P. Spear

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Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.

R. Eisenberg, G. Cohen, R. Geraghty, 1998, Science.

Infections with herpes simplex viruses (1).

L. Corey, P. Spear, L. Corey, 1986, The New England journal of medicine.

Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse.

P. Spear, M. D. Dal Canto, E. Rødahl, 2001, Virology.

Search for polymorphisms in the genes for herpesvirus entry mediator, nectin-1, and nectin-2 in immune seronegative individuals.

M. Van Ranst, L. Corey, P. Spear, 2002, The Journal of infectious diseases.

Herpesvirus Entry: an Update

R. Longnecker, P. Spear, Patricia G. Spear, 2003, Journal of Virology.

HveA (Herpesvirus Entry Mediator A), a Coreceptor for Herpes Simplex Virus Entry, also Participates in Virus-Induced Cell Fusion

R. Eisenberg, G. Cohen, J. C. Whitbeck, 1998, Journal of Virology.

Herpes simplex virus glycoprotein D mediates interference with herpes simplex virus infection

P. Spear, R. Johnson, Raymond M. Johnson, 1989, Journal of virology.

Membrane proteins specified by herpes simplex viruses. III. Role of glycoprotein VP7(B2) in virion infectivity

P. Spear, M. Sarmiento, M. Haffey, 1979, Journal of virology.

P. Spear, M. Para, L. Goldstein, 1982, Journal of virology.

Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1.

P. Spear, A. Noble, G. T. Lee, 1983, Virology.

Glycoproteins Specified by Herpes Simplex Viruses

P. Spear, 1985 .

Specificities of monoclonal and polyclonal antibodies that inhibit adsorption of herpes simplex virus to cells and lack of inhibition by potent neutralizing antibodies

A. Fuller, P. Spear, 1985, Journal of virology.

Potent neutralizing activity associated with anti-glycoprotein D specificity among monoclonal antibodies selected for binding to herpes simplex virions

P. Spear, M. Para, A. Noble, 1985, Journal of virology.

A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry

R. Eisenberg, G. Cohen, J. Esko, 1999, Cell.

Herpes simplex virus: receptors and ligands for cell entry

P. Spear, Patricia G Spear, 2004, Cellular microbiology.

PILRα Is a Herpes Simplex Virus-1 Entry Coreceptor That Associates with Glycoprotein B

L. Lanier, Y. Kawaguchi, Shinya Tanaka, 2008, Cell.

Cell surface receptors for herpes simplex virus are heparan sulfate proteoglycans

J. Esko, P. Spear, D. WuDunn, 1992, The Journal of cell biology.

Evaluation of poly(styrene-4-sulfonate) as a preventive agent for conception and sexually transmitted diseases.

G. Doncel, R. Anderson, B. Herold, 2000, Journal of andrology.

Characterization of cysteamine as a potential contraceptive anti-HIV agent.

R. Anderson, P. Spear, L. Zaneveld, 1998, Journal of andrology.

Penetration of cells by herpes simplex virus does not require a low pH-dependent endocytic pathway.

P. Spear, M. Wittels, Michele Wittels, 1991, Virus research.

Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity.

P. Spear, S. Terhune, H. J. Dean, 1994, Virology.

Herpes Simplex Virus-1 Entry into Cells Mediated by a Novel Member of the TNF/NGF Receptor Family

P. Spear, R. Montgomery, M. Warner, 1996, Cell.

Monoclonal Antibodies to Distinct Sites on Herpes Simplex Virus (HSV) Glycoprotein D Block HSV Binding to HVEM

R. Eisenberg, G. Cohen, J. C. Whitbeck, 1998, Journal of Virology.

The First Immunoglobulin-Like Domain of HveC Is Sufficient To Bind Herpes Simplex Virus gD with Full Affinity, While the Third Domain Is Involved in Oligomerization of HveC

R. Eisenberg, G. Cohen, J. C. Whitbeck, 1999, Journal of Virology.

Cellular expression of alphaherpesvirus gD interferes with entry of homologous and heterologous alphaherpesviruses by blocking access to a shared gD receptor.

R. Geraghty, P. Spear, C. R. Jogger, 2000, Virology.

Use of chimeric nectin-1(HveC)-related receptors to demonstrate that ability to bind alphaherpesvirus gD is not necessarily sufficient for viral entry.

R. Eisenberg, G. Cohen, R. Geraghty, 2001, Virology.

Amino Acid Substitutions in the V Domain of Nectin-1 (HveC) That Impair Entry Activity for Herpes Simplex Virus Types 1 and 2 but Not for Pseudorabies Virus or Bovine Herpesvirus 1

P. Spear, W. Martinez, 2002, Journal of Virology.

Disruption of Adherens Junctions Liberates Nectin-1 To Serve as Receptor for Herpes Simplex Virus and Pseudorabies Virus Entry

P. Spear, M. Yoon, Miri Yoon, 2002, Journal of Virology.

Preparation of herpes simplex virus of high titer

B. Roizman, P. Spear, 1968, Journal of virology.

Virus-Induced Cell Fusion

P. Spear, 1987 .

Binding of Herpes Simplex Virus Glycoprotein B (gB) to Paired Immunoglobulin-Like Type 2 Receptor α Depends on Specific Sialylated O-Linked Glycans on gB

L. Lanier, Y. Kawaguchi, P. Spear, 2009, Journal of Virology.

Herpesviruses and heparan sulfate: an intimate relationship in aid of viral entry.

P. Spear, D. Shukla, 2001, The Journal of clinical investigation.

Portable sulphotransferase domain determines sequence specificity of heparan sulphate 3-O-sulphotransferases.

P. Seeberger, R. Rosenberg, P. Spear, 2001, The Biochemical journal.

Location of the glucuronosyltransferase domain in the heparan sulfate copolymerase EXT1 by analysis of Chinese hamster ovary cell mutants.

J. Esko, P. Spear, G. Wei, 2000, The Journal of biological chemistry.

O-linked oligosaccharides are acquired by herpes simplex virus glycoproteins in the Golgi apparatus

David C. Johnson, P. Spear, 1983, Cell.

Mutations in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs Alter Functional Interactions with the Entry/Fusion Receptors HVEM, Nectin-2, and 3-O-Sulfated Heparan Sulfate but Not with Nectin-1

P. Spear, D. Shukla, M. Yoon, 2003, Journal of Virology.

The Murine Homolog (Mph) of Human Herpesvirus Entry Protein B (HveB) Mediates Entry of Pseudorabies Virus but Not Herpes Simplex Virus Types 1 and 2

P. Spear, V. Racaniello, D. Shukla, 1999, Journal of Virology.

Functional Interaction between Herpes Simplex Virus Type 2 gD and HVEM Transiently Dampens Local Chemokine Production after Murine Mucosal Infection

P. Spear, Joann M. Taylor, W. Muller, 2011, PloS one.

Alternative entry receptors for herpes simplex virus and their roles in disease.

C. Ware, J. Miyoshi, K. Pfeffer, 2007, Cell host & microbe.

T Cell Intrinsic Heterodimeric Complexes between HVEM and BTLA Determine Receptivity to the Surrounding Microenvironment1

Matthew G. Macauley, S. Fukuyama, C. Ware, 2009, The Journal of Immunology.

The single base pair substitution responsible for the Syn phenotype of herpes simplex virus type 1, strain MP.

K. Pogue-Geile, P. Spear, Kay L. Pogue-Geile, 1987, Virology.

Cell Surface Receptors Required for Herpes simplex Virus Infection Include Heparan Sulfate Glycosaminoglycans

B. Herold, P. Spear, D. WuDunn, 1992 .

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

E. Scolnick, P. Spear, C. Wei, 1981, Journal of virology.

Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection

G. Leser, P. Spear, T. Martin, 1987, The Journal of cell biology.

INAUGURAL ARTICLES: Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism

P. Spear, M. Yoon, D. Myscofski, 2004 .

Unconventional ligand activation of herpesvirus entry mediator signals cell survival

Matthew G. Macauley, S. Fukuyama, C. Ware, 2009, Proceedings of the National Academy of Sciences.

Biochemistry. Viral glycoproteins and an evolutionary conundrum.

A. Steven, P. Spear, 2006, Science.

Transformation of hamster embryo fibroblasts by a specific fragment of the herpes simplex virus genome

P. Spear, A. Camacho, 1978, Cell.

Alternative entry receptors for herpes simplex virus and their roles in infection and disease

P. Spear, Joann M. Taylor, M. Yoon, 2007 .

Alanine substitution of conserved residues in the cytoplasmic tail of herpes simplex virus gB can enhance or abolish cell fusion activity and viral entry.

P. Spear, Nancy Ruel, A. Zago, 2006, Virology.

Inhibition of Herpes Simplex Virus gD and Lymphotoxin-α Binding to HveA by Peptide Antagonists

John D Lambris, C. Ware, R. Eisenberg, 1999, Journal of Virology.

The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues.

P. Toselli, E. Lamperti, R. Rosenberg, 2007, Matrix biology : journal of the International Society for Matrix Biology.

Macromolecular biosynthesis in animal cells infected with cytolytic viruses.

B. Roizman, P. Spear, 1969, Current topics in developmental biology.

Herpesvirus-induced cell fusion that is dependent on cell surface heparan sulfate or soluble heparin

P. Spear, M. Shieh, 1994, Journal of virology.

Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells

P. Spear, 1976, Journal of virology.

The anti-herpes simplex virus activity of n-docosanol includes inhibition of the viral entry process.

D. Katz, J. Lin, P. Spear, 1998, Antiviral research.

Herpes simplex virus glycoproteins associated with different morphological entities projecting from the virion envelope.

A. Fuller, P. Spear, L. Stannard, 1987, The Journal of general virology.

Cell fusion induced by herpes simplex virus is promoted and suppressed by different viral glycoproteins.

R. Manservigi, P. Spear, A. Buchan, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Molecular basis of the glycoprotein-C-negative phenotype of herpes simplex virus type 1 macroplaque strain

R. Costa, P. Spear, E. Wagner, 1984, Journal of virology.

Inhibition of TCR Signaling by Herpes Simplex Virus1

David C. Johnson, P. Spear, K. Jerome, 2006, The Journal of Immunology.

Different receptors binding to distinct interfaces on herpes simplex virus gD can trigger events leading to cell fusion and viral entry.

P. Spear, M. Yoon, D. Myscofski, 2006, Virology.

Viral interactions with receptors in cell junctions and effects on junctional stability.

P. Spear, 2002, Developmental cell.

Buoyant Density of Herpes Simplex Virus in Solutions of Caesium Chloride

B. Roizman, P. Spear, 1967, Nature.

Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry

P. Spear, W. Martinez, 2001, Journal of Virology.

Some biophysical properties of frog viruses and their DNA.

V. Morris, B. Roizman, P. Spear, 1966, Proceedings of the National Academy of Sciences of the United States of America.

Amino-terminal sequence, synthesis, and membrane insertion of glycoprotein B of herpes simplex virus type 1

P. Spear, L. Claesson-Welsh, 1987, Journal of virology.

Location of the structural genes for glycoproteins gD and gE and for other polypeptides in the S component of herpes simplex virus type 1 DNA

P. Spear, M. Para, G. T. Lee, 1982, Journal of virology.

Factors Governing Expression of the Herpes Simplex Virus Gene for Thymidine Kinase in Clonal Derivatives of Transformed Mouse L Cells

R. Buttyan, P. Spear, 1981, Journal of virology.

Proteins Specified by Herpes Simplex Virus

B. Roizman, P. Spear, J. Keller, 1970 .

Fibroblast growth factor receptor: does it have a role in the binding of herpes simplex virus?

P. Spear, M. Shieh, 1991, Science.

Insertional Mutations in Herpes Simplex Virus Type 1 gL Identify Functional Domains for Association with gH and for Membrane Fusion

P. Spear, Qing Fan, Erick Lin, 2009, Journal of Virology.

Neutralizing antibodies specific for glycoprotein H of herpes simplex virus permit viral attachment to cells but prevent penetration

A. Fuller, P. Spear, R. E. Santos, 1989, Journal of virology.

MATURATION OF THE HUMORAL IMMUNE RESPONSE IN MICE

G. Edelman, P. Spear, 1974, The Journal of experimental medicine.

MATURATION OF THE H UMORAL I MMUNE RESPONSE IN MICE

G. Edelman, P. Spear, 1974 .

Novel rearrangements of herpes simplex virus DNA sequences resulting from duplication of a sequence within the unique region of the L component

K. Pogue-Geile, P. Spear, G. T. Lee, 1985, Journal of virology.

Entry of alphaherpesviruses into cells

P. Spear, 1993 .

Infections with herpes simplex viruses (2).

L. Corey, P. Spear, 1986, The New England journal of medicine.

Three classes of cell surface receptors for alphaherpesvirus entry.

R. Eisenberg, G. Cohen, P. Spear, 2000, Virology.

Infection of neurons and encephalitis after intracranial inoculation of herpes simplex virus requires the entry receptor nectin-1

P. Osten, K. Grünewald, Ulrike E. Maurer, 2009, Proceedings of the National Academy of Sciences.

Differential Effects on Cell Fusion Activity of Mutations in Herpes Simplex Virus 1 Glycoprotein B (gB) Dependent on Whether a gD Receptor or a gB Receptor Is Overexpressed

P. Spear, T. Satoh, H. Arase, 2009, Journal of Virology.

Use of herpes simplex virus and pseudorabies virus chimeric glycoprotein D molecules to identify regions critical for membrane fusion.

P. Spear, C. R. Jogger, A. Zago, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Random mutagenesis of the gene encoding a viral ligand for multiple cell entry receptors to obtain viral mutants altered for receptor usage.

P. Spear, M. Yoon, Miri Yoon, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Effects of linker-insertion mutations in herpes simplex virus 1 gD on glycoprotein-induced fusion with cells expressing HVEM or nectin-1.

P. Spear, R. Montgomery, C. R. Jogger, 2004, Virology.

Differences in the N Termini of Herpes Simplex Virus Type 1 and 2 gDs That Influence Functional Interactions with the Human Entry Receptor Nectin-2 and an Entry Receptor Expressed in Chinese Hamster Ovary Cells

P. Spear, A. Zago, 2003, Journal of Virology.

A first step toward understanding membrane fusion induced by herpes simplex virus.

P. Spear, 2001, Molecular cell.

Contributions of gD receptors and glycosaminoglycan sulfation to cell fusion mediated by herpes simplex virus 1.

R. Geraghty, P. Spear, T. Terry-Allison, 2001, Virus research.

Limited variability of glycoprotein gene sequences and neutralizing targets in herpes simplex virus type 2 isolates and stability on passage in cell culture.

R. Sekulovich, P. Spear, R. Burke, 1998, The Journal of infectious diseases.

Heparan sulfate glycosaminoglycans as primary cell surface receptors for herpes simplex virus.

B. Herold, P. Spear, D. WuDunn, 1992, Advances in experimental medicine and biology.

Anti-glycoprotein D antibodies that permit adsorption but block infection by herpes simplex virus 1 prevent virion-cell fusion at the cell surface.

A. Fuller, P. Spear, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Virus Entry Two Structurally Unrelated Mediators of Protein 1 or Herpesvirus Entry Mediator , Bind to Poliovirus Receptor-Related Herpes Simplex Virus Glycoprotein D Can

R. Eisenberg, G. Cohen, J. Lambris, 1998 .

Partial resistance to gD-mediated interference conferred by mutations affecting herpes simplex virus type 1 gC and gK

P. Spear, P. Pertel, 1997, Journal of virology.

Response from Spear, Montgomery and Warner

P. Spear, R. Montgomery, M. Warner, 1997 .

Immunoglobulin G(Fc)-binding receptors on virions of herpes simplex virus type 1 and transfer of these receptors to the cell surface by infection

P. Spear, M. Para, R. Baucke, 1980, Journal of virology.

Human herpesvirus-8 glycoprotein B interacts with Epstein-Barr virus (EBV) glycoprotein 110 but fails to complement the infectivity of EBV mutants.

R. Longnecker, P. Spear, P. Pertel, 1998, Virology.

Monensin inhibits the processing of herpes simplex virus glycoproteins, their transport to the cell surface, and the egress of virions from infected cells

P. Spear, D. Johnson, David C. Johnson, 1982, Journal of virology.

The proteins specified by herpes simplex virus. I. Time of synthesis, transfer into nuclei, and properties of proteins made in productively infected cells.

B. Roizman, P. Spear, 1968, Virology.

CHEMICAL DISSECTION OF MAMMALIAN SPERMATOZOA

G. Edelman, Walter E. Gall, P. Spear, 1973, The Journal of cell biology.

Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells and in infectivity

B. Herold, P. Spear, D. WuDunn, 1991, Journal of virology.

Initial interaction of herpes simplex virus with cells is binding to heparan sulfate

P. Spear, D. WuDunn, 1989, Journal of virology.

Infections with herpes simplex viruses. (Second of two parts)

L. Corey, P. Spear, 1986 .

A murine CD4-, CD8- T cell receptor-gamma delta T lymphocyte clone specific for herpes simplex virus glycoprotein I.

J. Bluestone, P. Spear, D. Lancki, 1992, Journal of immunology.

Size and Composition of Marek's Disease Virus Deoxyribonucleic Acid

E. Kieff, S. Bachenheimer, B. Roizman, 1971, Journal of virology.

Proteins spcified by herpes simplex virus. II. Viral glycoprotins associated with cellular membranes.

P. Spear, B. Kellejmroian, 1970, Journal of virology.

Herpesvirus Antigens on Cell Membranes Detected by Centrifugation of Membrane-Antibody Complexes

B. Roizman, P. Spear, 1971, Science.

Herpesviruses: Current Information on the Composition and Structure

B. Roizman, P. Spear, 1971 .

Proteins Specified by Herpes Simplex Virus V. Purification and Structural Proteins of the Herpesvirion

B. Roizman, P. Spear, 1972, Journal of virology.

Herpes simplex virus gene expression in transformed cells. I. Regulation of the viral thymidine kinase gene in transformed L cells by products of superinfecting virus

R. Buttyan, J. Leiden, P. Spear, 1976, Journal of virology.

An isoelectric focusing study in herpes simplex virus encephalitis

L. Grimaldi, R. Manservigi, R. Roos, 1988, Annals of neurology.

Proteins specified by herpes simplex virus. 3. Viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins.

B. Roizman, P. Spear, J. Keller, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Membrane proteins specified by herpes simplex viruses. V. Identification of an Fc-binding glycoprotein

P. Spear, G. Spear, Patrícia, 1979, Journal of virology.

Membrane proteins specified by herpes simplex viruses. IV. Conformation of the virion glycoprotein designated VP7(B2)

P. Spear, M. Sarmiento, Patricia G. Spear, 1979, Journal of virology.

Proteins Specified by Herpes Simplex Virus VI. Viral Proteins in the Plasma Membrane

B. Roizman, P. Spear, J. Heine, 1972, Journal of virology.

CHARACTERIZATION OF SPLENIC LYMPHOID CELLS IN FETAL AND NEWBORN MICE

G. Edelman, U. Rutishauser, P. Spear, 1973, The Journal of experimental medicine.

LIGHT, a new member of the TNF superfamily, and lymphotoxin alpha are ligands for herpesvirus entry mediator.

C. Ware, R. Eisenberg, G. Cohen, 1998, Immunity.

Variability, Structural Glycoproteins, and Classification of Herpes Simplex Viruses

B. Roizman, W. Dowdle, P. Spear, 1970, Nature.

Characterization of a herpes simplex virus type 2 75,000-molecular-weight glycoprotein antigenically related to herpes simplex virus type 1 glycoprotein C

P. Spear, K. M. Zezulak, 1983, Journal of virology.

Glycoprotein gE of herpes simplex virus type 1: effects of anti-gE on virion infectivity and on virus-induced fc-binding receptors

P. Spear, M. Para, R. Baucke, 1982, Journal of virology.

Selective failure of protein synthesis in herpesvirus-infected cells deprived of arginine.

B. Roizman, P. Spear, S. B. Spring, 1969, Virology.

Viral and cellular factors that influence cell fusion induced by herpes simplex virus.

P. Spear, G. T. Lee, 1980, Virology.

Alterations in Glycoprotein gB Specified by Mutants and Their Partial Revertants in Herpes Simplex Virus Type 1 and Relationship to Other Mutant Phenotypes

P. Spear, M. Haffey, 1980, Journal of virology.

Oligomerization of herpes simplex virus glycoprotein B

P. Spear, L. Claesson-Welsh, 1986, Journal of virology.

Mapping of the structural gene for the herpes simplex virus type 2 counterpart of herpes simplex virus type 1 glycoprotein C and identification of a type 2 mutant which does not express this glycoprotein

P. Spear, K. M. Zezulak, 1984, Journal of virology.

Use of Monoclonal Antibodies Against Two 75,000-Molecular-Weight Glycoproteins Specified by Herpes Simplex Virus Type 2 in Glycoprotein Identification and Gene Mapping

P. Spear, M. Weinberger, M. Para, 1983, Journal of virology.

Glycoprotein C-independent binding of herpes simplex virus to cells requires cell surface heparan sulphate and glycoprotein B.

B. Herold, P. Spear, C. Brandt, 1994, The Journal of general virology.

Fine mapping of mutations in the fusion-inducing MP strain of herpes simplex virus type 1.

K. Pogue-Geile, P. Spear, G. T. Lee, 1984, Virology.

Kinetics of expression of herpes simplex virus type 1-specific glycoprotein species on the surfaces of infected murine, simian, and human cells: flow cytometric analysis

S. Jennings, P. Spear, S. Tevethia, 1987, Journal of virology.

Insertion mutants of herpes simplex virus have a duplication of the glycoprotein D gene and express two different forms of glycoprotein D

P. Spear, M. Gibson, 1983, Journal of virology.

Glycoprotein D of herpes simplex virus (HSV) binds directly to HVEM, a member of the tumor necrosis factor receptor superfamily and a mediator of HSV entry

W. T. Moore, John D Lambris, R. Eisenberg, 1997, Journal of virology.

Modified entry and syncytium formation by herpes simplex virus type 1 mutants selected for resistance to heparin inhibition.

P. Spear, P. Pertel, 1996, Virology.

Enhanced rate of conversion or recombination of markers within a region of unique sequence in the herpes simplex virus genome

K. Pogue-Geile, P. Spear, 1986, Journal of virology.

Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase

R. Ueda, J. Rhodes, P. Spear, 2004, The Journal of cell biology.

Viral Glycoproteins and an Evolutionary Conundrum

A. Steven, P. Spear, 2006, Science.

MATURATION OF THE HUMORAL IMMUNE RESPONSE IN MICE

G. Edelman, P. Spear, 1974, The Journal of experimental medicine.

Cross-regulation between herpesviruses and the TNF superfamily members

C. Ware, P. Spear, J. Šedý, 2008, Nature Reviews Immunology.

Binding to cells of virosomes containing herpes simplex virus type 1 glycoproteins and evidence for fusion

P. Spear, M. Wittels, D. Johnson, 1984, Journal of virology.

Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway.

C. Benedict, C. Ware, K. Murphy, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Cell fusion induced by herpes simplex virus glycoproteins gB, gD, and gH-gL requires a gD receptor but not necessarily heparan sulfate.

P. Spear, M. Parish, A. Fridberg, 2001, Virology.

The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells

Keith R. Jerome, P. Spear, K. Jerome, 2009, Journal of Virology.

Glycoprotein gB (gII) of pseudorabies virus can functionally substitute for glycoprotein gB in herpes simplex virus type 1

T. Mettenleiter, P. Spear, 1994, Journal of virology.

Unique antigen recognition by a herpesvirus-specific TCR-gamma delta cell.

P. Linsley, J. Bluestone, R. Sciammas, 1994, Journal of immunology.

Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry

John D Lambris, R. Eisenberg, G. Cohen, 1998, Journal of Virology.

Random linker-insertion mutagenesis to identify functional domains of herpes simplex virus type 1 glycoprotein B

P. Spear, Erick Lin, 2007, Proceedings of the National Academy of Sciences.

A Welcome Mat for Leprosy and Lassa Fever

P. Spear, 1998, Science.

Glycoprotein D-Independent Spread of Pseudorabies Virus Infection in Cultured Peripheral Nervous System Neurons in a Compartmented System

L. Enquist, P. Spear, T. H. Ch’ng, 2007, Journal of Virology.

A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.

R. Eisenberg, G. Cohen, J. C. Whitbeck, 1998, Virology.

Glycoproteins specified by herpes simplex virus type 1: their synthesis, processing and antigenic relatedness to HSV -2 glycoproteins.

P. Spear, 1975, IARC scientific publications.

Viral determinants of the variable sensitivity of herpes simplex virus strains to gD-mediated interference

P. Spear, S. Terhune, R. Johnson, 1995, Journal of virology.

Localization of epitopes of herpes simplex virus type 1 glycoprotein D

Eisenberg, D. Long, R. Eisenberg, 1985, Journal of virology.

Limited proteolysis of herpes simplex virus glycoproteins that occurs during their extraction from vero cells

P. Spear, K. M. Zezulak, 1984, Journal of virology.

Evidence forTranslational Regulation ofHerpesSimplex VirusType 1gDExpression

David C. Johnson, P. Spear, 1984 .

The structural proteins and glycoproteins of herpesviruses: a review.

R. Manservigi, P. Spear, M. Sarmiento, 1978, IARC scientific publications.

Proteins specified by herpes simplex virus, IV. Site of glycosylation and accumulation of viral membrane proteins.

B. Roizman, P. Spear, 1970, Proceedings of the National Academy of Sciences of the United States of America.

Herpes simplex virus glycoprotein D is recognized as antigen by CD4+ and CD8+ T lymphocytes from infected mice. Characterization of T cell clones.

P. Spear, D. Lancki, F. Fitch, 1990, Journal of immunology.

12 Herpes Simplex Viruses

B. Roizman, P. Spear, 1980 .

Organization of the rat Tage4 gene and herpesvirus entry activity of the encoded protein.

M. Denis, R. Geraghty, P. Spear, 2001, Gene.

Neomycin inhibits glycoprotein C (gC)-dependent binding of herpes simplex virus type 1 to cells and also inhibits postbinding events in entry.

B. Herold, P. Spear, 1994, Virology.

Comparison of the virion proteins specified by herpes simplex virus types 1 and 2

P. Spear, E. Cassai, M. Sarmiento, 1975, Journal of virology.

Comparison oftheVirion Proteins Specified byHerpes Simplex Virus Types1and2

P. Spear, E. Cassai, M. Sarmiento, 1975 .

Mutations in the N-Terminal Domains of Nectin-1 and Nectin-2 Reveal Differences in Requirements for Entry of Various Alphaherpesviruses and for Nectin-Nectin Interactions

P. Spear, F. Struyf, W. Martinez, 2002, Journal of Virology.

P. Spear, M. D. Dal Canto, D. Shukla, 2000, Journal of Virology.

Cell SurfaceReceptors for Herpes Simplex Virus Are Heparan Sulfate Proteoglycans

J. Esko, P. Spear, R. Montgomery, 2022 .

Evidence for translational regulation of herpes simplex virus type 1 gD expression

P. Spear, D. Johnson, 1984, Journal of virology.

cells: flow cytometric analysis. surfaces of infected murine, simian, and human type 1-specific glycoprotein species on the Kinetics of expression of herpes simplex virus

S. Jennings, P. Spear, L. Pereira, 2014 .

Insertion Mutations in Herpes Simplex Virus 1 Glycoprotein H Reduce Cell Surface Expression, Slow the Rate of Cell Fusion, or Abrogate Functions in Cell Fusion and Viral Entry

R. Longnecker, P. Spear, Erick Lin, 2009, Journal of Virology.

Herpes simplex virus glycoproteins gC-1 and gC-2 bind to the third component of complement and provide protection against complement- mediated neutralization of viral infectivity

J. Atkinson, V. Holers, P. Spear, 1987, The Journal of experimental medicine.

Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides.

D. Bunka, P. Stockley, M. D. Moore, 2011, The Journal of general virology.

An improved procedure for H-3 and C-14 counting in acrylamide gels with a nonaqueous scintillation system.

B. Roizman, P. Spear, 1968, Analytical biochemistry.

Characterization of the DNA of herpesviruses associated with Lucké adenocarcinoma of the frog and Burkitt lymphoma of man.

B. Roizman, P. Spear, E. Wagner, 1970, Virology.

Deletion of the Second Immunoglobulin-Like Domain of Nectin-1 Alters Its Intracellular Processing and Localization and Ability To Mediate Entry of Herpes Simplex Virus

P. Spear, F. Struyf, Aileen E Plate, 2005, Journal of Virology.

The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells

P. Spear, K. Jerome, M. Aubert, 2009, Journal of Virology.

Binding of Herpes Simplex Virus Glycoprotein B (gB) to Paired Immunoglobulin-Like Type 2 Receptor α Depends on Specific Sialylated O-Linked Glycans on gB

L. Lanier, Y. Kawaguchi, P. Spear, 2009, Journal of Virology.

Insertion Mutations in Herpes Simplex Virus 1 Glycoprotein H Reduce Cell Surface Expression, Slow the Rate of Cell Fusion, or Abrogate Functions in Cell Fusion and Viral Entry

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Structural and Antigenic Analysis of a Truncated Form of the Herpes Simplex Virus Glycoprotein gH-gL Complex

John D Lambris, R. Eisenberg, G. Cohen, 1998, Journal of Virology.

The fusion loops and membrane proximal region of Epstein-Barr virus glycoprotein B (gB) can function in the context of herpes simplex virus 1 gB when substituted individually but not in combination.

R. Longnecker, P. Spear, A. Zago, 2013, Virus research.

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Variability of herpes simplex virus 1 gL and anti-gL antibodies that inhibit cell fusion but not viral infectivity.

P. Spear, M. Parish, M. J. Novotny, 1996, Virology.

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Chemical dissection of mammalian spermatozoa.

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