R. Higgs

发表

Targeting IRFs by ubiquitination: regulating antiviral responses.

R. Higgs, C. Jefferies, 2008, Biochemical Society transactions.

TRIM68 Negatively Regulates IFN-β Production by Degrading TRK Fused Gene, a Novel Driver of IFN-β Downstream of Anti-Viral Detection Systems

C. Biron, S. Cryan, R. Higgs, 2014, PloS one.

Retinoic acid expression associates with enhanced IL-22 production by γδ T cells and innate lymphoid cells and attenuation of intestinal inflammation

A. Bracken, K. Mills, R. Higgs, 2013, The Journal of experimental medicine.

A novel TLR2 agonist from Bordetella pertussis is a potent adjuvant that promotes protective immunity with an acellular pertussis vaccine

K. Mills, R. Higgs, A. Dunne, 2014, Mucosal Immunology.

Diarrhea: Impaired feedback inhibition of bile acid synthesis associated with bile acid diarrhea

R. Higgs, 2010, Nature Reviews Gastroenterology &Hepatology.

Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus.

A. Sica, R. Higgs, C. Jefferies, 2012, Arthritis and rheumatism.

Title: Enhanced interferon regulatory factor 3 binding to the IL-23p19 promoter correlates with enhanced IL-23 expression in systemic lupus erythematosus. Running Title: IRF3-IL-23p19 promoter interaction in SLE

Stacey, A. Sica, Bell, 2011 .

Genetics: PTPRC mutation associated with response to anti-TNF therapy in rheumatoid arthritis

R. Higgs, 2010, Nature Reviews Rheumatology.

Medical oncology: Carcinoembryonic antigen mRNA expression—a marker for early pancreatic cancer recurrence?

R. Higgs, 2010, Nature Reviews Clinical Oncology.

Recognition by Polyubiquitin-Mediated Production Post-Pathogen β Regulates IFN- The E3 Ubiquitin Ligase Ro52 Negatively

R. Higgs, C. Jefferies, K. Fitzgerald, 2013 .

Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors

R. Higgs, C. Jefferies, M. Wahren-Herlenius, 2010, PloS one.

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN- Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF3

R. Higgs, C. Jefferies, Breen, 2008 .

The E3 Ubiquitin Ligase Ro52 Negatively Regulates IFN-β Production Post-Pathogen Recognition by Polyubiquitin-Mediated Degradation of IRF31

R. Higgs, C. Jefferies, K. Fitzgerald, 2008, The Journal of Immunology.

Degradation of IRF 3 Recognition by Polyubiquitin-Mediated Production Post-Pathogen β Regulates IFN-The E 3 Ubiquitin Ligase Ro 52 Negatively

R. Higgs, C. Jefferies, K. Fitzgerald, 2008 .

Avian beta-defensin nomenclature: a community proposed update.

D. Lynn, F. Brinkman, A. T. Lloyd, 2007, Immunology letters.

Prevention: Supplements not cardioprotective for patients with a history of CVD

R. Higgs, 2011, Nature Reviews Cardiology.

Coronary artery disease: Niacin combined with statin treatment reduces carotid intima-media thickness in patients at risk of heart disease

R. Higgs, 2010, Nature Reviews Cardiology.

TSH levels affect mobility in old age

R. Higgs, 2010, Nature Reviews Endocrinology.

Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

L. Boon, K. Mills, R. Higgs, 2012, Cancer research.

Modification of chicken avian β-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity

D. Lynn, A. T. Lloyd, R. Higgs, 2007, Immunogenetics.

Bioinformatic discovery and initial characterisation of nine novel antimicrobial peptide genes in the chicken

Mario A. Fares, David J. Lynn, Andrew T. Lloyd, 2004, Immunogenetics.

Screening: A re-evaluation of KRAS mutational 'hotspots'

R. Higgs, 2010, Nature Reviews Clinical Oncology.

Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?

R. Higgs, C. Jefferies, Claire Wynne, 2011, Nature Reviews Immunology.

Rejection of Murine Tumors Polyfunctional T Cells That Mediate + IL-17 + γ Induces IFN-Immunotherapy with PI 3 K Inhibitor and Toll-Like Receptor Agonist

L. Boon, K. Mills, R. Higgs, 2012 .

The synthetic form of a novel chicken β-defensin identified in silico is predominantly active against intestinal pathogens

D. Lynn, A. T. Lloyd, R. Higgs, 2005, Immunogenetics.

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23–Th17 pathway

V. Kuchroo, V. Dardalhon, R. Higgs, 2009, The Journal of experimental medicine.

Induction of a Novel Chicken Toll-Like Receptor following Salmonella enterica Serovar Typhimurium Infection

L. Babiuk, D. Lynn, A. T. Lloyd, 2006, Infection and Immunity.

Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-β Production

W. Thomas, G. Krystal, J. Damen, 2010, The Journal of Immunology.

This information is current as Production β and Enhanced TLR 3-Dependent IFN-Phosphorylation of Tank-Binding Kinase 1 Absence of SHIP-1 Results in Constitutive

W. Thomas, G. Krystal, J. Damen, 2010 .

Differential antimicrobial peptide gene expression patterns during early chicken embryological development.

A. T. Lloyd, K. Meade, R. Higgs, 2009, Developmental and comparative immunology.

Osteoporosis: Zoledronic acid for osteoporosis treatment—a matter of time

R. Higgs, 2010, Nature Reviews Rheumatology.

Osteoarthritis: Concentrated efforts to detect early OA

R. Higgs, 2010, Nature Reviews Rheumatology.

Alzheimer disease: Neutral lipid accumulation in PBMCs—a biomarker for AD?

R. Higgs, 2010, Nature Reviews Neurology.

Liver: Reduced mitochondrial dysfunction delays liver fibrosis

R. Higgs, 2010, Nature Reviews Gastroenterology &Hepatology.

Novel prognostic SNP in CN-AML

R. Higgs, 2010, Nature Reviews Clinical Oncology.

Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

L. Boon, K. Mills, R. Higgs, 2012, Cancer research.

Immunity to the respiratory pathogen Bordetella pertussis

K. Mills, R. Higgs, S. Higgins, 2012, Mucosal Immunology.

Targeting IRFs by ubiquitination: regulating antiviral responses.

R. Higgs, C. Jefferies, Rowan Higgs, 2008, Biochemical Society transactions.