C. Melander

发表

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis.

Jennifer C. Gifford, Jamee Bresee, Carly J. Carter, 2014, Chemical communications.

Cheminformatics Analysis of Fluoroquinolones and their Inhibition Potency Against Four Pathogens

D. Fourches, C. Melander, Alexandre Borrel, 2020, Molecular informatics.

Overcoming resistance to β-lactam antibiotics.

Christian Melander, C. Melander, R. Worthington, 2013, The Journal of organic chemistry.

Biologically inspired strategies for combating bacterial biofilms.

C. Melander, R. Worthington, M. Blackledge, 2013, Current opinion in pharmacology.

Narrow-Spectrum Antibacterial Agents.

D. Zurawski, R. Melander, C. Melander, 2018, MedChemComm.

Gold nanoparticles to improve HIV drug delivery.

D. Margolis, Daniel. C. Whitehead, Jamee Bresee, 2015, Future medicinal chemistry.

Inhibition of HIV fusion with multivalent gold nanoparticles.

Christian Melander, D. Margolis, C. Melander, 2008, Journal of the American Chemical Society.

Identification of antibiotics using small molecule variable ligand display on gold nanoparticles.

Keith E Maier, Keith E. Maier, Jamee Bresee, 2010, Chemical communications.

Nanoscale structure-activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics.

R. Shoemaker, Jennifer C. Gifford, Jamee Bresee, 2014, Journal of the American Chemical Society.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

J. Cavanagh, David Jung, Daina Zeng, 2018, Front. Mol. Biosci..

Arresting cancer proliferation by small-molecule gene regulation.

P. Dervan, P. Arora, C. Melander, 2004, Chemistry & biology.

Intercepting bacterial indole signaling with flustramine derivatives.

J. Cavanagh, C. Melander, R. Worthington, 2011, Journal of the American Chemical Society.

Growth inhibition of Staphylococcus aureus by mixed monolayer gold nanoparticles.

Keith E Maier, Keith E. Maier, Jamee Bresee, 2011, Small.

A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivo

C. Melander, W. Pan, M. Fan, 2015, Journal of applied microbiology.

Streptococcus mutans in multispecies biofilms

C. Melander, R. Worthington, Chang Liu, 2011 .

A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms

C. Melander, Hui Wu, R. Worthington, 2011, Antimicrobial Agents and Chemotherapy.

Antibiofilm activity of a diverse oroidin library generated through reductive acylation.

C. Melander, T. E. Ballard, Justin J. Richards, 2009, The Journal of organic chemistry.

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

J. Cavanagh, C. Melander, R. W. Huigens, 2010, Antimicrobial Agents and Chemotherapy.

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii.

C. Melander, R. W. Huigens, S. Rogers, 2010, Bioorganic & medicinal chemistry.

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria.

C. Melander, Justin J. Richards, Cynthia A Bunders, 2010, Bioorganic & medicinal chemistry letters.

Pyochelin biotransformation shapes bacterial competition

C. Melander, A. Horswill, C. Jenul, 2022, bioRxiv.

Sequence specific fluorescence detection of double strand DNA.

P. Dervan, C. Melander, Shane Foister, 2003, Journal of the American Chemical Society.

Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors.

C. J. Wright, R. Lamont, H. Wu, 2014, Molecular Oral Microbiology.

Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram‐negative bacteria

B. Koller, R. Melander, C. Melander, 2020, Chemical Biology and Drug Design.

Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae.

C. Melander, R. Worthington, Cynthia A Bunders, 2012, ACS medicinal chemistry letters.

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria.

R. Melander, C. Melander, R. Ernst, 2019, Bioorganic & medicinal chemistry.

1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii

D. Zurawski, R. Melander, C. Melander, 2016, ACS medicinal chemistry letters.

A scaffold hopping strategy to generate new aryl-2-amino pyrimidine MRSA biofilm inhibitors.

P. O'Connor, R. Melander, C. Melander, 2021, RSC medicinal chemistry.

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus.

C. Melander, M. Stephens, Nisakorn Yodsanit, 2016, Organic & biomolecular chemistry.

Structural Studies on 4,5‐Disubstituted 2‐Aminoimidazole‐Based Biofilm Modulators that Suppress Bacterial Resistance to β‐Lactams

C. Melander, Rui Su, Lingling Peng, 2012, ChemMedChem.

Evaluation of 4,5‐Disubstituted‐2‐Aminoimidazole–Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii

C. Melander, R. Worthington, Lingling Peng, 2011, ChemMedChem.

Modulating the development of E. coli biofilms with 2-aminoimidazoles.

C. Melander, R. W. Huigens, S. Rogers, 2010, Bioorganic & medicinal chemistry letters.

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity.

C. Melander, S. Rogers, Zhaoming Su, 2010, Organic & biomolecular chemistry.

Tandem dispersion and killing of bacteria from a biofilm.

J. Lindsey, C. Melander, M. Krayer, 2009, Organic & biomolecular chemistry.

Strategies for the Eradication of Biofilm-Based Bacterial Infections

R. Melander, C. Melander, 2019, Antibacterial Drug Discovery to Combat MDR.

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria.

R. Melander, C. Melander, W. Huggins, 2018, ACS medicinal chemistry letters.

Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper.

C. Melander, D. Ritchie, R. Worthington, 2012, Plant disease.

Meridianin D analogues possess antibiofilm activity against Mycobacterium smegmatis.

R. Melander, C. Melander, David F. Ackart, 2020, RSC medicinal chemistry.

Anti-biofilm activity of quinazoline derivatives against Mycobacterium smegmatis.

C. Melander, Karlie E Cox, 2019, MedChemComm.

A dual-therapy approach for the treatment of biofilm-mediated Salmonella gallbladder carriage

J. Gunn, C. Melander, W. Huggins, 2020, PLoS pathogens.

2-Aminobenzimidazoles as antibiofilm agents against Salmonella enterica serovar Typhimurium.

J. Gunn, R. Melander, C. Melander, 2018, MedChemComm.

The discovery of N-1 substituted 2-aminobenzimidazoles as zinc-dependent S. aureus biofilm inhibitors.

C. Melander, E. A. Lindsey, Trey Mullikin, 2012, MedChemComm.

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation.

R. Melander, C. Melander, T. Nguyen, 2019, MedChemComm.

N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization.

C. Melander, R. Worthington, Zhaoming Su, 2013, Organic & biomolecular chemistry.

Indole/triazole conjugates are selective inhibitors and inducers of bacterial biofilms.

C. Melander, Cynthia A Bunders, Marine J Minvielle, 2013, MedChemComm.

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria.

C. Melander, Andrew Yeagley, Robert E. Furlani, 2013, European journal of medicinal chemistry.

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Sean D. Stowe, J. Cavanagh, Richele J. Thompson, 2012, Drug and chemical toxicology.

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: antibiotic activity of a first generation library.

C. Melander, R. Worthington, Tyler L. Harris, 2011, Bioorganic & medicinal chemistry letters.

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

R. Melander, C. Melander, 2017, ACS infectious diseases.

Human Biology and Health

Daniel. C. Whitehead, C. Melander, 2010, The Quarterly Review of Biology.

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers.

R. Melander, C. Melander, David F. Ackart, 2015, Bioorganic & medicinal chemistry letters.

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives.

R. Melander, C. Melander, David F. Ackart, 2015, Tetrahedron letters.

Screening an established natural product library identifies secondary metabolites that potentiate conventional antibiotics.

R. Melander, C. Melander, R. Ernst, 2020, ACS infectious diseases.

DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia.

R. Wells, P. Dervan, C. Melander, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity.

R. Melander, C. Melander, S. Moskowitz, 2016, Tetrahedron.

Genetic Dissection of Antibiotic Adjuvant Activity

C. Melander, L. Gallagher, C. Manoil, 2022, mBio.

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii.

Alison J. Scott, R. Melander, C. Melander, 2019, ACS infectious diseases.

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa.

Brittany A. Hubbard, R. Melander, C. Melander, 2018, ACS infectious diseases.

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria.

R. Melander, C. Melander, R. Ernst, 2017, Bioorganic & Medicinal Chemistry.

1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.

D. Zurawski, R. Melander, C. Melander, 2017, ACS infectious diseases.

Marine sponge alkaloids as a source of anti-bacterial adjuvants.

C. Bewley, R. Melander, C. Melander, 2016, Bioorganic & medicinal chemistry letters.

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis.

J. Nick, I. Orme, C. Melander, 2014, Pathogens and disease.

Accessibility of nuclear chromatin by DNA binding polyamides.

P. Dervan, M. Wood, C. Melander, 2003, Chemistry & biology.

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibioﬁlm Agents (cid:1)

J. Cavanagh, C. Melander, R. W. Huigens, 2010 .

Augmenting the Activity of Macrolide Adjuvants against Acinetobacter baumannii.

R. Melander, C. Melander, Anne E. Mattingly, 2020, ACS medicinal chemistry letters.

Benzimidazole Isosteres of Salicylanilides Are Highly Active Colistin Adjuvants.

R. Melander, C. Melander, R. Ernst, 2021, ACS infectious diseases.

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands.

K. Luger, P. Dervan, C. Melander, 2003, Journal of molecular biology.

Identification of a Host-Targeted Compound to Control Typhoid Fever

J. Gunn, C. Melander, K. V. Hoang, 2022, Microbiology spectrum.

Augmenting Anti-Cancer Natural Products with a Small Molecule Adjuvant

J. Cavanagh, P. Moeller, C. Melander, 2014, Marine drugs.

A Clerodane Diterpene from Callicarpa americana Resensitizes Methicillin-Resistant Staphylococcus aureus to ß-Lactam Antibiotics.

C. Quave, R. Melander, C. Melander, 2020, ACS infectious diseases.

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.

R. Melander, C. Melander, David F. Ackart, 2017, Angewandte Chemie.

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism.

C. Melander, R. W. Huigens, S. Rogers, 2009, Journal of the American Chemical Society.

Controlling bacterial behavior with indole-containing natural products and derivatives.

R. Melander, C. Melander, Marine J Minvielle, 2014, Tetrahedron.

Synthesis and Biofilm Inhibition Studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones.

R. Melander, C. Melander, M. Vasudev, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and Screening of an Oroidin Library against Pseudomonas aeruginosa Biofilms

C. Melander, R. W. Huigens, T. E. Ballard, 2008, Chembiochem : a European journal of chemical biology.

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms.

J. Cavanagh, C. Melander, Cynthia A Bunders, 2011, Organic & biomolecular chemistry.

Programmable DNA-binding small molecules.

C. Melander, M. Blackledge, Meghan S. Blackledge, 2013, Bioorganic & medicinal chemistry.

Regulation of gene expression with pyrrole-imidazole polyamides.

Christian Melander, C. Melander, J. Gottesfeld, 2004, Journal of biotechnology.

Kinetic Analysis of Ester Aminolysis Catalyzed by Nucleosides in a Nonpolar Medium. Evidence of Bifunctional Catalysis

C. Melander, D. Horne, 1997 .

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling.

C. Melander, R. W. Huigens, Zhaoming Su, 2011, Organic & biomolecular chemistry.

Natural products as inspiration for the development of bacterial antibiofilm agents.

R. Melander, C. Melander, A. Basak, 2020, Natural product reports.

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs.

W. Zeng, C. Melander, D. Feldheim, 2006, Bioorganic & medicinal chemistry letters.

Discrimination of A/T sequences in the minor groove of DNA within a cyclic polyamide motif.

P. Dervan, C. Melander, P B Dervan, 2000, Chemistry.

Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants.

J. Cavanagh, R. Melander, C. Melander, 2016, MedChemComm.

Combination approaches to combat multidrug-resistant bacteria.

Christian Melander, C. Melander, R. Worthington, 2013, Trends in biotechnology.

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives.

Daniel. C. Whitehead, C. Melander, S. Rogers, 2010, Organic & biomolecular chemistry.

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates.

C. Melander, R. W. Huigens, S. Rogers, 2009, Organic & biomolecular chemistry.

Small molecule control of bacterial biofilms.

C. Melander, R. Worthington, Justin J. Richards, 2012, Organic & biomolecular chemistry.

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.

R. Melander, C. Melander, David F. Ackart, 2017, Angewandte Chemie.

Small-molecule suppression of β-lactam resistance in multidrug-resistant gram-negative pathogens.

J. Cavanagh, Richele J. Thompson, R. Melander, 2014, Journal of medicinal chemistry.

Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents

C. Melander, S. Rogers, Joseph D Bero, 2010, Chembiochem : a European journal of chemical biology.

Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-Aminoimidazole-based antibiofilm agent.

Sean D. Stowe, J. Cavanagh, B. Bobay, 2012, Biochemistry.

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

E. Lefkowitz, S. Michalek, C. Morrow, 2017, Journal of dental research.

Evaluation of dihydrooroidin as an antifouling additive in marine paint.

J. Cavanagh, P. Moeller, C. Melander, 2009, International biodeterioration & biodegradation.

Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants.

R. Melander, C. Melander, Anne E. Mattingly, 2022, Bioorganic & medicinal chemistry letters.

Anti-Biofilm Compounds Derived from Marine Sponges

Sean D. Stowe, J. Cavanagh, Richele J. Thompson, 2011, Marine drugs.

Influence of β‐Alanine on Hairpin Polyamide Orientation in the DNA Minor Groove

P. Dervan, C. Melander, Victor C. Rucker, 2003 .

Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides.

K. Luger, P. Dervan, C. Melander, 2001, Journal of molecular biology.

Analogue synthesis reveals decoupling of antibiofilm and β‐lactam potentiation activities of a lead 2‐aminoimidazole adjuvant against Mycobacterium smegmatis

C. Melander, R. Basaraba, Sara E Martin, 2018, Chemical biology & drug design.

Medicinal chemistry: Forcing an enemy into the open.

D. Margolis, C. Melander, 2012, Nature chemistry.

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum.

C. Melander, S. Rogers, 2008, Angewandte Chemie.

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2‐aminoimidazole‐based compounds

J. Cavanagh, David Jung, Daina Zeng, 2017, Molecular microbiology.

Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study.

C. Melander, T. E. Ballard, Justin J. Richards, 2008, Chemistry.

Blocking transcription through a nucleosome with synthetic DNA ligands.

Karolin Luger, Christian Melander, K. Luger, 2002, Journal of molecular biology.

From worms to targeting virulence factors.

R. Melander, C. Melander, 2015, Chemistry & biology.

Control of bacterial biofilms with marine alkaloid derivatives.

J. Cavanagh, P. Moeller, C. Melander, 2008, Molecular bioSystems.

Inhibition and dispersion of proteobacterial biofilms.

J. Cavanagh, C. Melander, T. E. Ballard, 2008, Chemical communications.

Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors.

R. Bosch, D. Margolis, P. Dervan, 2004, The Journal of infectious diseases.

Identification of Staphylococcus aureus Penicillin Binding Protein 4 (PBP4) Inhibitors

E. Schwarz, H. Awad, C. Melander, 2022, Antibiotics.

Non-Microbicidal Control of Bacterial Biofilms with Small Molecules

C. Melander, R. Worthington, Justin J. Richards, 2014 .

Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity.

Sean D. Stowe, J. Cavanagh, C. Melander, 2009, Journal of medicinal chemistry.

Electrochemical Detection of Small Molecule Induced Pseudomonas aeruginosa Biofilm Dispersion.

C. Melander, Eli G. Hvastkovs, M. Blackledge, 2018, Electrochimica acta.

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence.

C. Melander, R. Worthington, M. Blackledge, 2013, Future medicinal chemistry.

Kinetic consequences of covalent linkage of DNA binding polyamides.

D M Crothers, D. Crothers, P. Dervan, 2001, Biochemistry.

Analysis of kinamycin D-mediated DNA cleavage

C. Melander, Christine L. Heinecke, 2010 .

Kinamycin-mediated DNA cleavage under biomimetic conditions

C. Melander, T. E. Ballard, 2008 .

Library-Based Lead Compound Discovery: Antioxidants by an Analogous Synthesis/Deconvolutive Assay Strategy

L. A. Randall, C. Melander, M. Kurth, 1994 .

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

R. Melander, C. Melander, David F. Ackart, 2019, Scientific Reports.

Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida.

C. Melander, M. Stephens, Nisakorn Yodsanit, 2016, MedChemComm.

Development of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model.

J. Gunn, R. Melander, C. Melander, 2022, European journal of medicinal chemistry.

Antibacterials: Volume I

S. Mobashery, R. Melander, C. Melander, 2018 .

Controlling Bacterial Biofilms

Christian Melander, C. Melander, Justin J. Richards, 2009, Chembiochem : a European journal of chemical biology.

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit.

C. Melander, A. Nevzorov, Lingling Peng, 2011, Chemical communications.

Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities.

Januka Budhathoki-Uprety, C. Melander, Lingling Peng, 2012, ACS macro letters.

Innovative strategies for combating biofilm-based infections.

R. Melander, C. Melander, 2015, Advances in experimental medicine and biology.

Inhibition of Pseudomonas aeruginosa biofilm formation with Bromoageliferin analogues.

W. Zeng, C. Melander, R. Deora, 2007, Journal of the American Chemical Society.

Pyochelin biotransformation by Staphylococcus aureus shapes bacterial competition with Pseudomonas aeruginosa in polymicrobial infections

C. Melander, A. Horswill, C. Jenul, 2023, bioRxiv.

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

R. Melander, C. Melander, David F. Ackart, 2017, PloS one.

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display.

Christian Melander, R. Melander, C. Melander, 2017, Bioconjugate chemistry.

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole-based small molecules.

R. Melander, C. Melander, David F. Ackart, 2014, Pathogens and disease.

Targeting RNA with cysteine-constrained peptides.

J. Cavanagh, B. Bobay, C. Melander, 2008, Bioorganic & medicinal chemistry letters.

Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance.

D. Zurawski, C. Melander, L. Hittle, 2014, ACS chemical biology.

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

C. Melander, M. Jackson, C. Avanzi, 2022, International journal of molecular sciences.

Repurposing Eukaryotic Kinase Inhibitors as Colistin Adjuvants in Gram-negative Bacteria.

W. Zuercher, B. Koller, R. Melander, 2019, ACS infectious diseases.

Identification of Anti‐Mycobacterial Biofilm Agents Based on the 2‐Aminoimidazole Scaffold

R. Melander, C. Melander, Bradley M. Minrovic, 2019, ChemMedChem.

Second-Generation Tryptamine Derivatives Potently Sensitize Colistin Resistant Bacteria to Colistin.

B. Koller, R. Melander, C. Melander, 2019, ACS medicinal chemistry letters.

New Class of Adjuvants Enables Lower Dosing of Colistin Against Acinetobacter baumannii.

David Jung, R. Melander, C. Melander, 2018, ACS infectious diseases.

Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus.

C. Melander, R. Worthington, Tyler L. Harris, 2012, Angewandte Chemie.

Chemical Countermeasures for Antibiotic Resistance

R. Melander, C. Melander, R. Su, 2015 .

Re-sensitization of Multidrug-Resistant and Colistin-Resistant Gram-Negative Bacteria to Colistin by Povarov/Doebner-Derived Compounds.

R. Melander, C. Melander, R. Ernst, 2023, ACS infectious diseases.

Tuning the oxidation properties of vanadium(V) through ligand stoichiometry

W. Zeng, C. Melander, T. E. Ballard, 2006 .

Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii.

E. Johannes, Sean D. Stowe, J. Cavanagh, 2015, Current drug delivery.

Promoter Scanning for Transcription Inhibition with DNA-Binding Polyamides

P. Dervan, C. Melander, J. Gottesfeld, 2002, Molecular and Cellular Biology.

Highly active modulators of indole signaling alter pathogenic behaviors in Gram-negative and Gram-positive bacteria.

C. Melander, Kristen E. Eguren, Marine J Minvielle, 2013, Chemistry.

1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

J. Cavanagh, B. Bobay, C. Melander, 2012, Biomolecular NMR Assignments.

Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides

D. Margolis, P. Dervan, C. Melander, 2002, Journal of Virology.

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

K. Kirker, G. James, J. Cavanagh, 2017, Drug design, development and therapy.

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

C. Melander, Lingling Peng, Zhaoming Su, 2012 .

Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator

S. Michalek, R. Melander, C. Melander, 2023, mBio.

Synthesis, Stereochemical Confirmation, and Derivatization of a Clerodane Diterpene That Sensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactam Antibiotics

C. Quave, A. Oliver, R. Melander, 2022, Angewandte Chemie.

2-Aminoimidazole Analogs Target PhoP Altering DNA Binding Activity and Affect Outer Membrane Stability in Gram-Negative Bacteria.

J. Cavanagh, David Jung, Richele J. Thompson, 2022, Biochemistry.

Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study

M. Stack, Yueying Liu, R. Melander, 2023, International journal of molecular sciences.

Structure–Function Studies on IMD‐0354 Identifies Highly Active Colistin Adjuvants

P. O'Connor, B. Koller, R. Melander, 2019, ChemMedChem.

Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides.

P. Wright, P. Dervan, C. Melander, 2005, Biochemistry.

Second‐Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin‐Resistant Gram‐Negative Bacteria to Colistin

R. Melander, C. Melander, M. Zeiler, 2020, ChemMedChem.

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii.

C. Melander, Justin J. Richards, Catherine S Reed, 2008, Bioorganic & medicinal chemistry letters.

2-Aminopyrimidine as a novel scaffold for biofilm modulation.

C. Melander, R. Worthington, E. A. Lindsey, 2012, Organic & biomolecular chemistry.

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents.

Daniel. C. Whitehead, C. Melander, S. Rogers, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity relationship study.

C. Melander, Justin J. Richards, Amanda L. Wolfe, 2008, Chemistry.

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues.

C. Melander, Justin J. Richards, T. Ballard, 2008, Organic & biomolecular chemistry.

Small molecule control of bacterial biofilms.

C. Melander, R. Worthington, Justin J. Richards, 2012, Organic & biomolecular chemistry.

Synthesis and biological activity of 2-aminoimidazole triazoles accessed by Suzuki-Miyaura cross-coupling.

C. Melander, R. W. Huigens, Zhaoming Su, 2011, Organic & biomolecular chemistry.

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

J. Cavanagh, Richele J. Thompson, C. Melander, 2014, Biomolecular NMR assignments.

Chemical shift assignments and secondary structure prediction of the C-terminal domain of the response regulator BfmR from Acinetobacter baumannii

J. Cavanagh, Richele J. Thompson, C. Melander, 2012, Biomolecular NMR Assignments.

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence.

C. Melander, R. Worthington, Meghan S. Blackledge, 2013, Future medicinal chemistry.

Structural Studies on 4,5‐Disubstituted 2‐Aminoimidazole‐Based Biofilm Modulators that Suppress Bacterial Resistance to β‐Lactams

C. Melander, Rui Su, Lingling Peng, 2012, ChemMedChem.

Antibiofilm activity of a diverse oroidin library generated through reductive acylation.

C. Melander, Justin J. Richards, A. Aquino, 2009, The Journal of organic chemistry.