Brooke M. Rock

发表

Plasma and Liver Protein Binding of N-Acetylgalactosamine–Conjugated Small Interfering RNA

Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, 2019, Drug Metabolism and Disposition.

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

Sara C. Humphreys, D. Daniels, M. Urh, 2022, The Journal of biological chemistry.

Special Section on DMPK of Therapeutic Proteins Evaluation of Near Infrared Fluorescent Labeling of Monoclonal Antibodies as a Tool for Tissue Distribution

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

DMD060319 1906..1913

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

SRM-based measurements of proprotein convertase subtilisin/kexin type 9 and lipoprotein(a) kinetics in nonhuman primate serum.

D. Rock, Brooke M. Rock, J. Gibbs, 2016, Bioanalysis.

Therapeutic Monoclonal Antibody Intact Mass Analysis by Capillary Electrophoresis–Mass Spectrometry

D. Rock, Brooke M. Rock, J. Pearson, 2016 .

Immunoaffinity capture coupled with capillary electrophoresis - mass spectrometry to study therapeutic protein stability in vivo.

D. Rock, Brooke M. Rock, J. Pearson, 2017, Analytical biochemistry.

Mechanistic Studies of Cytochrome P450 3A4 Time Dependent Inhibition Using Two Cysteine- Targeting Electrophiles.

L. Wienkers, D. Rock, Xiaoshan Min, 2020, Drug metabolism and disposition: the biological fate of chemicals.

DMD059626 1698..1707

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

Altering Antibody-Drug Conjugate Binding to the Neonatal Fc Receptor Impacts Efficacy and Tolerability.

D. Rock, Brooke M. Rock, W. Fanslow, 2016, Molecular pharmaceutics.

Plasma and liver protein binding of GalNAc conjugated siRNA.

Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, 2019, Drug metabolism and disposition: the biological fate of chemicals.

Evaluation of Near IR Fluorescent Labeling of mAbs as a Tool for Tissue Distribution

D. Rock, Brooke M. Rock, J. Balthasar, 2014 .

Microsoft Word-28451548-file00.docx

Brooke M. Rock, W. Fanslow, K. J. Hamblett, 2015 .

Case Study 12: Roadmap to Quantifying Ago2-Mediated siRNA Metabolic Activation Kinetics.

Sara C. Humphreys, Babak Basiri, Brooke M. Rock, 2021, Methods in molecular biology.

SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm.

D. Rock, Brooke M. Rock, W. Fanslow, 2015, Cancer research.

POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices

Sara C. Humphreys, Mai B. Thayer, Julie M. Lade, 2020, Scientific Reports.

Quantification of siRNA-Antibody Conjugates in Biological Matrices by Triplex-Forming Oligonucleotide ELISA.

I. Campuzano, Sara C. Humphreys, Mai B. Thayer, 2019, Nucleic acid therapeutics.

Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics

Mai B. Thayer, Julie M. Lade, Babak Basiri, 2019, Scientific Reports.

Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)

Saptarsi M. Haldar, S. Melquist, G. Watts, 2022, Nature Medicine.

Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)

Saptarsi M. Haldar, S. Melquist, Hong Wang, 2022, Nature Medicine.

Characterization of Ritonavir-Mediated Inactivation of Cytochrome P450 3A4

L. Wienkers, D. Rock, Brooke M. Rock, 2014, Molecular Pharmacology.

Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker

D. Rock, Brooke M. Rock, W. Fanslow, 2015, Drug Metabolism and Disposition.

Novel Small-Molecule Troponin Activator Increases Cardiac Contractile Function Without Negative Impact on Energetics

J. Balschi, J. Reagan, Brooke M. Rock, 2021, Circulation. Heart failure.

Absorption, Distribution, Metabolism, and Excretion of [14C]-Sotorasib in Rats and Dogs: Interspecies Differences in Absorption, Protein Conjugation and Metabolism

Brooke M. Rock, John T. Rodgers, Upendra P. Dahal, 2022, Drug Metabolism and Disposition.

Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities

Brooke M. Rock, R. Foti, Robert S. Foti, 2019, Drug Metabolism and Disposition.

Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC

Sara C. Humphreys, Julie M. Lade, Bin Wu, 2020, Molecular therapy. Nucleic acids.

Characterization of the Active Site Properties of CYP4F12

L. Wienkers, D. Rock, Brooke M. Rock, 2014, Drug Metabolism and Disposition.

Universal Automated Immunoaffinity Purification-CE-MS Platform for Accelerating Next Generation Biologic Design.

D. Rock, Brooke M. Rock, Kevin D Cook, 2021, Analytical chemistry.

Emerging siRNA design principles and consequences for biotransformation and disposition in drug development.

Sara C. Humphreys, Julie M. Lade, Brooke M. Rock, 2020, Journal of medicinal chemistry.

Intact mass analysis of monoclonal antibodies by capillary electrophoresis-Mass spectrometry.

D. Rock, Brooke M. Rock, J. Pearson, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics

Julie M. Lade, Babak Basiri, Brooke M. Rock, 2019, Scientific Reports.

Characterization of the Active Site Properties of CYP 4 F 12 s

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

Strain-Dependent Variability of Early Discovery Small Molecule Pharmacokinetics in Mice: Does Strain Matter?

Brooke M. Rock, J. T. Barr, T. Tran, 2020, Drug Metabolism and Disposition.

Microsoft Word-92403395-file00.docx

L. Wienkers, D. Rock, Brooke M. Rock, 2014 .

Characterization of the Active Site Properties of CYP4F12

L. Wienkers, D. Rock, Brooke M. Rock, 2014, Drug Metabolism and Disposition.

Multienzyme kinetics and sequential metabolism.

L. Wienkers, Brooke M. Rock, 2014, Methods in molecular biology.

Characterization of Nefazodone Time‐dependent Inhibition of Cytochrome P450 3A

D. Rock, Brooke M. Rock, T. Tran, 2017, The FASEB Journal.