Xuechen Li

发表

A facile synthesis of sialylated oligolactosamine glycans from lactose via the Lafont intermediate

J. Nicholls, Peng Peng, Han Liu, 2014 .

Solution Structure of the LpxC Deacetylase of Lipid A Biosynthesis from Aquifex aeolicus with a Bound Substrate-Analog Inhibitor, TU-514

C. Raetz, Xuechen Li, B. E. Coggins, 2003 .

Ligation Technologies for the Synthesis of Cyclic Peptides.

Xuechen Li, H. Chow, Yue Zhang, 2019, Chemical reviews.

Development of DHQ-based chemical biology probe to profile cellular targets for HBV.

Xuechen Li, H. Chow, Yingjun Zhang, 2020, Bioorganic & medicinal chemistry letters.

Synthetic Pseudaminic-Acid-Based Antibacterial Vaccine Confers Effective Protection against Acinetobacter baumannii Infection

Han Liu, Xuechen Li, Xuemei Yang, 2021, ACS central science.

Chemical Synthesis and Biological Evaluations of Adiponectin Collagenous Domain Glycoforms.

Xuechen Li, Hongxiang Wu, Yiwei Zhang, 2021, Journal of the American Chemical Society.

Amygdalin isolated from Semen Persicae (Tao Ren) extracts induces the expression of follistatin in HepG2 and C2C12 cell lines

Xuechen Li, Chuanbin Yang, J. Rong, 2014, Chinese Medicine.

P-B Desulfurization: An Enabling Method for Protein Chemical Synthesis and Site-Specific Deuteration.

Han Liu, Xuechen Li, H. Chow, 2017, Angewandte Chemie.

Enabling N-to-C Ser/Thr Ligation for Convergent Protein Synthesis via Combining Chemical Ligation Approaches.

Han Liu, Xuechen Li, H. Chow, 2016, Journal of the American Chemical Society.

Serine/threonine ligation for natural cyclic peptide syntheses.

Xuechen Li, C. Lee, H. Lam, 2015, Natural product reports.

Effective synthesis of cyclic peptide yunnanin C and analogues via Ser/Thr ligation (STL)-mediated peptide cyclization

Xuechen Li, Clarence T. T. Wong, H. Lam, 2014 .

Synthesis and antibacterial studies of teixobactin analogues with non-isostere substitution of enduracididine.

Xuechen Li, Sheng Chen, K. Jin, 2018, Bioorganic & medicinal chemistry.

Adding a functional handle to nature's building blocks: the asymmetric synthesis of β-hydroxy-α-amino acids.

Xuechen Li, Yinfeng Zhang, H. Farrants, 2014, Chemistry, an Asian journal.

Ortho-Phthalaldehyde (OPA)-based chemoselective protein bioconjugation and peptide cyclization.

Xuechen Li, Yue Zhang, Qing Zhang, 2020, Methods in enzymology.

A Simple, Rapid and Sensitive FRET Assay for Botulinum Neurotoxin Serotype B Detection

Xuechen Li, Jiubiao Guo, Sheng Chen, 2014, PloS one.

Metal-Free C-B Bond Cleavage: An Acid Catalyzed Three-Component Reaction Construction of Imidazole-Containing Triarylmethanes.

Xuechen Li, H. Cao, Changcheng Wang, 2019, Organic letters.

Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice.

Ling Liu, F. Siu, C. Che, 2013, American journal of translational research.

Chemoselective Peptide Cyclization and Bicyclization Directly on Unprotected Peptides.

Xuechen Li, Yue Zhang, Qing Zhang, 2019, Journal of the American Chemical Society.

15th Chinese International Peptide Symposium

Xuechen Li, Lei Liu, Yanmei Li, 2018, Chinese Chemical Letters.

Mechanistic inferences from the binding of ligands to LpxC, a metal-dependent deacetylase.

C. Fierke, D. Whittington, D. Christianson, 2006, Biochemistry.

Design, synthesis and preliminary biological evaluation of indoline-2,3-dione derivatives as novel HDAC inhibitors.

Xuechen Li, Jian Zhang, Wenfang Xu, 2015, Bioorganic & medicinal chemistry.

Total synthesis of teixobactin

Ebrahim H Ghazvini Zadeh, Xuechen Li, Yu Yuan, 2016, Nature Communications.

A fascinating journey into history: exploration of the world of isonitriles en route to complex amides.

Xuechen Li, S. Danishefsky, Rebecca M. Wilson, 2012, Angewandte Chemie.

An atomic perspective on improving daptomycin's activity.

Xuechen Li, Yongsheng Wu, Pilar Blasco, 2021, Biochimica et biophysica acta. General subjects.

Ligation Embedding Aggregation Disruptor Strategy Enables the Chemical Synthesis of PD-1 Immunoglobulin and Extracellular Domains.

Xuechen Li, Hongxiang Wu, Tongyao Wei, 2022, Journal of the American Chemical Society.

Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de Novo Synthesis of Pseudaminic Acid.

Han Liu, Xuechen Li, Ruohan Wei, 2017, Journal of the American Chemical Society.

Substituent Effects on the Photodeprotection Reactions of Selected Ketoprofen Derivatives in Phosphate Buffered Aqueous Solutions

Han Liu, Xuechen Li, Jinqing Huang, 2016, Scientific Reports.

A fluorogenic probe for recognizing 5-hydroxylysine inspired by serine/threonine ligation.

Xuechen Li, Jianchao Xu, H. Lam, 2014, Chemical communications.

Ser/Thr Ligation for Protein Chemical Synthesis

Xuechen Li, C. Cheung, 2021 .

Cysteine/Penicillamine Ligation Independent of Terminal Steric Demands for Chemical Protein Synthesis

Xuechen Li, Jiamei Liu, Yi Tan, 2020, Angewandte Chemie.

Cysteine/Penicillamine ligation independent of terminal steric demands for protein chemical synthesis.

Xuechen Li, J. Yang, K. Jin, 2020, Angewandte Chemie.

Development of aspartic acid ligation for peptide cyclization derived from serine/threonine ligation

Han Liu, Xuechen Li, Jianchao Xu, 2018, Chinese Chemical Letters.

Development of Thiol-Independent Peptide Ligations for Protein Chemical Synthesis

Xuechen Li, H. Chow, 2015 .

Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification.

Xuechen Li, E. Fung, Clarence T T Wong, 2016, Organic letters.

Synthesis of human growth hormone-releasing hormone via three-fragment serine/threonine ligation (STL).

Xuechen Li, Yinfeng Zhang, Tianlu Li, 2013, Organic & biomolecular chemistry.

Imidazole Type Antifungal Drugs Are Effective Colistin Adjuvants That Resensitize Colistin‐Resistant Enterobacteriaceae

Ye Zhu, Kwok‐yin Wong, Xuechen Li, 2020, Advanced Therapeutics.

Superfast desulfurization for protein chemical synthesis and modification

Han Liu, Xuechen Li, X. Mo, 2022, Chem.

Synthesis of a daptomycin thiolactone analogue via the MeDbz‐linker‐based cyclative‐cleavage approach

Xuechen Li, H. Chow, Kaichao Chen, 2022, Peptide Science.

Realizing serine/threonine ligation: scope and limitations and mechanistic implication thereof

Xuechen Li, Yinfeng Zhang, Tianlu Li, 2014, Front. Chem..

Title Realizing serine / threonine ligation : scope and limitations andmechanistic implication thereof

Xuechen Li, Yinfeng Zhang, Tianlu Li, 2014 .

Thiophene‐2,3‐Dialdehyde Enables Chemoselective Cyclization on Unprotected Peptides, Proteins, and Phage Displayed Peptides

Han Liu, Haiyan Zhou, Xuechen Li, 2022, Small methods.

Synthesis of cyclogentiotriose by macrocyclization via a ring-closing glycosylation

Han Liu, Xuechen Li, 2014 .

A stereoselective ring-closing glycosylation via nonglycosylating pathway.

Han Liu, Xuechen Li, 2014, The Journal of organic chemistry.

Access to sulfonylated furans or imidazo[1,2-a]pyridines via a metal-free three-component, domino reaction

Zhiming Cui, Xuechen Li, H. Cao, 2018 .

Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate

Xuhui Huang, Dong Wang, Xin Gao, 2019, Nature Catalysis.

Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles.

Xuechen Li, S. Danishefsky, Xiangyang Wu, 2009, Tetrahedron letters.

A three-component reaction toward the synthesis of 1-carboxamido-isoindoles.

Han Liu, Xuechen Li, C. Lee, 2012, Organic Letters.

Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages

Xuechen Li, S. Danishefsky, 2008, Nature Protocols.

Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites.

B. Fasching, Xuechen Li, S. Danishefsky, 2009, Journal of the American Chemical Society.

Serine/Threonine Ligation: Origin, Mechanistic Aspects, and Applications.

Han Liu, Xuechen Li, 2018, Accounts of chemical research.

Ag-Catalyzed Tandem Three-Component Reaction toward the Synthesis of Multisubstituted Imidazoles.

Xuechen Li, H. Cao, Changcheng Wang, 2017, The Journal of organic chemistry.

Organocatalytic enantioselective [2 + 4]-annulation of γ-substituted allenoates with N-acyldiazenes for the synthesis of optically active 1,3,4-oxadiazines.

Xuechen Li, Xiaoyong Chang, Pengfei Li, 2021, Organic & biomolecular chemistry.

New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types.

Xuechen Li, S. Danishefsky, 2008, Journal of the American Chemical Society.

One-Pot Regiospecific Synthesis of Indolizines: A Solvent-Free, Metal-Free, Three-Component Reaction of 2-(Pyridin-2-yl)acetates, Ynals, and Alcohols or Thiols.

Xuechen Li, H. Cao, Yue Yu, 2018, Organic letters.

A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson's Reagent.

Xuechen Li, S. Danishefsky, P. Nagorny, 2009, Tetrahedron letters.

Salicylaldehyde ester-induced chemoselective peptide ligations: enabling generation of natural peptidic linkages at the serine/threonine sites.

Xuechen Li, Yinfeng Zhang, H. Lam, 2010, Organic letters.

Convergent Synthesis of Calcium-Dependent Antibiotic CDA3a and Analogues with Improved Antibacterial Activity via Late-Stage Serine Ligation.

Xuechen Li, Pilar Blasco, K. H. L. Po, 2020, Organic letters.

Establishing the Structure-Activity Relationship of Daptomycin.

Xuechen Li, H. Chow, X. Ye, 2020, ACS medicinal chemistry letters.

Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under mild conditions.

Xuechen Li, S. Danishefsky, Xiangyang Wu, 2009, Tetrahedron letters.

Studies on the sialylation of galactoses with different C-5 modified sialyl donors.

J. Nicholls, Han Liu, J. Gong, 2012, Carbohydrate research.

Advances in Native Chemical Ligation-Desulfurization: A Powerful Strategy for Peptide and Protein Synthesis.

Xuechen Li, K. Jin, 2018, Chemistry.

Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis.

C. Raetz, Xuechen Li, T. Uchiyama, 2003, Organic letters.

Synthesis of constrained head-to-tail cyclic tetrapeptides by an imine-induced ring-closing/contraction strategy.

Xuechen Li, T. Song, H. Lam, 2013, Angewandte Chemie.

Click to join peptides/proteins together.

Xuechen Li, 2011, Chemistry, an Asian journal.

The total synthesis of moenomycin A.

D. Kahne, Xuechen Li, Wenjiang Zhu, 2006, Journal of the American Chemical Society.

Peptide 2-formylthiophenol esters do not proceed through a Ser/Thr ligation pathway, but participate in a peptide aminolysis to enable peptide condensation and cyclization.

Xuechen Li, Clarence T T Wong, C. Tung, 2015, Organic & biomolecular chemistry.

Protein chemical synthesis by serine and threonine ligation

Xuechen Li, Yinfeng Zhang, C. Lee, 2013, Proceedings of the National Academy of Sciences.

Chemical Protein Synthesis: Advances, Challenges, and Outlooks.

Xuechen Li, Hongxiang Wu, Tongyao Wei, 2020, Journal of the American Chemical Society.

Protocol for semisynthesis of serotonylated histone H3 by rapid protein desulfurization in tandem with native chemical ligation

Xuechen Li, Yihui Cao, Tongyao Wei, 2023, STAR protocols.

Development of Serine/Threonine Ligation and its Applications

Xuechen Li, Tianlu Li, 2017 .

Serine/threonine ligation for the chemical synthesis of proteins.

Xuechen Li, C. Lee, 2014, Current opinion in chemical biology.

Development and application of serine/threonine ligation for synthetic protein chemistry.

Han Liu, Xuechen Li, 2014, Organic & biomolecular chemistry.

Structure of the LpxC deacetylase with a bound substrate-analog inhibitor

Brian E. Coggins, C. Raetz, Xuechen Li, 2003, Nature Structural Biology.

Establishing the structure-activity relationship of teixobactin

Xuechen Li, Eilidh Matheson, K. Jin, 2019, Chinese Chemical Letters.

Effective synthesis of kynurenine-containing peptides via on-resin ozonolysis of tryptophan residues: synthesis of cyclomontanin B.

Xuechen Li, H. Lam, Clarence T T Wong, 2013, Organic & biomolecular chemistry.

Synthesis and structure-activity relationship of teixobactin analogues via convergent Ser ligation.

Xuechen Li, Sheng Chen, K. Jin, 2017, Bioorganic & medicinal chemistry.

Total synthesis of daptomycin by cyclization via a chemoselective serine ligation.

Han Liu, Xuechen Li, Yinfeng Zhang, 2013, Journal of the American Chemical Society.

Studies on daptomycin lactam‐based analogues

Xuechen Li, H. Chow, K. H. L. Po, 2022, Journal of peptide science : an official publication of the European Peptide Society.

Thioglycosylation of 1,2-cis-glycosyl acetates: a long-standing overlooked issue in preparative carbohydrate chemistry.

Han Liu, Xuechen Li, Ci Xu, 2011, Carbohydrate research.

A Solution to Chemical Pseudaminylation via Development of a Bimodal Glycosyl Donor to Enable Highly Stereocontrolled α- and β-Glycosylation

R. Payne, Han Liu, Xuechen Li, 2019 .

Total Synthesis of Mannopeptimycin β via β-Hydroxyenduracididine Ligation.

Han Liu, Xuechen Li, M. Liu, 2021, Journal of the American Chemical Society.

A Solution to Chemical Pseudaminylation via a Bimodal Glycosyl Donor for Highly Stereocontrolled α- and β-Glycosylation.

R. Payne, Han Liu, Xuechen Li, 2019, Organic letters.

De novo synthesis of novel bacterial monosaccharide fusaminic acid

Han Liu, Han Liu, Xuechen Li, 2019, The Journal of Antibiotics.

Metabolic Labeling of Pseudaminic Acid-Containing Glycans on Bacterial Surfaces.

H. Cao, A. Yan, Han Liu, 2018, ACS chemical biology.

Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds.

Xuechen Li, S. Danishefsky, Y. Rao, 2009, Journal of the American Chemical Society.

Time-Resolved Spectroscopic Observation of Diphenylnitrenium Ion Reactions with Guanosine.

Wenjian Tang, Xuechen Li, D. Phillips, 2020, The Journal of organic chemistry.

Phosphorylation-regulated HMGA1a-P53 interaction unveils the function of HMGA1a acidic tail phosphorylations via synthetic proteins.

Xuechen Li, T. Wei, Pilar Blasco, 2021, Cell chemical biology.

Chemical Synthesis of HMGA1a Proteins with Post-translational Modifications via Ser/Thr Ligation.

Xuechen Li, Tianlu Li, Heng Liu, 2016, Organic letters.

A journey to the total synthesis of daptomycin.

Xuechen Li, H. Lam, Rannveig Ingebrigtsen Gaarden, 2014, Chemical record.

Salicylaldehyde ester-mediated protein semi-synthesis enables studies on the tetra-acetylation of HMGB1

Xuechen Li, Jinzheng Wang, Ruohan Wei, 2021 .

Studies on 2‐Formylphenylboronic Acid‐Based Ser/Thr Ligation and Cys/Pen Ligation †

Xuechen Li, Zhenquan Sun, 2021, Chinese Journal of Chemistry.

Use of Serine/Threonine Ligation for the Total Chemical Synthesis of HMGA1a Protein with Site-Specific Lysine Acetylations.

Han Liu, Xuechen Li, Heng Liu, 2019, ChemPlusChem.

Photoconversion of β-Lapachone to α-Lapachone via a Protonation-Assisted Singlet Excited State Pathway in Aqueous Solution: A Time-Resolved Spectroscopic Study.

Xuechen Li, J. Xue, Ruixue Zhu, 2015, The Journal of organic chemistry.

Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction

G. Zhu, Xuechen Li, Changdong Liu, 2015, Journal of peptide science : an official publication of the European Peptide Society.

Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins

Han Liu, Xuechen Li, Qiu-Chen Chen, 2023, Exploration of Drug Science.

Refined solution structure of the LpxC-TU-514 complex and pKa analysis of an active site histidine: insights into the mechanism and inhibitor design.

J. Rudolph, C. Raetz, Xuechen Li, 2005, Biochemistry.

Lipoteichoic acid from an Enterococcus faecalis clinical strain promotes TNF-α expression through the NF-κB and p38 MAPK signaling pathways in differentiated THP-1 macrophages.

C. Seneviratne, Xuechen Li, Lijian Jin, 2015, Biomedical reports.

Synthesis of protected sugar-amino acid hybrid molecules as platform for further derivatization

Han Liu, Xuechen Li, 2012 .

Phototriggered release of a leaving group in Ketoprofen derivatives via a benzylic carbanion pathway, but not via a biradical pathway.

Han Liu, Xuechen Li, Jiani Ma, 2013, Chemistry.

Serine/threonine ligation-assisted chemical synthesis of HMGA1a protein with site-specific post-translational modifications

Xuechen Li, Hongxiang Wu, Tongyao Wei, 2021, STAR Protocols.

OPA-based bifunctional linker for protein labeling and profiling.

Xuechen Li, H. Chow, Yue Zhang, 2020, Biochemistry.

Synthetic cysteine surrogates used in native chemical ligation.

Xuechen Li, Clarence T T Wong, C. Tung, 2013, Molecular bioSystems.

Peptide Stapling through Site-Directed Conjugation of Triazine Moieties to the Tyrosine Residues of a Peptide.

Tao Jiang, Xuechen Li, Yue Zhang, 2023, Organic Letters.

Total Synthesis and Structural Establishment/Revision of Antibiotics A54145.

Xuechen Li, M. Liu, Sheng Chen, 2019, Organic letters.

Total synthesis and a systematic structure-activity relationship study of WAP-8294A2.

Xuechen Li, K. H. L. Po, Sheng Chen, 2020, Bioorganic & medicinal chemistry.

Methylation of Daptomycin Leading to the Discovery of Kynomycin, a Cyclic Lipodepsipeptide Active Against Resistant Pathogens.

Xuefu You, Xuechen Li, Congran Li, 2020, Journal of medicinal chemistry.

Structure-activity relationship of daptomycin analogues with substitution at (2S, 3R) 3-methyl glutamic acid position.

Xuechen Li, Bhaumik A. Pandya, H. Lam, 2017, Bioorganic & medicinal chemistry letters.

Improved total synthesis of the antibiotic A54145B.

Xuechen Li, H. Chow, Delin Chen, 2020, Organic & biomolecular chemistry.

Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides.

Xuechen Li, S. Danishefsky, Xiangyang Wu, 2011, Journal of the American Chemical Society.

Click to Join Peptides/Proteins Together

Xuechen Li, 2012 .

Triazine-pyridine chemistry for protein labelling on tyrosine.

Xuechen Li, Zheng Zhong, Pilar Blasco, 2022, Chemical Communications.

Construction of diverse peptide structural architectures via chemoselective peptide ligation†

Xuhui Huang, D. Bierer, Xuechen Li, 2021, Chemical science.

Site-Selective Lysine Reactions Guided by Protein-Peptide Interaction.

Xuechen Li, Jiang Xia, F. Huang, 2019, Biochemistry.

Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain

Xuhui Huang, Mingjie Zhang, Siqin Cao, 2021, RSC chemical biology.

Daptomycin exerts bactericidal effect through induction of excessive ROS production and blocking the function of stress response protein Usp2

Xuechen Li, Xin Deng, E. Chan, 2021, Natural Sciences.

Chemical Synthesis of Proteins with Base-labile Posttranslational Modifications Enabled by a Boc-SPPS Based General Strategy Towards Peptide C-terminal Salicylaldehyde Esters.

Han Liu, Xuechen Li, Hongxiang Wu, 2022, Angewandte Chemie.

Convergent synthesis of MUC1 glycopeptides via serine ligation.

Xuechen Li, Yinfeng Zhang, H. Lam, 2013, Chemical communications.

Revealing the function of HMGB1 N-terminal acetylation by a protein semi-synthesis approach

Xuechen Li, Hongxiang Wu, Jinzheng Wang, 2021, bioRxiv.

Glycopeptide/Glycoprotein Synthesis

Xuechen Li, Ci Xu, 2015 .

Revealing the extracellular function of HMGB1 N-terminal region acetylation assisted by a protein semi-synthesis approach

Xuechen Li, Ruohan Wei, Tongyao Wei, 2023, Chemical science.

Chemical synthesis of glycoproteins

Xuechen Li, C. Lee, 2016, Science China Chemistry.

Rational Design of Reversible Redox Shuttle for Highly Efficient Light-Driven Microswimmer.

S. Feng, Xuechen Li, Jinyao Tang, 2020, ACS nano.

The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms.

K N Houk, Xuechen Li, Gavin O Jones, 2008, Organic letters.

Total Synthesis of Pseudomonas aeruginosa 1244 Pilin Glycan via de Novo Synthesis of Pseudaminic Acid.

Han Liu, Xuechen Li, Ruohan Wei, 2017, Journal of the American Chemical Society.