P. Groot

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Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.

Stephen L. Pinkosky, P. Groot, N. Lalwani, 2017, Trends in molecular medicine.

Chemokines and atherosclerosis.

P. Groot, T. Reape, 1999, Atherosclerosis.

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.

I. Forbes, P. Groot, R. Ife, 2000, Bioorganic & Medicinal Chemistry Letters.

Role of Macrophage-Derived Lipoprotein Lipase in Lipoprotein Metabolism and Atherosclerosis

R. Zechner, R. Zimmermann, T. V. van Berkel, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Synthetic LXR agonists increase LDL in CETP species Published, JLR Papers in Press, July 16, 2005. DOI 10.1194/jlr.M500116-JLR200

M. Jaye, C. Doe, R. Willette, 2005, Journal of Lipid Research.

Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice.

F. Kuipers, P. Groot, A. Groen, 2005, Gastroenterology.

Insulin sensitivity of hepatic glucose and lipid metabolism in animal models of hepatic

J. Romijn, A. Grefhorst, L. Havekes, 2006 .

3.P.183 Bone marrow transplantation in apolipoprotein E deficient mice: Effect of apoE gene-dosage on serum lipid concentrations, βVLDL catabolism, and atherosclerosis

T. J. Berkel, P. Groot, P. Hoogerbrugge, 1997 .

The effect of oral calcium carbonate administration on serum lipoproteins of children with familial hypercholesterolaemia (type II-A)

P. Groot, J. Fernandes, W. Grose, 1980, European Journal of Pediatrics.

THE EFFECTS OF COLESTIPOL HYDROCHLORIDE ON SERUM LIPOPROTEIN LIPID AND APOLIPOPROTEIN B AND A‐I CONCENTRATIONS IN CHILDREN HETEROZYGOUS FOR FAMILIAL HYPERCHOLESTEROLEMIA

P. Groot, J. Fernandes, W. Grose, 1983, Acta paediatrica Scandinavica.

Liver lipase and high-density lipoprotein. Lipoprotein changes after incubation of human serum with rat liver lipase.

P. Groot, H. Jansen, L. Scheek, 1983, Biochimica et biophysica acta.

A one-step separation of human serum high density lipoproteins 2 and 3 by rate-zonal density gradient ultracentrifugation in a swinging bucket rotor.

F. V. van’t Hooft, L. Havekes, P. Groot, 1982, Journal of lipid research.

Serum lipoproteins of healthy persons fed a low-fat diet or a polyunsaturated fat diet for three months. A comparison of two cholesterol-lowering diets.

J. Hautvast, L. Havekes, M. Katan, 1982, Atherosclerosis.

Effects of amount and type of dietary fat on serum lipids, lipoproteins and apolipoproteins in man. A controlled 8-week trial.

M. Katan, P. Groot, G. Dallinga-Thie, 1980, Atherosclerosis.

CHAPTER 2 Reduced cholesterol absorption upon PPAR activation coincides with decreased intestinal expression of NPC 1 L 1

B. Staels, F. Kuipers, P. Groot, 2017 .

Reduced cholesterol absorption upon PPARδ activation coincides with decreased intestinal expression of NPC1L1 Published, JLR Papers in Press, December 16, 2004. DOI 10.1194/jlr.M400400-JLR200

B. Staels, F. Kuipers, P. Groot, 2005, Journal of Lipid Research.

C3H apoE(-/-) mice have less atherosclerosis than C57BL apoE(-/-) mice despite having a more atherogenic serum lipid profile.

J. Latcham, P. Groot, D. Grimsditch, 2000, Atherosclerosis.

Postprandial lipoprotein metabolism in normolipidemic men with and without coronary artery disease.

A. Hofman, L. Havekes, P. Groot, 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

Effects of fat ingestion on high density lipoprotein profiles in human sera.

P. Groot, L. Scheek, 1984, Journal of lipid research.

Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice.

B. Wieringa, R. Frants, L. Havekes, 1994, Atherosclerosis.

Selective degradation of the high density lipoprotein‐2 subfraction by heparin‐releasable liver lipase

P. Groot, A. van Tol, H. Jansen, 1981, FEBS letters.

Effect of dietary fat composition on the metabolism of triacylglycerol-rich plasma lipoproteins in the postprandial phase in meal-fed rats.

P. Groot, U. Houtsmuller, W. C. Hülsmann, 1988, Journal of lipid research.

The effect of (-)-hydroxycitrate on the activity of the low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase levels in the human hepatoma cell line Hep G2.

L. Havekes, P. Groot, T. Berkhout, 1990, The Biochemical journal.

Cloning, in Vitro Expression, and Functional Characterization of a Novel Human CC Chemokine of the Monocyte Chemotactic Protein (MCP) Family (MCP-4) That Binds and Signals through the CC Chemokine Receptor 2B*

H. Sarau, J. Foley, N. Elshourbagy, 1997, The Journal of Biological Chemistry.

Electroimmunoassay of rat apolipoproteins A-I, A-IV, and E. A procedure for sample treatment to increase the sensitivity in diluted fractions.

P. Groot, G. Dallinga-Thie, A. van Tol, 1985, Journal of lipid research.

Is the ratio of apo B/apo A-I an early predictor of coronary atherosclerosis?

A. Hofman, P. Groot, R. Vermeeren, 1986, Atherosclerosis.

Leucocyte cathepsin K affects atherosclerotic lesion composition and bone mineral density in low-density lipoprotein receptor deficient mice.

T. V. van Berkel, T. V. Berkel, I. Bot, 2008, Cardiovascular research.

Leukocyte Cathepsin K Influences Atherosclerotic Lesion Composition and Bone Mineral Density in LDL-Receptor Deficient Mice

P. Groot, S. Hoffman, E. Biessen, 2005 .

Effect of probucol on serum lipids, atherosclerosis and toxicology in fat-fed LDL receptor deficient mice.

J. Latcham, K. Suckling, P. Groot, 1998, Atherosclerosis.

Effects of cholestyramine on lipoprotein levels and metabolism in Syrian hamsters.

S. Eisenberg, K. Suckling, P. Groot, 1992, Biochimica et biophysica acta.

Essential role for the (hepatic) LDL receptor in macrophage apolipoprotein E-induced reduction in serum cholesterol levels and atherosclerosis.

K. V. van Dijk, T. V. van Berkel, M. Hofker, 2001, Atherosclerosis.

Interaction of the Reticuloendothelial System with Blood Lipid and Lipoprotein Metabolism

T. J. Berkel, P. Groot, A. Tol, 1984 .

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis.

K. Suckling, P. Groot, E. Niesor, 1997, Atherosclerosis.

Bone marrow transplantation in apolipoprotein E-deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, (beta)VLDL catabolism, and atherosclerosis.

T. V. van Berkel, P. Groot, P. Hoogerbrugge, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Accelerated atherosclerosis in C57Bl/6 mice transplanted with ApoE-deficient bone marrow.

T. V. van Berkel, P. Groot, P. Hoogerbrugge, 2000, Atherosclerosis.

Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158-->Cys) on cholesterol levels and atherosclerosis in ApoE-deficient mice.

K. V. van Dijk, T. V. van Berkel, L. Havekes, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Rat ATP citrate-lyase. Molecular cloning and sequence analysis of a full-length cDNA and mRNA abundance as a function of diet, organ, and age.

C. Southan, J. F. Young, J. Strickler, 1990, The Journal of biological chemistry.

The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076.

D. Tew, H. Boyd, A. Shaw, 1998, The Biochemical journal.

Fractalkine Is Expressed by Smooth Muscle Cells in Response to IFN-γ and TNF-α and Is Modulated by Metalloproteinase Activity1

P. Groot, A. Ludwig, K. Moores, 2002, The Journal of Immunology.

The presence of leukocyte CC-chemokine receptor 2 in CCR2 knockout mice promotes atherogenesis.

V. de Waard, N. Maeda, T. V. van Berkel, 2005, Biochimica et biophysica acta.

Effect of bone marrow transplantation on lipoprotein metabolism and atherosclerosis in LDL receptor-knockout mice.

T. V. van Berkel, P. Groot, P. Hoogerbrugge, 1997, Arteriosclerosis, thrombosis, and vascular biology.

Effects of diets supplemented with lard fat or mackerel oil on plasma lipoprotein lipid concentrations and lipoprotein lipase activities in domestic swine.

P. Groot, P. Verdouw, M. Dubelaar, 1989, Atherosclerosis.

Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity.

J. White, C. Imburgia, J. Fornwald, 1998, Journal of immunology.

THE EFFECT OF A VIRTUALLY CHOLESTEROL‐FREE, HIGH‐LINOLEIC‐ACID VEGETARIAN DIET ON SERUM LIPOPROTEINS OF CHILDREN WITH FAMILIAL HYPERCHOLESTEROLEMIA (TYPE II‐A)

P. Groot, J. Fernandes, W. Grose, 1981, Acta paediatrica Scandinavica.

Temporal Relationships Between Circulating Levels of CC and CXC Chemokines and Developing Atherosclerosis in Apolipoprotein E*3 Leiden Mice

P. Groot, K. Bruckdorfer, P. Overend, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Hypercholesterolaemia and circulating levels of CXC chemokines in apoE*3 Leiden mice.

P. Groot, P. Overend, D. Grimsditch, 2002, Atherosclerosis.

CCR2 and coronary artery disease: a woscops substudy

I. Gray, C. Packard, A. McMahon, 2010, BMC Research Notes.

Membrane‐bound apolipoprotein B is exposed at the cytosolic surface of liver microsomes

J. Higgins, E. Gherardi, P. Groot, 1992, FEBS letters.

Dietary Antioxidants Decrease Serum Soluble Adhesion Molecule (sVCAM-1, sICAM-1) but not Chemokine (JE/MCP-1, KC) Concentrations, and Reduce Atherosclerosis in C57BL but Not ApoE*3 Leiden Mice Fed an Atherogenic Diet

P. Groot, P. Overend, D. Grimsditch, 2006, Disease markers.

Triglyceridase and phospholipase A1 activities of rat-heart lipoprotein lipase. Influence of apolipoproteins C-II and C-III.

P. Groot, M. Oerlemans, L. Scheek, 1978, Biochimica et biophysica acta.

Time-course studies by synchrotron X-ray solution scattering of the structure of human low-density lipoprotein during Cu(2+)-induced oxidation in relation to changes in lipid composition.

D. F. Meyer, S. Perkins, K. Suckling, 1996, The Biochemical journal.

The long-term effect of alprenolol on plasma apolipoproteins A-I and B.

O. Faergeman, P. Groot, L. U. Gerdes, 2009, Acta medica Scandinavica.

Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure.

L. Havekes, M. Hofker, P. Groot, 1996, Arteriosclerosis, thrombosis, and vascular biology.

ATP-citrate Lyase: A Potential Target for Hypolipidemic Intervention

P. Groot, N. Pearce, A. Gribble, 2003 .

Targeted replacement of rodent CCR2 with the human orthologue CCR2B: A mouse model for in vivo analysis of human target‐selective small molecule MCP‐1 receptor antagonists

I. Forbes, H. Prosser, P. Groot, 2002 .

Modulation of Arteriosclerosis by Gene-Therapy

T. J. Berkel, P. Groot, P. Hoogerbrugge, 1997 .

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

I. Forbes, P. Groot, R. Ife, 2001, Bioorganic & medicinal chemistry letters.

The activation and oxidation of octanoate and palmitate by rat skeletal muscle mitochondria.

P. Groot, W. C. Hülsmann, 1973, Biochimica et biophysica acta.

Topography of apolipoprotein B in subcellular fractions of rabbit liver probed with a panel of monoclonal antibodies.

J. Higgins, E. Gherardi, P. Groot, 1993, Journal of lipid research.

Hyperlipidemia and Atherosclerosis in APOE Transgenic Mice

L. Havekes, M. Hofker, P. Groot, 1997 .

The Metabolism of Vldl Remnants in Apoe*3-Leiden Transgenic Mice

R. Frants, L. Havekes, M. Hofker, 1996 .

Identification of the palmitoyl-CoA synthetase present in the inner membrane-matrix fraction of rat liver mitochondria.

P. Groot, W. C. Hülsmann, C. Van Loon, 1974, Biochimica et biophysica acta.

Hyperlipidaemia and Atherosclerosis

K. Suckling, P. Groot, 1988 .

Distribution of apolipoproteins A-I and A-IV among lipoprotein classes in rat mesenteric lymph, fractionated by molecular sieve chromatography.

F. V. van’t Hooft, P. Groot, G. Dallinga-Thie, 1986, Biochimica et biophysica acta.

Cloning and expression of a human ATP-citrate lyase cDNA.

P. Groot, T. Wells, N. Elshourbagy, 1992, European journal of biochemistry.

Reduced cholesterol absorption upon PPARδ activation coincides with decreased intestinal expression of NPC1L1 Published, JLR Papers in Press, December 16, 2004. DOI 10.1194/jlr.M400400-JLR200

B. Staels, F. Kuipers, P. Groot, 2005, Journal of Lipid Research.

Effect of apolipoproteins E and C-III on the interaction of chylomicrons with parenchymal and non-parenchymal cells from rat liver.

T. V. van Berkel, J. K. Kruijt, P. Groot, 1983, The Biochemical journal.

Influence of diets on acyl-CoA:cholesterol acyltransferase and on acyl-CoA:retinol acyltransferase in villous and crypt cells from rat small intestinal mucosa and in the liver.

P. Groot, H. D. de Jonge, K. Norum, 1983, Biochimica et biophysica acta.

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

I. Forbes, F. Blaney, A. Bridges, 2003, Journal of medicinal chemistry.

Fatty acid activation: specificity, localization, and function.

P. Groot, W. C. Hülsmann, H. Scholte, 1976, Advances in lipid research.

Val 64 Ile Polymorphism in the C-C Chemokine Receptor 2 Is Associated With Reduced Coronary Artery Calcification

D. Rader, A. Valdés, W. Gefter, 2002 .

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis

Stephen L. Pinkosky, P. Groot, N. Lalwani, 2016, Nature Communications.

Synthesis of novel thiol-containing citric acid analogues. Kinetic evaluation of these and other potential active-site-directed and mechanism-based inhibitors of ATP citrate lyase.

P. Groot, R. Dolle, T. Wells, 1995, Journal of medicinal chemistry.

Metabolic fate of the phosphatidylcholine component of very low density lipoproteins during catabolism by the perfused rat heart.

P. Groot, A. van Tol, 1978, Biochimica et biophysica acta.

Low density lipoprotein receptor of macrophages facilitates atherosclerotic lesion formation in C57Bl/6 mice.

T. V. van Berkel, P. Groot, P. Hoogerbrugge, 2000, Arteriosclerosis, thrombosis, and vascular biology.

persistent knockdown of CCR2 function in vivo Lentiviral shRNA silencing of murine bone marrow cell CCR2 leads to

J. Seppen, T. V. van Berkel, T. V. Berkel, 2013 .

shRNA delivery using bone marrow transplantation 127

J. Seppen, I. Bot, P. Groot, 2005 .

The activation of short-chain fatty acids by the soluble fraction of guinea-pig heart and liver mitochondria. The search for a distinct propionyl-CoA synthetase.

P. Groot, 1975, Biochimica et Biophysica Acta.

Acyl-CoA synthetases in guinea-pig liver mitochondria. Purification and characterization of a distinct propionyl-CoA synthetase.

P. Groot, 1976, Biochimica et biophysica acta.

Organ and intracellular localization of short-chain acyl-CoA synthetases in rat and guinea-pig.

P. Groot, H. Scholte, 1975, Biochimica et biophysica acta.

Transplantation of Monocyte CC-Chemokine Receptor 2-Deficient Bone Marrow Into ApoE3-Leiden Mice Inhibits Atherogenesis

N. Maeda, T. V. van Berkel, P. Groot, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Val64Ile Polymorphism in the C-C Chemokine Receptor 2 Is Associated With Reduced Coronary Artery Calcification

D. Rader, W. Gefter, N. Spurr, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Repopulation of Apolipoprotein E Knockout Mice With CCR2-Deficient Bone Marrow Progenitor Cells Does Not Inhibit Ongoing Atherosclerotic Lesion Development

V. de Waard, N. Maeda, T. V. van Berkel, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Localisation of mRNA for JE/MCP-1 and Its Receptor CCR2 in Atherosclerotic Lesions of the ApoE Knockout Mouse

P. Groot, T. Reape, Sander van Eersel, 2000, Journal of Vascular Research.

Repeated Three-Dimensional Magnetic Resonance Imaging of Atherosclerosis Development in Innominate Arteries of Low-Density Lipoprotein Receptor-Knockout Mice

Graham J. Galloway, Keith E. Suckling, Toby Roberts, 2002, Circulation.

Low Density Lipoprotein Receptor of Macrophages Facilitates Atherosclerotic Lesion Formation in C 57 Bl / 6 Mice

P. Groot, P. Hoogerbrugge, M. Eck, 2000 .

Distribution of apolipoprotein A-IV among lipoprotein subclasses in rat serum.

P. Groot, G. Dallinga-Thie, A. van Tol, 1985, Journal of lipid research.

Expression and cellular localization of the CC chemokines PARC and ELC in human atherosclerotic plaques.

K. Burnand, P. Groot, T. Reape, 1999, The American journal of pathology.

Relative contributions of parenchymal and non-parenchymal (sinusoidal) liver cells in the uptake of chylomicron remnants.

T. V. van Berkel, P. Groot, A. van Tol, 1981, Metabolism: clinical and experimental.

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1).

J. White, P. Groot, K. Moores, 2000, Biochemical pharmacology.

Determination of the intracellular distribution and pool sizes of apolipoprotein B in rabbit liver.

J. Higgins, E. Gherardi, P. Groot, 1992, The Biochemical journal.

Effect of Human Scavenger Receptor Class A Overexpression in Bone Marrow–Derived Cells on Cholesterol Levels and Atherosclerosis in ApoE-Deficient Mice

T. V. van Berkel, L. Havekes, M. Hofker, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Variation with temperature of the apparent molecular weight of rat-liver mitochondrial RNA, determined by gel electrophoresis.

P. Borst, C. Aaij, P. Groot, 1970, Biochemical and biophysical research communications.

ATP-Citrate lyase as a target for hypolipidemic intervention. 2. Synthesis and evaluation of (3R,5S)-omega-substituted-3-carboxy-3, 5-dihydroxyalkanoic acids and their gamma-lactone prodrugs as inhibitors of the enzyme in vitro and in vivo.

D. Tew, H. Boyd, A. Shaw, 1998, Journal of medicinal chemistry.

ATP-citrate lyase as a target for hypolipidemic intervention. Design and synthesis of 2-substituted butanedioic acids as novel, potent inhibitors of the enzyme.

D. Tew, A. Shaw, P. Groot, 1996, Journal of medicinal chemistry.

The distribution of apolipoprotein B in endoplasmic reticulum and Golgi subfractions of rabbit liver.

J. Higgins, E. Gherardi, P. Groot, 1990, Biochemical Society Transactions.

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity.

P. Groot, A. Ludwig, K. Moores, 2002, Journal of immunology.

Apolipoprotein E*3-Leiden transgenic mice as a test model for hypolipidaemic drugs.

L. Havekes, M. Hofker, B. Staels, 1998, Arzneimittel-Forschung.

Dietary-fish effects on serum lipids and apolipoproteins, a controlled study.

P. Groot, A. Kester, G. Hornstra, 1990, The American journal of clinical nutrition.

Nuclear receptors in control of cholesterol transport

B. Staels, F. Kuipers, P. Groot, 2007 .

Reduced cholesterol absorption upon PPAR activation coincides with decreased intestinal expression of NPC 1 L 1

B. Staels, F. Kuipers, P. Groot, 2005 .

Effect of Human Scavenger Receptor Class A Overexpression in Bone Marrow–Derived Cells on Cholesterol Levels and Atherosclerosis in ApoE-Deficient Mice

T. V. van Berkel, L. Havekes, M. Hofker, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Differential effects of pharmacological liver X receptor activation on hepatic and peripheral insulin sensitivity in lean and ob/ob mice.

J. Romijn, A. Grefhorst, L. Havekes, 2005, American journal of physiology. Endocrinology and metabolism.

Time-course studies by neutron solution scattering and biochemical assays of the aggregation of human low-density lipoprotein during Cu(2+)-induced oxidation.

D. F. Meyer, S. Perkins, K. Suckling, 1995, The Biochemical journal.