Á. McKnight

发表

The evolution of structured illumination microscopy in studies of HIV.

Markus Posch, Áine McKnight, M. Posch, 2015, Methods.

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4

R. Weiss, Á. McKnight, P. Clapham, 1992, Journal of virology.

Apolipoprotein E‐derived antimicrobial peptide analogues with altered membrane affinity and increased potency and breadth of activity

P. Sinnis, S. Neil, D. Middleton, 2007, The FEBS journal.

Retroviral restriction: nature's own solution

Christopher E. Jones, Á. McKnight, 2016, Current opinion in infectious diseases.

Change in tropism upon immune escape by human immunodeficiency virus

R. Weiss, Y. Takeuchi, Á. McKnight, 1995, Journal of virology.

CD4 binding site broadly neutralizing antibody selection of HIV-1 escape mutants.

Lei Chen, C. Pade, Á. McKnight, 2015, The Journal of general virology.

In Vivo Emergence of HIV-1 Highly Sensitive to Neutralizing Antibodies

I. Williams, Á. McKnight, A. Forsman, 2011, PloS one.

Blocking the docking of HIV-1

R. Weiss, Á. McKnight, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Further characterization of an antigenic site of HIV-1 gp120 recognized by virus neutralizing human monoclonal antibodies.

J. Sodroski, J. McKeating, J. Goudsmit, 1993, AIDS.

Evaluation of human and simian immunodeficiency virus plaque and neutralization assays.

R. Weiss, J. McKeating, Á. McKnight, 1989, The Journal of general virology.

HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation.

R. Weiss, S. Neil, K. Gustafsson, 2005, Blood.

Studies on the immunogenicity of Chinese hamster ovary cell-derived recombinant gp120 (HIV-1IIIB).

P. Dilger, R. Thorpe, K. Mills, 1991, Vaccine.

Longitudinal assessment of symptoms and risk of SARS-CoV-2 infection in healthcare workers across 5 hospitals to understand ethnic differences in infection risk.

P. Tighe, C. Manisty, C. Menni, 2021, EClinicalMedicine.

Longitudinal Assessment of Symptoms and Risk of SARS-CoV-2 Infection in Healthcare Workers Across 5 Hospitals to Understand Ethnic Differences in Infection Risk

N. Chaturvedi, P. Tighe, C. Manisty, 2021 .

HLA‐DR polymorphism in SARS‐CoV‐2 infection and susceptibility to symptomatic COVID‐19

P. Tighe, C. Manisty, D. Altmann, 2022, Immunology.

Novel subtype C human immunodeficiency virus type 1 envelopes cloned directly from plasma: coreceptor usage and neutralization phenotypes.

R. Weiss, Á. McKnight, A. Forsman, 2010, The Journal of general virology.

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

W. Heywood, K. Mills, C. Manisty, 2022, Cell Reports Methods.

Accessing of recombinant human monoclonal antibodies from patient libraries by eukaryotic ribosome display.

Angray S. Kang, S. Jeffs, Á. McKnight, 2012, Human antibodies.

CD4-Independent Infection by HIV-2 Is Mediated by Fusin/CXCR4

R. Doms, J. Hoxie, M. Endres, 1996, Cell.

Control of HIV infection by IFN-α: implications for latency and a cure

Á. McKnight, N. Stevenson, C. Bergin, 2017, Cellular and Molecular Life Sciences.

Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial.

A. Dunton, A. Russell, Á. McKnight, 2022, Journal of Clinical Virology.

Influence of vitamin D supplementation on SARS-CoV-2 vaccine efficacy and immunogenicity

S. Faustini, Á. McKnight, E. S. Chambers, 2022, medRxiv.

Primary CCR5 only using HIV-1 isolates does not accurately represent the in vivo replicating quasi-species.

I. Williams, Á. McKnight, M. Aasa-Chapman, 2006, Virology.

Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off

J. Nguyen-Van-Tam, D. Altmann, V. Barber, 2022, BMJ Open.

Identification of a Subset of Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus Strains Able To Exploit an Alternative Coreceptor on Untransformed Human Brain and Lymphoid Cells

J. Bell, E. Clercq, J. Reeves, 2003, Journal of Virology.

Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure

Lauren M. Hickling, A. Hingorani, Tom Coleman, 2022, Science.

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

H. Williams, J. A. Cook, S. Hider, 2022, The Lancet Respiratory Medicine.

The β-NGF/TrkA Signalling Pathway Is Associated With the Production of Anti-Nucleoprotein IgG in Convalescent COVID-19

C. Pade, Á. McKnight, P. Kennedy, 2022, Frontiers in Immunology.

Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell Tropism In Vivo

G. Simmons, J. Reeves, Á. McKnight, 1999, Journal of Virology.

Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19

Lauren M. Hickling, A. Hingorani, S. Petersen, 2020, Wellcome open research.

Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19.

Lauren M. Hickling, A. Hingorani, S. Petersen, 2020, Wellcome open research.

Human immunodeficiency virus types 1 and 2 have different replication kinetics in human primary macrophage culture.

David J. Marchant, S. Neil, Á. McKnight, 2006, The Journal of general virology.

HIV-2 and SIV infection of nonprimate cell lines expressing human CD4: restrictions to replication at distinct stages.

R. Weiss, Á. McKnight, P. Clapham, 1994, Virology.

Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial

David A. Jolliffe, S. Faustini, C. Pade, 2022, Nutrients.

Is CD4 sufficient for HIV entry? Cell surface molecules involved in HIV infection.

G. Simmons, Á. McKnight, P. Clapham, 1993, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

CD4-independent infection by HIV-2 (ROD/B): use of the 7-transmembrane receptors CXCR-4, CCR-3, and V28 for entry.

R. Weiss, C. Power, S. Talbot, 1997, Virology.

Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent

J. Hoxie, L. Picard, S. Talbot, 1997, Journal of virology.

Inhibition of HIV fusion by a monoclonal antibody to a co-receptor ( CXCR4 ) is both cell type and virus strain dependent

J. Hoxie, L. Picard, S. Talbot, 1996 .

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection

W. Heywood, K. Mills, Leo Swadling, 2022, eBioMedicine.

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

C. Manisty, D. Altmann, R. Boyton, 2022, Science.

Cell-to-cell fusion, but not virus entry in macrophages by T-cell line tropic HIV-1 strains: a V3 loop-determined restriction.

G. Simmons, Á. McKnight, P. Clapham, 1995, Virology.

Novel Envelope Determinants for CCR3 Use by Human Immunodeficiency Virus

I. Williams, Á. McKnight, M. Aasa-Chapman, 2006, Journal of Virology.

The ins and outs of HIV restriction

Á. McKnight, 2013, Retrovirology.

A novel envelope mediated post entry restriction of murine leukaemia virus in human cells is Ref1/TRIM5α independent

Á. McKnight, N. Oliveira, Roochi Trikha, 2010, Retrovirology.

Human immunodeficiency virus type 2 infection and fusion of CD4-negative human cell lines: induction and enhancement by soluble CD4

R. Weiss, Á. McKnight, P. Clapham, 1992, Journal of virology.

HIV entry into cells by CD4-independent mechanisms

S. Talbot, Á. McKnight, P. Clapham, 1996 .

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

S. Reich-Zeliger, F. Balloux, J. Knight, 2022, bioRxiv.

The control of the antibody isotype response to recombinant human immunodeficiency virus gp120 antigen by adjuvants.

T. Andronova, R. Bomford, Á. McKnight, 1992, AIDS research and human retroviruses.

Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

Q. Sattentau, D. Montefiori, W. Weissenhorn, 2010, PloS one.

Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection

B. Chain, C. Manisty, D. Altmann, 2021, EBioMedicine.

Characterising heterogeneity and sero-reversion in antibody responses to mild SARS-CoV-2 infection: a cohort study using time series analysis and mechanistic modelling

B. Chain, C. Manisty, M. Noursadeghi, 2020, medRxiv.

Mapping of homologous, amino-terminal neutralizing regions of human T-cell lymphotropic virus type I and II gp46 envelope glycoproteins

R. Weiss, R. Scearce, Á. McKnight, 1992, Journal of virology.

HIV-1 receptors and cell tropism.

Á. McKnight, P. Clapham, 2001, British medical bulletin.

A Broad Range of Chemokine Receptors Are Used by Primary Isolates of Human Immunodeficiency Virus Type 2 as Coreceptors with CD4

H. Whittle, K. Ariyoshi, D. Whitby, 1998, Journal of Virology.

Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry.

J. Hoxie, R. Weiss, L. Picard, 1997, Virology.

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study

David A. Jolliffe, M. Talaei, S. Faustini, 2022, The Journal of infectious diseases.

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose

B. Chain, C. Manisty, D. Altmann, 2021, Science.

Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses

C. Pade, K. Marno, Á. McKnight, 2013, Retrovirology.

Cellular entry via an actin and clathrin-dependent route is required for Lv2 restriction of HIV-2.

Á. McKnight, I. Harrison, 2011, Virology.

An Envelope-Determined, pH-Independent Endocytic Route of Viral Entry Determines the Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 to Lv2 Restriction

David J. Marchant, S. Neil, Á. McKnight, 2005, Journal of Virology.

The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes

Robin A. Weiss, R. Weiss, R. Nibbs, 2005, Journal of Virology.

A whole genome screen for HIV restriction factors

Áine McKnight, D. Beach, M. Dittmar, 2011, Retrovirology.

Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

J. Moore, J. McKeating, Á. McKnight, 1991, Journal of virology.

RNA-Associated Early-Stage Antiviral Factor Is a Major Component of Lv2 Restriction

Christopher E. Jones, K. Marno, Á. McKnight, 2017, Journal of Virology.

CXCR4 as a Functional Coreceptor for Human Immunodeficiency Virus Type 1 Infection of Primary Macrophages

E. De Clercq, G. Simmons, J. Reeves, 1998, Journal of Virology.

Localization of the receptor gene for type D simian retroviruses on human chromosome 19

P. Goodfellow, R. Weiss, Á. McKnight, 1990, Journal of virology.

The Î²-NGF/TrkA signalling pathway is associated with the production of anti- nucleoprotein IgG in convalescent COVID-19

Á. McKnight, P. Kennedy, U. Gill, 2021, medRxiv.

Rapid synchronous type 1 IFN and virus-specific T cell responses characterize first wave non-severe SARS-CoV-2 infections

J. A. Guerra-Assunção, Leo Swadling, B. Chain, 2022, Cell Reports Medicine.

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

J. A. Guerra-Assunção, B. Chain, C. Manisty, 2021, The Lancet Microbe.

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection

Leo Swadling, B. Chain, W. Lee, 2020, Science Immunology.

Healthcare workers with mild / asymptomatic SARS-CoV-2 infection show T cell responses and neutralising antibodies after the first wave

Leo Swadling, B. Chain, C. Manisty, 2020, medRxiv.

COVID-19: PCR screening of asymptomatic health-care workers at London hospital

J. Moon, C. Manisty, M. Noursadeghi, 2020, The Lancet.

Disease Progression in HIV-1–Infected Viremic Controllers

C. Orkin, Á. McKnight, A. Stagg, 2012, Journal of acquired immune deficiency syndromes.

Detection of Antibody-Dependent Complement-Mediated Inactivation of both Autologous and Heterologous Virus in Primary Human Immunodeficiency Virus Type 1 Infection

D. Cornforth, I. Williams, P. Newton, 2005, Journal of Virology.

Development of the antibody response in acute HIV-1 infection

David Cornforth, Persephone Borrow, Peter Balfe, 2004, AIDS.

Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers

P. Kellman, E. Schelbert, J. Moon, 2021, JACC: Cardiovascular Imaging.

Short reportModulation of HIV-1 macrophage-tropism among R 5 envelopes occurs before detection of neutralizing antibodies

Á. McKnight, P. Clapham, Kathryn H. Richards, 2017 .

Modulation of HIV-1 macrophage-tropism among R5 envelopes occurs before detection of neutralizing antibodies

Á. McKnight, P. Clapham, Kathryn H. Richards, 2010, Retrovirology.

Immune escape and tropism of HIV.

Á. McKnight, P. Clapham, P R Clapham, 1995, Trends in microbiology.

HIV Vaccine Approaches

D. Pennington, Á. McKnight, 2009 .

Lessons learned from humoral responses of HIV patients

Á. McKnight, L. McCoy, 2017, Current opinion in HIV and AIDS.

Lessons learned from humoral responses of HIV patients.

Á. McKnight, L. McCoy, 2017, Current opinion in HIV and AIDS.

Neutralization activity in a geographically diverse East London cohort of human immunodeficiency virus type 1-infected patients: clade C infection results in a stronger and broader humoral immune response than clade B infection.

D. Montefiori, C. Orkin, H. Gao, 2010, The Journal of general virology.

HIV coreceptors, cell tropism and inhibition by chemokine receptor ligands.

G. Simmons, J. Reeves, Á. McKnight, 1999, Molecular membrane biology.

Lv2, a Novel Postentry Restriction, Is Mediated by both Capsid and Envelope

David J. Marchant, S. Neil, M. Dittmar, 2004, Journal of Virology.

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2 infection

F. Balloux, Leo Swadling, A. Bertoletti, 2021, medRxiv.

Cell surface receptors, virus entry and tropism of primate lentiviruses.

Á. McKnight, P. Clapham, 2002, The Journal of general virology.

Development of HIV‐1 group‐specific neutralizing antibodies after seroconversion

R. Weiss, J. Weber, Á. McKnight, 1992, AIDS.

Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120

R. Weiss, C. Kelly, Á. McKnight, 2008, Journal of Virology.

HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide.

L. Bacheler, M. Rayner, R. Pomerantz, 1990, AIDS research and human retroviruses.

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Lauren M. Hickling, Steffen E. Petersen, A. Hingorani, 2021, Nature.

Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals

J. Moon, C. Manisty, D. Altmann, 2021, The Lancet.

Characterization of a Late Entry Event in the Replication Cycle of Human Immunodeficiency Virus Type 2

M. Dittmar, Á. McKnight, P. Clapham, 2001, Journal of Virology.

CD4-dependent and CD4-independent HIV-2: consequences for neutralization

R. Weiss, Á. McKnight, P. Clapham, 2003, AIDS.

Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses

C. Pade, K. Marno, Á. McKnight, 2014, Retrovirology.

Interferon-Alpha Mediates Restriction of Human Immunodeficiency Virus Type-1 Replication in Primary Human Macrophages at an Early Stage of Replication

Á. McKnight, K. Cheney, K. M. Cheney, 2010, PloS one.

HIV-1 Accessory Protein Vpr Interacts with REAF/RPRD2 To Mitigate Its Antiviral Activity

Christopher E. Jones, W. Lee, Paul A. Rowley, 2018, Journal of Virology.

Location, exposure, and conservation of neutralizing and nonneutralizing epitopes on human immunodeficiency virus type 2 SU glycoprotein

I. Jones, G. Simmons, Á. McKnight, 1996, Journal of virology.

Human Leydig cells are productively infected by some HIV-2 and SIV strains but not by HIV-1

B. Jégou, N. Dejucq-Rainsford, J. Reeves, 2003, AIDS.

Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus (HIV)-1 Disease

C. Pade, Á. McKnight, N. Storey, 2022, Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America.

Generation of novel SARS-CoV-2 variants on B.1.1.7 lineage in three patients with advanced HIV disease

Á. McKnight, Melissa S. Murphy, A. Riddell, 2022, medRxiv.

Correlation between post-vaccination titres of combined IgG, IgA, and IgM anti-Spike antibodies and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study (COVIDENCE UK)

S. Faustini, Á. McKnight, E. S. Chambers, 2022, medRxiv.

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants

C. Manisty, D. Altmann, R. Boyton, 2021, Science.

COVID-19 vaccine boosted immunity against Omicron in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

D. Altmann, R. Boyton, C. Pade, 2022, Leukemia.

HIV-1 tropism and co-receptor use

P. Simmonds, R. Weiss, M. Dittmar, 1997, Nature.

The EuroSciCon's 2015 Innate Immunity Summit

Á. McKnight, F. Peri, C. Matteucci, 2016 .

Productive HIV-2 infection in the brain is restricted to macrophages/microglia

Á. McKnight, S. Lucas, A. Mörner, 2003, AIDS.

Non-severe SARS-CoV-2 infection is characterised by very early T cell proliferation independent of type 1 interferon responses and distinct from other acute respiratory viruses.

J. A. Guerra-Assunção, Leo Swadling, B. Chain, 2021, medRxiv.

Anti-infective activity of apolipoprotein domain derived peptides in vitro: identification of novel antimicrobial peptides related to apolipoprotein B with anti-HIV activity

Á. McKnight, C. Dobson, I. Harrison, 2010, BMC Immunology.

Novel restriction factor RNA-associated early-stage anti-viral factor (REAF) inhibits human and simian immunodeficiency viruses

C. Pade, K. Marno, Á. McKnight, 2013, Retrovirology.

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity

Leo Swadling, C. Manisty, D. Altmann, 2023, Nature communications.

Clade specific neutralising vaccines for HIV: an appropriate target?

Á. McKnight, M. Aasa-Chapman, 2007, Current HIV Research.

Evaluating the efficacy and safety of a novel prophylactic nasal spray in the prevention of SARS-CoV-2 infection: A multi-centre, double blind, placebo-controlled, randomised trial. Journal of Clinical Virology

A. Dunton, A. Russell, Á. McKnight, 2022 .

Human immunodeficiency viruses: neutralization and receptors.

Q. Sattentau, A. Dalgleish, R. Weiss, 1988, Journal of acquired immune deficiency syndromes.

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

F. Balloux, Leo Swadling, A. Bertoletti, 2021, Nature.

The innate immune factor RPRD2/REAF and its role in the Lv2 restriction of HIV

Á. McKnight, Kathryn A. Jackson-Jones, Richard D Sloan, 2023, mBio.

Control of HIV infection by IFN-α: implications for latency and a cure

Á. McKnight, N. Stevenson, C. Bergin, 2017, Cellular and Molecular Life Sciences.

CD4 binding site broadly neutralizing antibody selection of HIV-1 escape mutants.

Lei Chen, C. Pade, Á. McKnight, 2015, The Journal of general virology.

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Lauren M. Hickling, Leo Swadling, W. Lee, 2021, Nature.

Comparison of CD4-independent infection by HIV-1, HIV-2 and SIV strains, and relevance of receptors other than CCR5 and CXCR4 for infection of primary cell types

G. Simmons, J. Reeves, Á. McKnight, 2000 .