M. Bova

发表

M. Bova, L. Ding, J. Horwitz, 1997, The Journal of Biological Chemistry.

Subunit Exchange, Conformational Stability, and Chaperone-like Function of the Small Heat Shock Protein 16.5 fromMethanococcus jannaschii *

M. Bova, L. Ding, J. Horwitz, 2002, The Journal of Biological Chemistry.

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.

H. Sham, N. Yao, T. Yednock, 2010, Bioorganic & medicinal chemistry letters.

Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.

G. Drewes, M. Bantscheff, N. Ramsden, 2011, ACS chemical biology.

Subunit Exchange of Small Heat Shock Proteins

M. Bova, B. K. Fung, H. Mchaourab, 2000, The Journal of Biological Chemistry.

Quantifying Amyloid Beta (Aβ)–Mediated Changes in Neuronal Morphology in Primary Cultures

Mike Lee, W. Zago, M. Bova, 2012, Journal of biomolecular screening.

A Label-Free Approach to Identify Inhibitors of α4β7-Mediated Cell Adhesion to MadCAM

M. Bova, F. Bard, Ying-zi Xu, 2011, Journal of biomolecular screening.

Combining label-free technologies: discovery in strength.

M. Bova, R. Barbour, 2012, Bioanalysis.

Monitoring signaling by the p75(NTR) receptor utilizing a caspase-3 activation assay amenable to small-molecule screening.

J. M. Bradshaw, M. Bova, J. Sauer, 2012, Assay and drug development technologies.

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

H. Sham, T. Yednock, M. Bova, 2009, Bioorganic & medicinal chemistry letters.

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.

R. Motter, D. Kholodenko, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

The oxidative mechanism of action of ortho-quinone inhibitors of protein-tyrosine phosphatase alpha is mediated by hydrogen peroxide.

Stefan Vasile, Terence Hui, Gerald McMahon, 2004, Archives of biochemistry and biophysics.

Lens alpha-crystallin: chaperone-like properties.

M. Bova, L. Ding, J. Horwitz, 1998, Methods in enzymology.

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.

P. Stewart, M. Bova, L. Ding, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Emerging drug targets in amyotrophic lateral sclerosis

M. Bova, G. Kinney, 2013 .

Pharmacological, Pharmacokinetic, and Primate Analgesic Efficacy Profile of the Novel Bradykinin B1 Receptor Antagonist ELN441958

Jon E Hawkinson, Anna Liao, A. Malmberg, 2007, Journal of Pharmacology and Experimental Therapeutics.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Kent Fitzgerald, Paul Beroza, Lee Latimer, 2013, ChemMedChem.

Small heat-shock protein structures reveal a continuum from symmetric to variable assemblies.

P. Stewart, M. Bova, H. Mchaourab, 2000, Journal of molecular biology.

Structure and Function of the Conserved Domain in αA-Crystallin. Site-Directed Spin Labeling Identifies a β-Strand Located near a Subunit Interface†

M. Bova, H. Mchaourab, A. R. Berengian, 1997 .

Lens α-crystallin: Function and structure

P. Stewart, M. Bova, L. Ding, 1999, Eye.

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.

P. Beroza, R. Motter, R. Neitz, 2013, Bioorganic & medicinal chemistry letters.

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

Alexander K. Buell, Tuomas P. J. Knowles, Michele Vendruscolo, 2014, PloS one.

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.

Paul Beroza, Zhao Ren, Dean R Artis, 2013, Bioorganic & medicinal chemistry letters.

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

R. Motter, D. Kholodenko, R. Barbour, 2010, Alzheimer's Research & Therapy.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitor

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

T. Shaler, N. Yao, T. Yednock, 2013, Nature Communications.

Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors.

P. Beroza, R. Barbour, N. Yao, 2013, Biochemical and biophysical research communications.

Structure and function of the conserved domain in alphaA-crystallin. Site-directed spin labeling identifies a beta-strand located near a subunit interface.

M. Bova, H. Mchaourab, A. R. Berengian, 1997, Biochemistry.

Subunit exchange of alphaA-crystallin.

M. Bova, L. Ding, J. Horwitz, 1997, The Journal of biological chemistry.

Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.

P. Beroza, Jiangli Yan, H. Sham, 2013, Bioorganic & medicinal chemistry letters.

Acute and chronic administration of cocaine produces hyperthermia in the rat.

M. Bova, R. Pechnick, R. George, 1991, Proceedings of the Western Pharmacology Society.

Mutation of αB-crystallin: effects on chaperone-like activity

M. Bova, L. Ding, J. Horwitz, 1998 .

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.

H. Sham, L. Latimer, M. Bova, 2013, Bioorganic & medicinal chemistry letters.

Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.

G. Mcmahon, M. Bova, D. Tam, 2005, Toxicology letters.

Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions

D. Agard, E. Masliah, G. Tóth, 2019, Scientific Reports.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

G. Tóth, H. Sham, N. Yao, 2010, Bioorganic & medicinal chemistry letters.

Peracid oxidation of an N-hydroxyguanidine compound: a chemical model for the oxidation of N omega-hydroxyl-L-arginine by nitric oxide synthase.

M. Bova, D. Stuehr, J. Fukuto, 1993, Journal of medicinal chemistry.

Effects of subcutaneous and intracerebroventricular administration of the sigma receptor ligand 1,3-Di-o-tolylguanidine on body temperature in the rat: interactions with BMY 14802 and rimcazole.

M. Bova, R. Pechnick, R. George, 1991, Journal of Pharmacology and Experimental Therapeutics.

Pharmacokinetic and pharmacodynamic investigation of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain, CSF and plasma of multiple nonclinical species following oral administration

R. Motter, D. Kholodenko, K. Hu, 2010, Alzheimer's & Dementia.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.

R. Neitz, M. Adler, H. Sham, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2011, Bioorganic & Medicinal Chemistry Letters.

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

M. Bova, J. Sauer, G. Basi, 2011, Bioorganic & medicinal chemistry letters.

Lens alpha-crystallin: function and structure.

P. Stewart, M. Bova, L. Ding, 1999, Eye.

Development of a Novel β-Secretase Binding Assay Using the AlphaScreen Platform

H. Cheung, H. Sham, M. Bova, 2013, Journal of biomolecular screening.

N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.

H. Sham, M. Bova, J. Sauer, 2009, Bioorganic & medicinal chemistry letters.

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Correction: Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target

P. Beroza, K. Regnström, Jiangli Yan, 2013, PLoS ONE.

Label Free Fragment Screening Using Surface Plasmon Resonance as a Tool for Fragment Finding – Analyzing Parkin, a Difficult CNS Target

P. Beroza, K. Regnström, Jiangli Yan, 2013, PloS one.

Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.

John-Michael Sauer, Gergely Toth, G. Tóth, 2009, Bioorganic & medicinal chemistry letters.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

P. Beroza, R. Motter, R. Neitz, 2013, ChemMedChem.