W. Gerhard

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Enhancement of neutralizing activity of influenza virus-specific antibodies by serum components.

K. Mozdzanowska, Jingqi Feng, M. Eid, 2006, Virology.

Heterosubtypic immunity to influenza type A virus in mice. Effector mechanisms and their longevity.

K. Mozdzanowska, W. Gerhard, S. Liang, 1994, Journal of immunology.

Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2.

L. Otvos, K. Mozdzanowska, M. Eid, 2003, Vaccine.

Prospects for Universal Influenza Virus Vaccine

K. Mozdzanowska, D. Zharikova, W. Gerhard, 2006, Emerging infectious diseases.

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

L. Staudt, M. Weigert, W. Gerhard, 1984, Proceedings of the National Academy of Sciences of the United States of America.

A viral polymerase involved in recognition of influenza virus-infected cells by a cytotoxic T-cell clone

J. Yewdell, J. Bennink, W. Gerhard, 1982, Nature.

Identification of eight determinants in the hemagglutinin molecule of influenza virus A/PR/8/34 (H1N1) which are recognized by class II-restricted T cells from BALB/c mice

A. Taylor, P. Scherle, W. Gerhard, 1991, Journal of virology.

Influenza Type A Virus Escape Mutants Emerge In Vivo in the Presence of Antibodies to the Ectodomain of Matrix Protein 2

K. Mozdzanowska, Jingqi Feng, D. Zharikova, 2005, Journal of Virology.

The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice

W. Gerhard, N. Klinman, M. Cancro, 1978, The Journal of experimental medicine.

A set of closely related antibodies dominates the primary antibody response to the antigenic site CB of the A/PR/8/34 influenza virus hemagglutinin.

L. Staudt, W. Gerhard, J. Kavaler, 1990, Journal of immunology.

Many variable region genes are utilized in the antibody response of BALB/c mice to the influenza virus A/PR/8/34 hemagglutinin.

L. Staudt, W. Gerhard, J. Kavaler, 1991, Journal of immunology.

The diversity of the CD4+ T cell response in influenza.

W. Gerhard, A. Caton, Caton Aj, 1992, Seminars in immunology.

Selection of influenza A virus adsorptive mutants by growth in the presence of a mixture of monoclonal antihemagglutinin antibodies

J. Yewdell, W. Gerhard, J W Yewdell, 1986, Journal of virology.

Antigenic drift in influenza A viruses. I. Selection and characterization of antigenic variants of A/PR/8/34 [HON1] influenza virus with monoclonal antibodies

W. Gerhard, R. Webster, 1978, The Journal of experimental medicine.

Antigenic characterization of viruses by monoclonal antibodies.

J. Yewdell, W. Gerhard, 1981, Annual review of microbiology.

Delineation of four antigenic sites on a paramyxovirus glycoprotein via which monoclonal antibodies mediate distinct antiviral activities.

J. Yewdell, W. Gerhard, 1982, Journal of immunology.

Characterization of host cell binding variants of influenza virus by monoclonal antibodies.

W. Gerhard, I. Schulze, B. Nohinek, 1985, Virology.

V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.

L. Staudt, M. Weigert, W. Gerhard, 1990, Journal of immunology.

Role of receptor-binding activity of the viral hemagglutinin molecule in the presentation of influenza virus antigens to helper T cells

L. Eisenlohr, W. Gerhard, C. Hackett, 1987, Journal of virology.

The rapid determination of binding constants for antiviral antibodies by a radioimmunoassay. An analysis of the interaction between hybridoma proteins and influenza virus.

W. Gerhard, M. E. Frankel, 1979, Molecular immunology.

Enhancement of antigen presentation of influenza virus hemagglutinin by the natural human anti-Gal antibody.

K. Mozdzanowska, W. Gerhard, U. Galili, 1996, Vaccine.

A pulmonary influenza virus infection in SCID mice can be cured by treatment with hemagglutinin-specific antibodies that display very low virus-neutralizing activity in vitro

K. Mozdzanowska, W. Gerhard, J. Mozdzanowski, 1997, Journal of virology.

Structure-function relationships among highly diverse T cells that recognize a determinant from influenza virus hemagglutinin

A. Taylor, W. Gerhard, A. Haberman, 1990, The Journal of experimental medicine.

B CELL ACTIVATION

M. Leptin, J. Zeuthen, F. Melchers, 1983 .

Regulation of B lymphocyte replication and maturation

M. Leptin, J. Zeuthen, F. Melchers, 1982, Journal of cellular biochemistry.

Complement Component C1q Enhances the Biological Activity of Influenza Virus Hemagglutinin-Specific Antibodies Depending on Their Fine Antigen Specificity and Heavy-Chain Isotype

K. Mozdzanowska, Jingqi Feng, W. Gerhard, 2002, Journal of Virology.

Roles of adjuvant and route of vaccination in antibody response and protection engendered by a synthetic matrix protein 2-based influenza A virus vaccine in the mouse

L. Otvos, K. Mozdzanowska, D. Zharikova, 2007, Virology Journal.

Analysis of a predominant immunoglobulin population in the cerebrospinal fluid of a multiple sclerosis patient by means of an anti-idiotypic hybridoma antibody.

M. Sandberg‐Wollheim, A. Taylor, W. Gerhard, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Production of antibodies against influenza virus by somatic cell hybrids between mouse myeloma and primed spleen cells.

W. Gerhard, H. Koprowski, C. Croce, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Enumeration and characterization of virus-specific B cells by multicolor flow cytometry.

L. Brown, W. Gerhard, N. Baumgarth, 2005, Journal of immunological methods.

Synthesis of α-gal epitopes on influenza virus vaccines, by recombinant α1,3galactosyltransferase, enables the formation of immune complexes with the natural anti-Gal antibody

W. Gerhard, U. Galili, T. Henion, 1997 .

Activity of CD4+ T-cell clones of type 1 and type 2 in generation of influenza virus-specific cytotoxic responses in vitro

P. Scherle, W. Gerhard, G. Palladino, 1991, Journal of virology.

Influenza A virus infection engenders a poor antibody response against the ectodomain of matrix protein 2

R. Couch, K. Mozdzanowska, Jingqi Feng, 2006, Virology Journal.

Monoclonal antibodies to the hemagglutinin Sa antigenic site of a/pr/8/34 influenza virus distinguish biologic mutants of swine influenza virus.

W. Gerhard, E. D. Kilbourne, C. Whitaker, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Murine cell lines stably expressing the influenza virus hemagglutinin gene introduced by a recombinant retrovirus vector are constitutive targets for MHC class I- and class II-restricted T lymphocytes.

J. Yewdell, J. Bennink, L. Eisenlohr, 1989, Journal of immunology.

Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule

F. Melchers, W. Gerhard, B. Dietzschold, 1983, The Journal of experimental medicine.

Identification ofEight Determinants intheHemagglutinin Molecule ofInfluenza Virus A/PRI8/34 (HlNi)WhichAreRecognized byClass II-Restricted TCells fromBALB/cMice

W. Gerhard, 1991 .

RoleofReceptor-Binding Activity oftheViral Hemagglutinin Molecule inthePresentation ofInfluenza VirusAntigens to Helper T Cells

W. Gerhard, 1987 .

Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule.

R. Steinman, C. Bona, W. Gerhard, 1993, Science.

Analysis of antigenic drift in recently isolated influenza A (H1N1) viruses using monoclonal antibody preparations.

R. Webster, A. Kendal, W. Gerhard, 1979, Virology.

Antigenic drift in type A influenza virus: peptide mapping and antigenic analysis of A/PR/8/34 (HON1) variants selected with monoclonal antibodies.

G. Air, R. Webster, W. G. Laver, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Virus-Neutralizing Activity Mediated by the Fab Fragment of a Hemagglutinin-Specific Antibody Is Sufficient for the Resolution of Influenza Virus Infection in SCID Mice

K. Mozdzanowska, Jingqi Feng, W. Gerhard, 2003, Journal of Virology.

Individual class II-restricted antigenic determinants of the same protein exhibit distinct kinetics of appearance and persistence on antigen-presenting cells.

L. Eisenlohr, W. Gerhard, C. Hackett, 1988, Journal of immunology.

Acid-induced conformational modification of the hemagglutinin molecule alters interaction of influenza virus with antigen-presenting cells.

L. Eisenlohr, W. Gerhard, C. Hackett, 1988, Journal of immunology.

A synthetic decapeptide of influenza virus hemagglutinin elicits helper T cells with the same fine recognition specificities as occur in response to whole virus.

W. Gerhard, B. Dietzschold, J. Hurwitz, 1985, Journal of immunology.

Murine TH response to influenza virus: recognition of hemagglutinin, neuraminidase, matrix, and nucleoproteins.

W. Gerhard, J. Hurwitz, C. Hackett, 1985, Journal of immunology.

The recognition specificity of a murine helper T cell for hemagglutinin of influenza virus A/PR/8/34.

F. Melchers, W. Gerhard, C. Hackett, 1983, Journal of immunology.

Influenza virus-specific murine T cell hybridomas which recognize virus hemagglutinin in conjunction with H-2d and display helper functions for B cells.

J. Zeuthen, F. Melchers, W. Gerhard, 1982, Current topics in microbiology and immunology.

Inhibition of influenza-immune T cell effector function by virus-specific hybridoma antibody.

P. Doherty, R. Effros, W. Gerhard, 1979, Journal of immunology.

Roles of CD4+ T and B cells in influenza virus infection

K. Mozdzanowska, W. Gerhard, 2001 .

Virus-immune T cells and monoclonal antibodies in the mouse influenza model.

N. Greenspan, P. Doherty, W. Gerhard, 1983, Advances in experimental medicine and biology.

Morphogenesis of Influenza A Virus in Ehrlich Ascites Tumor Cells as Revealed by Thin-Sectioning and Freeze-Etching

T. Bächi, W. Gerhard, K. Mühlethaler, 1969, Journal of virology.

Treatment of influenza virus-infected SCID mice with nonneutralizing antibodies specific for the transmembrane proteins matrix 2 and neuraminidase reduces the pulmonary virus titer but fails to clear the infection.

K. Mozdzanowska, W. Gerhard, M. Furchner, 1999, Virology.

Role of host immune response in the development of either encephalitic or paralytic disease after experimental rabies infection in mice

W. Gerhard, H. Clark, Y. Iwasaki, 1977, Infection and immunity.

Longitudinal analysis of three intrathecally produced immunoglobulin subpopulations in an MS patient.

M. Sandberg‐Wollheim, A. Taylor, W. Gerhard, 1985, Journal of immunology.

Possible relationship between antigenic properties and isolation history of HSV-1 strains.

W. Gerhard, Z. Wróblewska, H. Koprowski, 1985, Virus research.

T cell derived IL-6 is differentially required for antigen-specific antibody secretion by primary and secondary B cells.

S. Rudikoff, D. Hilbert, R. Nordan, 1989, Journal of immunology.

THE MECHANISM OF ANTIGENIC DRIFT IN INFLUENZA VIRUSES: ANALYSIS OF HONG KONG (H3N2) VARIANTS WITH MONOCLONAL ANTIBODIES TO THE HEMAGGLUTININ MOLECULE *

G. Air, R. Webster, W. G. Laver, 1980, Annals of the New York Academy of Sciences.

Breakdown of the blood-cerebrospinal fluid barrier to immunoglobulin in mice injected intracerebrally with a neurotropic influenza A virus Post-exposure treatment with monoclonal antibody promotes recovery

P. Doherty, W. Gerhard, 1981, Journal of Neuroimmunology.

Persistence of virus-specific memory B cells in mice CNS

W. Gerhard, H. Koprowski, 1977, Nature.

The central nervous system-associated immune response to parainfluenza type I virus in mice.

W. Gerhard, H. Koprowski, Y. Iwasaki, 1978, Journal of immunology.

Repertoire of antiviral antibodies expressed by somatic cell hybrids.

W. Gerhard, H. Koprowski, C. Croce, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Cell-mediated cytotoxicity against murine cells infected with 6/94 virus, a parainfluenza type 1 isolate from multiple sclerosis brain tissue

W. Gerhard, L. Lewandowski, J. Palmer, 1976, Infection and immunity.

Antigenic drift in type A influenza virus: sequence differences in the hemagglutinin of Hong Kong (H3N2) variants selected with monoclonal hybridoma antibodies.

G. Air, R. Webster, W. G. Laver, 1979, Virology.

The analysis of the monoclonal immune response to influenza virus. I. Production of monoclonal anti‐viral antibodies in vitro

W. Gerhard, N. Klinman, T. Braciale, 1975, European journal of immunology.

Antigenic structure of influenza virus haemagglutinin defined by hybridoma antibodies

R. Webster, J. Yewdell, W. Gerhard, 1981, Nature.

Conformational changes at topologically distinct antigenic sites on the influenza A/PR/8/34 virus HA molecule are induced by the binding of monoclonal antibodies.

M. Lubeck, W. Gerhard, M. Lubeck, 1982, Virology.

Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses

J. Bennink, P. Doherty, R. Effros, 1977, The Journal of experimental medicine.

Expression of influenza A virus internal antigens on the surface of infected P815 cells.

J. Yewdell, W. Gerhard, E. Frank, 1981, Journal of immunology.

Antigenic variation in three distinct determinants of an influenza type A haemagglutinin molecule

R. Webster, J. Yewdell, W. Gerhard, 1979, Nature.

Anti-viral and anti-tumor antibodies produced by somatic cell hybrids.

W. Gerhard, H. Koprowski, C. Croce, 1978, Current topics in microbiology and immunology.

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin

L. Staudt, M. Weigert, W. Gerhard, 1985, The Journal of experimental medicine.

Differential ability of B cells specific for external vs. internal influenza virus proteins to respond to help from influenza virus-specific T-cell clones in vivo.

P. Scherle, W. Gerhard, P A Scherle, 1988, Proceedings of the National Academy of Sciences of the United States of America.

ANTIINFLUENZA HEMAGGLUTININ ANTIBODY DIVERSITY secondary immunizat ion with influenza virus

L. Staudt, M. Weigert, W. Gerhard, 2003 .

THE FUTURE IN VIRAL IMMUNOLOGY AND IMMUNOPATHOLOGY

W. Gerhard, H. Koprowski, 1975 .

Functional analysis of influenza-specific helper T cell clones in vivo. T cells specific for internal viral proteins provide cognate help for B cell responses to hemagglutinin

P. Scherle, W. Gerhard, P A Scherle, 1986, The Journal of experimental medicine.

Role of the B‐cell response in recovery of mice from primary influenza virus infection

K. Mozdzanowska, W. Gerhard, G. Washko, 1997, Immunological reviews.

Monoclonal antibodies detect different forms of influenza virus hemagglutinin during viral penetration and biosynthesis

J. Yewdell, T. Bächi, W. Gerhard, 1985, Journal of virology.

Roles of CD4+ T-Cell-Independent and -Dependent Antibody Responses in the Control of Influenza Virus Infection: Evidence for Noncognate CD4+ T-Cell Activities That Enhance the Therapeutic Activity of Antiviral Antibodies

K. Mozdzanowska, Jingqi Feng, D. Zharikova, 2005, Journal of Virology.

The antigenic structure of the influenza virus A/PR/8/34 hemagglutinin (H1 subtype)

J. Yewdell, W. Gerhard, G. Brownlee, 1982, Cell.

Specific low-affinity recognition of major histocompatibility complex plus peptide by soluble T-cell receptor

F. Oliveri, K. Karjalainen, W. Gerhard, 1992, Nature.

The role of the antibody response in influenza virus infection.

W. Gerhard, 2001, Current topics in microbiology and immunology.

(HlNi) Which Are Recognized by Class II-Restricted T Cells from BALB/c Mice

P. Scherle, W. Gerhard, G. Palladino, 2022 .

Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.

P. Scherle, W. Gerhard, G. Palladino, 1992, Journal of immunology.

A large degree of functional diversity exists among helper T cells specific for the same antigenic site of influenza hemagglutinin.

W. Gerhard, A. Haberman, C. Moller, 1990, Journal of immunology.

Structural and functional implications of a restricted antibody response to a defined antigenic region on the influenza virus hemagglutinin.

L. Staudt, W. Gerhard, G. Brownlee, 1986, The EMBO journal.

Fine specificity and sequence of antibodies directed against the ectodomain of matrix protein 2 of influenza A virus.

L. Otvos, K. Mozdzanowska, D. Zharikova, 2006, Molecular immunology.

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. I. Significant variation in repertoire expression between individual mice

L. Staudt, W. Gerhard, 1983, The Journal of experimental medicine.

The idiotypes of Vκ21 light chains

L. Staudt, M. Weigert, W. Gerhard, 1984 .

Antigen processing of two H2-IEd-restricted epitopes is differentially influenced by the structural changes in a viral glycoprotein.

L. Eisenlohr, W. Gerhard, J. Monaco, 1998, Journal of immunology.

Structural Changes in a Viral Glycoprotein Epitopes Is Differentially Influenced by the -Restricted d Antigen Processing of Two H2-IE

L. Eisenlohr, W. Gerhard, J. Monaco, 1998 .

A monoclonal antibody to viral glycoprotein blocks virus-immune effector T cells operating at H-2Dd but not at H-2Kd1.

P. Doherty, R. Effros, W. Gerhard, 1979, Journal of immunology.

Analysis of the humoral immune response to influenza virus in vitro.

T. Braciale, W. Gerhard, N. Klinman, 1976, Journal of immunology.

Activity ofCD4+T-Cell ClonesofType1andType2inGeneration ofInfluenza Virus-Specific Cytotoxic Responses InVitro

W. Gerhard, G. Palladino, 1991 .

A B cell population that dominates the primary response to influenza virus hemagglutinin does not participate in the memory response

L. Staudt, W. Gerhard, J. Kavaler, 1991, European journal of immunology.

Ex vivo perfusion of a tumor-containing colon with monoclonal antibody.

M. Herlyn, W. Gerhard, H. Koprowski, 1981, The Journal of surgical research.

Th Cell-Deficient Mice Control Influenza Virus Infection More Effectively Than Th- and B Cell-Deficient Mice: Evidence for a Th-Independent Contribution by B Cells to Virus Clearance1

K. Mozdzanowska, W. Gerhard, K. Maiese, 2000, The Journal of Immunology.

Virus-neutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice

K. Mozdzanowska, W. Gerhard, G. Palladino, 1995, Journal of virology.

Characterization of the murine TH response to influenza virus hemagglutinin: evidence for three major specificities.

W. Gerhard, J. Hurwitz, C. Hackett, 1984, Journal of immunology.

Enumeration of antigenic sites of influenza virus hemagglutinin

D. Jackson, W. Gerhard, D. O. White, 1982, Infection and immunity.

CD4+ T cells are ineffective in clearing a pulmonary infection with influenza type A virus in the absence of B cells.

K. Mozdzanowska, W. Gerhard, M. Furchner, 1997, Virology.

Influenza-specific immunity induced by recombinant Listeria monocytogenes vaccines.

D. Portnoy, W. Gerhard, Y. Paterson, 1997, Vaccine.

Topological mapping antigenic sites on the influenza A/PR/8/34 virus hemagglutinin using monoclonal antibodies.

W. Gerhard, M. Lubeck, 1981, Virology.

Monoclonal Antibodies against Influenza Virus

L. Staudt, J. Yewdell, W. Gerhard, 1980 .

Monoclonal anti-hemagglutinin antibodies detect irreversible antigenic alterations that coincide with the acid activation of influenza virus A/PR/834-mediated hemolysis

J. Yewdell, W. Gerhard, T. Bachi, 1983, Journal of virology.

Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.

W. Gerhard, D. Wylie, N. Klinman, 1979, Proceedings of the National Academy of Sciences of the United States of America.

The Delineation of Antigenic Determinants of the Hemagglutinin of Influenza a Viruses by Means of Monoclonal Antibodies

W. Gerhard, 1978 .

Cell-Deficient Mice : Evidence for a Virus Infection More Effectively Than Th-Th Cell-Deficient Mice Control Influenza

K. Mozdzanowska, W. Gerhard, K. Maiese, 2000 .

Influence of a V kappa 8 L chain transgene on endogenous rearrangements and the immune response to the HA(Sb) determinant on influenza virus.

S. Camper, M. Weigert, W. Gerhard, 1991, Journal of immunology.

Mutations in or near the fusion peptide of the influenza virus hemagglutinin affect an antigenic site in the globular region

J. Yewdell, T. Bächi, A. Taylor, 1993, Journal of virology.

Synthesis of a disulfide-linked octameric peptide construct carrying three different antigenic determinants.

J. Wade, L. Otvos, W. Gerhard, 2001, Bioorganic & medicinal chemistry letters.

The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.

L. Staudt, R. Rickert, M. Weigert, 1990, Journal of immunology.

Antigenic variation in influenza virus.

J. Yewdell, F. Raymond, W. Gerhard, 1983, Biochemical Society Transactions.

The mechanism of antigenic drift in influenza virus: sequence changes in the haemagglutinin of variants selected with monoclonal hybridoma antibodies.

G. Air, R. Webster, W. G. Laver, 1980, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

The analysis of the monoclonal immune response to influenza virus. II. The antigenicity of the viral hemagglutinin

W. Gerhard, 1976, Journal of Experimental Medicine.

A new mouse T-cell receptorα chain variable region family

P. Scherle, W. Gerhard, R. Sutherland, 2005, Immunogenetics.

Influenza virus site recognized by a murine helper T cell specific for H1 strains. Localization to a nine amino acid sequence in the hemagglutinin molecule

F. Melchers, W. Gerhard, B. Dietzschold, 1983, The Journal of experimental medicine.

THE ANTIGENIC TOPOLOGY OF THE HEMAGGLUTININ MOLECULE OF INFLUENZA VIRUS A/PR/8/34

W. Gerhard, G. Russ, G. Laver, 1981 .

STUDY OF GENETIC VARIABILITY OF VIRUSES THROUGH THE USE OF MONOCLONAL ANTIBODIES

W. Gerhard, H. Koprowski, 1980 .