R. Law

发表

Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing.

Dennis E Discher, D. Discher, A. Hategan, 2003, Biophysical journal.

A gating mechanism proposed from a simulation of a human alpha7 nicotinic acetylcholine receptor.

J Andrew McCammon, Richard H. Henchman, Richard H Henchman, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Prediction of Small Molecule Hydration Thermodynamics with Grid Cell Theory.

Richard H. Henchman, G. Calabró, J. Michel, 2014, Journal of chemical theory and computation.

TEMPERATURE-COUPLED FORCED UNFOLDING OF SINGLE PROTEINS

D. Speicher, D. Discher, R. Law, 2022 .

3D CELL BIOPRINTING FOR REGENERATIVE MEDICINE RESEARCH AND THERAPIES

Marie Csete, Chirag Khatiwala, M. Csete, 2012 .

Hit and Lead Identification from Fragments

Michael P. Mazanetz, R. Law, M. Whittaker, 2013 .

From Receptors to Ligands: Fragment-assisted Drug Design for GPCRsApplied to the Discovery of H3 and H4 Receptor Antagonists

Michael P. Mazanetz, P. Biggin, R. Law, 2013 .

Homology modelling and molecular dynamics simulations: comparative studies of human aquaporin-1

M. Sansom, R. Law, 2004, European Biophysics Journal.

Using electrophysiology and in silico three-dimensional modeling to reduce human Ether-à-go-go related gene K(+) channel inhibition in a histamine H3 receptor antagonist program.

Michael P. Mazanetz, A. Heifetz, R. Law, 2010, Assay and drug development technologies.

Assessment of Hydration Thermodynamics at Protein Interfaces with Grid Cell Theory.

Richard H. Henchman, Michael P. Mazanetz, M. Bodkin, 2016, The journal of physical chemistry. B.

Evaluation of water displacement energetics in protein binding sites with grid cell theory.

M. Bodkin, J. Michel, A. Heifetz, 2015, Physical chemistry chemical physics : PCCP.

Compound Design by Fragment‐Linking

Mark Whittaker, R. Law, J. Barker, 2011, Molecular informatics.

Fragments: past, present and future.

Thomas Hesterkamp, Mark Whittaker, Richard J. Law, 2010, Drug discovery today. Technologies.

Membrane proteins: Aquaporins — channels without ions

M. Sansom, R. Law, Richard J Law, 2001, Current Biology.

Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains.

D. Speicher, D. Discher, R. Law, 2003, Biophysical journal.

Influence of Lateral Association on Forced Unfolding of Antiparallel Spectrin Heterodimers*

Dennis E Discher, David W Speicher, D. Speicher, 2004, Journal of Biological Chemistry.

Molecular extensibility of mini-dystrophins and a dystrophin rod construct.

D. Discher, H. Sweeney, D. Safer, 2005, Journal of molecular biology.

Electrostatics studies and molecular dynamics simulations of a homology model of the Shaker K+ channel pore

Graham R. Smith, M. Sansom, R. Law, 2001, European Biophysics Journal.

Toward an Understanding of Agonist Binding to Human Orexin-1 and Orexin-2 Receptors with G-Protein-Coupled Receptor Modeling and Site-Directed Mutagenesis

Philip C. Biggin, Oliver Barker, Richard J. Law, 2013, Biochemistry.

Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms.

S. Buckingham, D. Sattelle, C. Franks, 2005, Trends in pharmacological sciences.

Structure and dynamics of the pore‐lining helix of the nicotinic receptor: MD simulations in water, lipid bilayers, and transbilayer bundles

D. Tieleman, L. Forrest, M. Sansom, 2000, Proteins.

Cooperativity in forced unfolding of tandem spectrin repeats.

Dennis E Discher, David W Speicher, D. Speicher, 2003, Biophysical journal.

The multiple roles of computational chemistry in fragment-based drug design

Mark Whittaker, Ole Andersen, Richard Law, 2009, J. Comput. Aided Mol. Des..

An ion gating mechanism of gastric H,K-ATPase based on molecular dynamics simulations.

G. Sachs, F. Lightstone, R. Law, 2008, Biophysical journal.

Embedded cholesterol in the nicotinic acetylcholine receptor

M. Klein, R. Eckenhoff, J. Hénin, 2008, Proceedings of the National Academy of Sciences.

Fighting Obesity with a Sugar-Based Library: Discovery of Novel MCH-1R Antagonists by a New Computational-VAST Approach for Exploration of GPCR Binding Sites

Mark Whittaker, Norbert Wimmer, Alexander Heifetz, 2013, J. Chem. Inf. Model..

Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis.

Philip C Biggin, Tara Fryatt, Oliver Barker, 2012, Biochemistry.

Cell-free expression for nanolipoprotein particles: building a high-throughput membrane protein solubility platform.

T. Sulchek, Vicki L. Walsworth, B. Chromy, 2009, Methods in molecular biology.

Prediction of cyclin-dependent kinase 2 inhibitor potency using the fragment molecular orbital method

Mark Whittaker, Richard Law, Osamu Ichihara, 2011, J. Cheminformatics.

Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis.

Benzhuo Lu, Xiaolin Cheng, J Andrew McCammon, 2006, Journal of molecular biology.

Pores formed by the nicotinic receptor m2delta Peptide: a molecular dynamics simulation study.

D. Tieleman, M. Sansom, R. Law, 2003, Biophysical journal.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

Gebhard F. X. Schertler, Christofer S. Tautermann, Philip C. Biggin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Gaba Receptor Insecticide Non-Competitive Antagonists May Bind at Allosteric Modulator Sites

Felice C Lightstone, F. Lightstone, R. Law, 2008, The International journal of neuroscience.

Evaluation of Host-Guest Binding Thermodynamics of Model Cavities with Grid Cell Theory.

Julien Michel, Richard H. Henchman, Richard H Henchman, 2014, Journal of chemical theory and computation.

Membrane protein structure quality in molecular dynamics simulation.

Marc Baaden, Peter J Bond, George Patargias, 2005, Journal of molecular graphics & modelling.

Modeling neuronal nicotinic and GABA receptors: important interface salt-links and protein dynamics.

Felice C Lightstone, F. Lightstone, R. Law, 2009, Biophysical journal.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1–2 September 2014

T. Ceska, P. Biggin, M. Bodkin, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

Low force cooperativity in the extensible unfolding of cytoskeletal proteins

D. Discher, R. Law, S. Harper, 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.