C. Sephton

发表

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Robert V Farese, B. Miller, W. Seeley, 2014, The Journal of experimental medicine.

Identification of Neuronal RNA Targets of TDP-43-containing Ribonucleoprotein Complexes

Frederick P. Roth, Can Cenik, Junmin Peng, 2010, The Journal of Biological Chemistry.

Widespread alterations in microRNA biogenesis in human Huntington’s disease putamen

S. Hébert, C. Sephton, Karolina Pircs, 2022, Acta Neuropathologica Communications.

The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1.

M. Scheid, D. Mousseau, C. Sephton, 2009, Cellular signalling.

Metabolic Networks Influencing Skeletal Muscle Fiber Composition

C. Sephton, Paul A. Dutchak, Isabelle Bourdeau Julien, 2018, Front. Cell Dev. Biol..

FUS contributes to mTOR-dependent inhibition of translation

C. Sephton, Myriam Sévigny, Paul A. Dutchak, 2020, The Journal of Biological Chemistry.

TDP-43 aggregation in neurodegeneration: Are stress granules the key?

C. Sephton, J. Herz, B. Cenik, 2012, Brain Research.

Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease

C. Sephton, Paul A. Dutchak, Pauline A. Gelon, 2022, Frontiers in Molecular Neuroscience.

Dephosphorylation of Akt in C6 cells grown in serum‐free conditions corresponds with redistribution of p85/PI3K to the nucleus

D. Mousseau, C. Sephton, 2008, Journal of neuroscience research.

NPRL2 Inhibition of mTORC1 Controls Sodium Channel Expression and Brain Amino Acid Homeostasis

Christophe D. Proulx, C. Sephton, M. Chahine, 2022, eNeuro.

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

Ian Mitchelle S. de Vera, B. Leavitt, J. Morley, 2022, bioRxiv.

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

Gang Yu, C. Sephton, 2015, Cellular and Molecular Life Sciences.

Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration*

C. Sephton, J. Herz, B. Cenik, 2012, The Journal of Biological Chemistry.

γ-Secretase-regulated Proteolysis of the Notch Receptor by Mitochondrial Intermediate Peptidase*

Daniel R. Dries, Yun Wang, Bing Wang, 2011, The Journal of Biological Chemistry.

TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor

Daniel R. Dries, C. Sephton, J. Herz, 2010, Molecular and Cellular Biology.

SHP-1 and PDK1 Form a Phosphotyrosine-Dependent Nucleo-Cytoplasmic Shuttling Complex: Implications for Differentiation

C. Sephton, 2007 .

hnRNP A1B, a Splice Variant of HNRNPA1, Is Spatially and Temporally Regulated

R. Robitaille, C. Sephton, Jade-Emmanuelle Deshaies, 2021, Frontiers in Neuroscience.

A postzygotic de novo NCDN mutation identified in a sporadic FTLD patient results in neurochondrin haploinsufficiency and altered FUS granule dynamics

C. Duyckaerts, D. Campion, V. Deramecourt, 2022, Acta neuropathologica communications.

Activity-dependent FUS dysregulation disrupts synaptic homeostasis

Michael Q. Zhang, E. Huang, Ashwinikumar Kulkarni, 2014, Proceedings of the National Academy of Sciences.

TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration

Gang Yu, C. Sephton, J. Herz, 2012, Biological chemistry.

TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development*

C. Sephton, J. Herz, S. Atkin, 2009, The Journal of Biological Chemistry.

Suberoylanilide Hydroxamic Acid (Vorinostat) Up-regulates Progranulin Transcription

Robert V Farese, Daniel R. Dries, D. Geschwind, 2011, The Journal of Biological Chemistry.

Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways

Christophe D. Proulx, I. Timofeev, J. Seigneur, 2020, Biological Psychiatry.

The function of RNA-binding proteins at the synapse: implications for neurodegeneration

Gang Yu, C. Sephton, 2015, Cellular and Molecular Life Sciences.

Chronic Stress Induces Sex-Specific Functional and Morphological Alterations in Corticoaccumbal and Corticotegmental Pathways

I. Timofeev, J. Seigneur, B. Labonté, 2021, Biological Psychiatry.

Antisense oligonucleotide strategies to increase progranulin levels for frontotemporal dementia

Ian Mitchelle S. de Vera, B. Leavitt, J. Morley, 2022 .

FUS contributes to mTOR-dependent inhibition of translation.

C. Sephton, Myriam Sévigny, Paul A. Dutchak, 2020, Journal of Biological Chemistry.

TDP-43 is a developmentally regulated protein essential for early embryonic development.

C. Sephton, J. Herz, S. Atkin, 2010, The Journal of Biological Chemistry.

Abeta predictor of Alzheimer disease symptoms.

Gang Yu, C. Sephton, 2008, Archives of neurology.

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation

Ian Mitchelle S. de Vera, B. Leavitt, J. Morley, 2022, bioRxiv.

Haloperidol induces the nuclear translocation of phosphatidylinositol 3'-kinase to disrupt Akt phosphorylation in PC12 cells.

D. Mousseau, C. Sephton, Di Zhang, 2007, Journal of psychiatry & neuroscience : JPN.

Theme 03 - In Vitro Experimental Models

C. Sephton, S. Pozzi, D. Eyerman, 2022, Amyotrophic lateral sclerosis & frontotemporal degeneration.

GATOR1 Mutations Impair PI3 Kinase-Dependent Growth Factor Signaling Regulation of mTORC1

C. Sephton, Paul A. Dutchak, Maéline Muller, 2024, International journal of molecular sciences.

Neuronal dysfunction caused by FUSR521G promotes ALS-associated phenotypes that are attenuated by NF-κB inhibition

C. Sephton, D. Phaneuf, Paul A. Dutchak, 2023, Acta Neuropathologica Communications.