M. Krystal

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Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy

C. Cianci, S. Gerritz, Carol Deminie, 2012, Antiviral chemistry & chemotherapy.

Two nuclear location signals in the influenza virus NS1 nonstructural protein

P. Palese, M. Krystal, D. Greenspan, 1988, Journal of virology.

Characterization of a hemagglutinin-specific inhibitor of influenza A virus.

M. Krystal, G. Luo, R. Colonno, 1996, Virology.

Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes.

O. Ryder, N. Arnheim, E. Zimmer, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Targeting a binding pocket within the trimer-of-hairpins: small-molecule inhibition of viral fusion.

N. Meanwell, D. Langley, C. Cianci, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors

N. Meanwell, Hong Yang, Zeyu Lin, 2016, PLoS pathogens.

Maturation Inhibitor with Improved Potency, Anti-viral Spectrum and Gag Polymorphic

N. Meanwell, Zeyu Lin, M. Krystal, 2016 .

Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage

N. Meanwell, Zeyu Lin, M. Krystal, 2016, Antimicrobial Agents and Chemotherapy.

Increased sensitivity of HIV variants selected by attachment inhibitors to broadly neutralizing antibodies.

L. Alexander, M. Krystal, R. Colonno, 2010, Virology.

Cells expressing an H chain Ig gene carrying a viral T cell epitope are lysed by specific cytolytic T cells.

C. Bona, M. Krystal, T. Moran, 1992, Journal of immunology.

Biochemical studies on capped RNA primers identify a class of oligonucleotide inhibitors of the influenza virus RNA polymerase.

T. Chung, C. Cianci, M. Krystal, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB2 subunit.

S. Inglis, C. Cianci, M. Krystal, 1996, The Journal of general virology.

Determination of influenza virus proteins required for genome replication

P. Palese, M. Krystal, T. Huang, 1990, Journal of virology.

Amplification, expression, and packaging of a foreign gene by influenza virus

J. Parvin, P. Palese, M. Krystal, 1989, Cell.

Introduction of site-specific mutations into the genome of influenza virus.

P. Palese, M. Krystal, W. Luytjes, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.

B. Beno, N. Meanwell, Zeyu Lin, 2016, ACS medicinal chemistry letters.

Biochemical Analysis of HIV-1 Integrase Variants Resistant to Strand Transfer Inhibitors*

Zeyu Lin, M. Krystal, B. Terry, 2008, Journal of Biological Chemistry.

Overexpression of the influenza virus polymerase can titrate out inhibition by the murine Mx1 protein

M. Krystal, P. Staeheli, J. Pavlovic, 1992, Journal of virology.

Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

N. Meanwell, D. Langley, M. Krystal, 2014, Proteins.

Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study

Samit R. Joshi, B. Beno, M. Krystal, 2019, PloS one.

(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.

Murugaiah A. M. Subbaiah, S. Mandlekar, N. Meanwell, 2020, European journal of medicinal chemistry.

Antiviral Activity, Pharmacokinetics, and Safety of BMS-488043, a Novel Oral Small-Molecule HIV-1 Attachment Inhibitor, in HIV-1-Infected Subjects

M. Krystal, R. Colonno, D. Grasela, 2010, Antimicrobial Agents and Chemotherapy.

Entecavir Exhibits Inhibitory Activity against Human Immunodeficiency Virus under Conditions of Reduced Viral Challenge

N. Parkin, M. Krystal, R. Colonno, 2008, Antimicrobial Agents and Chemotherapy.

Entecavir Exhibits Inhibitory Activity against Human Immunodeﬁciency Virus under Conditions of Reduced Viral Challenge (cid:1)

N. Parkin, M. Krystal, R. Colonno, 2008 .

Discovery and Development of Orally Active RSV Fusion Inhibitors

N. Meanwell, C. Cianci, M. Krystal, 2011 .

Respiratory syncytial virus fusion inhibitors. Part 6: an examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety.

N. Meanwell, D. Langley, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 5: Optimization of benzimidazole substitution patterns towards derivatives with improved activity.

N. Meanwell, D. Langley, C. Cianci, 2007, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo.

N. Meanwell, I. Medina, C. Cianci, 2006, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives.

N. Meanwell, C. Cianci, M. Krystal, 2004, Bioorganic & medicinal chemistry letters.

Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor.

N. Meanwell, C. Cianci, M. Krystal, 2003, Bioorganic & medicinal chemistry letters.

Development of a photoaffinity label for respiratory syncytial virus inhibitors

N. Meanwell, P. Williams, C. Cianci, 2003 .

Efavirenz Capsule Sprinkle and Liquid Formulations With Didanosine and Emtricitabine in HIV-1-infected Infants and Children 3 Months to 6 Years of Age: Study AI266-922

M. Krystal, T. Bunupuradah, X. Sáez-Llorens, 2015, The Pediatric infectious disease journal.

Genomic RNAs of influenza viruses are held in a circular conformation in virions and in infected cells by a terminal panhandle.

J. Parvin, S. Gupta, P. Palese, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Differential effect of modified capped RNA substrates on influenza virus transcription.

C. Cianci, M. Krystal, R. Colonno, 1997, Virus research.

Genotypic correlates of susceptibility to HIV-1 attachment inhibitor BMS-626529, the active agent of the prodrug BMS-663068.

D. Langley, M. Krystal, N. Ray, 2014, The Journal of antimicrobial chemotherapy.

Structure-activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-trimethyl-5-hydroxy-cyclohexylmethylamine.

N. Meanwell, C. Cianci, M. Krystal, 2002, Bioorganic & medicinal chemistry letters.

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.

K. Kish, N. Meanwell, M. Krystal, 2022, Bioorganic & medicinal chemistry.

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.

K. Kish, N. Meanwell, C. Cianci, 2022, ACS medicinal chemistry letters.

Use of microphysiometry for analysis of heterologous ion channels expressed in yeast

M. Krystal, K. Hahnenberger, Weimin Tang, 1996, Nature Biotechnology.

Growth impairment resulting from expression of influenza virus M2 protein in Saccharomyces cerevisiae: identification of a novel inhibitor of influenza virus

K. Numata, M. Krystal, G. Luo, 1995, Antimicrobial agents and chemotherapy.

Prediction of Virological Response and Assessment of Resistance Emergence to the HIV-1 Attachment Inhibitor BMS-626529 During 8-Day Monotherapy With Its Prodrug BMS-663068

M. Krystal, J. Whitcomb, N. Ray, 2013, Journal of acquired immune deficiency syndromes.

Activity of the HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068, against CD4-Independent Viruses and HIV-1 Envelopes Resistant to Other Entry Inhibitors

M. Krystal, N. Ray, G. Hanna, 2013, Antimicrobial Agents and Chemotherapy.

Human nucleolus organizers on nonhomologous chromosomes can share the same ribosomal gene variants.

P. D’Eustachio, F. Ruddle, N. Arnheim, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Susceptibility of global HIV-1 clinical isolates to fostemsavir using the PhenoSense® Entry assay

M. Krystal, C. Llamoso, A. Clark, 2020, The Journal of antimicrobial chemotherapy.

Comparison of the three large polymerase proteins of influenza A, B, and C viruses.

M. Yamashita, P. Palese, M. Krystal, 1989, Virology.

Complementation and analysis of an NP mutant of influenza virus.

P. Palese, M. Krystal, R. Li, 1989, Virus research.

Discovery and Characterization of a Novel CD4-Binding Adnectin with Potent Anti-HIV Activity

D. Fabrizio, M. Krystal, M. Cockett, 2017, Antimicrobial Agents and Chemotherapy.

Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor.

N. Meanwell, C. Cianci, M. Krystal, 2005, The Journal of antimicrobial chemotherapy.

Evidence that the matrix protein of influenza C virus is coded for by a spliced mRNA.

M. Yamashita, P. Palese, M. Krystal, 1988, Journal of virology.

Inhibition of the influenza virus RNA-dependent RNA polymerase by antisera directed against the carboxy-terminal region of the PB 2 subunit

S. Inglis, C. Cianci, M. Krystal, 2007 .

Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2022, Journal of medicinal chemistry.

Pharmacodynamics, safety, and pharmacokinetics of BMS-663068, an oral HIV-1 attachment inhibitor in HIV-1-infected subjects.

M. Krystal, R. Bertz, D. Grasela, 2012, The Journal of infectious diseases.

In vivo model for pseudo-templated transcription in Sendai virus

K. H. Park, M. Krystal, K. Park, 1992, Journal of virology.

Overexpression oftheInfluenza VirusPolymerase CanTitrate OutInhibition bytheMurineMxlProtein

M. Krystal, P. Staeheli, Taosheng Huang, 1992 .

Determination ofInfluenza Virus Proteins Required forGenomeReplication

M. Krystal, 1990 .

Antiviral Activity, Safety, and Exposure–Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Tria

P. Ravindran, M. Krystal, A. Hüser, 2017, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Rescue of a foreign gene by Sendai virus.

F. F. Correia, K. H. Park, M. Krystal, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The influenza C virus glycoprotein (HE) exhibits receptor-binding (hemagglutinin) and receptor-destroying (esterase) activities.

M. Nacht, P. Palese, M. Krystal, 1987, Virology.

Expression of the three influenza virus polymerase proteins in a single cell allows growth complementation of viral mutants.

P. Palese, G. Pavlakis, M. Krystal, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Evolution of influenza A and B viruses: conservation of structural features in the hemagglutinin genes.

R. Elliott, J. F. Young, P. Palese, 1982, Proceedings of the National Academy of Sciences of the United States of America.

5,6,7,8-Tetrahydro-1,6-naphthyridine Derivatives as Potent HIV-1-Integrase-Allosteric-Site Inhibitors.

Barry L. Johnson, K. Kish, N. Meanwell, 2019, Journal of medicinal chemistry.

Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.

N. Meanwell, Zeyu Lin, S. Gerritz, 2010, Journal of combinatorial chemistry.

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase.

J. Snyder, V. Bond, D. Liotta, 2015, ACS medicinal chemistry letters.

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.

Martin D. Eastgate, N. Meanwell, D. Langley, 2018, Journal of medicinal chemistry.

Antiviral Drug Discovery

N. Meanwell, C. Cianci, M. Krystal, 2013 .

Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.

K. Kish, G. Trainor, N. Meanwell, 2020, Journal of medicinal chemistry.

Identification of N-Hydroxamic Acid and N-Hydroxyimide Compounds that Inhibit the Influenza Virus Polymerase

T. Chung, N. Meanwell, C. Cianci, 1996 .

Design, Synthesis and SAR Study of Novel C2-Pyrazolopyrimidine Amides and Amide Isosteres as Allosteric Integrase Inhibitors.

N. Meanwell, C. Cianci, M. Krystal, 2020, Bioorganic & medicinal chemistry letters.

Respiratory syncytial virus fusion inhibitors. Part 4: optimization for oral bioavailability.

A. Marino, N. Meanwell, I. Medina, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.

N. Meanwell, Zeyu Lin, M. Krystal, 2015, Bioorganic & medicinal chemistry letters.

Oral Efficacy of a Respiratory Syncytial Virus Inhibitor in Rodent Models of Infection

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Orally Active Fusion Inhibitor of Respiratory Syncytial Virus

N. Meanwell, I. Medina, C. Cianci, 2004, Antimicrobial Agents and Chemotherapy.

Respiratory syncytial virus fusion inhibitors. Part 7: structure-activity relationships associated with a series of isatin oximes that demonstrate antiviral activity in vivo.

A. Marino, N. Meanwell, I. Medina, 2009, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2019, Journal of medicinal chemistry.

Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.

S. Mandlekar, N. Meanwell, M. Krystal, 2018, Journal of medicinal chemistry.

Promoter analysis of influenza virus RNA polymerase

J. Parvin, A. Ishihama, P. Palese, 1989, Journal of virology.

Pharmacokinetics and inhibitory quotient of atazanavir/ritonavir versus lopinavir/ritonavir in HIV-infected, treatment-naive patients who participated in the CASTLE Study.

M. Krystal, R. Bertz, A. Persson, 2012, The Journal of antimicrobial chemotherapy.

Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in NS gene.

W. Fitch, J. Parvin, P. Palese, 1986, Science.

Analysis of an influenza A virus mutant with a deletion in the NS segment

H. Maassab, P. Palese, M. Krystal, 1984, Journal of virology.

Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A.

N. Meanwell, M. Krystal, S. Snyder, 2013, Bioorganic & medicinal chemistry letters.

Recombinant influenza virus polymerase: requirement of both 5' and 3' viral ends for endonuclease activity

T. Chung, M. Krystal, M. Hagen, 1994, Journal of virology.

Purification and molecular structure of RNA polymerase from influenza virus A/PR8.

A. Ishihama, K. Nagata, A. Honda, 1990, Journal of biochemistry.

Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

Eric T Baldwin, Samuel W Gerritz, Michael Sinz, 2011, Proceedings of the National Academy of Sciences.

Week 96 Genotypic and Phenotypic Results of the Fostemsavir Phase 3 BRIGHTE Study in Heavily Treatment-Experienced Adults Living with Multidrug-Resistant HIV-1

M. Kozal, P. Cahn, M. Krystal, 2022, Antimicrobial agents and chemotherapy.

Differential activation of the influenza virus polymerase via template RNA binding

C. Cianci, M. Krystal, L. Tiley, 1995, Journal of virology.

Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5' ends of the viral RNAs

M. Krystal, L. Tiley, M. Hagen, 1994, Journal of virology.

Illuminating HIV gp120-Ligand Recognition through Computationally-Driven Optimization of Antibody-Recruiting Molecules.

Markus K. Dahlgren, Robert A. Domaoal, W. L. Jorgensen, 2014, Chemical science.

Expression of influenza virus NS2 nonstructural protein in bacteria and localization of NS2 in infected eucaryotic cells

P. Palese, M. Krystal, D. Greenspan, 1985, Journal of virology.

Changes to the HIV Long Terminal Repeat and to HIV Integrase Differentially Impact HIV Integrase Assembly, Activity, and the Binding of Strand Transfer Inhibitors*

D. Langley, M. Krystal, M. A. Walker, 2007, Journal of Biological Chemistry.

Molecular mechanism underlying the action of a novel fusion inhibitor of influenza A virus

N. Meanwell, C. Cianci, M. Krystal, 1997, Journal of virology.

Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.

N. Meanwell, D. Langley, Zeyu Lin, 2019, Bioorganic & medicinal chemistry letters.

Simple and Accurate In Vitro Method for Predicting Serum Protein Binding of HIV Integrase Strand Transfer Inhibitors

N. Meanwell, Zeyu Lin, M. Krystal, 2011 .

Noncumulative sequence changes in the hemagglutinin genes of influenza C virus isolates.

P. Palese, M. Krystal, U. Desselberger, 1985, Virology.

Sequential mutations in the NS genes of influenza virus field strains

J. F. Young, P. Palese, M. Krystal, 1983, Journal of virology.

Influenza B virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza A and C viruses.

W. Fitch, M. Yamashita, P. Palese, 1988, Virology.

In Vitro Antiviral Characteristics of HIV-1 Attachment Inhibitor BMS-626529, the Active Component of the Prodrug BMS-663068

N. Meanwell, M. Krystal, J. Kadow, 2012, Antimicrobial Agents and Chemotherapy.

The Genesis and Future Prospects of Small Molecule HIV-1 Attachment Inhibitors.

N. Meanwell, M. Krystal, J. Kadow, 2022, Advances in experimental medicine and biology.

Novel Bent Conformation of CD4 Induced by HIV-1 Inhibitor Indirectly Prevents Productive Viral Attachment.

C. Mazzucco, M. Krystal, D. Dixon, 2021, Journal of molecular biology.

Clinical evidence for a lack of cross-resistance between temsavir and ibalizumab or maraviroc

M. Krystal, M. Cockett, R. Rose, 2021, AIDS.

Prevalence of gp160 polymorphisms known to be related to decreased susceptibility to temsavir in different subtypes of HIV-1 in the Los Alamos National Laboratory HIV Sequence Database

B. Foley, M. Krystal, E. Arnoult, 2021, The Journal of antimicrobial chemotherapy.

In Vivo Patterns of Resistance to the HIV Attachment Inhibitor BMS-488043

D. Langley, L. Alexander, M. Krystal, 2010, Antimicrobial Agents and Chemotherapy.

Viral Drug Resistance Through 48 Weeks, in a Phase 2b, Randomized, Controlled Trial of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir

Samit R. Joshi, M. Krystal, G. Hanna, 2017, Journal of acquired immune deficiency syndromes.

International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK

Raúl Tabarés Gutiérrez, Samit R. Joshi, H. Jessen, 2016, Journal of the International AIDS Society.

Structure and evolution of human and African ape rDNA pseudogenes.

N. Arnheim, M. Krystal, Yusuf Tutar, 1983, Molecular biology and evolution.

GSK3732394: a Multi-specific Inhibitor of HIV Entry

D. Langley, P. Nef, M. Krystal, 2019, Journal of Virology.

A Novel gp41-Binding Adnectin with Potent Anti-HIV Activity Is Highly Synergistic when Linked to a CD4-Binding Adnectin

D. Fabrizio, M. Krystal, M. Cockett, 2018, Journal of Virology.

The N17 region of gp41 in HIV-1 is the most conserved region in gp160. mRNA selection

D. Fabrizio, M. Krystal, M. Cockett, 2018 .

Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains.

I. Wilson, J. Skehel, D. Wiley, 1983, Proceedings of the National Academy of Sciences of the United States of America.

A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human δ and β globin genes

M. Krystal, R. Miesfeld, Roger L. Miesfeld, 1981 .

GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile

N. Meanwell, Zeyu Lin, Joseph L. Cantone, 2021, Antimicrobial agents and chemotherapy.

Length heterogeneity in a region of the human ribosomal gene spacer is not accompanied by extensive population polymorphism.

N. Arnheim, M. Krystal, 1978, Journal of molecular biology.

Influenza C virus hemagglutinin: comparison with influenza A and B virus hemagglutinins

R. P. Aaronson, P. Palese, M. Krystal, 1984, Journal of virology.

Resistance Mutations (NRTI) BMS-986001 against Known NRTI Nucleoside Reverse Transcriptase Inhibitor Cross-Resistance Profile of In Vitro

M. Krystal, G. Hanna, Tricia L. Protack, 2014 .

In Vitro Cross-Resistance Profile of Nucleoside Reverse Transcriptase Inhibitor (NRTI) BMS-986001 against Known NRTI Resistance Mutations

M. Krystal, G. Hanna, Tricia L. Protack, 2013, Antimicrobial Agents and Chemotherapy.

endonuclease activity. requirement of both 5' and 3' viral ends for Recombinant influenza virus polymerase:

T. Chung, M. Krystal, M. Hagen, 2013 .

Development of antivirals against influenza.

C. Cianci, M. Krystal, 1998, Expert opinion on investigational drugs.

Taking aim at a moving target — inhibitors of influenza virus Part 2: viral replication, packaging and release

N. Meanwell, M. Krystal, 1996 .

The role of template-primer interactions in cleavage and initiation by the influenza virus polymerase.

T. Chung, M. Krystal, L. Tiley, 1995, The Journal of general virology.

Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,1

B. Beno, N. Meanwell, V. Arora, 2018, Journal of medicinal chemistry.

The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Prevalence and Clinical Significance of HIV Drug Resistance Mutations by Ultra-Deep Sequencing in Antiretroviral-Naïve Subjects in the CASTLE Study

Marco Mancini, M. Egholm, M. Kozal, 2010, PloS one.

Impact of Integrase Sequences from HIV-1 Subtypes A6/A1 on the In Vitro Potency of Cabotegravir or Rilpivirine

J. van Lunzen, Ping Wang, M. Krystal, 2022, Antimicrobial agents and chemotherapy.

Infectious influenza A and B virus variants with long carboxyl terminal deletions in the NS1 polypeptides.

P. Palese, M. Krystal, D. Greenspan, 1987, Virology.

Complete nucleotide sequence of the influenza C/California/78 virus nucleoprotein gene.

P. Palese, M. Krystal, S. Nakada, 1984, Virus research.

Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

R. Lamb, L. Pinto, M. Krystal, 1996, Journal of virology.

A Phase 1 randomized study of GSK3732394, an investigational long-acting biologic treatment regimen for HIV-1 infection

M. Krystal, Allen Wolstenholme, Shiven B Chabria, 2022, Antiviral Therapy.

Antiviral Properties of HIV-1 Capsid Inhibitor GSK878

M. Krystal, J. Kadow, M. Cockett, 2023, Antimicrobial agents and chemotherapy.

Triketoacid inhibitors of HIV-integrase: a new chemotype useful for probing the integrase pharmacophore.

N. Meanwell, Zeyu Lin, Carol Deminie, 2006, Bioorganic & medicinal chemistry letters.

The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.

N. Meanwell, Zeyu Lin, M. Krystal, 2018, Bioorganic & medicinal chemistry letters.

Benzyl amide-ketoacid inhibitors of HIV-integrase.

N. Meanwell, Zeyu Lin, M. Krystal, 2007, Bioorganic & Medicinal Chemistry Letters.

Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype.

N. Meanwell, Zeyu Lin, Carol Deminie, 2006, Bioorganic & medicinal chemistry letters.

Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.

Stephen R. Johnson, N. Meanwell, D. Langley, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Preclinical Profiling of GSK3739936 (BMS-986180), an Allosteric Inhibitor of HIV-1 Integrase with Broad-Spectrum Activity toward 124/125 Polymorphs.

K. Kish, N. Meanwell, H. Lewis, 2022, Journal of medicinal chemistry.

Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.

A. Mathur, N. Meanwell, Zeyu Lin, 2020, Bioorganic & Medicinal Chemistry.

THE NONSTRUCTURAL GENE SEGMENT OF INFLUENZA A VIRUS: EXPRESSION OF NS1 PROTEIN IN MAMMALIAN CELLS; ANALYSIS OF A DELETION MUTANT

H. Maassab, P. Palese, M. Krystal, 1984 .

Taking aim at a moving target-inhibitors of influenza virus Part 1 : virus adsorption, entry and uncoating

N. Meanwell, M. Krystal, 1996 .

The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.

D. Langley, Zeyu Lin, M. Krystal, 2008, Biochemistry.

Expression of antisense RNA fails to inhibit influenza virus replication

P. Palese, M. Krystal, J. Leiter, 1989, Virus Research.

Fundamental Structure—Activity Relationships Associated with a New Structural Class of Respiratory Syncytial Virus Inhibitor.

N. Meanwell, C. Cianci, M. Krystal, 2003 .

pH-Dependent Changes in Photoaffinity Labeling Patterns of the H1 Influenza Virus Hemagglutinin by Using an Inhibitor of Viral Fusion

N. Meanwell, M. Deshpande, C. Cianci, 1999, Journal of Virology.

Influenza C virus RNA 7 codes for a nonstructural protein

P. Palese, M. Krystal, U. Desselberger, 1985, Journal of virology.

Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.

B. Beno, N. Meanwell, M. Krystal, 2021, Bioorganic & medicinal chemistry letters.

The Second-Generation Maturation Inhibitor GSK3532795 Maintains Potent Activity Toward HIV Protease Inhibitor–Resistant Clinical Isolates

Zeyu Lin, M. Krystal, M. Nijhuis, 2017, Journal of acquired immune deficiency syndromes.

Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.

N. Meanwell, M. Krystal, Tricia L. Protack, 2016, Bioorganic & medicinal chemistry letters.

Salicylamide inhibitors of influenza virus fusion.

N. Meanwell, M. Deshpande, C. Cianci, 2000, Bioorganic & medicinal chemistry letters.

The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.

A. Mathur, N. Meanwell, Zeyu Lin, 2022, Journal of medicinal chemistry.

An approach to the identification of potent inhibitors of influenza virus fusion using parallel synthesis methodology.

N. Meanwell, M. Deshpande, C. Cianci, 2001, Bioorganic & medicinal chemistry letters.

Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.

N. Meanwell, Zeyu Lin, M. Krystal, 2022, Journal of Medicinal Chemistry.

C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.

B. Beno, N. Meanwell, Zeyu Lin, 2016, Bioorganic & medicinal chemistry.

Novel quinolizidine salicylamide influenza fusion inhibitors.

N. Meanwell, C. Cianci, M. Krystal, 1999, Bioorganic & medicinal chemistry letters.

Pharmacodynamics, safety, and pharmacokinetics of BMS-663068, an oral HIV-1 attachment inhibitor in HIV-1-infected subjects.

M. Krystal, R. Bertz, D. Grasela, 2012, The Journal of infectious diseases.

Respiratory syncytial virus: recent progress towards the discovery of effective prophylactic and therapeutic agents.

N. Meanwell, M. Krystal, Meanwell, 2000, Drug discovery today.

The HIV-1 Capsid-Targeted Inhibitor GSK878 Alters Selection of Target Sites for HIV DNA Integration.

Alexander G. McFarland, F. Bushman, J. Everett, 2023, AIDS research and human retroviruses.

Inhibition of influenza viral polymerases by minimal viral RNA decoys.

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