D. Abankwa

发表

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

Robert G. Parton, Pierre Sens, Pierre Nassoy, 2011, Cell.

Ras nanoclusters: molecular structure and assembly.

A. Gorfe, J. Hancock, D. Abankwa, 2007, Seminars in cell & developmental biology.

A novel switch region regulates H‐ras membrane orientation and signal output

J Andrew McCammon, Daniel Abankwa, Robert G Parton, 2008, The EMBO journal.

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

Guillermo A. Gomez, I. Wilson, A. Mark, 2014, Science.

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane

D. Abankwa, M. Philips, Ian M Ahearn, 2021, Life Science Alliance.

FRET-reporter nanoparticles to monitor redox-induced intracellular delivery of active compounds

J. Sarfraz, D. Karaman, J. Rosenholm, 2014 .

A subset of flavaglines inhibits KRAS nanoclustering and activation

Hong Liang, Yong Zhou, K. Rajalingam, 2020, Journal of Cell Science.

Cellular FRET-Biosensors to Detect Membrane Targeting Inhibitors of N-Myristoylated Proteins

K. Alexandrov, D. Abankwa, M. Solman, 2013, PloS one.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering

A. Wittinghofer, M. Ahmadian, A. Papageorgiou, 2016, Scientific Reports.

Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again

A. Gorfe, D. Abankwa, 2020, Biomolecules.

Nanoclustering and heterogeneous membrane diffusion of Ras studied by FRAP and RICS analysis.

D. Abankwa, C. Guzmán, M. Solman, 2014, Methods in molecular biology.

An N-Terminal Polybasic Motif of Gαq Is Required for Signaling and Influences Membrane Nanodomain Distribution

J. Hancock, D. Abankwa, Marykate Crouthamel, 2010, Molecular Pharmacology.

The Effects of Transmembrane Sequence and Dimerization on Cleavage of the p75 Neurotrophin Receptor by γ-Secretase*

J. Hancock, D. Matusica, D. Abankwa, 2012, The Journal of Biological Chemistry.

Automated High-Throughput Fluorescence Lifetime Imaging Microscopy to Detect Protein–Protein Interactions

D. Abankwa, C. Guzmán, C. Oetken-Lindholm, 2016, Journal of laboratory automation.

ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

Jukka Westermarck, Daniel Abankwa, J. Westermarck, 2014, PloS one.

Targeting a broad spectrum of KRAS-mutant cancers by hyperactivation-induced cell death

O. Sansom, I. Vattulainen, Guillaume Jacquemet, 2022, bioRxiv.

Flexible and General Synthesis of Functionalized Phosphoisoprenoids for the Study of Prenylation in vivo and in vitro

R. Goody, H. Waldmann, D. Das, 2012, Chembiochem : a European journal of chemical biology.

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.

L. Joachimiak, D. Abankwa, K. Błażewska, 2014, European journal of medicinal chemistry.

Medium-Throughput Detection of Hsp90/Cdc37 Protein–Protein Interaction Inhibitors Using a Split Renilla Luciferase-Based Assay

D. Abankwa, Ganesh babu Manoharan, H. Parkkola, 2020, SLAS discovery : advancing life sciences R & D.

A subset of flavaglines inhibits KRAS nanoclustering and activation.

Hong Liang, Yong Zhou, K. Rajalingam, 2020, Journal of cell science.

Populism: Utility of its Approaches and the Prospects of the Phenomenon's Resurgence in America

D. Abankwa, 2021 .

Cancer stem cell drugs target K-ras signaling in a stemness context

T Aittokallio, T. Aittokallio, A. Jaiswal, 2016, Oncogene.

SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling

D. Abankwa, E. Siljamäki, 2016, Molecular and Cellular Biology.

Stability of the Phosphotriester PDE6D Inhibitors

D. Abankwa, Ahmed Sabt, M. Ora, 2021, ChemistrySelect.

PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

C. Alam, A. Stephen, A. Papageorgiou, 2019, ACS omega.

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

S. Gygi, Mark P. Jedrychowski, J. Hancock, 2009, The Journal of cell biology.

PTRF-Cavin, a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

M. Kirkham, J. Hancock, R. Parton, 2008, Cell.

Promotion of cancer cell stemness by Ras

D. Abankwa, Rohan Chippalkatti, 2021, Biochemical Society transactions.

Figures and figure supplements Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

T. Aittokallio, Hong Liang, Yong Zhou, 2015 .

High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors.

D. Abankwa, H. Härmä, Ganesh babu Manoharan, 2019, Analytical biochemistry.

Ski-interacting protein (SKIP) interacts with androgen receptor in the nucleus and modulates androgen-dependent transcription

G. Buchanan, L. Butler, W. Tilley, 2013, BMC Biochemistry.

Supplemental Data PTRF-Cavin , a Conserved Cytoplasmic Protein Required for Caveola Formation and Function

M. Kirkham, R. Parton, Sally Martin, 2007 .

Drug targeting opportunities en route to Ras nanoclusters.

Karolina Pavic, D. Abankwa, Rohan Chippalkatti, 2022, Advances in cancer research.

Bruceine D Identified as a Drug Candidate against Breast Cancer by a Novel Drug Selection Pipeline and Cell Viability Assay

Maria Pires Pacheco, T. Sauter, D. Abankwa, 2022, Pharmaceuticals.

Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A

A. Leitner, J. Nilsson, J. Westermarck, 2023, Nature Communications.

ASPP2 Is a Novel Pan-Ras Nanocluster Scaffold

Yong Zhou, D. Abankwa, I. M. Posada, 2016, PloS one.

Structure and dynamics of the full-length lipid-modified H-Ras protein in a 1,2-dimyristoylglycero-3-phosphocholine bilayer.

J. Mccammon, A. Gorfe, J. Hancock, 2007, Journal of medicinal chemistry.

Eliminating oncogenic RAS: back to the future at the drawing board

D. Abankwa, E. Schaffner-Reckinger, Pelin Kaya, 2023, Biochemical Society transactions.

Mechanisms of Ras membrane organization and signaling: Ras on a rocker

A. Gorfe, J. Hancock, D. Abankwa, 2008, Cell cycle.

Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.

Yong Zhou, J. Hancock, D. Abankwa, 2015, Biochemistry.

Opposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1

D. Abankwa, I. M. Posada, B. Lectez, 2017, Scientific Reports.

Gene expression profiling reveals multiple novel intrinsic and extrinsic factors associated with axonal regeneration failure

H. Müller, D. Abankwa, P. Küry, 2004, The European journal of neuroscience.

Dynamic Changes in Gene Expression Profiles Following Axotomy of Projection Fibres in the Mammalian CNS

H. Müller, D. Abankwa, P. Küry, 2002, Molecular and Cellular Neuroscience.

AXOTOMY-INDUCED GENE EXPRESSION IN RAT BRAIN

D. Abankwa, 2001 .

FLIM-FRET Analysis of Ras Nanoclustering and Membrane-Anchorage.

D. Abankwa, H. Parkkola, F. Siddiqui, 2021, Methods in molecular biology.

Jcb: Article

S. Gygi, Mark P. Jedrychowski, J. Hancock, 2022 .

Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems

Ion Petre, Maren Preis, Niklas Sandler, 2017, Advanced healthcare materials.

Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity

T. Salminen, D. Abankwa, V. Vukić, 2021, Biomolecules.

Novel Small Molecule Hsp90/Cdc37 Interface Inhibitors Indirectly Target K-Ras-Signaling

T. Aittokallio, T. Salminen, Karolina Pavic, 2021, Cancers.

A FRET map of membrane anchors suggests distinct microdomains of heterotrimeric G proteins

H. Vogel, D. Abankwa, 2007, Journal of Cell Science.

Ras membrane orientation and nanodomain localization generate isoform diversity

A. Gorfe, J. Hancock, K. Inder, 2010, Proceedings of the National Academy of Sciences.

The Efficacy of Raf Kinase Recruitment to the GTPase H-ras Depends on H-ras Membrane Conformer-specific Nanoclustering*♦

L. Reymond, C. Eggeling, D. Abankwa, 2014, The Journal of Biological Chemistry.

Monitoring the diffusion of single heterotrimeric G proteins in supported cell-membrane sheets reveals their partitioning into microdomains.

K. L. Martinez, H. Vogel, D. Abankwa, 2006, Journal of molecular biology.

Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner

T. Aittokallio, Yong Zhou, L. Yetukuri, 2017, Oncotarget.

Hormone Receptor Mechanism of Activation of Protein Kinase JAK 2 by the Growth

Mara, Guillermo A. Gomez, I. Wilson, 2014 .

S-7 : A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor

Guillermo A. Gomez, A. Mark, M. Doxastakis, 2014 .

A Pharmacophore Model for SARS-CoV-2 3CLpro Small Molecule Inhibitors and in Vitro Experimental Validation of Computationally Screened Inhibitors

E. Glaab, D. Abankwa, G. B. Manoharan, 2021, bioRxiv.

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors.

Andrew M. Piggott, R. Parton, E. Lacey, 2012, Chemistry & biology.

A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness

F. McCormick, J. Yli-Kauhaluoma, D. Abankwa, 2021, Frontiers in Cell and Developmental Biology.

Targeting prohibitins at the cell surface prevents Th17‐mediated autoimmunity

S. Tenzer, F. Zipp, B. Thiede, 2018, The EMBO journal.

A homogeneous quenching resonance energy transfer assay for the kinetic analysis of the GTPase nucleotide exchange reaction

P. Hänninen, D. Abankwa, S. Veltel, 2014, Analytical and Bioanalytical Chemistry.

RhoGDI facilitates geranylgeranyltransferase-I-mediated RhoA prenylation.

K. Alexandrov, D. Abankwa, Z. Tnimov, 2014, Biochemical and biophysical research communications.

Quantitative Analysis of Prenylated RhoA Interaction with Its Chaperone, RhoGDI*

Herbert Waldmann, Brett M. Collins, Roger S. Goody, 2012, The Journal of Biological Chemistry.

Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

D. Abankwa, Sunday Okutachi, G. B. Manoharan, 2021, bioRxiv.

K-Ras Binds Calmodulin-Related Centrin1 with Potential Implications for K-Ras Driven Cancer Cell Stemness

D. Abankwa, C. Laurini, G. B. Manoharan, 2023, Cancers.

Rab-NANOPS: FRET biosensors for Rab membrane nanoclustering and prenylation detection in mammalian cells.

D. Abankwa, I. M. Posada, C. Guzmán, 2015, Methods in molecular biology.

An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth

E. Glaab, Karolina Pavic, D. Abankwa, 2023, bioRxiv.

Detection of Ras nanoclustering-dependent homo-FRET using fluorescence anisotropy measurements.

D. Abankwa, Camilo Guzmán, Ganesh babu Manoharan, 2023, European journal of cell biology.

GTP-specific fab fragment-based GTPase activity assay.

D. Abankwa, S. Veltel, H. Härmä, 2015, Analytical chemistry.

SPRED1 Interferes with K-ras but Not H-ras Membrane Anchorage and Signaling

D. Abankwa, E. Siljamäki, 2016, Molecular and Cellular Biology.

A novel switch region regulates H‐ras membrane orientation and signal output

A. Gorfe, J. Hancock, S. Plowman, 2008, The EMBO journal.

A pharmacophore model for SARS-CoV-2 3CLpro small molecule inhibitors and experimental validation of computationally screened inhibitors

D. Abankwa, G. B. Manoharan, Enrico Glaab, 2021 .

RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation

D. Abankwa, Rohan Chippalkatti, Nesrine Ben Fredj, 2023, bioRxiv.

Identification of an H-Ras nanocluster disrupting peptide

T. Grossmann, D. Abankwa, Alejandro Yeste-Vázquez, 2023, bioRxiv.

Protocol to measure and analyze protein interactions in mammalian cells using bioluminescence resonance energy transfer.

D. Abankwa, C. L. Steffen, Karolina Pavic, 2024, STAR protocols.

Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation

T. Aittokallio, Hong Liang, D. Abankwa, 2015, eLife.