Mark D. Ericson

发表

Metabolically Stabilized Long-Circulating PEGylated Polyacridine Peptide Polyplexes Mediate Hydrodynamically Stimulated Gene Expression in Liver

K. Rice, N. J. Baumhover, S. Khargharia, 2010, Gene Therapy.

Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2018, Journal of medicinal chemistry.

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AGRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists.

I. Pogozheva, Mark D. Ericson, H. Mosberg, 2019, Journal of medicinal chemistry.

Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.

Mark D. Ericson, K. Freeman, Sathya M. Schnell, 2017, Journal of medicinal chemistry.

A Macrocyclic Agouti-Related Protein/[Nle4,DPhe7]α-Melanocyte Stimulating Hormone Chimeric Scaffold Produces Subnanomolar Melanocortin Receptor Ligands.

Mark D. Ericson, K. Freeman, Sathya M. Schnell, 2017, Journal of medicinal chemistry.

A Review of Single-Nucleotide Polymorphisms (SNPs) in Orexigenic Neuropeptides Targeting G-Protein Coupled Receptors (GPCRs)

Mark D. Ericson, C. Haskell-Luevano, 2018 .

Incorporation of Indoylated Phenylalanine Yields a Sub-Micromolar Selective Melanocortin-4 Receptor Antagonist Tetrapeptide

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2022, ACS omega.

Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2021, Journal of medicinal chemistry.

Multiresidue Tetrapeptide Substitutions Yield a 140-fold Selective Melanocortin-3 over Melanocortin-4 Receptor Agonist.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020, ACS medicinal chemistry letters.

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and Efficacy.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2019, ACS medicinal chemistry letters.

Structure–Activity Relationships of the Tetrapeptide Ac-His-Arg-(pI)DPhe-Tic-NH2 at the Mouse Melanocortin Receptors: Modification at the (pI)DPhe Position Leads to mMC3R Versus mMC4R Selective Ligands

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2019, Molecules.

Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2018, ACS chemical neuroscience.

Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.

Mark D. Ericson, M. M. Lunzer, K. Freeman, 2018, ACS chemical neuroscience.

A fragment of the Escherichia coli ClpB heat-shock protein is a micromolar melanocortin 1 receptor agonist.

Mark D. Ericson, K. Freeman, Sathya M. Schnell, 2015, Bioorganic & medicinal chemistry letters.

Peptoid NPhe4 in AGRP-Based c[Pro1-Arg2-Phe3-Phe4-Xxx5-Ala6-Phe7-DPro8] Scaffolds Maintain Mouse MC4R Antagonist Potency.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020, ACS medicinal chemistry letters.

Peptoid NPhe in AGRP-Based c[Pro‐Arg‐Phe‐Phe‐Xxx‐Ala‐Phe‐DPro] Scaffolds Maintain Mouse MC4R Antagonist Potency

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020 .

Human β-Defensin 1 and β-Defensin 3 (Mouse Ortholog mBD14) Function as Full Endogenous Agonists at Select Melanocortin Receptors.

Mark D. Ericson, R. Speth, B. Smeester, 2018, Journal of medicinal chemistry.

PEG length and chemical linkage controls polyacridine peptide DNA polyplex pharmacokinetics, biodistribution, metabolic stability and in vivo gene expression.

K. Rice, N. J. Baumhover, S. Khargharia, 2013, Journal of controlled release : official journal of the Controlled Release Society.

Discovery of Molecular Interactions of the Human Melanocortin-4 Receptor (hMC4R) Asp189 (D189) Amino Acid with the Endogenous G-Protein-Coupled Receptor (GPCR) Antagonist Agouti-Related Protein (AGRP) Provides Insights to AGRP's Inverse Agonist Pharmacology at the hMC4R.

Mark D. Ericson, R. Speth, K. Freeman, 2021, ACS chemical neuroscience.

A novel iterative reducible ligation strategy for the synthesis of homogeneous gene delivery polypeptides

Mark D. Ericson, 2012 .

Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.

Mark D. Ericson, Cody J Lensing, C. Haskell-Luevano, 2017, Biochimica et biophysica acta. Molecular basis of disease.

The melanocortin pathway and energy homeostasis: From discovery to obesity therapy

K. Clément, S. Luquet, G. Yeo, 2021, Molecular metabolism.

Comparative intracerebroventricular (ICV) and intrathecal (IT) administration of a nanomolar macrocyclic melanocortin receptor agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) decreases food intake in mice.

Mark D. Ericson, M. M. Lunzer, C. Haskell-Luevano, 2020, ACS chemical neuroscience.

Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign.

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2021, Journal of medicinal chemistry.

Discovery of a β-Hairpin Octapeptide, c[Pro-Arg-Phe-Phe-Dap-Ala-Phe-DPro], Mimetic of Agouti-Related Protein(87-132) [AGRP(87-132)] with Equipotent Mouse Melanocortin-4 Receptor (mMC4R) Antagonist Pharmacology.

Mark D. Ericson, C. Haskell-Luevano, Z. Xiang, 2015, Journal of medicinal chemistry.

Comparative Functional Alanine Positional Scanning of the α-Melanocyte Stimulating Hormone and NDP-Melanocyte Stimulating Hormone Demonstrates Differential Structure-Activity Relationships at the Mouse Melanocortin Receptors.

Mark D. Ericson, Ryan Palusak, C. Haskell-Luevano, 2016, ACS chemical neuroscience.

A Convergent Synthesis of Homogeneous Reducible Polypeptides.

K. Rice, Mark D. Ericson, 2013, Tetrahedron letters.

A Review of Single-Nucleotide Polymorphisms in Orexigenic Neuropeptides Targeting G Protein-Coupled Receptors.

Mark D. Ericson, C. Haskell-Luevano, 2018, ACS chemical neuroscience.

The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands

Radleigh G. Santos, M. Giulianotti, R. Houghten, 2023, International journal of molecular sciences.

Single Nucleotide Polymorphisms in the Melanocortin His-Phe-Arg-Trp Sequences Decrease Tetrapeptide Potency and E ﬃ cacy

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2020 .

Iterative Reducible Ligation to form Homogeneous Penicillamine Cross-linked Polypeptides.

K. Rice, Mark D. Ericson, 2013, Tetrahedron letters.

Synthesis of homogenous disulfide cross‐linked polypeptides by iterative reducible ligation

K. Rice, Mark D. Ericson, 2012, Biopolymers.

Discovery of a Pan-Melanocortin Receptor Antagonist [Ac-DPhe(pI)-Arg-Nal(2')-Orn-NH2] at the MC1R, MC3R, MC4R, and MC5R that Mediates an Increased Feeding Response in Mice and a 40-Fold Selective MC1R Antagonist [Ac-DPhe(pI)-DArg-Nal(2')-Arg-NH2].

Mark D. Ericson, M. M. Lunzer, K. Freeman, 2023, Journal of medicinal chemistry.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2019, Molecules.

Mark D. Ericson, K. Freeman, C. Haskell-Luevano, 2018, Journal of medicinal chemistry.

Change in surface hardness of enamel by a cola drink and a CPP-ACP paste.

D. Tantbirojn, Mark D. Ericson, A. Huang, 2008, Journal of dentistry.