S. de Castro

发表

N-benzyl 4,4-disubstituted piperidines as a potent class of influenza H1N1 virus inhibitors showing a novel mechanism of hemagglutinin fusion peptide interaction.

F. J. Luque, L. Naesens, F. Gago, 2020, European journal of medicinal chemistry.

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.

Jacobson, K. Jacobson, T. K. Harden, 2011, Journal of medicinal chemistry.

First example of peptides targeting the dimer interface of Leishmania infantum trypanothione reductase with potent in vitro antileishmanial activity.

F. Gago, M. Toro, S. de Castro, 2017, European journal of medicinal chemistry.

Peptides Mimicking the β7/β8 Loop of HIV-1 Reverse Transcriptase p51 as "Hotspot-Targeted" Dimerization Inhibitors.

F. Gago, L. Menéndez-Arias, S. de Castro, 2020, ACS medicinal chemistry letters.

TSAO derivatives, inhibitors of HIV-1 reverse transcriptase dimerization: recent progress.

S. de Castro, M. Camarasa, S. Velázquez, 2006, Current pharmaceutical design.

Discovery and SAR studies of a novel class of cytotoxic 1,4-disubstituted piperidines via Ugi reaction.

J. Balzarini, S. de Castro, M. Camarasa, 2014, European journal of medicinal chemistry.

Development of selective agonists and antagonists of P2Y receptors

K. Jacobson, T. K. Harden, S. de Castro, 2008, Purinergic Signalling.

Novel 2- and 4-substituted 1H-imidazo[4,5-c]quinolin-4-amine derivatives as allosteric modulators of the A3 adenosine receptor.

K. Jacobson, A. IJzerman, Zhang-Guo Gao, 2009, Journal of medicinal chemistry.

Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500).

K. Jacobson, T. K. Harden, C. Gachet, 2010, Pharmacological research.

Small Molecule–Peptide Conjugates as Dimerization Inhibitors of Leishmania infantum Trypanothione Disulfide Reductase

F. Gago, S. de Castro, M. Camarasa, 2021, Pharmaceuticals.

Trypanothione reductase inhibition and anti-leishmanial activity of all-hydrocarbon stapled α-helical peptides with improved proteolytic stability.

F. Gago, M. Toro, S. de Castro, 2018, European journal of medicinal chemistry.

Improved proteolytic stability and potent activity against Leishmania infantum trypanothione reductase of α/β-peptide foldamers conjugated to cell-penetrating peptides.

F. Gago, M. Toro, S. de Castro, 2017, European journal of medicinal chemistry.

4-Benzyloxy-gamma-sultone derivatives: discovery of a novel family of non-nucleoside inhibitors of human cytomegalovirus and varicella zoster virus.

J. Balzarini, S. de Castro, M. Camarasa, 2009, Journal of medicinal chemistry.

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme.

I. De Meester, G. Mulder, J. Balzarini, 2013, European journal of medicinal chemistry.

Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.

K. Jacobson, S. van Calenbergh, T. K. Harden, 2008, Bioorganic & medicinal chemistry.

Polypharmacology in HIV inhibition: can a drug with simultaneous action against two relevant targets be an alternative to combination therapy?

S. de Castro, M. Camarasa, S. De Castro, 2018, European journal of medicinal chemistry.

Molecular and structural basis of oligopeptide recognition by the Ami transporter system in pneumococci.

S. de Castro, M. Camarasa, S. Velázquez, 2024, PLoS pathogens.

Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability.

J. Balzarini, S. de Castro, M. Camarasa, 2015, Current medicinal chemistry.

Identification of 1,2,3-triazolium salt-based inhibitors of Leishmania infantum trypanothione disulfide reductase with enhanced antileishmanial potency in cellulo and increased selectivity.

F. Gago, J. Hermoso, S. de Castro, 2022, European journal of medicinal chemistry.

Interrogation of Essentiality in the Reconstructed Haemophilus influenzae Metabolic Network Identifies Lipid Metabolism Antimicrobial Targets: Preclinical Evaluation of a FabH β-Ketoacyl-ACP Synthase Inhibitor

M. Menéndez, S. de Castro, M. Camarasa, 2022, mSystems.

Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.

K. Jacobson, C. Gachet, S. M. Kilbey, 2010, Bioconjugate chemistry.

(F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase

F. Gago, N. Verdaguer, S. de Castro, 2019, Molecules.