K. Wagstaff

发表

Nucleocytoplasmic shuttling of the Duchenne muscular dystrophy gene product dystrophin Dp71d is dependent on the importin α/β and CRM1 nuclear transporters and microtubule motor dynein.

D. Jans, R. Suárez-Sánchez, A. Aguilar, 2014, Biochimica et biophysica acta.

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

D. Jans, K. Wagstaff, L. Caly, 2020, Antiviral Research.

Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?

D. Jans, K. Wagstaff, L. Caly, 2012, Antiviral research.

Histone-mediated transduction as an efficient means for gene delivery.

Dominic J. Glover, D. Tremethick, D. Jans, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Investigating dengue virus nonstructural protein 5 (NS5) nuclear import.

D. Jans, Chunxiao Wang, J. Fraser, 2014, Methods in molecular biology.

Internalized Functional DNA Aptamers as Alternative Cancer Therapies

K. Wagstaff, M. Marshall, Morgan L. Marshall, 2020, Frontiers in Pharmacology.

Novel Flavivirus Antiviral That Targets the Host Nuclear Transport Importin α/β1 Heterodimer

J. Forwood, N. Borg, D. Jans, 2019, Cells.

Quantitative analysis of localization and nuclear aggregate formation induced by GFP‐lamin A mutant proteins in living HeLa cells

D. Jans, S. Hübner, K. Wagstaff, 2006, Journal of cellular biochemistry.

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

K. Loveland, D. Jans, Chunxiao Wang, 2014, The Biochemical journal.

The C‐terminus of apoptin represents a unique tumor cell‐enhanced nuclear targeting module

G. Alvisi, D. Jans, K. Wagstaff, 2008, International journal of cancer.

The Type III Effectors NleE and NleB from Enteropathogenic E. coli and OspZ from Shigella Block Nuclear Translocation of NF-κB p65

J. Whisstock, G. Holloway, M. Dunstone, 2010, PLoS pathogens.

The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2 ?

D. Jans, K. Wagstaff, 2020, Biochemical and Biophysical Research Communications.

Use of fluorescence photobleaching techniques to measure the kinetics of intracellular transport

D. Jans, K. Wagstaff, R. Davies, 2010 .

Quantitative Analysis of Protein–Protein Interactions by Native Page/Fluorimaging

G. Alvisi, D. Jans, K. Wagstaff, 2005, Journal of Fluorescence.

Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress.

M. Bogoyevitch, D. Jans, K. Wagstaff, 2014, Biochimica et biophysica acta.

An AlphaScreen®-Based Assay for High-Throughput Screening for Specific Inhibitors of Nuclear Import

D. Jans, K. Wagstaff, S. Rawlinson, 2011, Journal of biomolecular screening.

PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function.

D. Jans, K. Wagstaff, Wenbo Lin, 2018, The Biochemical journal.

Protein transduction: cell penetrating peptides and their therapeutic applications.

D. Jans, K. Wagstaff, 2006, Current medicinal chemistry.

Nuclear import of the respiratory syncytial virus matrix protein is mediated by importin beta1 independent of importin alpha.

D. Jans, R. Ghildyal, K. Wagstaff, 2005, Biochemistry.

Ivermectin as a Broad-Spectrum Host-Directed Antiviral: The Real Deal?

D. Jans, K. Wagstaff, 2020, Cells.

Nuclear localization and secretion competence are conserved among henipavirus matrix proteins.

G. Moseley, D. Jans, H. Netter, 2017, The Journal of general virology.

Adenovirus Terminal Protein Contains a Bipartite Nuclear Localisation Signal Essential for Its Import into the Nucleus

D. Jans, A. Johnston, C. Pouton, 2021, International journal of molecular sciences.

Enhanced tumour cell nuclear targeting in a tumour progression model

D. Jans, K. Wagstaff, H. Thissen, 2015, BMC Cancer.

TUMOUR SELECTIVE NUCLEAR TARGETING IN A TUMOUR 1 PROGRESSION MODEL 2 3

D. Jans, K. Wagstaff, H. Thissen, 2014 .

Molecular dissection of an inhibitor targeting the HIV integrase dependent preintegration complex nuclear import

D. Jans, K. Wagstaff, S. Headey, 2018, Cellular microbiology.

Nucleocytoplasmic shuttling of the West Nile virus RNA‐dependent RNA polymerase NS5 is critical to infection

D. Jans, Adam J Lopez-Denman, J. Mackenzie, 2018, Cellular microbiology.

Targeted delivery to the nucleus.

G. Moseley, D. Jans, C. Pouton, 2007, Advanced drug delivery reviews.

Nuclear drug delivery to target tumour cells.

D. Jans, K. Wagstaff, 2009, European journal of pharmacology.

Inhibitors of nuclear transport.

D. Jans, K. Wagstaff, A. J. Martin, 2019, Current opinion in cell biology.

Nuclear import and export inhibitors alter capsid protein distribution in mammalian cells and reduce Venezuelan Equine Encephalitis Virus replication.

K. Kehn-Hall, Lindsay Lundberg, Chelsea Pinkham, 2013, Antiviral research.

Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

D. Harrich, D. Jans, K. Wagstaff, 2012, The Biochemical journal.

Interactome of the inhibitory isoform of the nuclear transporter Importin 13.

P. Tam, K. Loveland, D. Jans, 2017, Biochimica et biophysica acta. Molecular cell research.

Interactome of the negative regulator of nuclear import BRCA1-binding protein 2

K. Loveland, D. Jans, K. Wagstaff, 2015, Scientific Reports.

Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

K. Kehn-Hall, J. Graham, C. Clarke, 2019, Scientific Reports.

Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin &agr;/&bgr;1 heterodimer through high‐throughput screening

K. Kehn-Hall, J. Baell, Lindsay Lundberg, 2018, Antiviral research.

Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design

K. Kehn-Hall, Lindsay Lundberg, Chelsea Pinkham, 2017, Scientific Reports.

A nuclear transport inhibitor that modulates the unfolded protein response and provides in vivo protection against lethal dengue virus infection.

P. Sexton, S. Vasudevan, D. Jans, 2014, The Journal of infectious diseases.

data through the use of genome and expressed sequence Identification of human exons overexpressed in tumors

G. Alvisi, P. Fortina, M. Lisanti, 2005 .

Nuclear transporter Importin-13 plays a key role in the oxidative stress transcriptional response

M. Ramialison, D. Jans, K. Wagstaff, 2021, Nature Communications.

The nuclear transporter importin 13 is critical for cell survival during embryonic stem cell differentiation.

D. Jans, K. Wagstaff, J. Polo, 2020, Biochemical and biophysical research communications.

The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins.

K. Loveland, D. Jans, K. Wagstaff, 2013, Biochimica et biophysica acta.

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

J. Forwood, C. Basler, S. Nicolis, 2021, Nature Communications.

Structural basis for nuclear import selectivity of pioneer transcription factor SOX2

J. Forwood, C. Basler, S. Nicolis, 2021, Nature Communications.

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

K. Kehn-Hall, Lindsay Lundberg, Chelsea Pinkham, 2016, PLoS neglected tropical diseases.

Importins and Beyond: Non‐Conventional Nuclear Transport Mechanisms

D. Jans, K. Wagstaff, 2009, Traffic.

Selective Targeting of Protein Kinase C (PKC)-θ Nuclear Translocation Reduces Mesenchymal Gene Signatures and Reinvigorates Dysfunctional CD8+ T Cells in Immunotherapy-Resistant and Metastatic Cancers

P. Milburn, A. Bain, J. Forwood, 2022, Cancers.

Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses

M. Bray, C. Rayner, D. Jans, 2020, Antiviral Research.

Nuclear Trafficking of the Rabies Virus Interferon Antagonist P-Protein Is Regulated by an Importin-Binding Nuclear Localization Sequence in the C-Terminal Domain

G. Moseley, Dominic J. Glover, D. Jans, 2016, PloS one.

Harnessing sortase A transpeptidation for advanced targeted therapeutics and vaccine engineering.

A. Fulcher, K. Wagstaff, E. M. Obeng, 2023, Biotechnology advances.

Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.

G. Alvisi, G. Palù, J. Forwood, 2018, Biochimica et biophysica acta. Molecular cell research.

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus V

G. Moseley, A. Buckle, N. Borg, 2018, Scientific Reports.

Nuclear Import of β-Dystroglycan Is Facilitated by Ezrin-Mediated Cytoskeleton Reorganization

A. Ortega, D. Jans, K. Wagstaff, 2014, PloS one.

Nuclear localization of the dystrophin‐associated protein α‐dystrobrevin through importin α2/β1 is critical for interaction with the nuclear lamina/maintenance of nuclear integrity

D. Jans, R. Suárez-Sánchez, A. Aguilar, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Intramolecular masking of nuclear localization signals: analysis of importin binding using a novel AlphaScreen-based method.

D. Jans, K. Wagstaff, 2006, Analytical biochemistry.

Nucleocytoplasmic transport of DNA: enhancing non-viral gene transfer.

D. Jans, K. Wagstaff, 2007, The Biochemical journal.

Global enhancement of nuclear localization‐dependent nuclear transport in transformed cells

G. Alvisi, D. Jans, K. Wagstaff, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Conservation of Importin α Function in Apicomplexans: Ivermectin and GW5074 Target Plasmodium falciparum Importin α and Inhibit Parasite Growth in Culture

S. Patankar, D. Jans, K. Wagstaff, 2022, International journal of molecular sciences.

High-Throughput Screening to Identify Inhibitors of Plasmodium falciparum Importin α

S. Patankar, D. Jans, K. Wagstaff, 2022, Cells.

Nuclear Protein Import: Methods

D. Jans, K. Wagstaff, 2014 .

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner*

T. Velkov, D. Jans, K. Wagstaff, 2015, The Journal of Biological Chemistry.

The Nuclear Transporter Importin 13 Can Regulate Stress-Induced Cell Death through the Clusterin/KU70 Axis

D. Jans, K. Wagstaff, K. Gajewska, 2023, Cells.

Transcriptomic profile dataset of embryonic stem cells (Wild-type and IPO13-Knock Out) with and without oxidative stress

M. Ramialison, D. Jans, K. Wagstaff, 2022, Data in brief.

Efficient gene delivery using reconstituted chromatin enhanced for nuclear targeting

D. Tremethick, D. Jans, K. Wagstaff, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

High Throughput Screening Targeting the Dengue NS3-NS5 Interface Identifies Antivirals against Dengue, Zika and West Nile Viruses

D. Jans, Chunxiao Wang, J. Fraser, 2022, Cells.

The N-terminal basic domain of the HIV-1 matrix protein does not contain a conventional nuclear localization sequence but is required for DNA binding and protein self-association.

D. Jans, K. Wagstaff, A. Hearps, 2008, Biochemistry.

Tumor cell-specific photothermal killing by SELEX-derived DNA aptamer-targeted gold nanorods.

Lim Wei Yap, Wenlong Cheng, D. Jans, 2016, Nanoscale.

Ivermectin as Broad-Spectrum Host-Directed Antiviral

D. Jans, K. Wagstaff, 2020 .

Steric-Deficient Oligoglycine Surrogates Facilitate Multivalent and Bifunctional Nanobody Synthesis via Combined Sortase A Transpeptidation and Click Chemistry.

A. Fulcher, K. Wagstaff, D. Steer, 2023, Bioconjugate chemistry.

Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity

Christine L. Clarke, Kylene Kehn-Hall, J. Dinny Graham, 2019, Scientific Reports.

Importins and Beyond: Non‐Conventional Nuclear Transport Mechanisms

D. Jans, K. Wagstaff, 2009, Traffic.

Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus

David M. Shackleford, D. Jans, K. Wagstaff, 2023, Pharmaceutics.

Overlapping binding sites for importin β1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.

K. Loveland, D. Jans, Chunxiao Wang, 2014, The Biochemical journal.