J. Horwitz

发表

M. Bova, L. Ding, J. Horwitz, 1997, The Journal of Biological Chemistry.

Identification and functional clustering of global gene expression differences between human age-related cataract and clear lenses.

Douglas A. Hosack, R. Lempicki, M. Kantorow, 2003, Molecular vision.

Cloning, sequencing and differential expression of αB-crystallin in the zebrafish, Danio rerio

M. Kantorow, J. Horwitz, M. Posner, 1999 .

Characterization of polypeptides from human nuclear cataracts by Western blot analysis.

L. Takemoto, J. Horwitz, J. Zigler, 1985, Experimental eye research.

The quaternary organization and dynamics of the molecular chaperone HSP26 are thermally regulated.

Florian Stengel, Eman Basha, Elizabeth Vierling, 2010, Chemistry & biology.

Alpha crystallin: the quest for a homogeneous quaternary structure.

J. Horwitz, 2009, Experimental eye research.

Subunit Exchange of Polydisperse Proteins

C. Robinson, J. Benesch, J. Aquilina, 2005, Journal of Biological Chemistry.

Subunit Exchange, Conformational Stability, and Chaperone-like Function of the Small Heat Shock Protein 16.5 fromMethanococcus jannaschii *

M. Bova, L. Ding, J. Horwitz, 2002, The Journal of Biological Chemistry.

Rpe65 Is a Retinyl Ester Binding Protein That Presents Insoluble Substrate to the Isomerase in Retinal Pigment Epithelial Cells*

J. Horwitz, R. Radu, G. Travis, 2004, Journal of Biological Chemistry.

Is a Retinyl Ester Binding Protein That Presents Insoluble Substrate to the Isomerase in Retinal Pigment Epithelial Cells *

J. Horwitz, R. Radu, G. Travis, 2003 .

Crystallin γB-I4F Mutant Protein Binds to α-Crystallin and Affects Lens Transparency*

J. Yates, B. Beutler, Xin Du, 2005, Journal of Biological Chemistry.

Expression of βB2-Crystallin mRNA and Protein in Retina, Brain, and Testis

M. Kantorow, J. Piatigorsky, J. Horwitz, 2000 .

Near-ultraviolet absorption bands of tryptophan. Studies using indole and 3-methylindole as models.

J. Horwitz, E. H. Strickland, C. Billups, 1970, Biochemistry.

Conversion from oligomers to tetramers enhances autophosphorylation by lens alpha A-crystallin. Specificity between alpha A- and alpha B-crystallin subunits.

W. D. de Jong, M. Kantorow, J. Piatigorsky, 1995, The Journal of biological chemistry.

Conversion from Oligomers to Tetramers Enhances Autophosphorylation by Lens A-Crystallin

W. D. de Jong, M. Kantorow, J. Piatigorsky, 1995, The Journal of Biological Chemistry.

The small heat-shock protein, alphaB-crystallin, has a variable quaternary structure.

P. Stewart, J. Horwitz, D. A. Haley, 1998, Journal of molecular biology.

Mimicking phosphorylation of alphaB-crystallin affects its chaperone activity.

C. Robinson, C. MacPhee, J. Carver, 2007, The Biochemical journal.

The function of alpha-crystallin in vision.

J. Horwitz, 2000, Seminars in cell & developmental biology.

Structural features of δ-crystallin of turtle lens

J. Piatigorsky, J. Horwitz, L. A. Williams, 1982 .

τ-crystallin from the turtle lens: Purification and partial characterization

J. Piatigorsky, L. Ding, J. Horwitz, 1985 .

The ability of lens alpha crystallin to protect against heat-induced aggregation is age-dependent.

L. Takemoto, J. Horwitz, T. Emmons, 1992, Current eye research.

Proctor Lecture. The function of alpha-crystallin.

J. Horwitz, 1993, Investigative ophthalmology & visual science.

Chaperone-like activity of alpha-crystallin. The effect of NADPH on its interaction with zeta-crystallin.

J. Horwitz, J. Zigler, P. Rao, 1994, The Journal of biological chemistry.

Dietary restriction retards age-related loss of gamma crystallins in the mouse lens.

R. Weindruch, D. Bok, R. Walford, 1984, Science.

Immunochemical characterization of the major low molecular weight polypeptide (10K) from human cataractous lenses.

L. Takemoto, J. Horwitz, B. Straatsma, 1989, Experimental eye research.

Immunocytochemical localization of the lens main intrinsic polypeptide (MIP26) in communicating junctions

D. Bok, J. Horwitz, J. Dockstader, 1982, The Journal of cell biology.

Spatial and temporal mapping of the age-related changes in human lens crystallins.

L. Takemoto, M. McFall-Ngai, L. Ding, 1985, Experimental eye research.

Partial Characterization of Three Distinct Populations of Human 7-Crystallins

L. Takemoto, J. Horwitz, P. Russell, 2005 .

Degradation of C-terminal Truncated αA-crystallins by the Ubiquitin–Proteasome Pathway

L. Ding, J. Horwitz, F. Shang, 2007 .

Age-dependent changes in the heat-stable crystallin, βBp, of the human lens

M. McFall-Ngai, L. Ding, J. Horwitz, 1986 .

GammaD-crystallin associated protein aggregation and lens fiber cell denucleation.

Catherine Cheng, J. Horwitz, Haiquan Liu, 2007, Investigative ophthalmology & visual science.

Sequence and spatial expression of zebrafish (Danio rerio) alphaA-crystallin.

M. Kantorow, J. Horwitz, M. Posner, 2002, Molecular vision.

Nutritional factors in cataract.

J. Horwitz, G. E. Bunce, J. Kinoshita, 1990, Annual review of nutrition.

Up-regulation of osteonectin/SPARC in age-related cataractous human lens epithelia.

M. Kantorow, J. Horwitz, D. Carper, 1998, Molecular vision.

Evidence that alpha-crystallin prevents non-specific protein aggregation in the intact eye lens.

J. Horwitz, J. Zigler, P. Rao, 1995, Biochimica et biophysica acta.

Evidence that α-crystallin prevents non-specific protein aggregation in the intact eye lens

J. Horwitz, J. Zigler, P. Rao, 1995 .

Interaction of alpha-crystallin with spin-labeled peptides.

H. Steinhoff, C. Altenbach, W. Hubbell, 1995, Biochemistry.

Alpha-crystallin, a molecular chaperone, forms a stable complex with carbonic anhydrase upon heat denaturation.

J. Horwitz, J. Zigler, P. Rao, 1993, Biochemical and biophysical research communications.

Altered Chaperone-like Activity of α-Crystallins Promotes Cataractogenesis*

Catherine Cheng, L. Ding, J. Horwitz, 2010, The Journal of Biological Chemistry.

Arginine 54 and Tyrosine 118 residues of {alpha}A-crystallin are crucial for lens formation and transparency.

M. Wang, Catherine Cheng, J. Horwitz, 2006, Investigative Ophthalmology and Visual Science.

Immunochemical studies on the major intrinsic polypeptides from human lens membrane.

J. Horwitz, J. Zigler, 1981, Investigative ophthalmology & visual science.

The gene for the major intrinsic protein (MIP) of the ocular lens is assigned to human chromosome 12cen-q14.

T. Mohandas, J. Bateman, M. Gorin, 1986, Investigative ophthalmology & visual science.

Antisera to synthetic peptides of MIP26K as probes of membrane changes during human cataractogenesis.

L. Takemoto, J. Horwitz, M. Takehana, 1986, Experimental eye research.

Interspecies conservation of the Main Intrinsic Polypeptide (MIP) of the lens membrane

L. Takemoto, J. Horwitz, J. Hansen, 1981 .

Analysis of microdissected cataractous human lenses.

J. Horwitz, J. Dockstader, R. Neuhaus, 1981, Investigative ophthalmology & visual science.

Phagocytosis of outer segments by retinal pigment epithelium: phagosome-lysosome interaction.

D. Bok, J. Horwitz, E. Bosch, 1993, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Changes in zebrafish (Danio rerio) lens crystallin content during development

L. Ding, J. Horwitz, M. Posner, 2013, Molecular vision.

Presence of low molecular weight polypeptides in human brunescent cataracts.

L. Takemoto, J. Horwitz, B. Straatsma, 1983, Biochemical and biophysical research communications.

Structural and functional characterization of recombinant human cellular retinaldehyde‐binding protein

D. Bok, J. Horwitz, L. Luck, 1998, Protein science : a publication of the Protein Society.

A reinvestigation of the secondary structure of functionally active vSGLT, the vibrio sodium/galactose cotransporter.

E. Wright, J. Horwitz, E. Turk, 2006, Biochemistry.

Oxidation of the N-terminal methionine of lens alpha-A crystallin.

L. Takemoto, J. Horwitz, T. Emmons, 1992, Current eye research.

Alpha B-crystallin exists as an independent protein in the heart and in the lens.

L. Ding, J. Horwitz, S. Bhat, 1991, European journal of biochemistry.

Uptake, processing and release of retinoids by cultured human retinal pigment epithelium.

J. Flannery, D. Bok, J. Horwitz, 1990, Experimental eye research.

Assignment of a human beta-crystallin gene to 17cen-q23

T. Mohandas, M. Gorin, J. Horwitz, 1986, Human Genetics.

Photoselection and Linear Dichroism of Retinal Isomers and Visual Pigments

J. Horwitz, J. Heller, 1973 .

R120G αB‐crystallin promotes the unfolding of reduced α‐lactalbumin and is inherently unstable

C. Robinson, J. Carver, J. Aquilina, 2005 .

A conserved disulfide motif in human tear lipocalins influences ligand binding.

B. Glasgow, W. Hubbell, J. Horwitz, 1998, Biochemistry.

The Mutation Asp69→Ser Affects the Chaperone‐Like Activity of αA‐Crystallin

W. W. Jong, L. Takemoto, J. Horwitz, 1995 .

Increased expression of osteonectin/SPARC mRNA and protein in age-related human cataracts and spatial expression in the normal human lens.

M. Kantorow, E. Sage, J. Horwitz, 2000, Molecular vision.

x-Crystallin / tx-Enolase : One Gene Encodes Both an Enzyme and a Lens Structural Protein

W. W. Jong, J. Horwitz, S. Stapel, 2002 .

Glutathione reductase in human lens epithelium: FAD-induced in vitro activation.

J. Horwitz, B. Straatsma, A. Dovrat, 1987, Current eye research.

J. Horwitz, B. Straatsma, R. Foos, 1985, Annals of internal medicine.

Near-ultraviolet absorption bands of tryptophan. Studies using horseradish peroxidase isoenzymes, bovine and horse heart cytochrome c, and N-stearyl-L-tryptophan n-hexyl ester.

M. Wilchek, J. Horwitz, L. Shannon, 1971, Biochemistry.

The native oligomeric organization of alpha-crystallin, is it necessary for its chaperone function?

L. Ding, J. Horwitz, Qingling Huang, 2004, Experimental eye research.

Conformational changes following interaction between retinol isomers and human retinol-binding protein and between the retinol-binding protein and prealbumin.

J. Horwitz, J. Heller, 1973, The Journal of biological chemistry.

Differential display detects altered gene expression between cataractous and normal human lenses.

M. Kantorow, J. Piatigorsky, J. Horwitz, 1998, Investigative ophthalmology & visual science.

The temperature and pH dependence of conformational transitions of the chromatin subunit.

D. E. Olins, V. Schumaker, C. Knobler, 1979, Nucleic acids research.

DL-propranolol inhibits lens hexokinase activity and affects lens optics.

J. Sivak, J. Horwitz, M. Silbermann, 1993, Experimental eye research.

Enzyme activities and crystallin profiles of clear and cataractous lenses of the RCS rat.

L. Ding, J. Horwitz, A. Dovrat, 1993, Experimental eye research.

Nucleotide sequence for the cDNA of the bovine beta B2 crystallin and assignment of the orthologous human locus to chromosome 22.

T. Mohandas, L. Tsui, M. Gorin, 1987, Current eye research.

Immunocytochemical localization of the main intrinsic polypeptide (MIP) in ultrathin frozen sections of rat lens

D. Bok, J. Horwitz, P. Fitzgerald, 1983, The Journal of cell biology.

Cloning, sequencing and differential expression of alphaB-crystallin in the zebrafish, Danio rerio.

M. Kantorow, J. Horwitz, M. Posner, 1999, Biochimica et biophysica acta.

αA-Crystallin and αB-Crystallin Reside in Separate Subcellular Compartments in the Developing Ocular Lens*

J. Horwitz, S. Kohan, S. Bhat, 2012, The Journal of Biological Chemistry.

Lens capsule and epithelium in age-related cataract.

J. Horwitz, B. Straatsma, D. O. Lightfoot, 1991, American journal of ophthalmology.

A biochemical characterization of the photophore lenses of the midshipman fish, Porichthys notatus Girard

M. McFall-Ngai, J. Horwitz, S. Dove, 1993, Journal of Comparative Physiology A.

High molecular weight aggregates from human cataracts: characterization by Western blot analysis.

L. Takemoto, J. Horwitz, J. Hansen, 1984, Biochemical and biophysical research communications.

Cleavage from the N-terminal region of beta Bp crystallin during aging of the human lens.

L. Takemoto, J. Horwitz, J. Smith, 1987, Experimental eye research.

Distribution and activity of glutathione-S-transferase in normal human lenses and in cataractous human epithelia.

J. Horwitz, M. Lou, B. Straatsma, 1993, Current eye research.

Lens and Cataract

J. Horwitz, N. Jaffe, 1992, All about Your Eyes, Second Edition, revised and updated.

Peroxidase isoenzymes from horseradish roots. 3. Circular dichroism of isoenzymes and apoisoenzymes.

J. Horwitz, L. Shannon, E. H. Strickland, 1968, The Journal of biological chemistry.

Analysis of vibrational structure in the near-ultraviolet circular dichroism and absorption spectra of phenylalanine and its derivatives.

J. Horwitz, E. H. Strickland, C. Billups, 1969, Journal of the American Chemical Society.

Analysis of the vibrational structure in the near-ultraviolet circular dichroism and absorption spectra of tyrosine derivatives and ribonuclease-A at 77 degrees K.

J. Horwitz, E. H. Strickland, C. Billups, 1970, Journal of the American Chemical Society.

Conformational properties of the main intrinsic polypeptide (MIP26) isolated from lens plasma membranes.

D. Bok, J. Horwitz, 1987, Biochemistry.

Circular dichroism of native and illuminated bovine visual pigment 500 at 77 degrees K in the 620- to 320-nm region.

J. Horwitz, J. Heller, 1971, Biochemistry.

Fine structure in the near-ultraviolet circular dichroism and absorption spectra of tryptophan derivatives and chymotrypsinogen A at 77 degrees K.

J. Horwitz, E. H. Strickland, C. Billups, 1969, Biochemistry.

Reflectins: The Unusual Proteins of Squid Reflective Tissues

M. McFall-Ngai, L. Ding, J. Horwitz, 2004, Science.

Increased resolution of circular dichroic spectra using a computer of average transients.

J. Horwitz, E. H. Strickland, E. Kay, 1968, Analytical biochemistry.

BetaB1-crystallin: identification of a candidate ciliary body uveitis antigen.

L. Goodglick, L. Gordon, J. Braun, 2003, Investigative ophthalmology & visual science.

Lens alpha-crystallin: chaperone-like properties.

M. Bova, L. Ding, J. Horwitz, 1998, Methods in enzymology.

Alpha-crystallin can function as a molecular chaperone.

J. Horwitz, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Biochemical analysis of microdissected sections from the normal and cataractous human lens.

L. Takemoto, J. Horwitz, J. Hansen, 1982, Current eye research.

Circular dichroism studies at variable temperature: urobilinoid conformation.

J. Horwitz, D. Lightner, E. Docks, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Human β-crystallin: I. Comparative studies on the β1, β2 and β3-crystallins

J. Horwitz, J. Zigler, J. Kinoshita, 1980 .

Resonance Raman detection of a carotenoid in the lens of the deep-sea hatchetfish.

M. McFall-Ngai, J. Horwitz, N. Yu, 1991, Experimental eye research.

Biochemical Characteristics of the Pigmentation of Mesopelagic Fish Lenses

J. Childress, M. McFall-Ngai, L. Ding, 1988 .

Some properties of the low molecular weight alpha-crystallin from normal human lens: comparison with bovine lens.

J. Horwitz, 1976, Experimental eye research.

Studies on the low molecular weight proteins of human lens.

J. Horwitz, J. Zigler, J. Kinoshita, 1981, Experimental eye research.

Chaperone function of mutant versions of αA‐ and αB‐crystallin prepared to pinpoint chaperone binding sites

John I. Clark, W. W. de Jong, John J. Harding, 2001 .

Disruption of α3 Connexin Gene Leads to Proteolysis and Cataractogenesis in Mice

N. Gilula, Nalin M. Kumar, J. Horwitz, 1997, Cell.

Chaperone function of mutant versions of alpha A- and alpha B-crystallin prepared to pinpoint chaperone binding sites.

W. D. de Jong, P. Muchowski, B. Derham, 2001, European journal of biochemistry.

Comparison of in vitro proteolysis products of the normal human lens with putative in vivo proteolysis products of the cataractous lens.

L. Takemoto, J. Horwitz, J. Hansen, 1982, Current eye research.

Antisera to synthetic peptides of lens MIP26K (major intrinsic polypeptide): characterization and use as site-specific probes of membrane changes in the aging human lens.

L. Takemoto, J. Horwitz, J. Hansen, 1985, Experimental eye research.

Structural and functional similarities of bovine alpha-crystallin and mouse small heat-shock protein. A family of chaperones.

W. D. de Jong, H. Bloemendal, J. Horwitz, 1993, The Journal of biological chemistry.

Evolutionary and developmental differences in delta-crystallin from bird and reptile lenses. Circular dichroism and fluorescence studies.

J. Piatigorsky, J. Horwitz, 1980, Biochimica et biophysica acta.

Partial dissociation and renaturation of embryonic chick delta-crystallin. Characterization by ultracentrifugation and circular dichroism.

J. Piatigorsky, J. Horwitz, R. Simpson, 1977, Biochimica et biophysica acta.

Localization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina.

D. Bok, J. Horwitz, A. F. Wiechmann, 1985, Investigative ophthalmology & visual science.

Melatonin-binding in the frog retina: autoradiographic and biochemical analysis.

D. Bok, J. Horwitz, A. F. Wiechmann, 1986, Investigative ophthalmology & visual science.

Conformation of gamma-crystallins of the calf lens: effects of temperature and denaturing agents.

J. Horwitz, J. Kinoshita, I. Kabasawa, 1977, Experimental eye research.

Properties of the chromophore binding site of retinol-binding protein from human plasma.

J. Horwitz, J. Heller, 1974, The Journal of biological chemistry.

Interactions of all-trans, 9-, 11-, and 13-cis-retinal, all-trans-retinyl acetate, and retinoic acid with human retinol-binding protein and prealbumin.

J. Horwitz, J. Heller, 1973, The Journal of biological chemistry.

Interactions of retinol-binding protein with various chromophores and with thyroxine-binding protein. A model for visual pigments.

J. Horwitz, J. Heller, 1974, Experimental eye research.

Correction-Circular Dichroism of Native and Illuminated Bovine Visual Pigment500 at 77°K in the 620-320-nm Region

J. Horwitz, J. Heller, 1971 .

The binding stoichiometry of human plasma retinol-binding protein to prealbumin.

J. Horwitz, J. Heller, 1974, The Journal of biological chemistry.

Joram Heller 1934–1980

D. Bok, J. Horwitz, B. Straatsma, 1980, Vision Research.

Photoselection and linear dichroism of retinals. A method for identification and measurement of various geometrical isomers.

J. Horwitz, J. Heller, 1973, The Journal of biological chemistry.

Clinicobiochemical correlations in aging-related human cataract. The Pan American Association and American Journal of Ophthalmology lecture.

L. Takemoto, J. Horwitz, B. Straatsma, 1984, American journal of ophthalmology.

Protein carboxyl methyltransferase from cow eye lens.

S. Clarke, J. Horwitz, P. N. Mcfadden, 1983, Biochemical and biophysical research communications.

Association of the Chaperone αB-crystallin with Titin in Heart Muscle*

Wolfgang A. Linke, Belinda Bullard, Mark C. Leake, 2004, Journal of Biological Chemistry.

Association of the chaperone alphaB-crystallin with titin in heart muscle.

Belinda Bullard, Dietmar Labeit, Siegfried Labeit, 2004, The Journal of biological chemistry.

The major intrinsic protein (MIP) of the bovine lens fiber membrane: Characterization and structure based on cDNA cloning

J. Revel, M. Gorin, J. Horwitz, 1984, Cell.

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

David Eisenberg, Meytal Landau, Duilio Cascio, 2010, Protein science : a publication of the Protein Society.

Mutation R120G in alphaB-crystallin, which is linked to a desmin-related myopathy, results in an irregular structure and defective chaperone-like function.

P. Stewart, M. Bova, L. Ding, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The small heat-shock protein, αb-crystallin, has a variable quaternary structure

P. Stewart, J. Horwitz, D. A. Haley, 1998 .

The induction of tRNAphe in mammalian lens cortex: a possible control point in the synthesis of alpha-crystallin.

J. Horwitz, O. Chu-Der, B. Orthwerth, 1982, Experimental eye research.

Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens.

J. Horwitz, I. Niesman, J. Han, 2001, Investigative ophthalmology & visual science.

Properties of channels reconstituted from the major intrinsic protein of lens fiber membranes

G. Zampighi, D. Bok, J. Horwitz, 1990, The Journal of general physiology.

The Energy Expenditure of Tinikling : A Culturally Relevant Filipino Dance

A. Angosta, D. Bok, D. Heil, 2018 .

Vertebrate-like βγ-crystallins in the ocular lenses of a copepod

J. Piatigorsky, Jonathan H. Cohen, L. Ding, 2005, Journal of Comparative Physiology A.

Interaction of troponin subunits. The interaction between the inhibitory and tropomyosin-binding subunits.

D. Mercola, J. Horwitz, B. Bullard, 1979, Journal of Biological Chemistry.

Partial characterization of three distinct populations of human gamma-crystallins.

L. Takemoto, J. Horwitz, J. Zigler, 1985, Investigative ophthalmology & visual science.

Sequence and spatial expression of zebrafish ( Danio rerio ) α A-crystallin

M. Kantorow, J. Horwitz, M. Posner, 2010 .

Cloning and characterization of a cow beta crystallin cDNA.

M. Gorin, J. Horwitz, 1984, Current eye research.

Omega -crystallin of the scallop lens. A dimeric aldehyde dehydrogenase class 1/2 enzyme-crystallin.

Z. Kozmík, J. Piatigorsky, P. J. Steinbach, 2000, The Journal of biological chemistry.

Expression of betaB(2)-crystallin mRNA and protein in retina, brain, and testis.

M. Kantorow, J. Piatigorsky, J. Horwitz, 2000, Investigative ophthalmology & visual science.

Patterns of pigmentation in the eye lens of the deep-sea hatchetfish,Argyropelecus affinis Garman

J. Childress, F. Crescitelli, M. McFall-Ngai, 1986, Journal of Comparative Physiology A.

Absorption and circular dichroism spectra of ribonuclease-S at 77 degrees K.

J. Horwitz, E. H. Strickland, 1971, The Journal of biological chemistry.

Effects of hydrogen bonding and temperature upon the near ultraviolet circular dichroism and absorption spectra of tyrosine and O-methyl tyrosine derivatives.

M. Wilchek, J. Horwitz, E. H. Strickland, 1972, The Journal of biological chemistry.

Decreased expression of ribosomal proteins in human age-related cataract.

M. Kantorow, J. Horwitz, J. Hawse, 2002, Investigative ophthalmology & visual science.

The cellular eye lens and crystallins of cubomedusan jellyfish

J. Piatigorsky, J. Horwitz, C. Cutress, 1989, Journal of Comparative Physiology A.

Scallop lens Ω-crystallin (ALDH1A9): A novel tetrameric aldehyde dehydrogenase

Vasilis Vasiliou, V. Vasiliou, J. Piatigorsky, 2006 .

J3-crystallin of the jellyfish lens: Similarity to saposins

Z. Kozmík, J. Piatigorsky, P. J. Steinbach, 2001, Proceedings of the National Academy of Sciences of the United States of America.

J1-crystallins of the cubomedusan jellyfish lens constitute a novel family encoded in at least three intronless genes.

J. Piatigorsky, J. Horwitz, J Piatigorsky, 1993, The Journal of biological chemistry.

Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein

W. D. de Jong, J. Piatigorsky, J. Horwitz, 1988, The Journal of cell biology.

V-Crystallin of the Scallop Lens

Z. Kozmík, J. Piatigorsky, P. J. Steinbach, 2000 .

Two roles for mu-crystallin: a lens structural protein in diurnal marsupials and a possible enzyme in mammalian retinas.

L. Segovia, J. Horwitz, G. Wistow, 1997, Molecular vision.

The visual pigment sensitivity hypothesis: further evidence from fishes of varying habitats

F. Crescitelli, M. McFall-Ngai, J. Horwitz, 1985, Journal of Comparative Physiology A.

Zebrafish alpha-crystallins: protein structure and chaperone-like activity compared to their mammalian orthologs.

L. Ding, J. Horwitz, M. Posner, 2005, Molecular vision.

The distribution of the main intrinsic membrane polypeptide in ocular lens.

D. Bok, J. Horwitz, P. Fitzgerald, 1985, Current eye research.

Peptide mapping by limited proteolysis in sodium dodecyl sulfate of the main intrinsic polypeptides isolated from human and bovine lens plasma membranes.

J. Horwitz, M. M. Wong, 1980, Biochimica et biophysica acta.

Heat induced aggregation of the sodium dodecyl sulfate-solubilized main intrinsic polypeptide isolated from bovine lens plasma membrane.

J. Horwitz, N. Robertson, M. M. Wong, 1978, Biochemical and biophysical research communications.

Antibodies to a microbial peptide sharing sequence homology with betaA3-crystallin damage lens epithelial cells in vitro and in vivo.

L. Chylack, J. Horwitz, T. Kikuchi, 1999, Autoimmunity.

Lens α-crystallin: Function and structure

P. Stewart, M. Bova, L. Ding, 1999, Eye.

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

L. Donoso, J. Horwitz, C. Craft, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Identification and functional clustering of global gene expression differences between age-related cataract and clear human lenses and aged human lenses.

M. Kantorow, J. Horwitz, J. Hawse, 2004, Experimental eye research.

Oligomerization with wt αA- and αB-crystallins reduces proteasome-mediated degradation of C-terminally truncated αA-crystallin.

L. Ding, J. Horwitz, F. Shang, 2012, Investigative ophthalmology & visual science.

Lens Oligomerization with wt a Aand a B-Crystallins Reduces Proteasome-Mediated Degradation of C-Terminally Truncated a A-Crystallin

L. Ding, J. Horwitz, F. Shang, 2012 .

R120G alphaB-crystallin promotes the unfolding of reduced alpha-lactalbumin and is inherently unstable.

C. Robinson, J. Carver, J. Aquilina, 2005, The FEBS journal.

Retinol transfer from rat liver cytosol retinyl ester lipoprotein complex to serum retinol-binding protein.

J. Horwitz, J. Heller, L. Ding, 1981, Archives of Biochemistry and Biophysics.

Involvement of tyrosine and lysine residues of retinol-binding protein in the interaction between retinol and retinol-binding protein and between retinol-binding protein and prealbumin. Acetylation with N-acetylimidazole and alkaline titration.

J. Horwitz, J. Heller, 1975, The Journal of biological chemistry.

Modification of tryptophan residues in retinol-binding protein and prealbumin with 2-hydroxy-5-nitrobenzyl bromide. Effects of the modification of the protein-retinol and protein-protein interaction.

J. Horwitz, J. Heller, 1974, The Journal of biological chemistry.

Catalytic subunit isoforms of mammalian lens Na,K-ATPase.

J. Horwitz, M. Garner, 1994, Current eye research.

Mimicking phosphorylation of αB-crystallin affects its chaperone activity

Cait E. MacPhee, Carol V. Robinson, Justin L. P. Benesch, 2007 .

Comparison of the homologous carboxy-terminal domain and tail of α-crystallin and small heat shock protein

W. W. Jong, M. Gaestel, J. Horwitz, 1993, Molecular Biology Reports.

The C-terminal region of alpha-crystallin: involvement in protection against heat-induced denaturation.

L. Takemoto, J. Horwitz, J Horwitz, 1993, The Biochemical journal.

Associations of seroreactivity against crystallin proteins with disease activity and cataract in patients with uveitis.

F. Yu, L. Gordon, K. Lampi, 2008, Investigative ophthalmology & visual science.

Some properties of lens plasma membrane polypeptides isolated from normal human lenses.

J. Horwitz, J. Zigler, J. Kinoshita, 1979, Experimental eye research.

Identification of a missense mutation in the alphaA-crystallin gene of the lop18 mouse.

T. Roderick, J. Heckenlively, M. Davisson, 1999, Molecular vision.

Identification of a missense mutation in the α A-crystallin gene of the lop 18 mouse

T. Roderick, J. Heckenlively, M. Davisson, 2022 .

Mechanism of Cataract Formation in A-crystallin Y 118 D Mutation

Catherine Cheng, L. Ding, J. Horwitz, 2009 .

Subunit exchange of alphaA-crystallin.

M. Bova, L. Ding, J. Horwitz, 1997, The Journal of biological chemistry.

Low temperature circular dichroism of tyrosyl and tryptophanyl diketopiperazines.

M. Wilchek, J. Horwitz, E. H. Strickland, 1970, The Journal of biological chemistry.

Absence of α3 (Cx46) and α8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells

Catherine Cheng, J. Horwitz, Chun-hong Xia, 2006 .

Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells.

Catherine Cheng, J. Horwitz, Chun-hong Xia, 2006, Experimental eye research.

Mutation of αB-crystallin: effects on chaperone-like activity

M. Bova, L. Ding, J. Horwitz, 1998 .

Phosphorylation of αB-Crystallin Alters Chaperone Function through Loss of Dimeric Substructure*

Carol V Robinson, C. Robinson, J. Benesch, 2004, Journal of Biological Chemistry.

Frederick Bettelheim (1923–2004)

J. Piatigorsky, J. Horwitz, J. Zigler, 2004 .

A comparative study of the thermal stability of the vertebrate eye lens: Antarctic ice fish to the desert iguana.

M. McFall-Ngai, J. Horwitz, J Horwitz, 1990, Experimental eye research.

Degradation of C-terminal truncated alpha A-crystallins by the ubiquitin-proteasome pathway.

L. Ding, J. Horwitz, F. Shang, 2007, Investigative ophthalmology & visual science.

Major intrinsic polypeptide of lens membrane. Biochemical and immunological characterization of the major cyanogen bromide fragment.

M. Hunkapiller, J. Revel, L. Takemoto, 1983, Biochimica et biophysica acta.

Covalent changes in MIP26K during aging of the human lens membrane.

L. Takemoto, J. Horwitz, M. Takehana, 1986, Investigative ophthalmology & visual science.

Characterization and enzyme activity of argininosuccinate lyase/delta-crystallin of the embryonic duck lens.

J. Piatigorsky, J. Horwitz, J Piatigorsky, 1996, Biochimica et biophysica acta.

Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure

Zhongyu Yang, Zhongyu Yang, W. Hubbell, 2015, Proceedings of the National Academy of Sciences.

tau-Crystallin from the turtle lens: purification and partial characterization.

J. Piatigorsky, L. Ding, J. Horwitz, 1985, Experimental eye research.

Lens alpha-crystallin: function and structure.

P. Stewart, M. Bova, L. Ding, 1999, Eye.

Mechanism of cataract formation in alphaA-crystallin Y118D mutation.

Catherine Cheng, L. Ding, J. Horwitz, 2009, Investigative ophthalmology & visual science.

The l-isoaspartate modification within protein fragments in the aging lens can promote protein aggregation

S. Clarke, J. Loo, J. Horwitz, 2019, The Journal of Biological Chemistry.

Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin

W. Hubbell, J. Horwitz, M. Lerch, 2013, Proceedings of the National Academy of Sciences.

Mimicking phosphorylation of αB-crystallin affects its chaperone activity

C. Robinson, C. MacPhee, J. Carver, 2007 .

Localization of hydroxyindole-O-methyltransferase in the mammalian pineal gland and retina.

D. Bok, J. Horwitz, A. F. Wiechmann, 1985, Investigative ophthalmology & visual science.

Circular dichroism and site-directed spin labeling reveal structural and dynamical features of high-pressure states of myoglobin

W. Hubbell, J. Horwitz, M. Lerch, 2013, Proceedings of the National Academy of Sciences.

The nucleotide sequence of two bovine lens phenylalanine tRNAs. Possible activation of a new phenylalanine tRNA gene during differentiation of lens cells.

J. Horwitz, P. Agris, F. Lin, 1980, The Journal of biological chemistry.

Structure-relaxation mechanism for the response of T4 lysozyme cavity mutants to hydrostatic pressure

Zhongyu Yang, W. Hubbell, J. Horwitz, 2015, Proceedings of the National Academy of Sciences.