P. Thompson

发表

A gel-capture assay for characterizing the sialyl-glycan selectivity of influenza viruses.

O. El-Kabbani, S. Rockman, J. Stambas, 2011, Acta virologica.

Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors.

R. Johnstone, I. Jennings, P. Thompson, 2020, European journal of medicinal chemistry.

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

J. Whisstock, J. Irving, A. Buckle, 2009, Proceedings of the National Academy of Sciences.

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, Australian journal of chemistry.

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A

R. Nation, T. Velkov, Abigail Clements, 2013, Innate immunity.

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.

R. Norton, R. Anders, S. McGowan, 2016, Journal of molecular biology.

Heterodimeric analogues of the potent Y1R antagonist 1229U91, lacking one of the pharmacophoric C-terminal structures, retain potent Y1R affinity and show improved selectivity over Y4R.

N. Holliday, S. Briddon, P. Thompson, 2020, Journal of medicinal chemistry.

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase.

J. Baell, R. Norton, P. Thompson, 2016, Journal of medicinal chemistry.

Regioselection in the synthesis of 4-benzyltetral-1-ones and the new 4-arylbenzosuber-1-ones

P. Thompson, Daniel Truong, B. L. Howard, 2021 .

Structural Determinants of Isoform Selectivity in PI3K Inhibitors

Michelle S. Miller, S. Gabelli, P. Thompson, 2019, Biomolecules.

Thiazolidinedione-Based PI3Kα Inhibitors: An Analysis of Biochemical and Virtual Screening Methods

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2011, ChemMedChem.

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

P. Sexton, A. Christopoulos, C. Reynolds, 2016, Cell.

PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues.

P. Thompson, Belinda M. Abbott, 2004, Bioorganic & medicinal chemistry letters.

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2008, The Biochemical journal.

Identification and development of specific inhibitors for insulin‐regulated aminopeptidase as a new class of cognitive enhancers

M. Parker, J. Holien, P. Thompson, 2011, British journal of pharmacology.

A Novel Serpin Regulatory Mechanism

P. Bird, P. Thompson, D. Kaiserman, 2015, The Journal of Biological Chemistry.

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

C. Gachet, I. Jennings, P. Thompson, 2020, Science Translational Medicine.

Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein.

R. Nation, T. Velkov, Jian Li, 2012, Biochemical pharmacology.

Comparison of the binding of α‐helical and β‐sheet peptides to a hydrophobic surface

R. Houghten, S. Blondelle, M. Aguilar, 2009 .

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

Michael W Parker, David B Ascher, M. Parker, 2008, BMC Neuroscience.

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

Jesmin Akter, J. Li, R. Nation, 2013, The Journal of Antibiotics.

Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401.

C. Galea, T. Velkov, P. Thompson, 2017, Journal of natural products.

Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes.

T. Velkov, E. Schneider, M. Baker, 2017, ACS infectious diseases.

IRAP Inhibitors: M1-Aminopeptidase Family Inspiration

P. Thompson, N. Barlow, 2020, Frontiers in Pharmacology.

Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP).

J. Åqvist, H. Gutiérrez‐de‐Terán, A. Hallberg, 2020, RSC medicinal chemistry.

Cyclic Hexapeptide Mimics of the LEDGF Integrase Recognition Loop in Complex with HIV‐1 Integrase

M. Parker, J. Wielens, P. Thompson, 2018, ChemMedChem.

An apically located hybrid guanylate cyclase–ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

Christopher J. Tonkin, M. McConville, P. Thompson, 2019, The Journal of Biological Chemistry.

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition.

R. Johnstone, I. Jennings, P. Thompson, 2019, Bioorganic & medicinal chemistry.

Use of Kv1.3 blockers for inflammatory skin conditions.

D. Manallack, P. White, H. Wulff, 2010, Current medicinal chemistry.

The effects of exosite occupancy on the substrate specificity of thrombin.

P. Bird, P. Thompson, R. Pike, 2009, Archives of biochemistry and biophysics.

Imidazolidin-4-ones: Their Syntheses and Applications

P. Thompson, T. Blackmore, 2011 .

Quantitative structure-activity relationships of (+)-anatoxin-a derivatives

D. Manallack, D. Livingstone, P. Thompson, 1994 .

History, Chemistry and Antibacterial Spectrum.

Phillip J. Bergen, T. Velkov, P. Thompson, 2019, Advances in experimental medicine and biology.

Antibodies to the ganglioside GD1b in a patient with motor neuron disease and thyroid adenoma.

M. Shy, P. Fishman, P. Thompson, 1991, Archives of neurology.

Polymyxins: a new hope in combating Gram-negative superbugs?

J. Li, T. Velkov, P. Thompson, 2016, Future medicinal chemistry.

Analysis of anti-PDE3 activity of 2-morpholinochromone derivatives reveals multiple mechanisms of anti-platelet activity.

P. Thompson, Belinda M. Abbott, 2006, Bioorganic & medicinal chemistry letters.

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

P. Thompson, S. Jackson, S. Schoenwaelder, 2002, The Journal of biological chemistry.

Synthesis of α-aminosuccinimide-containing peptides in Fmoc-based SPPS

M. Hearn, P. Thompson, V. Cavallaro, 1995, Letters in Peptide Science.

Definition of the binding mode of a new class of phosphoinositide 3-kinase α-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, The Biochemical journal.

Pharmacology of polymyxins: new insights into an 'old' class of antibiotics.

R. Nation, T. Velkov, Jian Li, 2013, Future microbiology.

Identification of a Cyanine-Dye Labeled Peptidic Ligand for Y1R and Y4R, Based upon the Neuropeptide Y C-Terminal Analogue, BVD-15.

Lei Zhang, H. Herzog, N. Holliday, 2016, Bioconjugate chemistry.

An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

A. Mitchell, I. Marusic, A. Ooi, 2022, BMC Biology.

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions.

I. Larson, R. Nation, T. Velkov, 2011, Analytical biochemistry.

Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe.

J. Li, R. Nation, T. Velkov, 2016, Journal of pharmaceutical sciences.

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent.

R. Norton, R. Law, P. Thompson, 2018, ACS chemical biology.

Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation.

M. Hearn, M. Aguilar, P. Thompson, 1998, Bioorganic & medicinal chemistry letters.

Conformational stability of a type II' beta-turn motif in human growth hormone [6-13] peptide analogues at hydrophobic surfaces.

M. Hearn, M. Aguilar, P. Thompson, 2009, The journal of peptide research : official journal of the American Peptide Society.

Teaching ‘Old’ Polymyxins New Tricks: New-Generation Lipopeptides Targeting Gram-Negative ‘Superbugs’

J. Li, R. Nation, T. Velkov, 2014, ACS chemical biology.

Hypoglycaemic activity of an analogue of human growth hormone [6-13] incorporating a D-Ala-Pro dipeptide unit

M. Hearn, P. Thompson, F. Ng, 1993 .

L-Aminoacyl-triazine derivatives are isoform-selective PI3Kβ inhibitors that target non-conserved Asp862 of PI3Kβ

Michelle S. Miller, I. Jennings, P. Thompson, 2013, ACS medicinal chemistry letters.

Isoform-Selective Inhibition of Phosphoinositide 3-Kinase: Identification of a New Region of Nonconserved Amino Acids Critical for p110α Inhibition

I. Jennings, P. Thompson, S. Amran, 2011, Molecular Pharmacology.

Membrane Permeating Macrocycles: Design Guidelines from Machine Learning

T. Le, R. Norton, P. Thompson, 2022, J. Chem. Inf. Model..

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

David M. Shackleford, I. Jennings, P. Thompson, 2016, European journal of medicinal chemistry.

Synthesis and biological evaluation of 4H-benzo[e][1,3]oxazin-4-ones analogues of TGX-221 as inhibitors of PI3Kβ.

J. Al-Rawi, I. Jennings, P. Thompson, 2022, Bioorganic & medicinal chemistry.

Class II but Not Second Class-Prospects for the Development of Class II PI3K Inhibitors.

I. Jennings, P. Thompson, S. Mountford, 2015, ACS medicinal chemistry letters.

Mechanisms of PI3Kβ-selective inhibition revealed by reciprocal mutagenesis.

Michelle S. Miller, I. Jennings, P. Thompson, 2013, ACS chemical biology.

PI 3-kinase p110beta: a new target for antithrombotic therapy.

A. Robertson, P. Shepherd, P. Thompson, 2005, Nature medicine.

Potent Inhibitors of Phosphatidylinositol 3 (PI3) Kinase that have Antiproliferative Activity Only When Delivered as Prodrug Forms

I. Jennings, P. Thompson, S. Amran, 2013, ChemMedChem.

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging.

Lei Zhang, H. Herzog, N. Holliday, 2014, Organic & biomolecular chemistry.

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ.

Michelle S. Miller, I. Jennings, P. Thompson, 2016, Bioorganic & medicinal chemistry letters.

Beta amino acid‐modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

S. Moriya, P. Thompson, D. Chalmers, 2016, Journal of peptide science : an official publication of the European Peptide Society.

Structural modification of anatoxin-a. Synthesis of model affinity ligands for the nicotinic acetylcholine receptor

S. Wonnacott, P. Thompson, T. Gallagher, 1991 .

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase.

Michael W Parker, Jessica K Holien, M. Parker, 2014, Journal of medicinal chemistry.

Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

M. Parker, C. Morton, J. Holien, 2010, Molecular Pharmacology.

The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases.

David T Manallack, D. Manallack, P. Thompson, 2005, Journal of medicinal chemistry.

Natural product peptidomimetics

C. Barrow, P. Thompson, 1997 .

(S)-(−)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines

D. Manallack, P. Thompson, D. Chalmers, 2019, Tetrahedron.

The Phytosulfokine (PSK) Receptor Is Capable of Guanylate Cyclase Activity and Enabling Cyclic GMP-dependent Signaling in Plants*

Chris Gehring, P. Thompson, C. Gehring, 2011, The Journal of Biological Chemistry.

(+)-Fluorenylethylchloroformate (FLEC)--improved synthesis for application in chiral analysis and peptidomimetic synthesis.

P. Thompson, D. Chalmers, M. Camerino, 2013, Organic & biomolecular chemistry.

Conformational analysis of human growth hormone [6-13] peptide analogues.

M. Hearn, P. Thompson, K. A. Higgins, 2009, International journal of peptide and protein research.

Solid phase synthesis of cyclic peptides: model studies involving i−(i+4) side chain‐to‐side chain cyclisation

M. Hearn, P. Thompson, V. Cavallaro, 1998 .

Solid‐phase synthesis of cyclic analogues related to the hypoglycaemic peptide hGH[6–13]: Comparison of two i→i+4 lactam cyclization procedures

P. Thompson, M. Hearn, V. Cavallaro, 2001, Journal of peptide science : an official publication of the European Peptide Society.

Synthesis of peptide amides using Fmoc-based solid-phase procedures on 4-methylbenzhydrylamine resins.

M. Hearn, P. Thompson, P. Stanton, 2009, International journal of peptide and protein research.

Structure and in vivo activity of hypoglycaemic analogues of human growth hormone (6-13).

M. Hearn, N. Ede, P. Thompson, 1995, Drug design and discovery.

Carbohydrate-mimetic peptides: structural aspects of mimicry and therapeutic implications

P. Thompson, M. Sandrin, P. Ramsland, 2011, Expert opinion on biological therapy.

Aqueous extracts of Urtica dioica (stinging nettle) leaf contain a P2-purinoceptor antagonist—Implications for male fertility

P. Thompson, J. Simpson, S. Ventura, 2022, PloS one.

Structure--activity relationships of polymyxin antibiotics.

Jian Li, Tony Velkov, R. Nation, 2010, Journal of medicinal chemistry.

Importance of the P4′ Residue in Human Granzyme B Inhibitors and Substrates Revealed by Scanning Mutagenesis of the Proteinase Inhibitor 9 Reactive Center Loop*

J. Whisstock, P. Bird, P. Thompson, 2001, The Journal of Biological Chemistry.

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria.

J. Li, R. Nation, T. Velkov, 2015, ACS infectious diseases.

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

Matthew D. Johnson, J. Li, R. Nation, 2016, mSphere.

Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate.

R. Norton, P. Thompson, C. Nowell, 2022, Bioorganic chemistry.

Use of synthetic peptides to delineate discontinuous sequence regions involved in epitope sites of the thyrotropin β-subunit

J. Whisstock, M. Hearn, P. Thompson, 2006, Letters in Peptide Science.

Characterization of epitope regions of thyrotropin beta-subunit recognized by the monoclonal antibodies mAb279 and mAb299: a chimeric peptide approach.

J. Whisstock, M. Hearn, P. Thompson, 2008, The journal of peptide research : official journal of the American Peptide Society.

Re-discovering PDE3 inhibitors--new opportunities for a long neglected target.

E. Degerman, V. Manganiello, P. Thompson, 2007, Current topics in medicinal chemistry.

A reversed-phase HPLC-based method for the assay of cyclic nucleotide phosphodiesterase activity.

P. Thompson, Belinda M. Abbott, 2005, Analytical biochemistry.

Class II Phosphoinositide 3-Kinases as Novel Drug Targets.

M. Falasca, P. Thompson, A. Adamska, 2017, Journal of medicinal chemistry.

Inflammatory twins from PI3K gang brought to justice?

I. Jennings, P. Thompson, J. Pinson, 2010, Chemistry & biology.

The major human and mouse granzymes are structurally and functionally divergent

James C. Whisstock, Philip E. Thompson, Dion Kaiserman, 2006, The Journal of cell biology.

Preparation of morpholinyl and pyridinyl substituted heterobicyclic ketones as selective inhibitors of phosphoinositide 3-kinase beta for use against thrombosis

A. Robertson, P. Thompson, S. Jackson, 2004 .

Structural basis of nSH2 regulation and lipid binding in PI3Kα

L. Mario Amzel, Philip E. Thompson, Bert Vogelstein, 2014, Oncotarget.

Structural basis of nSH 2 regulation and lipid binding in PI 3 Kα

Michelle S. Miller, K. Kinzler, B. Vogelstein, 2014 .

Identification of potent phosphodiesterase inhibitors that demonstrate cyclic nucleotide-dependent functions in apicomplexan parasites.

Christopher J. Tonkin, D. Manallack, P. Gilson, 2015, ACS chemical biology.

RhoA Sustains Integrin αIIbβ3Adhesion Contacts under High Shear*

P. Thompson, S. Jackson, S. Schoenwaelder, 2002, The Journal of Biological Chemistry.

A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin-2 Receptor-Positive Cancer.

R. Hicks, P. Thompson, C. Ang, 2021, Journal of medicinal chemistry.

The drug vehicle and solvent N-methylpyrrolidone is an immunomodulator and antimyeloma compound.

P. L. Bergsagel, M. Doyle, W. Denny, 2014, Cell reports.

Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells.

J. Li, Lushan Wang, Jingliang Li, 2020, ACS infectious diseases.

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes.

R. Nation, O. Dolezal, T. Velkov, 2016, ACS infectious diseases.

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

J. Li, R. Nation, T. Velkov, 2015, Antimicrobial Agents and Chemotherapy.

Is There an Interplay Between the Functional Domains of IRAP?

P. Thompson, S. Chai, T. Gaspari, 2020, Frontiers in Cell and Developmental Biology.

Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase.

C. Galea, J. Li, T. Velkov, 2017, Biochemistry.

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.

J. Li, R. Nation, T. Velkov, 2017, Journal of natural products.

Molecular Mechanisms of Cereblon-Interacting Small Molecules in Multiple Myeloma Therapy

P. Thompson, J. Shortt, M. Costacurta, 2021, Journal of personalized medicine.

PI 3-kinase p110β: a new target for antithrombotic therapy

A. Robertson, P. Shepherd, P. Thompson, 2005, Nature Medicine.

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent.

R. Norton, C. Galea, P. Thompson, 2014, Journal of medicinal chemistry.

In silico analysis of antibody-carbohydrate interactions and its application to xenoreactive antibodies.

Elizabeth Yuriev, Paul A Ramsland, Mark Agostino, 2009, Molecular immunology.

Lipophilic Salts and Lipid-Based Formulations: Enhancing the Oral Delivery of Octreotide

C. Pouton, P. Thompson, C. Porter, 2021, Pharmaceutical Research.

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.

P. Thompson, S. Jackson, Mark Frazzetto, 2005, The Biochemical journal.

Optically Pure, Structural, and Fluorescent Analogues of a Dimeric Y4 Receptor Agonist Derived by an Olefin Metathesis Approach.

N. Holliday, P. Thompson, S. Mountford, 2016, Journal of medicinal chemistry.

Redox‐stable cyclic peptide inhibitors of the SPSB2–iNOS interaction

J. Baell, R. Norton, P. Thompson, 2016, FEBS letters.

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

N. Voelcker, J. Li, R. Nation, 2022, Nature Communications.

Synthesis of linear and angular aryl-morpholino-naphth-oxazines, their DNA-PK, PI3K, PDE3A and antiplatelet activity.

J. Al-Rawi, I. Jennings, P. Thompson, 2016, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 8-aryl-2-morpholino-7-O-substituted benzo[e][1,3]oxazin-4-ones against DNA-PK, PI3K, PDE3A enzymes and platelet aggregation.

J. Al-Rawi, P. Thompson, Z. Zheng, 2017, Bioorganic & medicinal chemistry.

Synthesis, structure elucidation, DNA-PK and PI3K and anti-cancer activity of 8- and 6-aryl-substituted-1-3-benzoxazines.

J. Al-Rawi, I. Jennings, P. Thompson, 2016, European journal of medicinal chemistry.

Pharmacokinetics of four different brands of colistimethate and formed colistin in rats.

J. Li, R. Nation, T. Velkov, 2013, The Journal of antimicrobial chemotherapy.

Discovery of Phosphodiesterase-4 Inhibitors: Serendipity and Rational Drug Design

M. Parker, C. Morton, S. Feil, 2014 .

Conformational studies on (+)-anatoxin-a and derivatives

Frank E. Blaney, David T. Manallack, Timothy Gallagher, 1992, J. Comput. Aided Mol. Des..

Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

C. Pouton, P. Thompson, D. Chalmers, 2023, Journal of medicinal chemistry.

Solid Phase Synthesis and Circular Dichroism Analysis of (i → i + 4) Cyclic Lactam Analogues of Kisspeptin

P. Thompson, D. Chalmers, M. Camerino, 2008, International Journal of Peptide Research and Therapeutics.

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes*

S. Bottomley, J. Rossjohn, N. Borg, 2009, The Journal of Biological Chemistry.

Structure-activity relationship exploration of Kv1.3 blockers based on diphenoxylate.

D. P. Jenkins, D. Manallack, H. Wulff, 2012, Bioorganic & medicinal chemistry letters.

Identification of preferred carbohydrate binding modes in xenoreactive antibodies by combining conformational filters and binding site maps.

Elizabeth Yuriev, Paul A Ramsland, Mark Agostino, 2010, Glycobiology.

Peptide inhibitors of xenoreactive antibodies mimic the interaction profile of the native carbohydrate antigens

Elizabeth Yuriev, Paul A Ramsland, Mark Agostino, 2011, Biopolymers.

Controlled Construction of Cyclic d / l Peptide Nanorods.

P. Thompson, D. Chalmers, M. Scanlon, 2018, Angewandte Chemie.

Controlled Construction of Cyclic d / l Peptide Nanorods

P. Thompson, D. Chalmers, M. Scanlon, 2018, Angewandte Chemie.

Parallel and antiparallel cyclic d/l peptide nanotubes.

S. Perrier, P. Thompson, D. Chalmers, 2017, Chemical communications.

Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity.

J. Li, T. Velkov, P. Thompson, 2023, Journal of medicinal chemistry.

Design and Evaluation of Novel Polymyxin Fluorescent Probes

Jian Li, Bo Yun, Kade D. Roberts, 2017, Sensors.

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

H. Mertens, J. Li, R. Nation, 2018, Cell chemical biology.

Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells

J. Li, T. Velkov, P. Thompson, 2023, Antibiotics.

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress

J. Li, R. Nation, T. Velkov, 2017, Antimicrobial Agents and Chemotherapy.

Significant Accumulation of Polymyxin in Single Renal Tubular Cells: A Medicinal Chemistry and Triple Correlative Microscopy Approach

M. D. de Jonge, D. Howard, S. James, 2015, Analytical chemistry.

A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii

F. Schreiber, Lushan Wang, T. Velkov, 2021, Chemical science.

Imaging the distribution of polymyxins in the kidney.

J. Li, R. Nation, T. Velkov, 2015, The Journal of antimicrobial chemotherapy.

Application of a sulfoxonium ylide electrophile to generate cathepsin X-selective activity-based probes.

M. Hoang, N. Bunnett, P. Thompson, 2020, ACS chemical biology.

Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2.

D. Manallack, M. Parker, C. Morton, 2011, Bioorganic & medicinal chemistry letters.

Polymyxins and Analogues Bind to Ribosomal RNA and Interfere with Eukaryotic Translation in Vitro

R. Nation, T. Velkov, Jian Li, 2013, Chembiochem : a European journal of chemical biology.

Structural and Biochemical Characterization of the Oxidoreductase NmDsbA3 from Neisseria meningitidis*

Amy L. Robertson, S. Bottomley, T. Beddoe, 2008, Journal of Biological Chemistry.

Side-Chain Interactions in d/l Peptide Nanotubes: Studies by Crystallography, NMR Spectroscopy and Molecular Dynamics.

H. Leiros, P. Thompson, D. Chalmers, 2021, Chemistry.

Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides

M. Parker, J. Wielens, Lei Zhang, 2015 .

Improving membrane permeation in the beyond rule-of-five space by using prodrugs to mask hydrogen bond donors.

R. Norton, P. Thompson, D. Chalmers, 2020, ACS chemical biology.

Fmoc-protected tropane-based amino acids for peptide structure-function studies

M. Hearn, P. Thompson, 1997 .

An extensional strain sensing mechanosome drives adhesion-independent platelet activation at supraphysiological hemodynamic gradients

A. Mitchell, I. Marusic, A. Ooi, 2022, BMC biology.

Measuring Polymyxin Uptake by Renal Tubular Cells: Is BODIPY-Polymyxin B an Appropriate Probe?

J. Li, R. Nation, T. Velkov, 2014, Antimicrobial Agents and Chemotherapy.

Synthesis, conformational analysis and application of tropane-based FMOC-amino acid derivatives: novel antagonists of fibrinogen receptor, GPIIb/IIIa

M. Hearn, P. Thompson, D. Steer, 1999 .

Regioselective synthesis of 5- and 6-methoxybenzimidazole-1,3,5-triazines as inhibitors of phosphoinositide 3-kinase.

Michelle S. Miller, I. Jennings, P. Thompson, 2013, Bioorganic & medicinal chemistry letters.

Comparison of the binding of alpha-helical and beta-sheet peptides to a hydrophobic surface.

R A Houghten, R. Houghten, S. Blondelle, 1998, The journal of peptide research : official journal of the American Peptide Society.

IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote Cryptococcus neoformans infection in a mouse model

A. Saiardi, T. Sorrell, J. Mackay, 2017, Virulence.

IP 3-4 kinase Arg 1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model

T. Sorrell, J. Mackay, P. Thompson, 2017 .

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

P. Sexton, A. Christopoulos, C. Reynolds, 2016, Cell.

Development of Highly Potent Clinical Candidates for Theranostic Applications against Cholecystokinin-2 Receptor Positive Cancers.

P. Thompson, C. Cullinane, C. Hutton, 2023, Journal of medicinal chemistry.

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase.

K. Kinzler, B. Vogelstein, O. Schmidt-Kittler, 2012, Australian journal of chemistry.

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

M. Parker, D. Ascher, P. Thompson, 2008, BMC Neuroscience.

Solid phase synthesis of cyclic peptides: model studies involving i−(i+4) side chain‐to‐side chain cyclisation

M. Hearn, P. Thompson, V. Cavallaro, 1998, Journal of peptide science : an official publication of the European Peptide Society.

TNP Analogues Inhibit the Virulence Promoting IP3-4 Kinase Arg1 in the Fungal Pathogen Cryptococcus neoformans

T. Sorrell, J. Mackay, J. Matthews, 2022, Biomolecules.

Structure of granzyme C reveals an unusual mechanism of protease autoinhibition

J. Whisstock, J. Irving, A. Buckle, 2009, Proceedings of the National Academy of Sciences.

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes*

S. Bottomley, J. Rossjohn, N. Borg, 2009, The Journal of Biological Chemistry.

Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma

R. Johnstone, C. Kearney, I. Jennings, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of “Difficult” Fluorescence Quenched Substrates of Granzyme C

P. Bird, P. Thompson, R. Pike, 2010, International Journal of Peptide Research and Therapeutics.

Phenylalanine-544 Plays a Key Role in Substrate and Inhibitor Binding by Providing a Hydrophobic Packing Point at the Active Site of Insulin-Regulated Aminopeptidase

M. Parker, C. Morton, J. Holien, 2010, Molecular Pharmacology.

David T. Manallack, Philip E. Thompson, Brittany L. Howard, 2011, J. Comput. Aided Mol. Des..

The major human and mouse granzymes are structurally and functionally divergent

J. Whisstock, J. Trapani, P. Bird, 2006, The Journal of cell biology.

Synthesis of BVD15 Peptide Analogues as Models for Radioligands in Tumour Imaging

Lei Zhang, I. Lee, H. Herzog, 2013, International Journal of Peptide Research and Therapeutics.