S. Sweitzer

发表

Rapid expression of recombinant proteins in modified CHO cells using the baculovirus system

P. McAllister, J. Trill, J. Kane, 2004, Cytotechnology.

BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.

D. Riddell, C. Dingwall, Christopher N. Johnson, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.

D. Riddell, C. Dingwall, J. Mosley, 2008, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.

C. Dingwall, J. Mosley, P. Rowland, 2009, Bioorganic & medicinal chemistry letters.

In vitro and in vivo characterization of a novel soluble epoxide hydrolase inhibitor.

R. Mayer, D. Behm, S. Sweitzer, 2013, Prostaglandins & other lipid mediators.

Mapping of a Cytoplasmic Domain of the Human Growth Hormone Receptor That Regulates Rates of Inactivation of Jak2 and Stat Proteins*

G. Feldman, Y. Wang, W. Wood, 1997, The Journal of Biological Chemistry.

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

F. Jiang, Beth L. Pietrak, T. Riera, 2014, Nature Communications.

Biochemical characterization of human HIF hydroxylases using HIF protein substrates that contain all three hydroxylation sites.

R. Annan, D. Mcnulty, R. Copeland, 2011, The Biochemical journal.

Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines*

J. Trill, C. Dingwall, J. Skehel, 2001, The Journal of Biological Chemistry.

Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation

J. Hinshaw, S. Sweitzer, Sharon M. Sweitzer, 1998, Cell.

Role of cytochrome P450 1A2 in bilirubin degradation Studies in Cyp1a2 (-/-) mutant mice.

D. Nebert, S. Sweitzer, P. Sinclair, 2001, Biochemical pharmacology.

A High-Throughput Dose-Response Cellular Thermal Shift Assay for Rapid Screening of Drug Target Engagement in Living Cells, Exemplified Using SMYD3 and IDO1

R. Annan, A. P. Graves, D. Mcnulty, 2018, SLAS discovery : advancing life sciences R & D.

Efficient expression of secreted proteases via recombinant BacMam virus.

S. Sweitzer, Huizhen J Zhao, Sundip S Modha, 2007, Protein expression and purification.

Development and Validation of Reagents and Assays for EZH2 Peptide and Nucleosome High-Throughput Screens

S. Thrall, G. Hofmann, L. Lafrance, 2012, Journal of biomolecular screening.

Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).

D. Holt, A. P. Graves, L. Shewchuk, 2015, Journal of medicinal chemistry.

Identi fi cation of Purines and 7 ‐ Deazapurines as Potent and Selective Type I Inhibitors of Troponin I ‐ Interacting Kinase ( TNNI 3 K )

D. Holt, A. P. Graves, L. Shewchuk, 2015 .

Mutant IDH1 enhances the production of 2-hydroxyglutarate due to its kinetic mechanism.

Nicholas D. Adams, S. Thrall, C. Duraiswami, 2013, Biochemistry.

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

Zhong Zhong, T. Riera, S. Sweitzer, 2012, PloS one.

Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon α Transmembrane Signaling (*)

R. Buller, O. Colamonici, S. Sweitzer, 1995, The Journal of Biological Chemistry.

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Neysa Nevins, R. Annan, D. Mcnulty, 2007, Nature chemical biology.

Cloning, expression, and initial characterization of a novel cytokine-like gene family.

Michael A. Briggs, G. Rose, B. Wolf, 2002, Genomics.

A tale of two subunits: how the neomorphic R132H IDH1 mutation enhances production of αHG.

Joseph G Boyer, R. Wooster, K. Brown, 2011, Biochemistry.

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

Dudley Lamming, D. Sinclair, K. Howitz, 2013, Science.

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Gang Yao, Bing Xia, Jing Chai, 2017, Nature Communications.

Component co-expression and purification of recombinant human pyruvate dehydrogenase complex from baculovirus infected SF9 cells.

Marc A. Holbert, Yong Jiang, S. Sweitzer, 2014, Protein expression and purification.

Tyrosine phosphorylation of DNA binding proteins by multiple cytokines.

D. S. Webb, E. Petricoin, G. Feldman, 1993, Science.

Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1α Endoribonuclease Activity

Leanna E. Shuster, K. Evans, S. Sweitzer, 2015, Molecular Pharmacology.

Dynamin Mediates Membrane Vesiculation

J. Hinshaw, S. Sweitzer, Sharon M. Sweitzer, 1998, Microscopy and Microanalysis.

Methyltransferases prefer monomer over core-trimmed nucleosomes as in vitro substrates.

S. Thrall, Yong Jiang, S. Sweitzer, 2011, Analytical biochemistry.

Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.

Brian Clarke, Phil Jeffrey, P. Jeffrey, 2008, Journal of medicinal chemistry.

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

D. Sinclair, K. Howitz, J. Moss, 2022 .

BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.

C. Dingwall, J. Mosley, P. Rowland, 2010, Bioorganic & medicinal chemistry letters.

Bace-1 Inhibitors Using Novel Edge-to-Face Interaction with Arg-296

C. Howes, C. Dingwall, J. Mosley, 2010 .

Biochemical characterization of human prolyl hydroxylase domain protein 2 variants associated with erythrocytosis.

R. Copeland, M. Pappalardi, Yong Jiang, 2008, Biochemistry.