Y. Yue

发表

Endosomal processing limits gene transfer to polarized airway epithelia by adeno-associated virus.

D. Duan, J. Engelhardt, Ziying Yan, 2000, The Journal of clinical investigation.

Enhancement of Muscle Gene Delivery with Pseudotyped Adeno-Associated Virus Type 5 Correlates with Myoblast Differentiation

D. Duan, J. Engelhardt, Ziying Yan, 2001, Journal of Virology.

Dynamin Is Required for Recombinant Adeno-Associated Virus Type 2 Infection

J. Pessin, A. Kao, D. Duan, 1999, Journal of Virology.

Preservation of muscle force in Mdx3cv mice correlates with low-level expression of a near full-length dystrophin protein.

D. Duan, Y. Yue, Dejia Li, 2008, The American journal of pathology.

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Gennifer E. Merrihew, Ying S. Ting, Lindsay K. Pino, 2020, bioRxiv.

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Gennifer E. Merrihew, Ying S. Ting, Lindsay K. Pino, 2020, bioRxiv.

A new dual-vector approach to enhance recombinant adeno-associated virus-mediated gene expression through intermolecular cis activation

D. Duan, J. Engelhardt, Ziying Yan, 2000, Nature Medicine.

Ectopic Catalase Expression in Mitochondria by Adeno-Associated Virus Enhances Exercise Performance in Mice

Chady H Hakim, P. Rabinovitch, D. Duan, 2009, PloS one.

α2 and α3 helices of dystrophin R16 and R17 frame a microdomain in the α1 helix of dystrophin R17 for neuronal NOS binding

D. Duan, Y. Yue, Y. Lai, 2012, Proceedings of the National Academy of Sciences.

Circular Intermediates of Recombinant Adeno-Associated Virus Have Defined Structural Characteristics Responsible for Long-Term Episomal Persistence in Muscle Tissue

Prerna Sharma, D. Duan, J. Engelhardt, 1998, Journal of Virology.

Expanding AAV packaging capacity with trans-splicing or overlapping vectors: a quantitative comparison.

D. Duan, J. Engelhardt, D. Duan, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

A hybrid vector system expands adeno-associated viral vector packaging capacity in a transgene-independent manner.

D. Duan, Arkasubhra Ghosh, Y. Yue, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Dual AAV Gene Therapy for Duchenne Muscular Dystrophy with a 7-kb Mini-Dystrophin Gene in the Canine Model.

Chady H Hakim, D. Duan, Xiufang Pan, 2017, Human gene therapy.

Delivering Large Therapeutic Genes for Muscle Gene Therapy

D. Duan, Y. Yue, B. Bostick, 2010 .

Adeno-Associated Virus

D. Duan, J. Engelhardt, Y. Yue, 2002 .

Treating Duchenne Cardiomyopathy in the Mouse Model by Gene Repair

C. Gersbach, D. Duan, N. Wasala, 2017 .

100-fold but not 50-fold dystrophin overexpression aggravates electrocardiographic defects in the mdx model of Duchenne muscular dystrophy

D. Duan, N. Wasala, Y. Yue, 2016, Molecular therapy. Methods & clinical development.

Prospect of gene therapy for cardiomyopathy in hereditary muscular dystrophy

D. Duan, Y. Yue, Timothy L Domeier, 2016, Expert opinion on orphan drugs.

AAV-8 is more efficient than AAV-9 in transducing neonatal dog heart.

Chady H Hakim, D. Duan, Xiufang Pan, 2015, Human gene therapy methods.

Systemic gene transfer reveals distinctive muscle transduction profile of tyrosine mutant AAV-1, -6, and -9 in neonatal dogs

Chady H Hakim, D. Duan, Jin-Hong Shin, 2014, Molecular therapy. Methods & clinical development.

Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy.

Chady H Hakim, D. Duan, Xiufang Pan, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Humoral immunity to AAV-6, 8, and 9 in normal and dystrophic dogs.

D. Duan, Jin-Hong Shin, Y. Yue, 2012, Human gene therapy.

AAV micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of Duchenne muscular dystrophy cardiomyopathy.

D. Duan, N. Wasala, Jin-Hong Shin, 2012, Journal of molecular and cellular cardiology.

AAV-microdystrophin therapy improves cardiac performance in aged female mdx mice.

D. Duan, Jin-Hong Shin, Y. Yue, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Duchenne Cardiomyopathy Gene Therapy

D. Duan, Jin-Hong Shin, Y. Yue, 2010 .

Marginal Level Dystrophin Expression Improves Clinical Outcome in a Strain of Dystrophin/Utrophin Double Knockout Mice

D. Duan, Y. Yue, Dejia Li, 2010, PloS one.

Adeno-associated virus serotype-9 microdystrophin gene therapy ameliorates electrocardiographic abnormalities in mdx mice.

D. Duan, Y. Yue, Dejia Li, 2008, Human gene therapy.

A single intravenous injection of adeno-associated virus serotype-9 leads to whole body skeletal muscle transduction in dogs.

J. Kornegay, D. Duan, Arkasubhra Ghosh, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficient whole-body transduction with trans-splicing adeno-associated viral vectors.

D. Duan, Arkasubhra Ghosh, Y. Yue, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Age-matched comparison reveals early electrocardiography and echocardiography changes in dystrophin-deficient dogs

D. Duan, Jin-Hong Shin, Y. Yue, 2011, Neuromuscular Disorders.

An intronic LINE-1 element insertion in the dystrophin gene aborts dystrophin expression and results in Duchenne-like muscular dystrophy in the corgi breed

J. Kornegay, D. Duan, Jin-Hong Shin, 2010, Laboratory Investigation.

Exclusive skeletal muscle correction does not modulate dystrophic heart disease in the aged mdx model of Duchenne cardiomyopathy.

D. Duan, N. Wasala, Y. Yue, 2013, Human molecular genetics.

Long-term robust myocardial transduction of the dog heart from a peripheral vein by adeno-associated virus serotype-8.

D. Duan, Xiufang Pan, Jin-Hong Shin, 2013, Human gene therapy.

Partial restoration of cardiac function with ΔPDZ nNOS in aged mdx model of Duchenne cardiomyopathy.

D. Duan, N. Wasala, Y. Yue, 2014, Human molecular genetics.

Cardiac-Specific Expression of ΔH2-R15 Mini-Dystrophin Normalized All Electrocardiogram Abnormalities and the End-Diastolic Volume in a 23-Month-Old Mouse Model of Duchenne Dilated Cardiomyopathy.

D. Duan, N. Wasala, Jin-Hong Shin, 2018, Human gene therapy.

Proteomic analysis identifies key differences in the cardiac interactomes of dystrophin and micro-dystrophin

D. Duan, N. Wasala, Y. Yue, 2021, Human molecular genetics.

Development of multiple cloning site cis-vectors for recombinant adeno-associated virus production.

Y. Yue, Du Dongsheng, 2002, BioTechniques.

Adeno-Associated Virus

D. Duan, J. Engelhardt, Y. Yue, 2002 .

Polarity influences the efficiency of recombinant adenoassociated virus infection in differentiated airway epithelia.

J. Engelhardt, Ziying Yan, Z. Yan, 1998, Human gene therapy.

Systemic AAV-9 transduction in mice is influenced by animal age but not by the route of administration

D. Duan, Y. Yue, B. Bostick, 2007, Gene Therapy.

Phenotyping cardiac gene therapy in mice.

D. Duan, Y. Yue, B. Bostick, 2011, Methods in molecular biology.

Full-length dystrophin expression in half of the heart cells ameliorates beta-isoproterenol-induced cardiomyopathy in mdx mice.

D. Duan, Y. Yue, J. Skimming, 2004, Human molecular genetics.

Viral serotype and the transgene sequence influence overlapping adeno‐associated viral (AAV) vector‐mediated gene transfer in skeletal muscle

D. Duan, Arkasubhra Ghosh, Y. Yue, 2006, The journal of gene medicine.

Gender influences cardiac function in the mdx model of duchenne cardiomyopathy

D. Duan, Y. Yue, B. Bostick, 2010, Muscle & nerve.

Prevention of Dystrophin-Deficient Cardiomyopathy in Twenty-One-Month-Old Carrier Mice by Mosaic Dystrophin Expression or Complementary Dystrophin/Utrophin Expression

D. Duan, Y. Yue, B. Bostick, 2008, Circulation research.

An engineered galactosylceramidase construct improves AAV gene therapy for Krabbe disease in twitcher mice.

S. Sands, D. Duan, Xiufang Pan, 2019, Human gene therapy.

Double strand interaction is the predominant pathway for intermolecular recombination of adeno-associated viral genomes.

D. Duan, Y. Yue, 2003, Virology.

Systemic Delivery of Adeno-Associated Viral Vectors in Mice and Dogs.

Chady H Hakim, D. Duan, Y. Yue, 2019, Methods in molecular biology.

Safe and bodywide muscle transduction in young adult Duchenne muscular dystrophy dogs with adeno-associated virus.

Chady H Hakim, D. Duan, Xiufang Pan, 2015, Human molecular genetics.

A simplified immune suppression scheme leads to persistent micro-dystrophin expression in Duchenne muscular dystrophy dogs.

D. Duan, A. Srivastava, Jin-Hong Shin, 2012, Human gene therapy.

Whole body skeletal muscle transduction in neonatal dogs with AAV-9.

D. Duan, Jin-Hong Shin, Y. Yue, 2011, Methods in molecular biology.

Efficient Whole-body Transduction with Trans-splicing Adeno-associated Viral Vectors.

D. Duan, Arkasubhra Ghosh, Y. Yue, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Consequences of DNA-Dependent Protein Kinase Catalytic Subunit Deficiency on Recombinant Adeno-Associated Virus Genome Circularization and Heterodimerization in Muscle Tissue

D. Duan, J. Engelhardt, Y. Yue, 2003, Journal of Virology.

The gRNA vector level determines the outcome of systemic AAV CRISPR therapy for Duchenne muscular dystrophy.

Chady H Hakim, Shi-jie Chen, D. Duan, 2022, Human gene therapy.

Uniform low-level dystrophin expression in the heart partially preserved cardiac function in an aged mouse model of Duchenne cardiomyopathy.

D. Duan, N. Wasala, Y. Yue, 2017, Journal of molecular and cellular cardiology.

Sarcolemmal nNOS anchoring reveals a qualitative difference between dystrophin and utrophin

K. Davies, D. Duan, J. Chamberlain, 2010, Journal of Cell Science.

SERCA2a gene transfer improves electrocardiographic performance in aged mdx mice

R. Hajjar, D. Duan, Jin-Hong Shin, 2011, Journal of Translational Medicine.

Systemic Trans-splicing adeno-associated viral delivery efficiently transduces the heart of adult mdx mouse, a model for duchenne muscular dystrophy.

D. Duan, Arkasubhra Ghosh, Jin-Hong Shin, 2009, Human gene therapy.

Cardiac expression of a mini-dystrophin that normalizes skeletal muscle force only partially restores heart function in aged Mdx mice.

J. Chen, D. Duan, Y. Yue, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Sub-physiological sarcoglycan expression contributes to compensatory muscle protection in mdx mice.

D. Duan, Y. Yue, Dejia Li, 2009, Human molecular genetics.

Trans-splicing adeno-associated viral vector-mediated gene therapy is limited by the accumulation of spliced mRNA but not by dual vector coinfection efficiency.

D. Duan, J. Qiu, D. Pintel, 2004, Human gene therapy.

Dual AAV therapy ameliorates exercise-induced muscle injury and functional ischemia in murine models of Duchenne muscular dystrophy.

Chady H Hakim, D. Duan, Y. Yue, 2013, Human molecular genetics.

Genomic removal of a therapeutic mini-dystrophin gene from adult mice elicits a Duchenne muscular dystrophy-like phenotype.

D. Duan, N. Wasala, Jin-Hong Shin, 2016, Human molecular genetics.

Recombinant adeno-associated viral vector production and purification.

D. Duan, Jin-Hong Shin, Y. Yue, 2012, Methods in molecular biology.

Evidence for the Failure of Adeno-associated Virus Serotype 5 to Package a Viral Genome ≥8.2 kb.

D. Duan, Y. Yue, Y. Lai, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

Dystrophin contains multiple independent membrane-binding domains.

Chady H Hakim, D. Duan, Xiufang Pan, 2016, Human molecular genetics.

Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

D. Duan, Y. Yue, Keqing Zhang, 2019, Molecular medicine.

Rational engineering of a functional CpG-free ITR for AAV gene therapy

D. Duan, Xiufang Pan, D. Pintel, 2021, Gene Therapy.

Single SERCA2a Therapy Ameliorated Dilated Cardiomyopathy for 18 Months in a Mouse Model of Duchenne Muscular Dystrophy.

R. Hajjar, D. Duan, N. Wasala, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

High-Resolution Histological Landscape of AAV DNA Distribution in Cellular Compartments and Tissues following Local and Systemic Injection

D. Duan, Y. Yue, Keqing Zhang, 2020, Molecular therapy. Methods & clinical development.

AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice.

Chady H Hakim, Shi-jie Chen, C. Gersbach, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

A Five-Repeat Micro-Dystrophin Gene Ameliorated Dystrophic Phenotype in the Severe DBA/2J-mdx Model of Duchenne Muscular Dystrophy

Chady H Hakim, D. Duan, Xiufang Pan, 2017, Molecular therapy. Methods & clinical development.

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

Chady H Hakim, D. Grimm, Shi-jie Chen, 2021, Nature Communications.

A Translational Pathway Toward a Clinical Trial Using the Second-Generation AAV Micro Dystrophin Vector

D. Duan, Y. Yue, Chady H. Hakim, 2015 .

Synthetic intron improves transduction efficiency of trans-splicing adeno-associated viral vectors.

D. Duan, Y. Yue, Y. Lai, 2006, Human gene therapy.

Brief Report: Synthetic Intron Improves Transduction Efficiency ofTrans-Splicing Adeno-associated Viral Vectors

D. Duan, Y. Yue, Y. Lai, 2006 .

Micro-dystrophin AAV Vectors Made by Transient Transfection and Herpesvirus System Are Equally Potent in Treating mdx Mouse Muscle Disease

B. Byrne, D. Duan, Xiufang Pan, 2020, Molecular therapy. Methods & clinical development.

AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice.

Keqing Zhang, Dongsheng Duan, Charles A. Gersbach, 2018, JCI insight.

Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1).

R. Grosschedl, W. Zhou, J. Engelhardt, 1999, Development.

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy.

D. Duan, J. Chamberlain, Y. Yue, 2009, The Journal of clinical investigation.

Dwarf Open Reading Frame (DWORF) Gene Therapy Ameliorated Duchenne Muscular Dystrophy Cardiomyopathy in Aged mdx Mice

D. Duan, Xiufang Pan, Y. Yue, 2023, Journal of the American Heart Association.

Dystrophin R16/17-syntrophin PDZ fusion protein restores sarcolemmal nNOSμ

D. Duan, Y. Yue, Keqing Zhang, 2018, Skeletal Muscle.

Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin‐null mice

D. Duan, Y. Yue, Dejia Li, 2011, Journal of Pathology.

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors

Dongsheng Duan, Yi Lai, D. Duan, 2005, Nature Biotechnology.

C-terminal-truncated microdystrophin recruits dystrobrevin and syntrophin to the dystrophin-associated glycoprotein complex and reduces muscular dystrophy in symptomatic utrophin/dystrophin double-knockout mice.

D. Duan, Y. Yue, Mingju Liu, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Characterization of 65 Epitope-Specific Dystrophin Monoclonal Antibodies in Canine and Murine Models of Duchenne Muscular Dystrophy by Immunostaining and Western Blot

D. Duan, M. Mcintosh, Jin-Hong Shin, 2014, PloS one.

Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.

S. Harper, R. Grange, D. Duan, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

The implication of hinge 1 and hinge 4 in micro-dystrophin gene therapy for Duchenne muscular dystrophy.

D. Duan, N. Wasala, Y. Yue, 2022, Human gene therapy.

Design of trans-splicing adeno-associated viral vectors for Duchenne muscular dystrophy gene therapy.

D. Duan, Y. Yue, Dejia Li, 2008, Methods in molecular biology.

Full-length dystrophin reconstitution with adeno-associated viral vectors.

D. Duan, Y. Yue, K. Kodippili, 2014, Human gene therapy.

Microdystrophin Gene Therapy of Cardiomyopathy Restores Dystrophin-Glycoprotein Complex and Improves Sarcolemma Integrity in the Mdx Mouse Heart

S. Harper, D. Duan, J. Chamberlain, 2003, Circulation.

Structural analysis of adeno-associated virus transduction circular intermediates.

D. Duan, J. Engelhardt, Ziying Yan, 1999, Virology.

Efficient transgene reconstitution with hybrid dual AAV vectors carrying the minimized bridging sequences.

D. Duan, Arkasubhra Ghosh, Y. Yue, 2011, Human gene therapy.

Adeno-associated virus serotype-9 efficiently transduces the retinal outer plexiform layer

D. Duan, Arkasubhra Ghosh, Y. Yue, 2009, Molecular vision.

Adeno-associated virus serotype-9 mediated retinal outer plexiform layer transduction is mainly through the photoreceptors.

D. Duan, Arkasubhra Ghosh, Y. Yue, 2010, Advances in experimental medicine and biology.

Formation of Adeno-Associated Virus Circular Genomes Is Differentially Regulated by Adenovirus E4 ORF6 and E2a Gene Expression

Rachael A. Lester, Y. Ye, Prerna Sharma, 1999, Journal of Virology.

Catalase overexpression does not impair extensor digitorum longus muscle function in normal mice

D. Duan, Y. Yue, Dejia Li, 2007, Muscle & nerve.

Dual vector expansion of the recombinant AAV packaging capacity.

D. Duan, J. Engelhardt, Y. Yue, 2003, Methods in molecular biology.

Dystrophin R16/17 protein therapy restores sarcolemmal nNOS in trans and improves muscle perfusion and function

D. Duan, Y. Yue, Keqing Zhang, 2019, Molecular Medicine.

Molecular Pathogenesis of Genetic and Inherited Diseases Preservation of Muscle Force in Mdx3cv Mice Correlates with Low-Level Expression of a Near Full-Length Dystrophin Protein

D. Duan, Y. Yue, Dejia Li, 2008 .

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy.

D. Duan, J. Chamberlain, Y. Yue, 2009, The Journal of clinical investigation.

Nitrosative stress elicited by nNOSµ delocalization inhibits muscle force in dystrophin‐null mice

D. Duan, Y. Yue, Dejia Li, 2011, The Journal of pathology.

Life-long outcomes of systemic AAV micro-dystrophin gene therapy in a murine Duchenne muscular dystrophy model.

D. Duan, N. Wasala, Jin-Hong Shin, 2022, Human gene therapy.

AAV micro-dystrophin gene therapy alleviates stress-induced cardiac death but not myocardial fibrosis in >21-m-old mdx mice, an end-stage model of Duchenne muscular dystrophy cardiomyopathy.

D. Duan, N. Wasala, Jin-Hong Shin, 2012, Journal of molecular and cellular cardiology.

Full-length dystrophin reconstitution with adeno-associated viral vectors.

D. Duan, Y. Yue, K. Kodippili, 2014, Human gene therapy.

Evidence for the failure of adeno-associated virus serotype 5 to package a viral genome > or = 8.2 kb.

D. Duan, Y. Yue, Yi Lai, 2010, Molecular therapy : the journal of the American Society of Gene Therapy.

A novel genetic model provides a unique perspective on the relationship between postexercise glycogen concentration and increases in the abundance of key metabolic proteins after acute exercise

G. Cartee, Xiufang Pan, Y. Yue, 2024, PloS one.

Microdystrophin ameliorates muscular dystrophy in the canine model of duchenne muscular dystrophy.

D. Duan, Xiufang Pan, Jin-Hong Shin, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

499. Intravenous Delivery of a Novel Micro-Dystrophin Vector Prevented Muscle Deterioration in Young Adult Canine Duchenne Muscular Dystrophy Dogs

Gregory J Jenkins, D. Duan, Xiufang Pan, 2016 .