S. Hufton

发表

Cross-Reactive and Lineage-Specific Single Domain Antibodies against Influenza B Hemagglutinin

C. Cheung, G. Carnell, N. Temperton, 2019, Antibodies.

A Large Non-immunized Human Fab Fragment Phage Library That Permits Rapid Isolation and Kinetic Analysis of High Affinity Antibodies*

Hennie R. Hoogenboom, Simon E. Hufton, J. Arends, 1999, The Journal of Biological Chemistry.

Construction and diversification of yeast cell surface displayed libraries by yeast mating: application to the affinity maturation of Fab antibody fragments.

A. Wehnert, T. van den Beucken, H. Hoogenboom, 2004, Gene.

E. (2020) Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity. Frontiers in Immunology,

N. Temperton, Yasuhiro Takeuchi, P. Risley, 2022 .

Building novel binding ligands to B7.1 and B7.2 based on human antibody single variable light chain domains.

S E Hufton, J. Desmet, T. van den Beucken, 2001, Journal of molecular biology.

Structure and function of the aromatic amino acid hydroxylases.

R. Cotton, I. Jennings, S. Hufton, 1995, The Biochemical journal.

Structure‐function analysis of the vitamin B12 receptor of Escherichia coli by means of informational suppression

J. Armstrong, R. Ward, S. Hufton, 1995, Molecular microbiology.

Antibody phage display technology and its applications.

H R Hoogenboom, A P de Bruïne, S E Hufton, 1998, Immunotechnology : an international journal of immunological engineering.

Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence

R. Cowan, J. Galson, W. Lee, 2020, bioRxiv.

Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity-determining-region diversity

E. H. Cohen, Robert Charles Ladner, S. Schoonbroodt, 2005, Nature Biotechnology.

A Panel of Candidate Tumor Antigens in Colorectal Cancer Revealed by the Serological Selection of a Phage Displayed cDNA Expression Library1

J. Arends, H. Hoogenboom, S. Hufton, 2002, The Journal of Immunology.

Direct selection of a human antibody fragment directed against the tumor T-cell epitope HLA-A1-MAGE-A1 from a nonimmunized phage-Fab library.

S E Hufton, P. Coulie, S. Hufton, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses

J. Galson, W. Lee, P. Pfeffer, 2021, Frontiers in Immunology.

Target validation for genomics using peptide‐specific phage antibodies: A study of five gene products overexpressed in colorectal cancer

J. Arends, J. V. van Beijnum, H. Hoogenboom, 2002, International journal of cancer.

Maintaining ‘standards’ for biosimilar monoclonal antibodies

M. Wadhwa, S. Hufton, C. Schneider, 2021, Nature Biotechnology.

A profile of differentially expressed genes in primary colorectal cancer using suppression subtractive hybridization

J. Arends, H. Hoogenboom, S. Hufton, 1999, FEBS letters.

Identification and Characterization of ErbB-3-Binding Protein-1 as a Target for Immunotherapy1

T. D. de Gruijl, H. Hoogenboom, E. Hooijberg, 2007, The Journal of Immunology.

Identification and Characterization of ErbB-3-Binding Protein-1 as a Target for Immunotherapy

Rik, H. Hoogenboom, E. Hooijberg, 2007 .

Affinity maturation of Fab antibody fragments by fluorescent‐activated cell sorting of yeast‐displayed libraries

Robert Charles Ladner, T. van den Beucken, H. Hoogenboom, 2003, FEBS letters.

Surrogate CD16‐expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies

M. Wadhwa, R. Thorpe, J. Derrick, 2017, Journal of pharmaceutical and biomedical analysis.

Structure/function analysis of the domains required for the multimerisation of phenylalanine hydroxylase.

R. Cotton, I. Jennings, S. Hufton, 1998, Biochimica et biophysica acta.

Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.

Janet E. Paulsen, S. Hufton, D. Gill, 2009, Journal of molecular biology.

International standards for monoclonal antibodies to support pre- and post-marketing product consistency: Evaluation of a candidate international standard for the bioactivities of rituximab

S. Hufton, B. Fox, A. Bristow, 2017, mAbs.

Cross-Neutralising Nanobodies Bind to a Conserved Pocket in the Hemagglutinin Stem Region Identified Using Yeast Display and Deep Mutational Scanning

T. Gaiotto, S. Hufton, 2016, PloS one.

Broad Reactivity Single Domain Antibodies against Influenza Virus and Their Applications to Vaccine Potency Testing and Immunotherapy

O. Engelhardt, S. Hufton, Y. Takeuchi, 2021, Biomolecules.

The Breadth of Cross Sub-Type Neutralisation Activity of a Single Domain Antibody to Influenza Hemagglutinin Can Be Increased by Antibody Valency

C. Ball, P. Risley, O. Engelhardt, 2014, PloS one.

Nanobodies mapped to cross-reactive and divergent epitopes on A(H7N9) influenza hemagglutinin using yeast display

G. Carnell, W. Ramage, T. Gaiotto, 2021, Scientific Reports.

Protection From Influenza by Intramuscular Gene Vector Delivery of a Broadly Neutralizing Nanobody Does Not Depend on Antibody Dependent Cellular Cytotoxicity

Y. Takeuchi, M. Collins, P. Risley, 2020, Frontiers in Immunology.

Phage display of cDNA repertoires: the pVI display system and its applications for the selection of immunogenic ligands.

J. Arends, H. Hoogenboom, S. Hufton, 1999, Journal of immunological methods.

Serological antigen selection of phage displayed colorectal tumour cDNA libraries.

J. Arends, H. Hoogenboom, S. Hufton, 1998, Biochemical Society transactions.

A Structure-Function Analysis of BtuB, the E.Coli . Vitamin B 12 Outer Membrane Transport Protein

R. Ward, S. Hufton, A. J. Fletcher, 1992 .

Development and application of cytotoxic T lymphocyte‐associated antigen 4 as a protein scaffold for the generation of novel binding ligands

J. Desmet, H. Hoogenboom, S. Hufton, 2000, FEBS letters.

Design and expression of soluble CTLA‐4 variable domain as a scaffold for the display of functional polypeptides

P. Hudson, H. Hoogenboom, S. Hufton, 1999, Proteins.

Dissection of the IgNAR V domain: molecular scanning and orthologue database mining define novel IgNAR hallmarks and affinity maturation mechanisms.

L. Wu, S. Hufton, M. Müller, 2010, Journal of molecular biology.

Antibody C Region Influences TGN1412-like Functional Activity In Vitro

P. Parren, R. Thorpe, C. Ball, 2012, The Journal of Immunology.

Development of an ELISA-Based Potency Assay for Inactivated Influenza Vaccines Using Cross-Reactive Nanobodies

W. Ramage, C. Ball, O. Engelhardt, 2022, Vaccines.