botta, Z. Debyser, 2007, Bioorganic & medicinal chemistry letters.

New 3'-azido-3'-deoxythymidin-5'-yl O-(4-hydroxyalkyl or -alkenyl or -alkylepoxide) carbonate prodrugs: synthesis and anti-HIV evaluation.

E. De Clercq, C. Pannecouque, J. Kraus, 2001, Journal of medicinal chemistry.

New 3'-azido-3'-deoxythymidin-5'-yl O-(omega-hydroxyalkyl) carbonate prodrugs: synthesis and anti-HIV evaluation.

E. De Clercq, C. Pannecouque, F. Bihel, 2001, Journal of medicinal chemistry.

Conversion of 2′,3′‐dideoxyadenosine (ddA) and 2′,3′‐didehydro‐2′,3′‐dideoxyadenosine (d4A) to their corresponding aryloxyphosphoramidate derivatives markedly potentiates their activity against human immunodeficiency virus and hepatitis B virus

E. De Clercq, C. Pannecouque, L. Naesens, 1997, FEBS letters.

Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.

E. De Clercq, C. Perno, J. Balzarini, 1996, Biochemical and biophysical research communications.

Discovery of a Tat HIV-1 Inhibitor through Computer-Aided Drug Design

C. Pannecouque, J. Sturgis, E. Clercq, 2003 .

Inhibition of Human Immunodeficiency Virus Type 1 Integration by Diketo Derivatives

E. De Clercq, C. Pannecouque, N. Neamati, 2002, Antimicrobial Agents and Chemotherapy.

Synthesis and anti-HIV evaluation of the novel 2-(m-chlorobenzyl)-4-substituted-7-methyl-1, 1, 3-trioxo-pyrazolo[4, 5-e] [1, 2, 4]thiadiazines

C. Pannecouque, Xinyong Liu, E. Clercq, 2006, Archives of pharmacal research.

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2008, Journal of medicinal chemistry.

Synthesis and Anti‐HIV Activity Evaluation of Novel 2,4‐Disubstituted 7‐Methyl‐1,1,3‐trioxo‐2,4‐dihydro‐pyrazolo‐[4,5‐e][1,2]thiadiazines

E. De Clercq, C. Pannecouque, P. Zhan, 2008, Archiv der Pharmazie.

Synthesis of New Potential HIV-1 Integrase Inhibitors

Z. Debyser, M. Witvrouw, S. Ferro, 2004 .

Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Farmaco.

Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines.

Myriam Witvrouw, Jean-Jacques Vasseur, Christophe Pannecouque, 2002, Farmaco.

Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV-1 reverse transcriptase inhibitors

C. Pannecouque, E. Clercq, M. Witvrouw, 2001 .

New 4‐[(1‐Benzyl‐1H‐indol‐3‐yl)carbonyl]‐3‐hydroxyfuran‐2(5H)‐ones, β‐Diketo Acid Analogs as HIV‐1 Integrase Inhibitors

Z. Debyser, M. Witvrouw, S. Ferro, 2007, Archiv der Pharmazie.

New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Bioorganic & medicinal chemistry letters.

Anti-HIV Activities of Anionic Metalloporphyrins and Related Compounds

E. De Clercq, J. Balzarini, D. Schols, 1997 .

Synthesis and Biological Activity of Novel 1H,3H-Thiazolo[3,4-a]Benzimidazoles: Non-nucleoside Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, J. Balzarini, 1999, Antiviral chemistry & chemotherapy.

Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

J. Vercammen, Z. Debyser, Y. Engelborghs, 2007, The Journal of antimicrobial chemotherapy.

Identification of Authentic Inhibitors of HIV-1 Integration

J. Vercammen, Z. Debyser, Y. Engelborghs, 2005 .

Novel inhibitors of HIV-1 integration.

C. Pannecouque, J. Vercammen, Z. Debyser, 2004, Current drug metabolism.

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors.

Myriam Witvrouw, Zeger Debyser, Angela Rao, 2005, Journal of medicinal chemistry.

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF (Z) AND (E) α-ETHENYL ACYCLONUCLEOSIDES

E. De Clercq, J. Balzarini, M. Witvrouw, 2001 .

Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines.

C. Pannecouque, J. Balzarini, E. Clercq, 1998 .

Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors.

Myriam Witvrouw, Zeger Debyser, Laith Q Al-Mawsawi, 2008, Journal of medicinal chemistry.

Heterocyclic rimantadine analogues with antiviral activity.

E. De Clercq, C. Pannecouque, J. Neyts, 2003, Bioorganic & medicinal chemistry.

Synthesis and Antiviral Studies of Novel N-Sulphonamidomethyl piperazinyl Fluoroquinolones

M. Witvrouw, P. Selvam, S. Karthikumar, 2009, Indian journal of pharmaceutical sciences.

Broad-Spectrum Antiviral Activity and Mechanism of Antiviral Action of the Fluoroquinolone Derivative K-12

E. De Clercq, C. Pannecouque, A. Vandamme, 1998, Antiviral chemistry & chemotherapy.

Antiviral activity against human immunodeficiency virus type 1 (HIV‐1) and type 2 (HIV‐2) of ethnobotanically selected Ethiopian medicinal plants

C. Pannecouque, M. Witvrouw, K. Asres, 2001, Phytotherapy research : PTR.

Antiviral activity of Hawaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1).

E. De Clercq, R. Pauwels, M. Witvrouw, 1996, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Polysulfonates Derived from Metal Thiolate Complexes as Inhibitors of HIV-1 and Various other Enveloped Viruses In Vitro

E. De Clercq, S. Ikeda, D. Bergstrom, 2002, Antiviral chemistry & chemotherapy.

Synthesis and Screening for Anti-HIV Activity of Some N-Mannich Bases of Isatin Derivatives

P. Yogeeswari, D. Sriram, E. De Clercq, 1999, Chemotherapy.

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action.

E. De Clercq, C. Pannecouque, P. Herdewijn, 2003, Journal of medicinal chemistry.

Discovery of novel non-cytotoxic salicylhydrazide containing HIV-1 integrase inhibitors.

R. Dayam, N. Neamati, Laith Q. Al‐Mawsawi, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents.

E. De Clercq, J. Balzarini, M. Witvrouw, 1996, Journal of medicinal chemistry.

Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeficiency Virus Integrase Strand Transfer Inhibitors

L. Vrang, Z. Debyser, F. Christ, 2008, Antimicrobial Agents and Chemotherapy.

A refined pharmacophore model for HIV-1 integrase inhibitors: Optimization of potency in the 1H-benzylindole series.

Myriam Witvrouw, Zeger Debyser, Alba Chimirri, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of novel derivatives of 4-amino-3-(2-furyl)-5-mercapto-1,2,4-triazole as potential HIV-1 NNRTIs.

E. De Clercq, C. Pannecouque, Xinyong Liu, 2007, Molecules.

Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase

J. Bats, Z. Debyser, M. Witvrouw, 2006 .

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors.

C. Tintori, M. Botta, Z. Debyser, 2009, Bioorganic & medicinal chemistry letters.

Synthesis, Structure and in Vitro Anti-Human Immunodeficiency virus Activity of Novel 3-Methyl-1H,3H-Thiazolo[3,4-a]Benzimidazoles

E. De Clercq, C. Pannecouque, M. Witvrouw, 1998, Antiviral chemistry & chemotherapy.

Structural Features and Anti-Human Immunodeficiency Virus (HIV) Activity of the Isomers of 1-(2′,6′-Difluorophenyl)-1H,3H-Thiazolo[3,4-a]Benzimidazole, a Potent Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitor

E. De Clercq, J. Balzarini, M. Witvrouw, 1997 .

Antiviral Activity of low-MW Dextran Sulphate (Derived from dextran MW 1000) Compared to Dextran Sulphate Samples of Higher MW

E. De Clercq, R. Pauwels, M. Hosoya, 1991 .

Anti‐HIV Activity of Thiosemicarbazone and Semicarbazone Derivatives of (±)‐3‐Menthone

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Archiv der Pharmazie.

Synthesis and anti-HIV activity of cosalane analogues incorporating two dichlorodisalicylmethane pharmacophore fragments.

E. De Clercq, C. Pannecouque, E. Clercq, 2001, Bioorganic & medicinal chemistry.

Synthesis and antiviral properties of some polyphenols related to Salvia genus.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Bioorganic & medicinal chemistry letters.

Synthesis of (Z) and (E) α-Alkenyl Phosphonic Acid Derivatives of Purines and Pyrimidines.

C. Pannecouque, J. Balzarini, E. Clercq, 1998 .

Pyridazines. Part 92. Synthesis of Dialkyldipyridazinodiazepinones as Potential HIV-1 Reverse Transcriptase Inhibitors.

C. Pannecouque, E. Clercq, M. Witvrouw, 2010 .

SRR-SB3, a disulfide-containing macrolide that inhibits a late stage of the replicative cycle of human immunodeficiency virus

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Antimicrobial agents and chemotherapy.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-2 replication by antagonism of the chemokine receptor CXCR4.

E. De Clercq, D. Schols, M. Witvrouw, 1999, Journal of medicinal chemistry.

Potent anti-HIV (type 1 and type 2) activity of polyoxometalates: structure-activity relationship and mechanism of action.

C. Pannecouque, D. Schols, M. Witvrouw, 2000, Journal of medicinal chemistry.

New 4‐[(1‐Benzyl‐1H‐indol‐3‐yl)carbonyl]‐3‐hydroxyfuran‐2(5H)‐ones, β‐Diketo Acid Analogues as HIV‐1 Integrase Inhibitors.

Z. Debyser, M. Witvrouw, S. Ferro, 2007 .

Efficient 3D Database Screening for Novel HIV-1 IN Inhibitors

Myriam Witvrouw, Zeger Debyser, M. Letizia Barreca, 2004, J. Chem. Inf. Model..

Design, Synthesis and antiHIV activity of Novel Isatine-Sulphonamides

Z. Debyser, M. Witvrouw, P. Selvam, 2008, Indian journal of pharmaceutical sciences.

Synthesis and anti-HIV activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulfonamide and its derivatives.

C. Pannecouque, M. Witvrouw, P. Selvam, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Studies of Antiviral Activity and Cytotoxicity of Wrightia tinctoria and Morinda citrifolia

J. Neyts, M. Witvrouw, P. Selvam, 2009, Indian Journal of Pharmaceutical Sciences.

Antiviral, Haemolytic and Molluscicidal Activities of Triterpenoid Saponins from Maesa lanceolata: Establishment of Structure-Activity Relationships

E. van Marck, S. Apers, M. Witvrouw, 2001, Planta medica.

Hypoglycemic, anticomplement and anti-HIV activities of Spathodea campanulata stem bark.

M. Witvrouw, L. Pieters, A. Vlietinck, 1999, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Susceptibility of HIV-2, Siv and Shiv to Various Anti-HIV-1 Compounds: Implications for Treatment and Postexposure Prophylaxis

W. Heneine, C. Pannecouque, E. Clercq, 2004, Antiviral therapy.

Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1).

S. Apers, M. Witvrouw, N. Hermans, 2002, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Biological evaluation of proanthocyanidin dimers and related polyphenols.

E. De Clercq, M. Witvrouw, T. De Bruyne, 1999, Journal of natural products.

Reaction of rosmarinic acid with nitrite ions in acidic conditions: discovery of nitro- and dinitrorosmarinic acids as new anti-HIV-1 agents.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, Journal of medicinal chemistry.

Chemical studies of essential oils of Juniperus oxycedrus ssp. badia.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2002, Journal of ethnopharmacology.

Synthesis and anti-HIV activity evaluation of novel N′-arylidene-2-[1-(naphthalen-1-yl)-1H-tetrazol-5-ylthio]acetohydrazides

C. Pannecouque, P. Zhan, Xinyong Liu, 2010, Medicinal Chemistry Research.

A second target for the peptoid Tat/transactivation response element inhibitor CGP64222: inhibition of human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry.

E. De Clercq, C. Pannecouque, T. Klimkait, 2000, Molecular pharmacology.

Differential Activity of Polyanionic Compounds and Castanospermine against HIV Replication and HIV-Induced Syncytium Formation Depending on Virus Strain and Cell Type

E. De Clercq, R. Pauwels, D. Schols, 1992 .

Activity of a Sulfated Polysaccharide Extracted from the Red Seaweed Aghardhiella Tenera against Human Immunodeficiency Virus and Other Enveloped Viruses

E. De Clercq, R. Pauwels, S. Ikeda, 1994 .

Sulphated Polymers are Potent and Selective Inhibitors of Various Enveloped Viruses, Including Herpes Simplex Virus, Cytomegalovirus, Vesicular Stomatitis Virus, Respiratory Syncytial Virus, and Toga-, Arena- and Retroviruses

E. De Clercq, R. Pauwels, M. Hosoya, 1990 .

Novel 1,1,3-trioxo-2H,4H-thieno[3,4-e][1,2,4]thiadiazine derivatives as non-nucleoside reverse transcriptase inhibitors that inhibit human immunodeficiency virus type 1 replication.

E. De Clercq, C. Pannecouque, J. Balzarini, 1998, Journal of medicinal chemistry.

Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.

E. De Clercq, J. Balzarini, Z. Debyser, 1995, Antiviral research.

Cell type-specific anti-human immunodeficiency virus type 1 activity of the transactivation inhibitor Ro5-3335

E. De Clercq, R. Pauwels, A. Vandamme, 1992, Antimicrobial Agents and Chemotherapy.

Synthesis, Biological Activity, Pharmacokinetic Properties and Molecular Modelling Studies of Novel 1H,3H-Oxazolo[3,4-a]Benzimidazoles: Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors

E. De Clercq, C. Pannecouque, G. De Sarro, 2001, Antiviral chemistry & chemotherapy.

Presence of 2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5"-(4"-amino-1",2"-oxath iole-2",2"-dioxide) (TSAO)-resistant virus strains in TSAO-inexperienced HIV patients.

R. Esnouf, E. De Clercq, B. Clotet, 2000, AIDS research and human retroviruses.

Definitive Solution Structures for the 6-Formylated Versions of 1-(βD-Ribofuranosyl)-, 1-(2′-Deoxy-β-D-Ribofuranosyl)-, and 1-β-D-Arabinofuranosyluracil, and of Thymidine

R. Lin, J. Balzarini, E. Clercq, 1996 .

Synthesis and Antiviral Activity of 1,3-Disubstituted Uracils against HIV-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2003, Antiviral chemistry & chemotherapy.

1,1,3-Trioxo-2H,4H-Thieno[3,4-e][1,2,4]Thiadiazine (TTD) Derivatives: a New Class of Nonnucleoside Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase Inhibitors with Anti-HIV-1 Activity

R. Esnouf, E. De Clercq, C. Pannecouque, 1998, Antimicrobial Agents and Chemotherapy.

Antiretroviral activities of acyclic nucleoside phosphonates [9-(2-phosphonylmethoxyethyl)adenine, 9-(2-phosphonylmethoxyethyl)guanine, (R)-9-(2-phosphonylmethoxypropyl)adenine, and MDL 74,968] in cell cultures and murine sarcoma virus-infected newborn NMRI mice

E. De Clercq, C. Pannecouque, J. Balzarini, 1997, Antimicrobial agents and chemotherapy.

Synthesis and anti-HIV activity of a bile acid analog of cosalane

C. Pannecouque, E. Clercq, M. Witvrouw, 2001 .

3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents.

E. De Clercq, C. Pannecouque, A. Kherbeche, 2001, Chemical & pharmaceutical bulletin.

Synthesis of imidazo[1,2-a]pyridines as antiviral agents.

E. De Clercq, J. Balzarini, M. Witvrouw, 1998, Journal of medicinal chemistry.

Synthesis and antiviral activity of 6-chloropurine arabinoside and its 2'-deoxy-2'-fluoro derivative.

E. De Clercq, M. Witvrouw, Y. Takahashi, 1996, Chemical & pharmaceutical bulletin.

Prevalence and Characteristics of Multinucleoside-Resistant Human Immunodeficiency Virus Type 1 among European Patients Receiving Combinations of Nucleoside Analogues

E. De Clercq, C. Pannecouque, B. Clotet, 2000, Antimicrobial Agents and Chemotherapy.

Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication.

E. De Clercq, C. Perno, J. Balzarini, 1996, Molecular pharmacology.

Anti-HIV-1 Activity of Benzothiadiazine Dioxide

E. De Clercq, C. Pannecouque, C. Pérez, 2001, Antiviral chemistry & chemotherapy.

Anti-HIV and anti-HCMV Activities of New Aurintricarboxylic Acid Analogues

E. De Clercq, J. Neyts, M. Witvrouw, 1995 .

Sulphated Cyclodextrins are Potent anti-HIV Agents Acting Synergistically with 2′,3′-dideoxynucleoside Analogues

A. Van Schepdael, E. De Clercq, R. Pauwels, 1991 .

Polyanionic (i.e., polysulfonate) dendrimers can inhibit the replication of human immunodeficiency virus by interfering with both virus adsorption and later steps (reverse transcriptase/integrase) in the virus replicative cycle.

E. De Clercq, C. Pannecouque, E. Clercq, 2000, Molecular pharmacology.

Antiviral activity of the bicyclam derivative JM3100 against drug-resistant strains of human immunodeficiency virus type 1.

E. De Clercq, A. Vandamme, M. Witvrouw, 1996, Antiviral research.

Quantification of HIV-1 RNA in plasma: comparable results with the NASBA HIV-1 RNA QT and the AMPLICOR HIV monitor test.

E. De Clercq, A. Vandamme, S. Van Dooren, 1996, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Anti-HIV Activity Of Some Mannich Bases Of Isatin Derivatives

D. Sriram, C. Pannecouque, E. Clercq, 1998 .

Phase I/II dose escalation and randomized withdrawal study with add-on azodicarbonamide in patients failing on current antiretroviral therapy

C. Pannecouque, F. Goebel, E. Clercq, 2001, AIDS.

Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV

E. De Clercq, C. Pannecouque, J. Balzarini, 2007, Nucleosides, nucleotides & nucleic acids.

Activity of non-nucleoside reverse transcriptase inhibitors against HIV-2 and SIV.

C. Pannecouque, A. Vandamme, K. Van Laethem, 1999, AIDS.

Synthesis and anti-HIV evaluation of novel 1,3-disubstituted thieno[3,2-c][1,2,6]thiadiazin-4(3H)-one 2,2-dioxides(TTDDs).

E. De Clercq, C. Pannecouque, Xinyong Liu, 2008, Bioorganic & medicinal chemistry.

Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?

E. De Clercq, C. Pannecouque, J. Kraus, 2003, Bioorganic & medicinal chemistry letters.

SRR-SB 3 , a Disulfide-Containing Macrolide That Inhibits a Late Stage of the Replicative Cycle of Human Immunodeficiency Virus

C. Pannecouque, A. Vandamme, J. Balzarini, 1997 .

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA.

E. De Clercq, C. Pannecouque, L. Naesens, 1999, International journal of pharmaceutics.

Resistance to Inhibitors of HIV‐1 Integrase

R. Clayton, A. Voet, Z. Debyser, 2011 .

Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360

E. De Clercq, C. Pannecouque, M. de Maeyer, 2004, AIDS.

Development of Resistance against Diketo Derivatives of Human Immunodeficiency Virus Type 1 by Progressive Accumulation of Integrase Mutations

E. De Clercq, C. Pannecouque, M. de Maeyer, 2003, Journal of Virology.

Cell type-dependent effect of sodium valproate on human immunodeficiency virus type 1 replication in vitro.

E. De Clercq, A. Vandamme, M. Witvrouw, 1997, AIDS research and human retroviruses.

Inhibition of HIV type 1 Tat-mediated trans-activation by oncostatin M in HLtat cells.

E. De Clercq, A. Vandamme, J. Tu, 1995, AIDS research and human retroviruses.

Pharmacokinetics of intravenous pentosan polysulphate (HOE/BAY 946) in HIV-positive patients.

M. Witvrouw, B. Ruf, E. De Clercq, 1991, AIDS.

S-adenosylhomocysteine hydrolase inhibitors interfere with the replication of human immunodeficiency virus type 1 through inhibition of the LTR transactivation.

E. De Clercq, C. Pannecouque, A. Vandamme, 1997, Molecular pharmacology.

Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

L. Stamatatos, E. De Clercq, C. Pannecouque, 2005, Journal of Virology.

Evaluating Clinical Isolates for Their Phenotypic and Genotypic Resistance Against Anti-HIV Drugs.

J Desmyter, E. De Clercq, C. Pannecouque, 2000, Methods in molecular medicine.

Mutations in the non-nucleoside binding-pocket interfere with the multi-nucleoside resistance phenotype

R. Esnouf, E. De Clercq, C. Pannecouque, 2001, AIDS.

Lamivudine resistance of HIV type 1 does not delay development of resistance to nonnucleoside HIV type 1-specific reverse transcriptase inhibitors as compared with wild-type HIV type 1.

E. De Clercq, M. Witvrouw, J. Anné, 1998, AIDS research and human retroviruses.

Polyanion inhibitors of human immunodeficiency virus and other viruses. Part 2. Polymerized anionic surfactants derived from amino acids and dipeptides.

E. De Clercq, S. Ikeda, J. Neyts, 1996, Journal of medicinal chemistry.

Inhibition of Human Immunodeficiency Virus Type (HIV-1) Replication by Some Diversely Functionalized Spirocyclopropyl Derivatives.

C. Pannecouque, E. Clercq, M. Witvrouw, 1999 .

Synthesis of 3‐Nitrosoimidazo[1,2‐a]pyridine Derivatives as Potential Antiretroviral Agents

E. De Clercq, C. Pannecouque, A. Kherbeche, 2001, Archiv der Pharmazie.

Correlation of anti-HIV activity with anion spacing in a series of cosalane analogues with extended polycarboxylate pharmacophores.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2001, Journal of medicinal chemistry.

Synthesis and anti-HIV activity of cosalane analogues incorporating nitrogen in the linker chain.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2000, Bioorganic & medicinal chemistry.

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

E. De Clercq, C. Pannecouque, D. Schols, 1999, Journal of medicinal chemistry.

Polyanion inhibitors of HIV and other viruses. 7. Polyanionic compounds and polyzwitterionic compounds derived from cyclodextrins as inhibitors of HIV transmission.

E. De Clercq, C. Pannecouque, J. Neyts, 1998, Journal of medicinal chemistry.

Polyanion inhibitors of human immunodeficiency virus and other viruses. 6. Micelle-like anti-HIV polyanionic compounds based on a carbohydrate core.

E. De Clercq, M. Witvrouw, J. Esté, 1997, Journal of medicinal chemistry.

Polyanion inhibitors of human immunodeficiency virus and other viruses. 5. Telomerized anionic surfactants derived from amino acids.

E. De Clercq, J. Montero, M. Witvrouw, 1997, Journal of medicinal chemistry.

Polyanion inhibitors of human immunodeficiency virus. Part IV. - polymerized anionic surfactants: Influence of the density and distribution of anionic groups on the antiviral activity

P. Barthélémy, E. Clercq, M. Witvrouw, 1996 .

Identification of optimal anion spacing for anti-HIV activity in a series of cosalane tetracarboxylates.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2000, Bioorganic & medicinal chemistry letters.

Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers

C. Pannecouque, E. Clercq, M. Witvrouw, 1999 .

Inhibition of Human Immunodeficiency Virus Type (HIV‐1) Replication by some Diversely Functionalized Spirocyclopropyl Derivatives

E. De Clercq, C. Pannecouque, M. Witvrouw, 1999, Archiv der Pharmazie.

ADA, a potential anti-HIV drug.

E. De Clercq, M. Witvrouw, J. Schmit, 1996, AIDS research and human retroviruses.

Evolution of HIV drug Resistance in Zidovudine/Zalcitabine- and Zidovudine/ Didanosine-Experienced Patients Receiving Lamivudine-Containing Combination Therapy

E. De Clercq, B. Clotet, J. Martinez-Picado, 1998 .

Chicoric acid analogues as HIV-1 integrase inhibitors.

K. Kohn, Y. Pommier, E. De Clercq, 1999, Journal of medicinal chemistry.

Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT.

E. De Clercq, D. Meijer, M. Witvrouw, 1999, Journal of drug targeting.

Viral entry as the primary target for the anti-HIV activity of chicoric acid and its tetra-acetyl esters.

Y. Pommier, E. De Clercq, C. Pannecouque, 2000, Molecular pharmacology.

Synthesis, Antiretroviral and Antioxidant Evaluation of a Series of New Benzo[b]furan Derivatives

C. Pannecouque, A. Tsotinis, J. Neyts, 2001, Arzneimittelforschung.

Transient and Stable Knockdown of the Integrase Cofactor LEDGF/p75 Reveals Its Role in the Replication Cycle of Human Immunodeficiency Virus

C. Van den Haute, R. Gijsbers, Z. Debyser, 2006, Journal of Virology.

Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex

C. Gabus, J. Darlix, Y. Mély, 2011, Nucleic acids research.

The total synthesis of fukiic acid, an HIV-1 integrase inhibitor.

F. Bailly, J. Mouscadet, Z. Debyser, 2008, European journal of medicinal chemistry.

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

G. Maga, M. Botta, M. Witvrouw, 2008, Journal of medicinal chemistry.

Virus Evolution Reveals an Exclusive Role for LEDGF/p75 in Chromosomal Tethering of HIV

Myriam Witvrouw, Zeger Debyser, Linos Vandekerckhove, 2007, PLoS pathogens.

Discovery of a small-molecule HIV-1 integrase inhibitor-binding site.

Myriam Witvrouw, Christoph H Borchers, Laith Q Al-Mawsawi, 2006, Proceedings of the National Academy of Sciences of the United States of America.

New Class of HIV Integrase Inhibitors that Block Viral Replication in Cell Culture

Myriam Witvrouw, Zeger Debyser, Erik De Clercq, 2002, Current Biology.

Preclinical Evaluation of 1H-Benzylindole Derivatives as Novel Human Immunodeﬁciency Virus Integrase Strand Transfer Inhibitors (cid:1)

L. Vrang, Z. Debyser, F. Christ, 2008 .

Patient HIV-1 strains carrying the multiple nucleoside resistance mutations are cross-resistant to abacavir.

E. De Clercq, T. Harrer, B. Clotet, 2000, AIDS.

New 2-arylnaphthalenediols and triol inhibitors of HIV-1 integrase--discovery of a new polyhydroxylated antiviral agent.

F. Bailly, H. Vezin, J. Mouscadet, 2010, Bioorganic & medicinal chemistry.

Potent and Selective Inhibition of HIV and SIV by Prostratin Interacting with Viral Entry

E. De Clercq, C. Pannecouque, M. Witvrouw, 2003, Antiviral chemistry & chemotherapy.

Multiple dideoxynucleoside analogue‐resistant (MddNR) HIV‐1 strains isolated from patients from different European countries

T. Harrer, B. Clotet, L. Ruiz, 1998, AIDS.

Synthesis of aryl semicarbazone of 4-aminoacetophenone and their anti-HIV activity.

C. Pannecouque, M. Witvrouw, S. Pandeya, 1998, Pharmaceutica acta Helvetiae.

Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus.

E. De Clercq, R. Pauwels, M. Baba, 1990, Journal of acquired immune deficiency syndromes.

Synthesis of new covalently bound kappa-carrageenan-AZT conjugates with improved anti-HIV activities.

Myriam Witvrouw, Christophe Pannecouque, Jean-Louis Kraus, 2002, Journal of medicinal chemistry.

Synthesis and anti-HIV activity of some new aminoadamantane heterocycles

C. Pannecouque, E. Clercq, M. Witvrouw, 1997 .

Mutations in Human Immunodeﬁciency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137 (cid:1)

A. Voet, Z. Debyser, M. Witvrouw, 2008 .

Walking on common ground: a cross-disciplinary scoping review on the clinical utility of digital mobility outcomes

Brian Mac Namee, Roberta De Michele, Mohand Tahar Kechadi, 2021, npj Digital Medicine.

Anti-HIV activity of a series of cosalane amino acid conjugates.

E. De Clercq, C. Pannecouque, M. Witvrouw, 2000, Bioorganic & medicinal chemistry letters.

N-DEOXYRIBOSIDES OF ERGOT ALKALOIDS : SYNTHESIS AND BIOLOGICAL ACTIVITY

V. Havlíček, V. Křen, M. Witvrouw, 1997 .

Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro.

E. Gunnarsson, G. Georgsson, M. Witvrouw, 1999, Sexually transmitted infections.

Synthesis and Antiviral Evaluation of N-β-D-Ribosides of Ergot Alkaloids

V. Havlíček, V. Křen, E. Clercq, 1997 .

Resistance of Human Immunodeficiency Virus Type 1 to the High-Mannose Binding Agents Cyanovirin N and Concanavalin A

L. Stamatatos, E. De Clercq, C. Pannecouque, 2005, Journal of Virology.

Mutations in Human Immunodeficiency Virus Type 1 Integrase Confer Resistance to the Naphthyridine L-870,810 and Cross-Resistance to the Clinical Trial Drug GS-9137

A. Voet, M. de Maeyer, Z. Debyser, 2008, Antimicrobial Agents and Chemotherapy.

Original article Hydrogels containing monocaprin have potent microbicidal activities against sexually transmitted viruses and bacteria in vitro

M. Witvrouw, T. Kristmundsdottir, G. Bergsson, 1999 .