A. Dickmanns

发表

High intranuclear mobility and dynamic clustering of the splicing factor U1 snRNP observed by single particle tracking

Ulrich Kubitscheck, Achim Dickmanns, R. Lührmann, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Nuclear Pore Complexes and Nucleocytoplasmic Transport: From Structure to Function to Disease.

B. Fahrenkrog, A. Dickmanns, R. Kehlenbach, 2015, International review of cell and molecular biology.

Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP

Thomas Monecke, Achim Dickmanns, Ralf Ficner, 2009, Science.

The importin-β binding domain of snurportin1 is responsible for the Ran- and energy-independent nuclear import of spliceosomal U snRNPs in vitro

R. Lührmann, A. Dickmanns, J. Huber, 2002, The Journal of cell biology.

Crystal structure of a bacterial class 2 histone deacetylase homologue.

R. Ficner, A. Dickmanns, T. Nielsen, 2005, Journal of molecular biology.

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs).

W. Sippl, E. Verdin, M. Jung, 2008, Bioorganic & medicinal chemistry.

Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus.

R. Ficner, A. Dickmanns, D. Wohlwend, 2007, Journal of molecular biology.

Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry

C. Lenz, H. Urlaub, B. Kastner, 2010, Nucleic acids research.

De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data.

M. Rudolph, A. Dickmanns, D. Roeser, 2005, Acta crystallographica. Section D, Biological crystallography.

Nucleocytoplasmic Shuttling Factors Including Ran and CRM1 Mediate Nuclear Export of NFAT In Vitro

A. Dickmanns, L. Gerace, R. Kehlenbach, 1998, The Journal of cell biology.

The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen

A. Wildeman, A. Dickmanns, E. Fanning, 1994, Journal of virology.

Crystal structure analysis of DNA uridine endonuclease Mth212 bound to DNA.

R. Ficner, A. Dickmanns, Elena Ciirdaeva, 2010, Journal of molecular biology.

Structural basis for c-di-AMP–dependent regulation of the bacterial stringent response by receptor protein DarB

H. Urlaub, P. Neumann, R. Ficner, 2022, The Journal of biological chemistry.

TheKinetics ofSimian Virus40-Induced Progression ofQuiescent Cells intoSPhaseDependon FourIndependent Functions ofLargeTAntigen

A. Dickmanns, E. Fanning, R. Weber, 1994 .

Allosteric control of the exportin CRM1 unraveled by crystal structure analysis

R. Ficner, A. Dickmanns, T. Monecke, 2014, The FEBS journal.

Crystal structure of the polysialic acid–degrading endosialidase of bacteriophage K1F

Achim Dickmanns, Ralf Ficner, Rita Gerardy-Schahn, 2005, Nature Structural &Molecular Biology.

Crystal structures of the c-di-AMP–synthesizing enzyme CdaA

P. Neumann, R. Ficner, A. Dickmanns, 2019, The Journal of Biological Chemistry.

MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression.

M. Lopes, M. Scheffner, M. Dobbelstein, 2022, Cell reports.

Disease-causing missense mutations affect enzymatic activity, stability and oligomerization of glutaryl-CoA dehydrogenase (GCDH).

B. Keyser, E. Christensen, A. Dickmanns, 2008, Human molecular genetics.

Thermodynamic Analysis of H1 Nuclear Import

R. Ficner, A. Dickmanns, D. Doenecke, 2007, Journal of Biological Chemistry.

Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex.

M. Weiss, R. Ficner, S. Port, 2015, Acta crystallographica. Section F, Structural biology communications.

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence

Alessandro Filosa, G. Ravenscroft, N. Laing, 2018, PLoS genetics.

Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells.

M. Dobbelstein, K. V. Van Zee, A. Dickmanns, 1992, Oncogene.

Title: Crystal structures of Physcomitrella patens AOC1 and 2: Insights into the enzyme mechanism and differences in substrate specificity

M. Hamberg, I. Feussner, P. Neumann, 2012 .

Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.

H. Hermeking, D. Eick, A. Dickmanns, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode.

R. Ficner, A. Dickmanns, T. Monecke, 2008, Journal of molecular biology.

Validating Resolution Revolution.

P. Neumann, R. Ficner, A. Dickmanns, 2018, Structure.

Molecular Basis for Multiple Sulfatase Deficiency and Mechanism for Formylglycine Generation of the Human Formylglycine-Generating Enzyme

T. Dierks, M. Rudolph, K. Figura, 2005, Cell.

Conserved Stem II of the Box C/D Motif Is Essential for Nucleolar Localization and Is Required, Along with the 15.5K Protein, for the Hierarchical Assembly of the Box C/D snoRNP

R. Lührmann, A. Dickmanns, N. Watkins, 2002, Molecular and Cellular Biology.

Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF.

E. Schulz, R. Ficner, A. Dickmanns, 2010, Journal of molecular biology.

Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity1[W][OA]

M. Hamberg, I. Feussner, P. Neumann, 2012, Plant Physiology.

Mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence

Alessandro Filosa, G. Ravenscroft, N. Laing, 2018 .

Mutations in nucleoporin NUP88 cause lethal neuromuscular disorder

Alessandro Filosa, G. Ravenscroft, N. Laing, 2018, bioRxiv.

Structural basis for m3G‐cap‐mediated nuclear import of spliceosomal UsnRNPs by snurportin1

Achim Dickmanns, Ralf Ficner, R. Lührmann, 2005, The EMBO journal.

Structural Basis of Targeting the Exportin CRM1 in Cancer

Thomas Monecke, Achim Dickmanns, Ralf Ficner, 2015, Cells.

Cyclin E‐mediated elimination of p27 requires its interaction with the nuclear pore‐associated protein mNPAP60

M. Eilers, A. Dickmanns, D. Müller, 2000, The EMBO journal.

Role of the 5’-cap in the biogenesis of spliceosomal snRNPs

R. Ficner, A. Dickmanns, 2005 .

A C-terminal phosphatase module conserved in vertebrate CMP-sialic acid synthetases provides a tetramerization interface for the physiologically active enzyme.

J. Tiralongo, R. Ficner, B. Weinhold, 2009, Journal of molecular biology.

The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress.

G. Braus, J. Schulz, R. Ficner, 2009, Molecular biology of the cell.

Validating Resolution Revolution.

Piotr Neumann, Achim Dickmanns, Ralf Ficner, 2018, Structure.

Studying structure and function of spliceosomal helicases.

P. Neumann, R. Ficner, A. Dickmanns, 2017, Methods.

Crystal structure of the borna disease virus nucleoprotein.

M. Rudolph, W. Garten, R. Ficner, 2003, Structure.

Monoallelic CRMP1 gene variants cause neurodevelopmental disorder

Y. Goshima, A. Dickmanns, Nobuto Arashiki, 2022, medRxiv.

A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis

R. Ficner, J. Stülke, A. Dickmanns, 2021, Nature Communications.

Impact of the crystallization condition on importin-β conformation.

S. Köster, P. Neumann, R. Ficner, 2016, Acta crystallographica. Section D, Structural biology.

A jack of all trades: the multiple roles of the unique essential second messenger cyclic di‐AMP

R. Ficner, J. Stülke, A. Dickmanns, 2015, Molecular microbiology.

The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB

G. Braus, S. C. Kim, P. Neumann, 2013, PLoS biology.

Structure of the novel α-amylase AmyC from Thermotoga maritima

W. Liebl, M. Ballschmiter, R. Ficner, 2006 .

Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography

H. Urlaub, R. Ficner, A. Dickmanns, 2009, BMC Structural Biology.

MD simulations and FRET reveal an environment-sensitive conformational plasticity of importin-β.

H. Grubmüller, J. Enderlein, R. Ficner, 2015, Biophysical journal.

Purification, crystallization and preliminary crystallographic data of the m3G cap-binding domain of human snRNP import factor snurportin 1.

M. Sekine, H. Urlaub, R. Lührmann, 2004, Acta crystallographica. Section D, Biological crystallography.

The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N.

F. Bischoff, R. Lührmann, A. Dickmanns, 1996, Journal of cell science.

A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA

R. Lührmann, K. V. Van Zee, A. Dickmanns, 1993, The Journal of cell biology.

A Role for RanBP1 in the Release of CRM1 from the Nuclear Pore Complex in a Terminal Step of Nuclear Export

A. Dickmanns, L. Gerace, R. Kehlenbach, 1999, The Journal of cell biology.

Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major.

E. Schulz, P. Neumann, R. Ficner, 2011, Journal of molecular biology.

Structural basis for m 3 Gcap-mediated nuclear import of spliceosomal UsnRNPs by snurportin 1

R. Lührmann, R. Ficner, A. Dickmanns, 2005 .

Crystal Structure of Human pFGE, the Paralog of the Cα-formylglycine-generating Enzyme*

T. Dierks, M. Rudolph, K. von Figura, 2005, Journal of Biological Chemistry.

Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes*

P. Neumann, R. Ficner, J. Stülke, 2015, The Journal of Biological Chemistry.

Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding PII-like Signal Transduction Protein DarA*

E. Hammer, P. Neumann, R. Ficner, 2014, The Journal of Biological Chemistry.

Crystal structure of an intramolecular chaperone mediating triple–β-helix folding

H. Urlaub, E. Schulz, R. Ficner, 2010, Nature Structural &Molecular Biology.

Characterization of inhibition reveals distinctive properties for human and Saccharomyces cerevisiae CRM1.

P. Neumann, R. Ficner, A. Dickmanns, 2020, Journal of medicinal chemistry.

Structure of the novel alpha-amylase AmyC from Thermotoga maritima.

W. Liebl, M. Ballschmiter, R. Ficner, 2006, Acta crystallographica. Section D, Biological crystallography.

Establishment of micrometastatic carcinoma cell lines: a novel source of tumor cell vaccines.

K. Pantel, G. Schlimok, A. Dickmanns, 1995, Journal of the National Cancer Institute.

Interaction of nucleoporins with nuclear transport receptors: a structural perspective

P. Neumann, R. Ficner, A. Dickmanns, 2023, Biological chemistry.

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export.

H. Urlaub, R. Ficner, S. Port, 2015, Cell reports.

A rendezvous of two second messengers: The c-di-AMP receptor protein DarB controls (p)ppGpp synthesis in Bacillus subtilis

R. Ficner, J. Stülke, A. Dickmanns, 2020 .

In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1.

F. Bischoff, R. Lührmann, A. Dickmanns, 1996, Nucleic acids research.

Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1

R. Ficner, A. Dickmanns, T. Monecke, 2009, Nucleic acids research.

De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse.

U. Mueller, R. Ficner, A. Dickmanns, 2009, Acta crystallographica. Section D, Biological crystallography.

Structural and Functional C haracterization of CRM 1-Nup 214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export Graphical

H. Urlaub, R. Ficner, S. Port, 2022 .

Bucky Ball Is a Novel Zebrafish Vasa ATPase Activator

R. Ficner, A. Dickmanns, K. Tittmann, 2021, Biomolecules.

Structure and function of spliceosomal DEAH-box ATPases

P. Neumann, R. Ficner, A. Dickmanns, 2023, Biological chemistry.

Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis

Christopher P. Zschiedrich, H. Urlaub, B. Görke, 2018, The Journal of Biological Chemistry.

Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1.

R. Ficner, A. Dickmanns, T. Monecke, 2009, Acta crystallographica. Section D, Biological crystallography.

Case report: Compound heterozygous NUP85 variants cause autosomal recessive primary microcephaly

A. Dickmanns, A. Kaindl, G. Lesca, 2023, Frontiers in Neurology.

Expanding the Phenotype of NUP85 Mutations beyond Nephrotic Syndrome to Primary Autosomal Recessive Microcephaly and Seckel Syndrome Spectrum Disorders

V. Tarabykin, B. Fahrenkrog, B. Kamien, 2021, Neuropediatrics.