M. Porotto

发表

The pH-sensitive action of cholesterol-conjugated peptide inhibitors of influenza virus.

N. Santos, Patrícia M Silva, M. T. Augusto, 2021, Biochimica et biophysica acta. Biomembranes.

Capturing a Fusion Intermediate of Influenza Hemagglutinin with a Cholesterol-conjugated Peptide, a New Antiviral Strategy for Influenza Virus*

Kelly K. Lee, L. Gui, M. Porotto, 2011, The Journal of Biological Chemistry.

Electron Tomography Imaging of Surface Glycoproteins on Human Parainfluenza Virus 3: Association of Receptor Binding and Fusion Proteins before Receptor Engagement

Kelly K. Lee, L. Gui, M. Porotto, 2015, mBio.

Identification of a Region in the Stalk Domain of the Nipah Virus Receptor Binding Protein That Is Critical for Fusion Activation

I. Wilson, J. Rose, R. Xu, 2013, Journal of Virology.

A three-dimensional model of human lung development and disease from pluripotent stem cells

Laura M. Palermo, J. Casanova, L. Notarangelo, 2017, Nature Cell Biology.

Human Parainfluenza Virus Type 3 HN-Receptor Interaction: Effect of 4-Guanidino-Neu5Ac2en on a Neuraminidase-Deficient Variant

M. Porotto, A. Moscona, O. Greengard, 2001, Journal of Virology.

Synthetic Protocells Interact with Viral Nanomachinery and Inactivate Pathogenic Human Virus

D. Laván, M. Porotto, A. Moscona, 2011, PloS one.

Circulating Clinical Strains of Human Parainfluenza Virus Reveal Viral Entry Requirements for In Vivo Infection

M. Porotto, A. Moscona, S. Jenkins, 2014, Journal of Virology.

Rapid Screening for Entry Inhibitors of Highly Pathogenic Viruses under Low-Level Biocontainment

M. Whitt, T. Briese, M. Porotto, 2012, PloS one.

Antiviral activity of gliotoxin, gentian violet and brilliant green against Nipah and Hendra virus in vitro

M. Porotto, A. Moscona, M. Aljofan, 2009, Virology Journal.

Viral Entry Inhibitors Targeted to the Membrane Site of Action

Laura M. Palermo, R. Cortese, L. M. Palermo, 2010, Journal of Virology.

Kinetic Dependence of Paramyxovirus Entry Inhibition

M. Porotto, A. Moscona, Christine C. Yokoyama, 2009, Journal of Virology.

Broad spectrum antiviral activity for paramyxoviruses is modulated by biophysical properties of fusion inhibitory peptides

Laura M. Palermo, L. M. Palermo, N. Santos, 2017, Scientific Reports.

Biophysical Properties and Antiviral Activities of Measles Fusion Protein Derived Peptide Conjugated with 25-Hydroxycholesterol

N. Santos, M. Porotto, Bárbara Gomes, 2017, Molecules.

of the JAK2 pathway Mechanisms of endothelial cell protection by blockade

S. Rivella, J. Gerdes, M. Cappellini, 2010 .

Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo

Laura M. Palermo, I. Wilson, L. M. Palermo, 2013, mBio.

Analysis of a Subacute Sclerosing Panencephalitis Genotype B3 Virus from the 2009-2010 South African Measles Epidemic Shows That Hyperfusogenic F Proteins Contribute to Measles Virus Infection in the Brain

B. Eley, M. Porotto, A. Moscona, 2018, Journal of Virology.

In vivo antiviral host response to SARS-CoV-2 by viral load, sex, and age

P. Shi, M. Porotto, A. Moscona, 2020, bioRxiv.

Structure-Stability-Function Mechanistic Links in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles.

M. Porotto, A. Moscona, M. N. Melo, 2018, ACS nano.

Parainfluenza virus entry at the onset of infection.

T. Marcink, M. Porotto, A. Moscona, 2021, Advances in virus research.

identification of a promising candidate for therapy.

M. Whitt, M. Porotto, A. Moscona, 2009 .

Simulating Henipavirus Multicycle Replication in a Screening Assay Leads to Identification of a Promising Candidate for Therapy

M. Whitt, M. Porotto, A. Moscona, 2009, Journal of Virology.

Infection of Primary Neurons Mediated by Nipah Virus Envelope Proteins: Role of Host Target Cells in Antiviral Action

M. Porotto, A. Pessi, A. Talekar, 2011, Journal of Virology.

Development and validation of a chemiluminescent immunodetection assay amenable to high throughput screening of antiviral drugs for Nipah and Hendra virus.

M. Porotto, A. Moscona, M. Aljofan, 2008, Journal of virological methods.

Fusion Inhibitory Lipopeptides Engineered for Prophylaxis of Nipah Virus in Primates

M. Porotto, A. Moscona, B. Horvat, 2018, The Journal of infectious diseases.

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.

S. Rivella, J. Gerdes, M. Cappellini, 2008, Blood.

1 Decreased Differentiation of Erythroid Cells Exacerbates Ineffective Erythropoiesis in β -Thalassemia

Yifang, Eliezer, Cappellini, 2008 .

erythropoiesis in Decreased differentiation of erythroid cells exacerbates ineffective

S. Rivella, J. Gerdes, M. Cappellini, 2008 .

Antiviral Lipopeptide-Cell Membrane Interaction Is Influenced by PEG Linker Length

N. Santos, M. T. Augusto, M. Porotto, 2017, Molecules.

Repurposing an In Vitro Measles Virus Dissemination Assay for Screening of Antiviral Compounds

C. Alabi, M. Porotto, A. Moscona, 2022, Viruses.

Intermediates in SARS-CoV-2 spike–mediated cell entry

T. Marcink, A. des Georges, M. Porotto, 2022, Science advances.

Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy

N. Ben-Tal, C. Alabi, T. Marcink, 2020, mBio.

Effects of single α-to-β residue replacements on recognition of an extended segment in a viral fusion protein.

S. Gellman, M. Porotto, A. Moscona, 2020, ACS infectious diseases.

In Vivo Efficacy of Measles Virus Fusion Protein-Derived Peptides Is Modulated by the Properties of Self-Assembly and Membrane Residence

Laura M. Palermo, C. Alabi, L. M. Palermo, 2016, Journal of Virology.

Prevention of Measles Virus Infection by Intranasal Delivery of Fusion Inhibitor Peptides

M. Porotto, A. Talekar, A. Moscona, 2014, Journal of Virology.

Rapid and Flexible Platform To Assess Anti-SARS-CoV-2 Antibody Neutralization and Spike Protein-Specific Antivirals

M. Galdiero, M. Whitt, M. Porotto, 2021, mSphere.

Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain

S. Gellman, Xuping Xie, P. Shi, 2020, mBio.

The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell–derived lung progenitors in 3D

H. Snoeck, M. Porotto, A. Moscona, 2021, Nature Protocols.

The Second Receptor Binding Site of the Globular Head of the Newcastle Disease Virus Hemagglutinin-Neuraminidase Activates the Stalk of Multiple Paramyxovirus Receptor Binding Proteins To Trigger Fusion

I. Wilson, R. Xu, M. Porotto, 2012, Journal of Virology.

A Second Receptor Binding Site on Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Contributes to Activation of the FusionMechanism

M. Fornabaio, G. Kellogg, M. Porotto, 2007, Journal of Virology.

Unity in diversity: shared mechanism of entry among paramyxoviruses.

Laura M. Palermo, L. M. Palermo, M. Porotto, 2015, Progress in molecular biology and translational science.

A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo.

L. Aschenbrenner, M. Porotto, A. Moscona, 2010, The Journal of infectious diseases.

Nebulized fusion inhibitory peptide protects cynomolgus macaques from measles virus infection

C. Alabi, M. Porotto, Yun Zhu, 2022, Nature Communications.

Regulation of Paramyxovirus Fusion Activation: the Hemagglutinin-Neuraminidase Protein Stabilizes the Fusion Protein in a Pretriggered State

Laura M. Palermo, Kelly K. Lee, Hong Lu, 2012, Journal of Virology.

Mechanism of Interference Mediated by Human Parainfluenza Virus Type 3 Infection

G. Gusella, M. Porotto, A. Moscona, 2000, Journal of Virology.

Measles Virus Fusion Machinery Activated by Sialic Acid Binding Globular Domain

M. Porotto, A. Talekar, A. Moscona, 2013, Journal of Virology.

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

E. Hod, J. Milner, M. Baldwin, 2020, Nature Immunology.

Human parainfluenza virus fusion complex glycoproteins imaged in action on authentic viral surfaces

T. Marcink, A. des Georges, Tong Wang, 2020, PLoS pathogens.

Effective in Vivo Targeting of Influenza Virus through a Cell-Penetrating/Fusion Inhibitor Tandem Peptide Anchored to the Plasma Membrane.

C. Alabi, N. Santos, M. T. Augusto, 2018, Bioconjugate chemistry.

Improvement of HIV fusion inhibitor C34 efficacy by membrane anchoring and enhanced exposure.

N. Santos, M. T. Augusto, M. Porotto, 2014, The Journal of antimicrobial chemotherapy.

Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection

N. Messaddeq, M. Porotto, A. Moscona, 2020, Nature Communications.

Influence of the Human Parainfluenza Virus 3 Attachment Protein's Neuraminidase Activity on Its Capacity To Activate the Fusion Protein

M. Porotto, A. Moscona, O. Greengard, 2005, Journal of Virology.

Modulation of Oncogenic DBL Activity by Phosphoinositol Phosphate Binding to Pleckstrin Homology Domain*

M. Falasca, Yi Zheng, M. Porotto, 2001, The Journal of Biological Chemistry.

Authentic Modeling of Human Respiratory Virus Infection in Human Pluripotent Stem Cell-Derived Lung Organoids

H. Snoeck, T. Briese, M. Porotto, 2019, mBio.

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

E. Hod, M. Baldwin, M. Porotto, 2020, Nature Immunology.

Viral Entry Properties Required for Fitness in Humans Are Lost through Rapid Genomic Change during Viral Isolation

A. des Georges, M. Porotto, A. Moscona, 2018, mBio.

Inhibition of Nipah Virus Infection In Vivo: Targeting an Early Stage of Paramyxovirus Fusion Activation during Viral Entry

Min Lu, Heinz Feldmann, Laura M. Palermo, 2010, PLoS pathogens.

Molecular Features of the Measles Virus Viral Fusion Complex That Favor Infection and Spread in the Brain

N. Dorrello, B. Corneo, T. Briese, 2021, mBio.

Measles Virus Bearing Measles Inclusion Body Encephalitis-Derived Fusion Protein Is Pathogenic after Infection via the Respiratory Route

M. Porotto, G. Sanna, A. Moscona, 2019, Journal of Virology.

Measles Fusion Machinery Is Dysregulated in Neuropathogenic Variants

Laura M. Palermo, L. M. Palermo, M. Porotto, 2015, mBio.

A broad-spectrum antiviral targeting entry of enveloped viruses

Robert Damoiseaux, Oscar A. Negrete, Alexander N Freiberg, 2010, Proceedings of the National Academy of Sciences.

Design and evaluation of neutralizing and fusion inhibitory peptides to Crimean-Congo hemorrhagic fever virus.

C. Alabi, M. Porotto, C. Mire, 2022, Antiviral research.

Premature Activation of the Paramyxovirus Fusion Protein before Target Cell Attachment with Corruption of the Viral Fusion Machinery*

Laura M. Palermo, M. Fornabaio, G. Kellogg, 2011, The Journal of Biological Chemistry.

Early Permissiveness of Central Nervous System Cells to Measles Virus Infection Is Determined by Hyperfusogenicity and Interferon Pressure

D. Gerlier, M. Porotto, D. Décimo, 2023, Viruses.

Human parainfluenza virus evolution during lung infection of immunocompromised humans promotes viral persistence.

M. Boeckh, T. Marcink, M. Porotto, 2021, The Journal of clinical investigation.

Measles fusion complexes from central nervous system clinical isolates: decreased interaction between hemagglutinin and fusion proteins

T. Marcink, M. Porotto, A. Moscona, 2021, bioRxiv.

Human parainfluenza virus evolution during lung infection of immunocompromised individuals promotes viral persistence

M. Boeckh, T. Marcink, M. Porotto, 2021 .

Self-assembly Stability Compromises the Efficacy of Tryptophan-Containing Designed Anti-measles Virus Peptides

M. Porotto, A. Moscona, A. S. Veiga, 2019, Journal of nanomedicine & nanotechnology.

Inhibiting Human Parainfluenza Virus Infection by Preactivating the Cell Entry Mechanism

C. Alabi, J. Melero, M. Porotto, 2019, mBio.

Fatal Measles Virus Infection Prevented by Brain-Penetrant Fusion Inhibitors

M. Porotto, A. Pessi, A. Talekar, 2013, Journal of Virology.

Mechanism of Fusion Triggering by Human Parainfluenza Virus Type III

Laura M. Palermo, L. M. Palermo, M. Porotto, 2011, The Journal of Biological Chemistry.

Spring-Loaded Model Revisited: Paramyxovirus Fusion Requires Engagement of a Receptor Binding Protein beyond Initial Triggering of the Fusion Protein

J. Yee, M. Porotto, A. Pessi, 2011, Journal of Virology.

Human Parainfluenza Virus Infection of the Airway Epithelium: Viral Hemagglutinin-Neuraminidase Regulates Fusion Protein Activation and Modulates Infectivity

Laura M. Palermo, L. M. Palermo, M. Porotto, 2009, Journal of Virology.

Inhibition of Hendra Virus Fusion

M. Fornabaio, G. Kellogg, M. Porotto, 2006, Journal of Virology.

Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets

C. Alabi, S. Gellman, N. Dorrello, 2021, Science.

Intranasal fusion inhibitory lipopeptide prevents direct contact SARS-CoV-2 transmission in ferrets

C. Alabi, S. Gellman, B. Haagmans, 2020, bioRxiv.

Inhibition of Parainfluenza Virus Type 3 and Newcastle Disease Virus Hemagglutinin-Neuraminidase Receptor Binding: Effect of Receptor Avidity and Steric Hindrance at the Inhibitor Binding Sites

M. Lawrence, M. Porotto, J. McKimm-Breschkin, 2004, Journal of Virology.

Fusion Promotion by a Paramyxovirus Hemagglutinin-Neuraminidase Protein: pH Modulation of Receptor Avidity of Binding Sites I and II

L. M. Palermo, M. Porotto, A. Moscona, 2007, Journal of Virology.

In vivo antiviral host transcriptional response to SARS-CoV-2 by viral load, sex, and age

P. Shi, M. Porotto, A. Moscona, 2020, PLoS biology.

Structure-Guided Improvement of a Dual HPIV3/RSV Fusion Inhibitor.

S. Gellman, M. Porotto, Yun Zhu, 2019, Journal of the American Chemical Society.

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent.

S. Gellman, M. Porotto, A. Moscona, 2019, Journal of the American Chemical Society.

A General Strategy to Endow Natural Fusion-protein-Derived Peptides with Potent Antiviral Activity

R. Cortese, T. Ketas, M. Porotto, 2012, PloS one.

Molecular Determinants of Antiviral Potency of Paramyxovirus Entry Inhibitors

G. Kellogg, M. Whitt, M. Porotto, 2007, Journal of Virology.

Modeling Infection and Tropism of Human Parainfluenza Virus Type 3 in Ferrets

B. Haagmans, M. Porotto, A. Moscona, 2022, mBio.

Engineering protease-resistant peptides to inhibit human parainfluenza viral respiratory infection

S. Gellman, Ross W. Cheloha, M. Porotto, 2021, bioRxiv.

Features of Circulating Parainfluenza Virus Required for Growth in Human Airway

Nora C. Toussaint, Laura M. Palermo, S. Germer, 2016, mBio.

Subnanometer structure of an enveloped virus fusion complex on viral surface reveals new entry mechanisms

T. Marcink, A. des Georges, M. Porotto, 2023, Science advances.

Antibody responses to SARS-CoV2 are distinct in children with MIS-C compared to adults with COVID-19

E. Hod, M. Baldwin, M. Porotto, 2020, medRxiv.

(Zanamivir)Sialic Acid Analog 4-GU-DANA Activity and Resistance to the Transition Causing Increased Receptor Binding Type 3 Hemagglutinin-Neuraminidase Mutations in Human Parainfluenza Virus

M. Porotto, A. Moscona, M. Murrell, 2013 .

Mutations in Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Causing Increased Receptor Binding Activity and Resistance to the Transition State Sialic Acid Analog 4-GU-DANA (Zanamivir)

T. Weber, M. Porotto, A. Moscona, 2003, Journal of Virology.

A Single Amino Acid Alteration in the Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Glycoprotein Confers Resistance to the Inhibitory Effects of Zanamivir on Receptor Binding and Neuraminidase Activity

M. Porotto, A. Moscona, O. Greengard, 2001, Journal of Virology.

SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19

E. L. Luning Prak, M. Porotto, A. Moscona, 2023, The Journal of experimental medicine.

Absence of COVID-19-associated changes in plasma coagulation proteins and pulmonary thrombosis in the ferret model

M. Porotto, A. Moscona, M. D. de Maat, 2021, Thrombosis Research.

Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein.

C. Alabi, T. Marcink, M. Porotto, 2021, ACS nano.

Triggering of Human Parainfluenza Virus 3 Fusion Protein (F) by the Hemagglutinin-Neuraminidase (HN) Protein: an HN Mutation Diminishes the Rate of F Activation and Fusion

M. Porotto, A. Moscona, O. Greengard, 2003, Journal of Virology.

Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern

B. Haagmans, M. Porotto, A. Moscona, 2022, mBio.

Paramyxovirus Receptor-Binding Molecules: Engagement of One Site on the Hemagglutinin-Neuraminidase Protein Modulates Activity at the Second Site

M. Fornabaio, G. Kellogg, M. Porotto, 2006, Journal of Virology.

A Second Receptor Binding Site on Human Parainﬂuenza Virus Type 3 Hemagglutinin-Neuraminidase Contributes to Activation of the Fusion Mechanism (cid:1)

M. Fornabaio, G. Kellogg, M. Porotto, 2007 .

Host Cell Membrane Capture by the SARS-CoV-2 Spike Protein Fusion Intermediate

T. Marcink, B. O’Shaughnessy, M. Porotto, 2023, ACS central science.

Adaptation of Human Parainfluenza Virus to Airway Epithelium Reveals Fusion Properties Required for Growth in Host Tissue

Laura M. Palermo, L. M. Palermo, M. Porotto, 2012, mBio.

Negative staining of proteins in polyacrylamide gels with methyl trichloroacetate.

G. Ghiggeri, M. Porotto, G. Candiano, 1996, Analytical biochemistry.

Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance

M. Porotto, A. Moscona, M. Castanho, 2017, Scientific Reports.

Spring-Loaded Model Revisited: Paramyxovirus Fusion Requires Engagement of a Receptor Binding Protein beyond Initial Triggering of the Fusion Protein

J. Yee, M. Porotto, A. Pessi, 2011, Journal of Virology.

Dual Inhibition of Human Parainfluenza Type 3 and Respiratory Syncytial Virus Infectivity with a Single Agent.

S. Gellman, M. Porotto, A. Moscona, 2019, Journal of the American Chemical Society.

Functional properties of measles virus proteins derived from a subacute sclerosing panencephalitis patient who received repeated remdesivir treatments

M. Porotto, D. van Riel, C. Geurtsvankessel, 2024, Journal of virology.