I. McGowan

Ross D. Cranston, T. Holtz, A. Carballo-Diéguez, 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

The Use of Droplet Digital PCR to Quantify HIV-1 Replication in the Colorectal Explant Model.

I. McGowan, A. Siegel, J. Engstrom, 2019, AIDS research and human retroviruses.

A Pilot Study of the Immunologic, Virologic, and Pathologic Consequences of Intra-anal 5% Imiquimod in HIV-1–Infected Men With High-Grade Squamous Intraepithelial Lesions

Ross D. Cranston, I. McGowan, L. Janocko, 2018, Diseases of the colon and rectum.

The Association Between Heterosexual anal Intercourse and HIV Acquisition in Three Prospective Cohorts of Women.

A. van der Straten, M. Boily, M. Maheu-Giroux, 2023, AIDS and behavior.

“Tell Juliana”: Acceptability of the Candidate Microbicide VivaGel® and Two Placebo Gels Among Ethnically Diverse, Sexually Active Young Women Participating in a Phase 1 Microbicide Study

A. Carballo-Diéguez, G. Zimet, C. Leu, 2012, AIDS and Behavior.

Acceptability of UC781 Gel as a Rectal Microbicide Among HIV-Uninfected Women and Men

A. Carballo-Diéguez, I. McGowan, P. Anton, 2009, AIDS and Behavior.

Chapter 4 – Microbicides

I. McGowan, 2009 .

Acceptability of UC 781 Gel as a Rectal Microbicide Among HIV-Uninfected Women and Men

A. Carballo-Diéguez, I. McGowan, P. Anton, 2009 .

Binding and Transfer of Human Immunodeﬁciency Virus by DC-SIGN (cid:1) Cells in Human Rectal Mucosa

E. Soilleux, Benhur Lee, I. McGowan, 2005 .

Sensitive and reproducible quantitation of mucosal HIV-1 RNA and DNA viral burden in patients with detectable and undetectable plasma viral HIV-1 RNA using endoscopic biopsies.

H. Lenz, I. Chen, I. McGowan, 2001, Journal of virological methods.

Extended Treatment With Tenofovir Disoproxil Fumarate in Treatment‐Experienced HIV‐1‐Infected Patients: Genotypic, Phenotypic, and Rebound Analyses

I. McGowan, Erica Isaacson, A. Cheng, 2003, Journal of acquired immune deficiency syndromes.

A Pilot Study of the Prevalence of Anal Human Papillomavirus and Dysplasia in a Cohort of Patients With IBD

Ross D. Cranston, M. Regueiro, N. Richardson-Harman, 2017, Diseases of the colon and rectum.

Prevalence of Anal Human Papillomavirus Vaccine Types in the Bangkok Men Who Have Sex With Men Cohort Study

Ross D. Cranston, T. Holtz, A. Althouse, 2015, Sexually transmitted diseases.

Binding and Transfer of Human Immunodeficiency Virus by DC-SIGN+ Cells in Human Rectal Mucosa

E. Soilleux, Benhur Lee, I. McGowan, 2005, Journal of Virology.

Gastrointestinal mucosal biopsy in HIV disease and AIDS.

I. McGowan, P. Anton, R. Cranston, 2000, Gastrointestinal endoscopy clinics of North America.

Intestinal microsporidiosis.

S. Croft, I. McGowan, J. Williams, 1997, Seminars in gastrointestinal disease.

Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF

R. Schooley, I. McGowan, Erica Isaacson, 2002, AIDS.

A Tunable, Biodegradable, Thin-Film Polymer Device as a Long-Acting Implant Delivering Tenofovir Alafenamide Fumarate for HIV Pre-exposure Prophylaxis

Erica B. Schlesinger, T. Desai, I. McGowan, 2016, Pharmaceutical Research.

Rectal Transmission of Transmitted/Founder HIV-1 Is Efficiently Prevented by Topical 1% Tenofovir in BLT Humanized Mice

M. Swanson, J. Garcia, I. McGowan, 2013, PloS one.

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

A. Carballo-Diéguez, W. Cumberland, C. Hendrix, 2012, AIDS research and human retroviruses.

First Phase 1 Double-Blind, Placebo-Controlled, Randomized Rectal Microbicide Trial Using UC781 Gel with a Novel Index of Ex Vivo Efficacy

A. Carballo-Diéguez, W. Cumberland, C. Mauck, 2011, PloS one.

Rectal microbicides

I. McGowan, P. Anton, 2008, Current opinion in HIV and AIDS.

Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women

H. Gundacker, A. van der Straten, C. Hendrix, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women.

Ashley J. Mayo, J. Baeten, A. van der Straten, 2016, The New England journal of medicine.

Long-acting rilpivirine for HIV prevention

I. McGowan, A. Jackson, 2015, Current opinion in HIV and AIDS.

Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Women

I. Frank, K. Mayer, C. Hendrix, 2017, Annals of Internal Medicine.

Phase 2 Study of the Safety and Tolerability of Maraviroc-Containing Regimens to Prevent HIV Infection in Men Who Have Sex With Men (HPTN 069/ACTG A5305)

I. Frank, K. Mayer, C. Hendrix, 2016, The Journal of infectious diseases.

The development of rectal microbicides for HIV prevention

I. McGowan, 2014, Expert opinion on drug delivery.

HHV8 DNA in normal gastrointestinal mucosa from HIV seropositive people

I. McGowan, D. Crawford, I. Weller, 1996, The Lancet.

Cytokine gene transcription of human colonic intraepithelial lymphocytes costimulated with epithelial cells bearing HLA-DR and its inhibition by 5-aminosalicylic acid

D. Jewell, I. McGowan, Daohong Chen, 1996, Journal of Clinical Immunology.

A Phase 1 Randomized, Open Label, Rectal Safety, Acceptability, Pharmacokinetic, and Pharmacodynamic Study of Three Formulations of Tenofovir 1% Gel (the CHARM-01 Study)

Ross D. Cranston, Kaleab Z. Abebe, C. Hendrix, 2015, PloS one.

Stability of 5P12-RANTES, A Candidate Rectal Microbicide, in Human Rectal Lavage.

R. Offord, F. Cerini, I. McGowan, 2017, AIDS Research and Human Retroviruses.

Lack of Decay of HIV-1 in Gut-Associated Lymphoid Tissue Reservoirs in Maximally Suppressed Individuals

W. Boscardin, I. McGowan, P. Anton, 2006, Journal of acquired immune deficiency syndromes.

Effective in vivo and ex vivo gene transfer to intestinal mucosa by VSV-G-pseudotyped lentiviral vectors

Takahiro Kimura, I. McGowan, P. Anton, 2010, BMC gastroenterology.

HIV and mucosal barrier interactions: consequences for transmission and pathogenesis.

I. McGowan, A. Burgener, N. Klatt, 2015, Current opinion in immunology.

Rectal 1% Tenofovir Gel Use Associates with Altered Epidermal Protein Expression

A. Carballo-Diéguez, K. Mayer, I. McGowan, 2016, AIDS research and human retroviruses.

Implications of HIV PrEP trials results.

V. DeGruttola, C. Fletcher, D. Burns, 2011, AIDS research and human retroviruses.

Safety, immunogenicity and effect on viral rebound of HTI vaccines in early treated HIV-1 infection: a randomized, placebo-controlled phase 1 trial

R. Paredes, B. Clotet, R. Geleziunas, 2022, Nature Medicine.

Rectal Microbicides: Can We Make Them and Will People Use Them?

I. McGowan, 2011, AIDS and Behavior.

A Phase 1 Randomized, Double Blind, Placebo Controlled Rectal Safety and Acceptability Study of Tenofovir 1% Gel (MTN-007)

James Y. Dai, Ross D. Cranston, A. Carballo-Diéguez, 2013, PloS one.

Injectable and implantable antiretroviral strategies for HIV prevention

I. McGowan, 2015 .

Rectal microbicides: a new focus for HIV prevention

I. McGowan, 2008, Sexually Transmitted Infections.

Microbicides 2006 conference

G. Ramjee, N. Morar, R. Shattock, 2006, AIDS research and therapy.

Modeling the potential impact of rectal microbicides to reduce hiv transmission in bathhouses.

Romulus Breban, Sally Blower, S. Blower, 2006, Mathematical biosciences and engineering : MBE.

Lessons for Rectal Microbicide Development From an Acceptability Trial of a Placebo Gel Applied Prior to Receptive Anal Intercourse

Ross D. Cranston, A. Carballo-Diéguez, K. Mayer, 2016, Archives of Sexual Behavior.

Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection

Ross D. Cranston, T. Holtz, J. Baeten, 2019, Cell reports. Medicine.

Awareness of Post-Exposure Prophylaxis (PEP) and Pre-Exposure Prophylaxis (PrEP) Is Low but Interest Is High Among Men Engaging in Condomless Anal Sex With Men in Boston, Pittsburgh, and San Juan.

Ross D. Cranston, A. Carballo-Diéguez, K. Mayer, 2015, AIDS education and prevention : official publication of the International Society for AIDS Education.

IS HIGH AMONG MEN ENGAGING IN CONDOMLESS ANAL SEX WITH MEN IN BOSTON , PITTSBURGH , AND

A. Carballo-Diéguez, K. Mayer, I. McGowan, 2015 .

Preference of Oral Tenofovir Disoproxil Fumarate/Emtricitabine Versus Rectal Tenofovir Reduced-Glycerin 1% Gel Regimens for HIV Prevention Among Cisgender Men and Transgender Women Who Engage in Receptive Anal Intercourse with Men

T. Holtz, A. Carballo-Diéguez, B. Richardson, 2017, AIDS and Behavior.

To Use a Rectal Microbicide, First Insert the Applicator: Gel and Applicator Satisfaction Among Young Men Who Have Sex With Men.

Ross D. Cranston, J. Bauermeister, A. Carballo-Diéguez, 2016, AIDS education and prevention : official publication of the International Society for AIDS Education.

Acceptability of a Dapivirine/Placebo Gel Administered Rectally to HIV-1 Seronegative Adults (MTN-026)

H. Gundacker, J. Bauermeister, J. Piper, 2021, AIDS and Behavior.

Project Gel a Randomized Rectal Microbicide Safety and Acceptability Study in Young Men and Transgender Women

Ross D. Cranston, A. Carballo-Diéguez, S. Park, 2016, PloS one.

Rectal-Specific Microbicide Applicator: Evaluation and Comparison with a Vaginal Applicator Used Rectally

Ross D. Cranston, J. Bauermeister, A. Carballo-Diéguez, 2014, AIDS and Behavior.

Adherence to Rectal Gel Use Among Mainly Ethnic Minority Young Men Who have Sex with Men During A 3-Month Placebo Gel Trial: Implications for Microbicide Research

J. Bauermeister, A. Carballo-Diéguez, K. Mayer, 2014, AIDS and Behavior.

Variations in microbicide gel acceptability among young women in the USA and Puerto Rico

A. Carballo-Diéguez, G. Zimet, I. McGowan, 2012, Culture, health & sexuality.

Increases in HIV Incidence Following Receptive Anal Intercourse Among Women: A Systematic Review and Meta-analysis

A. van der Straten, R. Baggaley, M. Boily, 2019, AIDS and Behavior.

Influence of Partner Type on Acceptability and Likelihood of Use of a Rectal Microbicide Among Young Men Who Have Sex With Men in the United States and Puerto Rico

J. Bauermeister, A. Carballo-Diéguez, K. Mayer, 2016, Journal of sex research.

Youth-Specific Considerations in the Development of Preexposure Prophylaxis, Microbicide, and Vaccine Research Trials

L. Bekker, G. Gray, P. Krogstad, 2010, Journal of acquired immune deficiency syndromes.

Lessons for Rectal Microbicide Development From an Acceptability Trial of a Placebo Gel Applied Prior to Receptive Anal Intercourse

A. Carballo-Diéguez, I. McGowan, R. Cranston, 2016, Archives of Sexual Behavior.

An Open-Label Pharmacokinetic and Pharmacodynamic Assessment of Tenofovir Gel and Oral Emtricitabine / Tenofovir Disoproxil Fumarate.

T. Holtz, G. Doncel, J. Piper, 2021, AIDS research and human retroviruses.

A Randomized, Double Blind, Placebo-Controlled, Phase 1 Safety and Pharmacokinetic Study of Dapivirine Gel (0.05%) Administered Rectally to HIV-1 Seronegative Adults (MTN-026).

Clara P Domínguez-Islas, H. Gundacker, J. Bauermeister, 2021, AIDS research and human retroviruses.

A Randomized, Open Label, Crossover Phase 1 Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel (the CHARM-03 Study).

Kaleab Z. Abebe, C. Hendrix, M. Marzinke, 2021, AIDS research and human retroviruses.

S01.1 An Update on Topical Microbicide Development

I. McGowan, 2013, Sexually Transmitted Infections.

Non-gonococcal urethritis in men practising "safe" sex.

G. Ridgway, I. McGowan, J. Bingham, 1991, Genitourinary medicine.

Factors Supporting and Hindering Adherence to Rectal Microbicide Gel Use with Receptive Anal Intercourse in a Phase 2 Trial

A. Carballo-Diéguez, K. Mayer, C. Leu, 2018, AIDS and Behavior.

High levels of adherence to a rectal microbicide gel and to oral Pre-Exposure Prophylaxis (PrEP) achieved in MTN-017 among men who have sex with men (MSM) and transgender women

T. Holtz, A. Carballo-Diéguez, B. Richardson, 2017, PloS one.

Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides

J. Grivel, L. Margolis, R. Shattock, 2006, AIDS.

Pharmacokinetics and Pharmacodynamics of Tenofovir Reduced-Glycerin 1% Gel in the Rectal and Vaginal Compartments in Women: A Cross-Compartmental Study With Directly Observed Dosing

James Y. Dai, J. Justman, J. Piper, 2018, Journal of acquired immune deficiency syndromes.

How common and frequent is heterosexual anal intercourse among South Africans? A systematic review and meta-analysis

A. van der Straten, R. Baggaley, M. Boily, 2017, Journal of the International AIDS Society.

Correlation between Compartmental Tenofovir Concentrations and an Ex Vivo Rectal Biopsy Model of Tissue Infectibility in the RMP-02/MTN-006 Phase 1 Study

Ross D. Cranston, C. Hendrix, N. Richardson-Harman, 2014, PloS one.

Brief Participant-Centered Convergence Interviews Integrate Self-Reports, Product Returns, and Pharmacokinetic Results to Improve Adherence Measurement in MTN-017

A. Carballo-Diéguez, J. Piper, C. Hendrix, 2018, AIDS and Behavior.

Acceptability of Three Novel HIV Prevention Methods Among Young Male and Transgender Female Sex Workers in Puerto Rico

A. Carballo-Diéguez, K. Mayer, I. McGowan, 2016, AIDS and Behavior.

The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing pre-exposure prophylaxis regimens in MSM.

Ross D. Cranston, K. Mayer, C. Hendrix, 2019, AIDS.

The pharmacokinetics, pharmacodynamics, and mucosal responses to maraviroc-containing PrEP Regimens in Men who have Sex with Men.

K. Mayer, C. Hendrix, M. Marzinke, 2018, AIDS.

Reverse Transcriptase Inhibitors as Potential Colorectal Microbicides

C. Herrera, R. Shattock, I. McGowan, 2009, Antimicrobial Agents and Chemotherapy.

Receptive anal sex contributes substantially to heterosexually acquired HIV infections among at‐risk women in twenty US cities: Results from a modelling analysis

A. Adimora, M. Boily, I. McGowan, 2020, American journal of reproductive immunology.

Heterosexual Anal Intercourse Has the Potential to Cause a Significant Loss of Power in Vaginal Microbicide Effectiveness Studies

Douglas J. Taylor, I. McGowan, 2010, Sexually transmitted diseases.

HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1

J. Grivel, L. Margolis, R. Shattock, 2007, AIDS.

Ranpirnase Reduces HIV-1 Infection and Associated Inflammatory Changes in a Human Colorectal Explant Model.

E. Metter, T. Hodge, R. Brand, 2018, AIDS research and human retroviruses.

Anal human papillomavirus and HIV: A cross-sectional study among men who have sex with men in Moscow, Russia, 2012-2013.

C. Latkin, C. Beyrer, N. Galai, 2015, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

HIV encephalopathy presenting as hypomania.

F. Scaravilli, R. Miller, I. McGowan, 1991, Genitourinary medicine.

Protection of HIV Neutralizing Aptamers against Rectal and Vaginal Nucleases

Ross D. Cranston, B. Sproat, M. D. Moore, 2010, The Journal of Biological Chemistry.

Higher colorectal tissue HIV infectivity in cisgender women compared with MSM before and during oral preexposure prophylaxis.

I. Frank, K. Mayer, C. Hendrix, 2021, AIDS.

Comparative Assessment of Small and Large Intestine Biopsies for Ex Vivo HIV-1 Pathogenesis Studies.

I. McGowan, P. Anton, J. Elliott, 2018, AIDS research and human retroviruses.

An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site.

D. Burton, B. Sproat, C. Cohen, 2008, Virology.

Prevalence and determinants of anal human papillomavirus infection in men who have sex with men and transgender women

Ross D. Cranston, H. Gundacker, A. Carballo-Diéguez, 2018, International journal of STD & AIDS.

Hydroxyurea does not enhance the anti-HIV activity of low-dose tenofovir disoproxil fumarate.

A. Collier, S. Deeks, I. McGowan, 2001, Journal of acquired immune deficiency syndromes.

Brief Report: Dipyridamole Decreases Gut Mucosal Regulatory T-Cell Frequencies Among People With HIV on Antiretroviral Therapy.

Kaleab Z. Abebe, J. Mellors, S. Riddler, 2020, Journal of acquired immune deficiency syndromes.

Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis

Takahiro Kimura, I. McGowan, P. Anton, 2014, BMC Gastroenterology.

DigitalCommons@UNO DigitalCommons

M. Swanson, J. Garcia, I. McGowan, 2022 .

Author response: Mucosal effects of tenofovir 1% gel

James Y. Dai, Ross D. Cranston, R. Gottardo, 2015 .

Exploring the Feasibility of Multi-Site Flow Cytometric Processing of Gut Associated Lymphoid Tissue with Centralized Data Analysis for Multi-Site Clinical Trials

A. Althouse, I. McGowan, P. Anton, 2015, PloS one.

A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4+ cell distribution in the human rectal mucosa

L. Meyn, N. Matoba, K. Palmer, 2023, Scientific reports.

Chapter 4 – Microbicides

I. McGowan, 2009 .

Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.

D. Bunka, P. Stockley, M. D. Moore, 2011, The Journal of general virology.

Immunological responsiveness of intestinal tissue explants and mucosal mononuclear cells to ex vivo stimulation.

Ross D. Cranston, R. Brand, I. McGowan, 2018, Journal of immunological methods.

HIV and mucosal barrier interactions: consequences for transmission and pathogenesis.

I. McGowan, A. Burgener, N. Klatt, 2015, Current opinion in immunology.

A germ-free humanized mouse model shows the contribution of resident microbiota to human-specific pathogen infection.

M. Hudgens, B. Liao, A. Rogala, 2023, Nature biotechnology.

A Multiple Dose Phase 1 Assessment of Rilpivirine Long-Acting in a Model of Pre-Exposure Prophylaxis against HIV.

Ross D. Cranston, Kaleab Z. Abebe, S. Khoo, 2019, AIDS research and human retroviruses.

RMP-02/MTN-006: A phase 1 rectal safety, acceptability, pharmacokinetic, and pharmacodynamic study of tenofovir 1% gel compared with oral tenofovir disoproxil fumarate.

Ross D. Cranston, A. Carballo-Diéguez, W. Cumberland, 2012, AIDS research and human retroviruses.

Human Semen or Seminal Plasma Does Not Enhance HIV-1BaL Ex Vivo Infection of Human Colonic Explants.

I. McGowan, P. Anton, J. Elliott, 2018, AIDS research and human retroviruses.

Long-acting rilpivirine for HIV prevention

I. McGowan, A. Jackson, 2015, Current opinion in HIV and AIDS.

Long-acting rilpivirine as potential pre-exposure prophylaxis for HIV-1 prevention (the MWRI-01 study): an open-label, phase 1, compartmental, pharmacokinetic and pharmacodynamic assessment.

Ross D. Cranston, Kaleab Z. Abebe, S. Khoo, 2016, The lancet. HIV.

Youth-Specific Considerations in the Development of Preexposure Prophylaxis, Microbicide, and Vaccine Research Trials

L. Bekker, G. Gray, P. Krogstad, 2010, Journal of acquired immune deficiency syndromes.

The Pharmacokinetics, Pharmacodynamics, and Mucosal Responses to Maraviroc-Containing PrEP Regimens in Men who have Sex with Men

Ross D. Cranston, K. Mayer, C. Hendrix, 2019 .