D. Holowka

发表

Differential targeting of secretory lysosomes and recycling endosomes in mast cells revealed by patterned antigen arrays

B. Baird, T. Baumgart, Min Wu, 2007, Journal of Cell Science.

The effect of receptor density on the forward rate constant for binding of ligands to cell surface receptors.

J. Erickson, B. Goldstein, B. Baird, 1987, Biophysical journal.

Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation

Lily A Chylek, William S Hlavacek, Eshan D Mitra, 2017, Scientific Reports.

Non-Faradaic Electrochemical Detection of Exocytosis from Mast and Chromaffin Cells Using Floating-Gate MOS Transistors

E. Kan, M. Lindau, K. Jayant, 2015, Scientific Reports.

Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity

S. Ibrahim, T. Tumbar, D. Holowka, 2018, Stem cells.

Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate.

L. Stryer, T. Meyer, D. Holowka, 1988, Science.

Large-scale co-aggregation of fluorescent lipid probes with cell surface proteins

W. Webb, B. Baird, D. Holowka, 1994, The Journal of cell biology.

Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles.

P. Sengupta, B. Baird, D. Holowka, 2008, Biochimica et biophysica acta.

Toxoplasma gondii inhibits mast cell degranulation by suppressing phospholipase Cγ-mediated Ca2+ mobilization

B. Butcher, E. Denkers, B. Baird, 2013, Front. Microbiol..

Clustering, mobility, and triggering activity of small oligomers of immunoglobulin E on rat basophilic leukemia cells

W. Webb, A. Menon, B. Baird, 1986, The Journal of cell biology.

Rab11 Regulates the Mast Cell Exocytic Response

B. Baird, D. Holowka, Sarah A. Shelby, 2016, Traffic.

Graphene Oxide Nanosheets Stimulate Ruffling and Shedding of Mammalian Cell Plasma Membranes.

William R. Dichtel, D. Muller, B. Baird, 2016, Chem.

Inhibitors of PI(4,5)P2 Synthesis Reveal Dynamic Regulation of IgE Receptor Signaling by Phosphoinositides in RBL Mast Cells

B. Baird, D. Holowka, Marcela de Souza Santos, 2013, Molecular Pharmacology.

Sphingosine derivatives inhibit cell signaling by electrostatically neutralizing polyphosphoinositides at the plasma membrane.

Deepti Gadi, B. Baird, S. Hammond, 2010, Self/nonself.

The β- and γ-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells

P. De Camilli, A. Jeromin, B. Baird, 2009, Journal of Cell Science.

Stimulated release of fluorescently labeled IgE fragments that efficiently accumulate in secretory granules after endocytosis in RBL-2H3 mast cells.

B. Baird, D. Holowka, R. M. Williams, 1998, Journal of cell science.

Disparate modulation of plasma membrane protein lateral mobility by various cell permeabilizing agents

W. Webb, T. Feder, D. Holowka, 1994, Journal of cellular physiology.

Association of the receptor for immunoglobulin E with an endogenous polypeptide on rat basophilic leukemia cells.

J. Kanellopoulos, H. Metzger, D. Holowka, 1980, Journal of receptor research.

Small oligomers of immunoglobulin E (IgE) cause large-scale clustering of IgE receptors on the surface of rat basophilic leukemia cells

A. Menon, B. Baird, D. Holowka, 1984, The Journal of cell biology.

Recent evidence for common signalling mechanisms among immunoreceptors that recognize foreign antigens.

B. Baird, D. Holowka, 1992, Cellular signalling.

In situ measurement of degranulation as a biosensor based on RBL-2H3 mast cells.

B. Baird, D. Holowka, J. Tabb, 2004, Biosensors & bioelectronics.

Interaction of photoreactive and fluorescent nucleotides with chloroplast coupling factor 1.

G. Hammes, D. Holowka, M. Carlier, 1979, Biochemistry.

Structural studies on the membrane-bound immunoglobulin E-receptor complex. 1. Characterization of large plasma membrane vesicles from rat basophilic leukemia cells and insertion of amphipathic fluorescent probes.

B. Baird, D. Holowka, 1983, Biochemistry.

Biomembrane liquid-liquid phase separation and detergent resistance: a relationship strengthened.

D. Holowka, 2009, The Biochemical journal.

Basic Amino Acids Within the Juxtamembrane Domain of the Epidermal Growth Factor Receptor Regulate Receptor Dimerization and Auto-phosphorylation

B. Baird, D. Holowka, A. Wagenknecht-Wiesner, 2020, The Protein Journal.

Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis.

B. Baird, D. Holowka, 2017, Biochimica et biophysica acta. Biomembranes.

A guanine nucleotide-binding protein participates in IgE receptor-mediated activation of endogenous and reconstituted phospholipase A2 in a permeabilized cell system.

B. Baird, D. Holowka, V. Narasimhan, 1990, The Journal of biological chemistry.

Mast Cell Activation on Patterned Lipid Bilayers of Subcellular Dimensions

H. Craighead, R. Orth, B. Baird, 2003 .

Fluorescence resonance energy transfer between lipid probes detects nanoscopic heterogeneity in the plasma membrane of live cells.

P. Sengupta, B. Baird, D. Holowka, 2007, Biophysical journal.

Visualization of plasma membrane compartmentalization with patterned lipid bilayers.

Barbara Baird, David Holowka, H. Craighead, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The FcεRI signaling cascade and integrin trafficking converge at patterned ligand surfaces

B. Baird, D. Holowka, D. Wakefield, 2017, Molecular biology of the cell.

Micropatterned ligand arrays to study spatial regulation in Fc receptor signaling.

B. Baird, D. Holowka, Alexis J. Torres, 2011, Methods in molecular biology.

IgE receptor-mediated alteration of membrane-cytoskeleton interactions revealed by mass spectrometric analysis of detergent-resistant membranes.

F. McLafferty, B. Baird, D. Holowka, 2009, Biochemistry.

Interactions between Fc(epsilon)RI and lipid raft components are regulated by the actin cytoskeleton.

B. Baird, D. Holowka, E. Sheets, 2000, Journal of cell science.

Lateral diffusion of membrane lipid-anchored probes before and after aggregation of cell surface IgE-receptors

W. Webb, P. Schwille, B. Baird, 2003 .

Roles for lipid heterogeneity in immunoreceptor signaling.

B. Baird, D. Holowka, 2016, Biochimica et biophysica acta.

How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E?

B. Baird, D. Holowka, E. Sheets, 1999, Biophysical chemistry.

Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model

D. Eliezer, B. Baird, D. Holowka, 2019, NPJ Parkinson's disease.

Editorial: Molecular Organization of Membranes: Where Biology Meets Biophysics

D. Holowka, M. Cebecauer, 2017, Front. Cell Dev. Biol..

A novel fluorescence-based biosynthetic trafficking method provides pharmacologic evidence that PI4-kinase IIIα is important for protein trafficking from the endoplasmic reticulum to the plasma membrane

B. Baird, D. Holowka, Kirsten L. Bryant, 2015, BMC Cell Biology.

FcϵRI and the T cell receptor for antigen activate similar signalling pathways in T cell-RBL cell hybrids

B. Baird, J. Slattery, D. Holowka, 1993 .

Structure of the high-affinity mast cell receptor for IgE.

J. Kanellopoulos, H. Metzger, D. Holowka, 1982, Federation proceedings.

The Fc segment of IgE influences the kinetics of dissociation of a symmetrical bivalent ligand from cyclic dimeric complexes.

B. Goldstein, B. Baird, K. Subramanian, 1996, Biochemistry.

Bivalent ligand dissociation kinetics from receptor-bound immunoglobulin E: evidence for a time-dependent increase in ligand rebinding at the cell surface.

J. Erickson, B. Goldstein, R. Posner, 1991, Biochemistry.

Characterization of model antigens composed of biotinylated haptens bound to avidin.

B. Baird, D. Holowka, P. Kane, 1990, Immunological investigations.

Molecular mechanisms of spontaneous and directed mast cell motility

B. Baird, D. Holowka, S. Veatch, 2012, Journal of leukocyte biology.

Transmembrane Sequences Are Determinants of Immunoreceptor Signaling 1

B. Baird, D. Holowka, J. Gosse, 2005, The Journal of Immunology.

Ca2+ Waves Initiate Antigen-Stimulated Ca2+ Responses in Mast Cells1

B. Baird, D. Holowka, R. Cohen, 2009, The Journal of Immunology.

Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress.

B. Baird, D. Holowka, C. Stefan, 2016, Biochemical Society transactions.

Disruption of lipid order by short-chain ceramides correlates with inhibition of phospholipase D and downstream signaling by FcϵRI

H. Brown, B. Baird, D. Holowka, 2003, Journal of Cell Science.

Spatiotemporal resolution of mast cell granule exocytosis reveals correlation with Ca2+ wave initiation

B. Baird, D. Holowka, R. Cohen, 2012, Journal of Cell Science.

Beyond Media Composition: Cell Plasma Membrane Disruptions by Graphene Oxide.

B. Baird, W. Dichtel, D. Holowka, 2017, Chem.

Kinetics of Multivalent Antigen DNP-BSA Binding to IgE-FcεRI in Relationship to the Stimulated Tyrosine Phosphorylation of FcεRI

Byron Goldstein, Barbara Baird, David Holowka, 1998, The Journal of Immunology.

Evidence supporting a role for microfilaments in regulating the coupling between poorly dissociable IgE-Fc epsilonRI aggregates downstream signaling pathways.

B. Baird, D. Holowka, L. Pierini, 1997, Biochemistry.

Heterologous desensitization of the high affinity receptor for IgE (Fc epsilon R1) on RBL cells.

B. Baird, D. Holowka, M. Weetall, 1993, Journal of immunology.

Short chain ceramides disrupt immunoreceptor signaling by inhibiting segregation of Lo from Ld Plasma membrane components

B. Baird, D. Holowka, Kankanit Thanapuasuwan, 2018, Biology Open.

Conformations of IgE bound to its receptor Fc epsilon RI and in solution.

B. Baird, D. Holowka, Y. Zheng, 1991, Biochemistry.

Fc DNA Spacers Reveal Structural Constraints Bivalent Ligands with Rigid Double-Stranded

B. Baird, D. Holowka, N. T. Harris, 2002 .

Structural mapping of Fc receptor bound immunoglobulin E: proximity to the membrane surface of the antibody combining site and another site in the Fab segments.

B. Baird, D. Holowka, 1985, Biochemistry.

Interaction of IgE with its high-affinity receptor. Structural basis and requirements for effective cross-linking.

J. Erickson, B. Baird, D. Holowka, 1989, International archives of allergy and applied immunology.

Functionalized surface arrays for spatial targeting of immune cell signaling.

P. Sengupta, C. Ober, B. Baird, 2006, Journal of the American Chemical Society.

Stimulated Tyrosine Phosphorylation of Fc RI in Relationship to the ε Binding to IgE-Fc Kinetics of Multivalent Antigen DNP-BSA

B. Goldstein, B. Baird, D. Holowka, 2013 .

Segmental flexibility of receptor-bound immunoglobulin E.

B. Baird, J. Slattery, D. Holowka, 1985, Biochemistry.

Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca2+ mobilization and degranulation in mast cells

Deepti Gadi, B. Baird, D. Holowka, 2011, Molecular biology of the cell.

Mapping the site of interaction between murine IgE and its high affinity receptor with chimeric Ig.

B. Baird, D. Holowka, M. Weetall, 1990, Journal of immunology.

Dissociation kinetics of bivalent ligand-immunoglobulin E aggregates in solution.

J. Erickson, B. Goldstein, R. Posner, 1991, Biochemistry.

Changes in intrinsic circular dichroism of several homogeneous anti-type 3 pneumococcal antibodies on binding of a small hapten.

E. Haber, A. Strosberg, D. Holowka, 1972, Proceedings of the National Academy of Sciences of the United States of America.

Rotational motion of monomeric and dimeric immunoglobulin E-receptor complexes.

B. Baird, D. Holowka, J. Myers, 1992, Biochemistry.

Microfilaments regulate the rate of exocytosis in rat basophilic leukemia cells.

B. Baird, D. Holowka, V. Narasimhan, 1990, Biochemical and biophysical research communications.

Real-time imaging of Ca(2+) mobilization and degranulation in mast cells.

B. Baird, D. Holowka, R. Cohen, 2015, Methods in molecular biology.

Proteolytic Digestion of the β and γ Subunits of the Receptor for Immunoglobulin E at the Cytoplasmic Face of the Plasma Membrane

S. Hammes, B. Baird, D. Holowka, 1989 .

The Role of Membrane Affinity and Binding Modes in Alpha-Synuclein Regulation of Vesicle Release and Trafficking

D. Eliezer, B. Baird, Ka Yee C. Lee, 2022, Biomolecules.

Bringing light to ER contacts and a new phase in organelle communication

B. Baird, D. Holowka, Nirmalya Bag, 2020, Proceedings of the National Academy of Sciences.

Aggregation of IgE-receptor complexes on rat basophilic leukemia cells does not change the intrinsic affinity but can alter the kinetics of the ligand-IgE interaction.

D. Conrad, B. Goldstein, R. Posner, 1992, Biochemistry.

Nanobiotechnology and cell biology: micro- and nanofabricated surfaces to investigate receptor-mediated signaling.

B. Baird, Min Wu, D. Holowka, 2008, Annual review of biophysics.

Cholera toxin increases the rate of antigen-stimulated calcium influx in rat basophilic leukemia cells.

B. Baird, D. Holowka, C. Fewtrell, 1988, Journal of Biological Chemistry.

Compartmentalized Activation of the High Affinity Immunoglobulin E Receptor within Membrane Domains*

B. Baird, D. Holowka, K. Field, 1997, The Journal of Biological Chemistry.

Structure and Function of the High-Affinity Receptor for Immunoglobulin E

B. Baird, D. Holowka, 1990 .

Lipid-based, protein-based, and steric interactions synergize to facilitate transmembrane signaling stimulated by antigen-clustering of IgE receptors

B. Baird, D. Holowka, Nirmalya Bag, 2020, bioRxiv.

Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes

B. Baird, D. Holowka, E. Sheets, 1999, The Journal of cell biology.

Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells

Jared L. Johnson, D. Holowka, R. Cerione, 2011, Proceedings of the National Academy of Sciences.

Nanosecond fluorescence spectroscopy of pyrenebutyrate anti-pyrene antibody complexes.

D. Holowka, C. Lovejoy, R. Cathou, 1977, Biochemistry.

Structural mapping of membrane-bound immunoglobulin E-receptor complexes: use of monoclonal anti-IgE antibodies to probe the conformation of receptor-bound IgE.

D. Conrad, B. Baird, D. Holowka, 1985, Biochemistry.

Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.

J. Kinet, M. Vig, B. Baird, 2009, Molecular biology of the cell.

Antigen-mediated IGE receptor aggregation and signaling: a window on cell surface structure and dynamics.

B. Baird, D. Holowka, 1996, Annual review of biophysics and biomolecular structure.

Bimolecular fluorescence complementation (BiFC) analysis as a probe of protein interactions in living cells.

Paul J. Choi, S. Ozkan, T. Kerppola, 2008, Annual review of biophysics.

Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.

B. Baird, D. Holowka, E. Hong-Geller, 2000, Molecular biology of the cell.

Activated Cdc42/Rac reconstitutes FcɛRI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells

B. Baird, D. Holowka, R. Cerione, 2001 .

Mutations in the Polybasic Juxtamembrane Sequence of Both Plasma Membrane- and Endoplasmic Reticulum-localized Epidermal Growth Factor Receptors Confer Ligand-independent Cell Transformation*

B. Baird, D. Holowka, R. Cerione, 2013, The Journal of Biological Chemistry.

An Interaction Library for the FcεRI Signaling Network

William S. Hlavacek, Lily A. Chylek, David A. Holowka, 2014, Front. Immunol..

Recombinant human IgG1-murine IgE chimeric Ig. Construction, expression, and binding to human Fc gamma receptors.

B. Baird, D. Holowka, M. Weetall, 1990, Journal of immunology.

Membrane Compartments in Immune Cell Signaling and Trafficking

B. Baird, D. Holowka, Stephanie Hammond, 2008 .

Effects of subunit mutation on the rotational dynamics of Fc epsilon RI, the high affinity receptor for IgE, in transfected cells.

H. Metzger, B. Baird, D. Holowka, 1995, Biochemistry.

Critical fluctuations in plasma membrane vesicles.

Prabuddha Sengupta, Barbara Baird, Pietro Cicuta, 2008, ACS chemical biology.

Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function.

P. Sengupta, B. Baird, D. Holowka, 2007, Seminars in cell & developmental biology.

Development of a mast cell-based biosensor.

Theresa Curtis, David Holowka, Carl Batt, 2008, Biosensors & bioelectronics.

Correlation Functions Quantify Super-Resolution Images and Estimate Apparent Clustering Due to Over-Counting

Benjamin B. Machta, Sarah L. Veatch, David A. Holowka, 2011, PloS one.

Bivalent binding of an anti-CD3 antibody to Jurkat cells induces association of the T cell receptor complex with the cytoskeleton.

B. Baird, D. Holowka, N. Marano, 1989, Journal of immunology.

Competition between solution and cell surface receptors for ligand. Dissociation of hapten bound to surface antibody in the presence of solution antibody.

D. Torney, J. Erickson, B. Goldstein, 1989, Biophysical journal.

Insights into immunoglobulin E receptor signaling from structurally defined ligands

B. Baird, D. Holowka, C. Torigoe, 2007, Immunological reviews.

Regulation of exocytosis and mitochondrial relocalization by Alpha-synuclein in a mammalian cell model

D. Eliezer, B. Baird, D. Holowka, 2018, npj Parkinson's Disease.

Structural Aspects of the Association of FcεRI with Detergent-resistant Membranes*

B. Baird, D. Holowka, K. Field, 1999, The Journal of Biological Chemistry.

FcεRI Signaling in Specialized Membrane Domains

B. Baird, D. Holowka, K. Field, 1999 .

N-chloroacetyl-[125I]iodotyramine: an alkylating agent with high specific activity.

D. Holowka, 1981, Analytical biochemistry.

Fluorescence anisotropy measurements of lipid order in plasma membranes and lipid rafts from RBL-2H3 mast cells.

B. Baird, D. Holowka, A. Gidwani, 2001, Biochemistry.

Lipid-based and protein-based interactions synergize transmembrane signaling stimulated by antigen clustering of IgE receptors

B. Baird, D. Holowka, Nirmalya Bag, 2021, Proceedings of the National Academy of Sciences.

Activation of Cdc42 is necessary for sustained oscillations of Ca2+ and PIP2 stimulated by antigen in RBL mast cells

B. Baird, D. Holowka, Joshua D. Wilson, 2014, Biology Open.

FcϵRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells

B. Baird, D. Holowka, 2001 .

Alteration of lipid composition modulates Fc epsilon RI signaling in RBL-2H3 cells.

B. Baird, D. Holowka, Y. Zheng, 1995, Biochemistry.

Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles

Watt W. Webb, Prabuddha Sengupta, Samuel T. Hess, 2007, Proceedings of the National Academy of Sciences.

Focal adhesion proteins connect IgE receptors to the cytoskeleton as revealed by micropatterned ligand arrays

Lavanya Vasudevan, David Holowka, B. Baird, 2008, Proceedings of the National Academy of Sciences.

Transbilayer Coupling of Lipids in Cells Investigated by Imaging Fluorescence Correlation Spectroscopy.

B. Baird, D. Holowka, E. London, 2022, The journal of physical chemistry. B.

Near-Field Fluorescence Cross-Correlation Spectroscopy on Planar Membranes

H. Craighead, B. Baird, D. Holowka, 2014, ACS nano.

Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells

Watt W. Webb, David A. Holowka, Daniel R. Larson, 2005, The Journal of cell biology.

Roles for Ca2+ Mobilization and Its Regulation in Mast Cell Functions

Deepti Gadi, B. Baird, D. Holowka, 2012, Front. Immun..

Lipid segregation and IgE receptor signaling: a decade of progress.

P. Sengupta, B. Baird, Min Wu, 2005, Biochimica et biophysica acta.

Quantitative analysis of phospholipids in functionally important membrane domains from RBL-2H3 mast cells using tandem high-resolution mass spectrometry.

F W McLafferty, F. McLafferty, B. Baird, 1999, Biochemistry.

Antigen‐Stimulated Trafficking from the Recycling Compartment to the Plasma Membrane in RBL Mast Cells

Eric P. Holowka, B. Baird, D. Holowka, 2003, Traffic.

Fc epsilon RI-mediated association of 6-micron beads with RBL-2H3 mast cells results in exclusion of signaling proteins from the forming phagosome and abrogation of normal downstream signaling

B. Baird, D. Holowka, L. Pierini, 1996, The Journal of cell biology.

Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes.

Frederick A. Heberle, G. Feigenson, B. Baird, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Cross-correlation analysis of inner-leaflet-anchored green fluorescent protein co-redistributed with IgE receptors and outer leaflet lipid raft components.

B. Baird, D. Holowka, P. S. Pyenta, 2001, Biophysical journal.

Membrane organization in immunoglobulin E receptor signaling.

B. Baird, D. Holowka, E. Sheets, 1999, Current opinion in chemical biology.

FceRI-mediated Association of 6-1 xm Beads with RBL-2 H 3 Mast Cells Results in Exclusion of Signaling Proteins from the Forming Phagosome and Abrogation of Normal Downstream Signaling

B. Baird, D. Holowka, L. Pierini, 2002 .

Chemical modification and fluorescence studies of chloroplast coupling factor.

G G Hammes, G. Hammes, D. Holowka, 1977, Biochemistry.

Electron spin resonance characterization of liquid ordered phase of detergent-resistant membranes from RBL-2H3 cells.

J. Freed, B. Baird, D. Holowka, 1999, Biophysical journal.

Coexisting domains in the plasma membranes of live cells characterized by spin-label ESR spectroscopy.

J. Freed, M. J. Swamy, B. Baird, 2006, Biophysical journal.

Cross-linking of receptor-bound IgE to aggregates larger than dimers leads to rapid immobilization

W. Webb, A. Menon, B. Baird, 1986, The Journal of cell biology.

Nanodomains in early and later phases of FcɛRI signalling.

B. Baird, D. Holowka, 2015, Essays in biochemistry.

Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P2 between distinct membrane pools

B. Baird, W. Rodgers, D. Holowka, 2011, Journal of Cell Science.

Reconstitution of Regulated Phosphorylation of FcϵRI by a Lipid Raft-excluded Protein-tyrosine Phosphatase*

B. Baird, D. Holowka, Xinmin Zheng, 2005, Journal of Biological Chemistry.

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling.

B. Baird, D. Holowka, K. Field, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Molecular anatomy of the early events in STIM1 activation – oligomerization or conformational change?

T. Balla, B. Baird, D. Holowka, 2017, Journal of Cell Science.

STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain

B. Baird, D. Holowka, Marek Korzeniowski, 2016, AIMS biophysics.

Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.

B. Baird, D. Holowka, Kirsten L. Bryant, 2014, Biochimica et Biophysica Acta.

Spatially defined EGF receptor activation reveals an F-actin-dependent phospho-Erk signaling complex.

S. Hammes, B. Baird, D. Holowka, 2014, Biophysical journal.

Imaging FCS delineates subtle heterogeneity in plasma membranes of resting mast cells

B. Baird, D. Holowka, Nirmalya Bag, 2019, bioRxiv.

Computation of a Theoretical Membrane Phase Diagram and the Role of Phase in Lipid-Raft-Mediated Protein Organization.

Eshan D. Mitra, Samuel C. Whitehead, J. Sethna, 2018, The journal of physical chemistry. B.

Distinct stages of stimulated FcεRI receptor clustering and immobilization are identified through superresolution imaging.

B. Baird, D. Holowka, S. Veatch, 2013, Biophysical journal.

Reconstitution of regulated phosphorylation of FcepsilonRI by a lipid raft-excluded protein-tyrosine phosphatase.

B. Baird, D. Holowka, Xinmin Zheng, 2005, The Journal of biological chemistry.

Fc(epsilon)RI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells.

B. Baird, D. Holowka, 2001, Seminars in immunology.

A basic sequence in STIM1 promotes Ca2+ influx by interacting with the C-terminal acidic coiled coil of Orai1.

B. Baird, D. Holowka, Nathaniel T Calloway, 2010, Biochemistry.

Heterogeneous glycosylation of immunoglobulin E constructs characterized by top-down high-resolution 2-D mass spectrometry.

F. McLafferty, A. Beavil, B. Baird, 2000, Biochemistry.

Trivalent ligands with rigid DNA spacers reveal structural requirements for IgE receptor signaling in RBL mast cells.

Barbara Baird, Dan Luo, David Holowka, 2007, ACS chemical biology.

Bivalent Ligands with Rigid Double-Stranded DNA Spacers Reveal Structural Constraints on Signaling by FcεRI1

B. Baird, D. Holowka, N. T. Harris, 2002, The Journal of Immunology.

Bivalent ligands with rigid double-stranded DNA spacers reveal structural constraints on signaling by Fc epsilon RI.

B. Baird, D. Holowka, N. T. Harris, 2002, Journal of immunology.

Antigen-decorated shell cross-linked nanoparticles: synthesis, characterization, and antibody interactions.

B. Baird, K. Wooley, D. Holowka, 2005, Bioconjugate chemistry.

In vitro modelling of rat mucosal mast cell function in Trichinella spiralis infection

D. Holowka, J. Appleton, S. M. Thrasher, 2013, Parasite immunology.

Responses in Mast Cells 2+ Waves Initiate Antigen-Stimulated Ca 2+ Ca

B. Baird, D. Holowka, R. Cohen, 2009 .

Conformation of immunoglobulin M. I. Characterization of anti-epsilon-1-dimethylamino-5-naphthalenesulfonyl-L-lysine immunoglobulin M antibodies from horse, pig, and shark.

D. Holowka, R. Cathou, 1976, Biochemistry.

Reaction of 5-iodonaphthyl-1-nitrene with the IgE receptor on normal and tumour mast cells

H. Metzger, D. Holowka, C. Gitler, 1981, Nature.

Further characterization of the β-component of the receptor for immunoglobulin E

H. Metzger, D. Holowka, 1982 .

Ordered and disordered phases coexist in plasma membrane vesicles of RBL-2H3 mast cells. An ESR study.

Barbara Baird, Jack H Freed, David Holowka, 2003, Biophysical journal.

A Lipid Raft Environment Enhances Lyn Kinase Activity by Protecting the Active Site Tyrosine from Dephosphorylation*

B. Baird, D. Holowka, R. Young, 2003, Journal of Biological Chemistry.

Cross-linking of IgE-receptor complexes by rigid bivalent antigens greater than 200 A in length triggers cellular degranulation

B. Baird, D. Holowka, P. Kane, 1988, The Journal of cell biology.

Cross-linking of immunoglobulin E-receptor complexes induces their interaction with the cytoskeleton of rat basophilic leukemia cells.

B. Baird, D. Holowka, D. Robertson, 1986, Journal of immunology.

Binding mechanisms of PEGylated ligands reveal multiple effects of the PEG scaffold.

B. Goldstein, Raibatak Das, B. Baird, 2008, Biochemistry.

Quantitative nanoscale analysis of IgE-FcεRI clustering and coupling to early signaling proteins.

P. Sengupta, B. Baird, D. Holowka, 2012, The journal of physical chemistry. B.

Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling

B. Baird, D. Holowka, S. Veatch, 2016, Molecular biology of the cell.

Cross-linking of IgE-receptor complexes at the cell surface: a fluorescence method for studying the binding of monovalent and bivalent haptens to IgE.

J. Erickson, B. Goldstein, B. Baird, 1986, Molecular immunology.

Dynamic conformations compared for IgE and IgG1 in solution and bound to receptors.

B. Baird, D. Holowka, B. Shopes, 1992, Biochemistry.

Conformation of immunoglobulin M. 2. Nanosecond fluorescence depolarization analysis of segmental flexibility in anti-epsilon-l-dimethylamino-5-naphthalenesulfonyl-L-lysine anti-immunoglobulin from horse, pig, and shark.

D. Holowka, R. Cathou, 1976, Biochemistry.

Real-time cross-correlation image analysis of early events in IgE receptor signaling.

Raibatak Das, B. Baird, D. Holowka, 2008, Biophysical journal.

Characterization of increased K+ permeability associated with the stimulation of receptors for immunoglobulin E on rat basophilic leukemia cells.

B. Baird, D. Holowka, G. Labrecque, 1991, The Journal of biological chemistry.

Antigen-triggered membrane potential changes in IgE-sensitized rat basophilic leukemia cells: evidence for a repolarizing response that is important in the stimulation of cellular degranulation.

B. Baird, D. Holowka, G. Labrecque, 1989, Journal of immunology.

Alpha Synuclein Modulates Mitochondrial Ca2+ Uptake from ER During Cell Stimulation and Under Stress Conditions

D. Eliezer, B. Baird, Tong Wang, 2023, bioRxiv.

Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells.

B. Baird, D. Holowka, R. Cerione, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Structural studies on the membrane-bound immunoglobulin E (IgE)-receptor complex. 2. Mapping of distances between sites on IgE and the membrane surface

B. Baird, D. Holowka, 1983 .

Molecular crowding on the cell surface.

W. Webb, T. A. Ryan, B. Baird, 1988, Science.

Highly effective poly(ethylene glycol) architectures for specific inhibition of immune receptor activation.

B. Baird, G. Coates, D. Holowka, 2003, Biochemistry.

Simultaneous cross-linking by two nontriggering bivalent ligands causes synergistic signaling of IgE Fc epsilon RI complexes.

B. Goldstein, R. Posner, B. Baird, 1995, Journal of immunology.

Kinetics of multivalent antigen DNP-BSA binding to IgE-Fc epsilon RI in relationship to the stimulated tyrosine phosphorylation of Fc epsilon RI.

B. Goldstein, B. Baird, D. Holowka, 1998, Journal of immunology.

B. Baird, D. Holowka, Kirsten L. Bryant, 2015, BMC Cell Biology.

Fluorescence Resonance Energy Transfer Reveals Interleukin (IL)-1-dependent Aggregation of IL-1 Type I Receptors That Correlates with Receptor Activation (*)

S. Dower, B. Baird, D. Holowka, 1995, The Journal of Biological Chemistry.

Structural mapping of IgE-Fc.epsilon.RI, an immunoreceptor complex

B. Baird, D. Holowka, Yi-Fan Zheng, 1993 .

Altered patterns of tyrosine phosphorylation and Syk activation for sterically restricted cyclic dimers of IgE-Fc epsilonRI.

B. Goldstein, B. Baird, D. Holowka, 1997, Biochemistry.

A nanosecond fluorescence depolarization study on the segmental flexibility of receptor-bound immunoglobulin E.

B. Baird, T. Wensel, D. Holowka, 1990, Biochemistry.

Roles for SH2 and SH3 domains in Lyn kinase association with activated FcepsilonRI in RBL mast cells revealed by patterned surface analysis.

B. Baird, D. Holowka, S. Veatch, 2009, Journal of structural biology.

Sustained T cell receptor-mediated Ca2+ responses rely on dynamic engagement of receptors.

B. Baird, J. Slattery, D. Holowka, 1996, Journal of Immunology.

Lactoperoxidase-catalyzed iodination of the receptor for immunoglobulin E at the cytoplasmic side of the plasma membrane.

B. Baird, D. Holowka, 1984, The Journal of biological chemistry.

Progress Toward Understanding the Molecular Details and Consequences of IgE-Receptor Crosslinking

J. Erickson, B. Goldstein, A. Menon, 2018 .

Membrane-bound IgE receptor complexes fused with rat basophilic leukemia cells mediate degranulation

S. Hammes, B. Baird, D. Holowka, 1987, The Journal of cell biology.

Analysis of Ligand Binding and Cross-Linking of Receptors in Solution and on Cell Surfaces

J. Erickson, B. Goldstein, R. Posner, 1991 .

Cross-linking of IgE-receptor complexes at the cell surface: synthesis and characterization of a long bivalent hapten that is capable of triggering mast cells and rat basophilic leukemia cells.

J. Erickson, B. Baird, D. Holowka, 1986, Molecular immunology.

Micropatterned Ligand Arrays to Investigate Spatial Regulation of Cellular Signaling Initiated by Clustered Fc Receptors.

B. Baird, D. Holowka, Jordan D. Mohr, 2021, Methods in molecular biology.

Evolution of conformational flexibility of immunoglobulin M.

D. Holowka, R. Cathou, 1975, Advances in experimental medicine and biology.

Functional nanoscale coupling of Lyn kinase with IgE-FcεRI is restricted by the actin cytoskeleton in early antigen-stimulated signaling

B. Baird, D. Holowka, S. Veatch, 2016, Molecular biology of the cell.

MOLECULAR MECHANISMS OF ANTIBODY ACTION: USE OF CROSS-LINKING REAGENTS

H. Metzger, D. Holowka, C. Fewtrell, 1980 .

Transbilayer Coupling of Lipids in Cells Investigated by Imaging Fluorescence Correlation Spectroscopy

B. Baird, D. Holowka, E. London, 2022, bioRxiv.

The β- and γ-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells

P. De Camilli, A. Jeromin, B. Baird, 2009, Journal of Cell Science.