C. Cianci

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Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy

C. Cianci, S. Gerritz, Carol Deminie, 2012, Antiviral chemistry & chemotherapy.

Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion.

N. Meanwell, D. Langley, C. Cianci, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical studies on capped RNA primers identify a class of oligonucleotide inhibitors of the influenza virus RNA polymerase.

T. Chung, C. Cianci, M. Krystal, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB2 subunit.

S. Inglis, C. Cianci, M. Krystal, 1996, The Journal of general virology.

Discovery and Development of Orally Active RSV Fusion Inhibitors

N. Meanwell, C. Cianci, M. Krystal, 2011 .

Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.

N. Meanwell, D. Langley, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.

N. Meanwell, D. Langley, C. Cianci, 2007, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo.

N. Meanwell, I. Medina, C. Cianci, 2006, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.

N. Meanwell, C. Cianci, M. Krystal, 2004, Bioorganic & medicinal chemistry letters.

Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor.

N. Meanwell, C. Cianci, M. Krystal, 2003, Bioorganic & medicinal chemistry letters.

Development of a photoaffinity label for respiratory syncytial virus inhibitors

N. Meanwell, P. Williams, C. Cianci, 2003 .

Differential effect of modified capped RNA substrates on influenza virus transcription.

C. Cianci, M. Krystal, R. Colonno, 1997, Virus Research.

Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.

N. Meanwell, C. Cianci, M. Krystal, 2002, Bioorganic & medicinal chemistry letters.

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.

K. Kish, N. Meanwell, C. Cianci, 2022, ACS medicinal chemistry letters.

Critical Lower Limb Ischemia from an Embolized Angio-Seal Closure Device

C. Cianci, James W Choi, R. Stoler, 2013, Proceedings.

Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor.

N. Meanwell, C. Cianci, M. Krystal, 2005, The Journal of antimicrobial chemotherapy.

Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

D. Drexler, C. Cianci, Jun Zhang, 2016, Journal of pharmaceutical sciences.

Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB 2 subunit

S. Inglis, C. Cianci, M. Krystal, 2007 .

Statin pretreatment is protective despite an association with greater coronary artery disease burden in patients presenting with a first ST-elevation myocardial infarction.

C. Cianci, M. Matsumura, Tyler Fugate, 2008, Preventive cardiology.

Lobucavir is phosphorylated in human cytomegalovirus-infected and -uninfected cells and inhibits the viral DNA polymerase

C. Cianci, R. Colonno, D. Tenney, 1997, Antimicrobial agents and chemotherapy.

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.

Barry L. Johnson, K. Kish, N. Meanwell, 2019, Journal of medicinal chemistry.

Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues.

T. Mitt, J. Clark, C. Cianci, 1991, Journal of medicinal chemistry.

Antiviral Drug Discovery

N. Meanwell, C. Cianci, M. Krystal, 2013 .

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Identification of N-Hydroxamic Acid and N-Hydroxyimide Compounds that Inhibit the Influenza Virus Polymerase

T. Chung, N. Meanwell, C. Cianci, 1996 .

Design, Synthesis and SAR Study of Novel C2-Pyrazolopyrimidine Amides and Amide Isosteres as Allosteric Integrase Inhibitors.

N. Meanwell, C. Cianci, M. Krystal, 2020, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.

A. Marino, N. Meanwell, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.

A. Marino, N. Meanwell, I. Medina, 2009, Bioorganic & medicinal chemistry letters.

Inhibition of herpes simplex virus type 1 DNA polymerase by [1R(1 alpha,2 beta,3 alpha)]-9-[2,3-bis(hydroxymethyl)cyclobutyl] guanine.

C. Cianci, B. Terry, M. Hagen, 1991, Molecular pharmacology.

Neutralization of purified herpes simplex virus DNA polymerase by two antipeptide sera

C. Cianci, M. Haffey, B. Terry, 1990, Virus Genes.

Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein.

K. Bush, C. Cianci, E. Meyers, 1992, The Journal of antibiotics.

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

Eric T Baldwin, Samuel W Gerritz, Michael Sinz, 2011, Proceedings of the National Academy of Sciences.

Differential activation of the influenza virus polymerase via template RNA binding

C. Cianci, M. Krystal, L. Tiley, 1995, Journal of virology.

Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus

N. Meanwell, C. Cianci, M. Krystal, 1997, Journal of virology.

Development of antivirals against influenza.

C. Cianci, M. Krystal, 1998, Expert opinion on investigational drugs.

Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.

Stephen R. Johnson, N. Meanwell, D. Langley, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.

K. Kish, N. Meanwell, H. Lewis, 2022, Journal of medicinal chemistry.

Fundamental Structure—Activity Relationships Associated with a New Structural Class of Respiratory Syncytial Virus Inhibitor.

N. Meanwell, C. Cianci, M. Krystal, 2003 .

pH-Dependent Changes in Photoaffinity Labeling Patterns of the H1 Influenza Virus Hemagglutinin by Using an Inhibitor of Viral Fusion

N. Meanwell, M. Deshpande, C. Cianci, 1999, Journal of Virology.

Salicylamide inhibitors of influenza virus fusion.

N. Meanwell, M. Deshpande, C. Cianci, 2000, Bioorganic & medicinal chemistry letters.

An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology.

N. Meanwell, M. Deshpande, C. Cianci, 2001, Bioorganic & medicinal chemistry letters.

Novel quinolizidine salicylamide influenza fusion inhibitors.

N. Meanwell, C. Cianci, M. Krystal, 1999, Bioorganic & medicinal chemistry letters.