Z. Ahmed

发表

A complex of Shc and Ran-GTPase localises to the cell nucleus

J. Ladbury, R. George, J. Timms, 2009, Cellular and Molecular Life Sciences.

What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.

J. Tainer, S. Lees-Miller, C. Brosey, 2017, Methods in enzymology.

Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin

J. Tainer, D. Cooper, M. Mort, 2020, Nucleic acids research.

Plakophilin-3 Catenin Associates with the ETV1/ER81 Transcription Factor to Positively Modulate Gene Activity

Moonsup Lee, William A. Muñoz, H. Ji, 2014, PloS one.

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

J. Tainer, J. Houl, M. Hung, 2019, Nature Communications.

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

G. Poncet-Montange, S. Arold, J. Ladbury, 2018, The international journal of biochemistry & cell biology.

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion

J. Ladbury, P. Leonard, Z. Ahmed, 2014, Nature Structural &Molecular Biology.

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase.

Z. Ahmed, T. S. Pillay, Kei Kotani, 1999 .

The APS adapter protein couples the insulin receptor to the phosphorylation of c‐Cbl and facilitates ligand‐stimulated ubiquitination of the insulin receptor

Z. Ahmed, T. S. Pillay, B.J Smith, 2000, FEBS letters.

Adapter protein with a pleckstrin homology (PH) and an Src homology 2 (SH2) domain (APS) and SH2-B enhance insulin-receptor autophosphorylation, extracellular-signal-regulated kinase and phosphoinositide 3-kinase-dependent signalling.

Z. Ahmed, T. S. Pillay, 2003, The Biochemical journal.

Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

Gilbert R. Lee, J. Ladbury, Z. Ahmed, 2015, Nature Communications.

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

G. Poncet-Montange, S. Arold, J. Ladbury, 2020, bioRxiv.

APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase.

Z. Ahmed, B. Smith, T. S. Pillay, 1999, The Biochemical journal.

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

J. Ladbury, Z. Ahmed, D. Lewis, 2013, The Biochemical journal.

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

J. Ladbury, K. Suhling, J. Levitt, 2013, The Journal of cell biology.

A Novel Dual Kinase Function of the RET Proto-oncogene Negatively Regulates Activating Transcription Factor 4-mediated Apoptosis*

Anupama E. Gururaj, O. Bogler, J. Ladbury, 2015, The Journal of Biological Chemistry.

The activation and inhibition of 5-nucleotidase.

Z. Ahmed, J. Reis, 1958, The Biochemical journal.

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling.

C. Tregidgo, J. Ladbury, K. Suhling, 2008, The Biochemical journal.

Grb2 binding induces phosphorylation-independent activation of Shp2

J. Ladbury, Z. Ahmed, K. M. Suen, 2019, bioRxiv.

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function.

J. Ladbury, R. George, K. Suhling, 2010, Cellular signalling.

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

S. Arold, J. Ladbury, Z. Ahmed, 2012, Cell.

Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1.

Yuan Zhang, Jun Yao, J. Tainer, 2022, Cancer discovery.

GRB2 enforces homology-directed repair initiation by MRE11

J. Tainer, G. Peng, Bin Wang, 2021, Science Advances.

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.

R. Liddington, G. Powis, R. G. Correa, 2019, Cancer research.

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

E. Miska, J. Ladbury, S. Evans, 2022, Molecular cell.

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

O. Lichtarge, J. Tainer, J. Houl, 2021, Progress in Biophysics and Molecular Biology.

Endothelin activation of phospholipase D: dual modulation by protein kinase C and Ca2+.

Z. Ahmed, M. Friedlaender, D. Jain, 1993, The American journal of physiology.

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer

G. Mills, Yiling Lu, M. Hung, 2016, Oncogene.

An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation

J. Tainer, J. Pink, David S. Shin, 2021, Progress in biophysics and molecular biology.

Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction.

J. Tainer, A. Bacolla, Z. Ahmed, 2019, Progress in biophysics and molecular biology.

T-cell receptor early signalling complex activation in response to interferon-α receptor stimulation

J. Ladbury, C. Baldari, S. John, 2010, The Biochemical journal.

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

Klaus Suhling, James A Levitt, J. Ladbury, 2008, The Biochemical journal.

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli

S. Arold, J. Ladbury, Swathi Arur, 2013, Nature Structural &Molecular Biology.

Corrigendum: Grb2 monomer–dimer equilibrium determines normal versus oncogenic function

John E. Ladbury, J. Ladbury, Z. Ahmed, 2015, Nature Communications.

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

G. Richardson, J. Ladbury, Z. Ahmed, 2018, Proceedings of the National Academy of Sciences.

An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2

O. Lichtarge, J. Tainer, A. Joachimiak, 2021, Methods in Enzymology.

Functional effects of APS and SH2-B on insulin receptor signalling.

Z. Ahmed, T. S. Pillay, 2001, Biochemical Society transactions.

PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.

R. Liddington, I. Wistuba, Shuxing Zhang, 2021, Experimental cell research.

Regulation of microRNA expression by the adaptor protein GRB2

E. Miska, J. Ladbury, Z. Ahmed, 2023, Scientific reports.

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation.

J. Ladbury, Z. Ahmed, Annika C Schüller, 2008, The Biochemical journal.

The combined action of the intracellular regions regulates FGFR2 kinase activity

G. Poncet-Montange, S. Arold, J. Ladbury, 2023, Communications biology.

Receptor tyrosine kinases regulate signal transduction through a liquid–liquid phase separated state

E. Miska, J. Ladbury, Z. Ahmed, 2019, bioRxiv.

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors.

Mark A. Williams, J. Ladbury, C. Baldari, 2005, Journal of molecular biology.

GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

J. Tainer, K. Schlacher, Z. Ahmed, 2024, Nature communications.

Epigenetic-Metabolic Interplay in the DNA Damage Response and Therapeutic Resistance of Breast Cancer.

J. Tainer, T. Pandita, C. Hunt, 2023, Cancer research.