Holly Shelton

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Association of Increased Receptor-Binding Avidity of Influenza A(H9N2) Viruses with Escape from Antibody-Based Immunity and Enhanced Zoonotic Potential

T. Peacock, R. Daniels, J. Sealy, 2019, Emerging infectious diseases.

Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial

Nguyen H. Tran, Kathryn Jones, Tao Dong, 2020, The Lancet.

Defining functional neuraminidase inhibitor drug resistance motifs in avian influenza viruses and the consequential impact on virus fitness in chicken cells

Holly Shelton, D. Bialy, 2019, bioRxiv.

A Single Amino Acid in the HA of pH1N1 2009 Influenza Virus Affects Cell Tropism in Human Airway Epithelium, but Not Transmission in Ferrets

W. Barclay, I. Jones, K. Roberts, 2011, PloS one.

Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines

Holly Shelton, R. L. La Ragione, K. Chrzastek, 2021, Animal microbiome.

Animal Models in Influenza Research.

Holly Shelton, Johanneke Dinie Hemmink, Catherine J. Whittaker, 2018, Methods in molecular biology.

A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses

R. Owens, Isabelle Dietrich, Anthony H Keeble, 2020, Nature Communications.

An influenza reassortant with polymerase of pH1N1 and NS gene of H3N2 influenza A virus is attenuated in vivo

Matthew Smith, W. Barclay, K. Roberts, 2012, The Journal of general virology.

Influenza A virus PB1-F2 protein prolongs viral shedding in chickens lengthening the transmission window

W. Barclay, V. Nair, Holly Shelton, 2016, The Journal of general virology.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

R. Owens, Isabelle Dietrich, Katy Moffat, 2020, npj Vaccines.

Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19

R. Owens, Isabelle Dietrich, Katy Moffat, 2020, npj Vaccines.

A random priming amplification method for whole genome sequencing of SARS-CoV-2 virus

J. Flannery, Chandana Tennakoon, Holly Shelton, 2022, BMC genomics.

Coinfection of Chickens with H9N2 and H7N9 Avian Influenza Viruses Leads to Emergence of Reassortant H9N9 Virus with Increased Fitness for Poultry and a Zoonotic Potential

J. Sealy, Pengxiang Chang, J. Sadeyen, 2022, Journal of virology.

Early apoptosis of porcine alveolar macrophages limits avian influenza virus replication and pro-inflammatory dysregulation

Pengxiang Chang, Holly Shelton, Jinhua Liu, 2015, Scientific Reports.

Variability in H9N2 haemagglutinin receptor-binding preference and the pH of fusion

Stephen R. Martin, T. Peacock, W. Barclay, 2017, Emerging Microbes &Infections.

PA-X is an avian virulence factor in H9N2 avian influenza virus

T. Peacock, P. Digard, J. Sealy, 2020, bioRxiv.

Adjuvant-Free Immunization with Hemagglutinin-Fc Fusion Proteins as an Approach to Influenza Vaccines

C. Colaco, W. Barclay, I. Jones, 2010, Journal of Virology.

Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus

B. Charleston, Holly Shelton, E. Tchilian, 2016, Journal of Immunology.

Avian ANP32B does not support influenza A virus polymerase and influenza A virus relies exclusively on ANP32A in chicken cells

S. Goodbourn, D. Goldhill, H. Sang, 2019, bioRxiv.

Contribution of Segment 3 to the Acquisition of Virulence in Contemporary H9N2 Avian Influenza Viruses

T. Peacock, P. Digard, J. Sealy, 2020, Journal of Virology.

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.

W. Barclay, K. Roberts, Holly Shelton, 2011, The Journal of general virology.

Low pathogenic avian influenza virus infection retards colon microbiota diversification in two different chicken lines

Holly Shelton, R. L. La Ragione, K. Chrzastek, 2021, Animal Microbiome.

A random priming amplification method for whole genome sequencing of SARS-CoV-2 and H1N1 influenza A virus

J. Flannery, Chandana Tennakoon, Holly Shelton, 2021, bioRxiv.

Immune Escape Variants of H9N2 Influenza Viruses Containing Deletions at the Hemagglutinin Receptor Binding Site Retain Fitness In Vivo and Display Enhanced Zoonotic Characteristics

Stephen R. Martin, T. Peacock, W. Barclay, 2017, Journal of Virology.

Co-infection of chickens with H9N2 and H7N9 avian influenza viruses leads to emergence of reassortant H9N9 virus with increased fitness for poultry and enhanced zoonotic potential

J. Sealy, Pengxiang Chang, J. Sadeyen, 2021, bioRxiv.

The Short Stalk Length of Highly Pathogenic Avian Influenza H5N1 Virus Neuraminidase Limits Transmission of Pandemic H1N1 Virus in Ferrets

W. Barclay, K. Roberts, Holly Shelton, 2013, Journal of Virology.

The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells.

S. Goodbourn, W. Barclay, P. Digard, 2019, The Journal of general virology.

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

Isabelle Dietrich, Helena J. Maier, D. Bailey, 2020, bioRxiv.

Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice

Hui Li, B. Cao, C. Johansson, 2018, PLoS pathogens.

Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape

T. Peacock, W. Barclay, Holly Shelton, 2016, Scientific Reports.

Species specific differences in use of ANP32 proteins by influenza A virus

S. Goodbourn, D. Goldhill, H. Sang, 2019, eLife.

Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

W. Barclay, K. Roberts, Holly Shelton, 2013, The Journal of general virology.

A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly

Holly Shelton, Allan G. N. Angus, S. Griffin, 2009, Journal of Virology.

Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction

Mark Harris, Holly Shelton, Holly Shelton, 2008, Virology Journal.

Mutations in H5N1 Influenza Virus Hemagglutinin that Confer Binding to Human Tracheal Airway Epithelium

W. Barclay, I. Jones, J. Ren, 2009, PloS one.

Transmission of a 2009 H1N1 Pandemic Influenza Virus Occurs before Fever Is Detected, in the Ferret Model

W. Barclay, K. Roberts, Holly Shelton, 2012, PloS one.

Receptor Binding Profiles of Avian Influenza Virus Hemagglutinin Subtypes on Human Cells as a Predictor of Pandemic Potential

Ian M. Jones, Wendy S. Barclay, W. Barclay, 2010, Journal of Virology.

Functional neuraminidase inhibitor resistance motifs in avian influenza A(H5Nx) viruses

Holly Shelton, D. Bialy, 2020, Antiviral research.

Further studies on hepatitis C virus NS5A-SH3 domain interactions: identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling.

R. Jackson, N. Burgoyne, Holly Shelton, 2005, The Journal of general virology.

The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells.

S. Goodbourn, W. Barclay, P. Digard, 2019, The Journal of general virology.

Alteration of the Chicken Upper Respiratory Microbiota, Following H9N2 Avian Influenza Virus Infection

Holly Shelton, K. Chrzastek, D. Bialy, 2023, bioRxiv.

Lack of transmission of a human influenza virus with avian receptor specificity between ferrets is not due to decreased virus shedding but rather a lower infectivity in vivo.

W. Barclay, K. Roberts, Holly Shelton, 2011, The Journal of general virology.

Hepatitis C virus NS5A protein binds the SH3 domain of the Fyn tyrosine kinase with high affinity: mutagenic analysis of residues within the SH3 domain that contribute to the interaction

Holly Shelton, M. Harris, 2008, Virology Journal.

Creating resistance to avian influenza infection through genome editing of the ANP32 gene family

Jonathan C. Brown, W. Barclay, Holly Shelton, 2023, Nature communications.