S. Chan

J. Cavalcante, M. Simon, S. Chan, 2017, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Update in Pulmonary Vascular Disease 2016 and 2017

R. Machado, B. Maron, E. Brittain, 2018, American journal of respiratory and critical care medicine.

Human Endogenous Retrovirus K and Pulmonary Arterial Hypertension: A New Take on a Retro Idea

S. Chan, M. Culley, S. Y. Chan, 2017, Circulation.

Treatment of exercise pulmonary hypertension improves pulmonary vascular distensibility

W. Wallace, S. Chan, M. Nouraie, 2018, Pulmonary circulation.

Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Macaca mulatta) Model of HIV Infection.

B. Lopresti, J. Carney, T. Bertero, 2018, Comparative medicine.

Update in Pulmonary Vascular Diseases and Right Ventricular Dysfunction in 2019.

M. Gladwin, N. Weissmann, R. Schermuly, 2020, American journal of respiratory and critical care medicine.

Aldosterone Inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to Decrease Pulmonary Endothelial Nitric Oxide Levels and Modulate Pulmonary Arterial Hypertension

J. Loscalzo, D. Handy, B. Maron, 2012, Circulation.

Upregulation of Steroidogenic Acute Regulatory Protein by Hypoxia Stimulates Aldosterone Synthesis in Pulmonary Artery Endothelial Cells to Promote Pulmonary Vascular Fibrosis

J. Loscalzo, B. Maron, S. Chan, 2014, Circulation.

Investigating pulmonary arterial hypertension from "stem" to stern. Focus on "Identification of a common Wnt-associated genetic signature across multiple cell types in pulmonary arterial hypertension".

S. Chan, K. Cottrill, S. Y. Chan, 2014, American journal of physiology. Cell physiology.

Inhibition of CHK1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension.

T. Bertero, S. Breuils-bonnet, È. Tremblay, 2019, Arteriosclerosis, thrombosis, and vascular biology.

Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function

T. Bertero, S. Chan, S. Shiva, 2022, bioRxiv.

VEGF receptor promotes hypoxia-induced hematopoietic progenitor proliferation and differentiation

S. Chan, P. Dutta, S. Vasamsetti, 2021 .

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

J. Asara, E. Henske, M. Sahin, 2017, Cancer research.

Amphiregulin loss in endothelial cells drives inflammation and apoptosis in pulmonary hypertension

Jianhui Zhu, S. Chan, P. Dutta, 2022 .

Ranolazine Improves Right Ventricular Function in Patients With Precapillary Pulmonary Hypertension: Results From a Double-Blind, Randomized, Placebo-Controlled Trial.

Yuchi Han, G. Ramani, S. Chan, 2020, Journal of cardiac failure.

Improved hospitalization rates in a specialty center for heart failure with preserved ejection fraction and pulmonary hypertension

S. Chan, M. Nouraie, S. Mulukutla, 2021, Pulmonary circulation.

Simultaneous Pharmacologic Inhibition of Yes‐Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic‐co‐Glycolic) Acid–Encapsulated Microparticles Improves Pulmonary Hypertension

T. Bertero, M. Königshoff, Abhinav P Acharya, 2021, Journal of the American Heart Association.

Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertension

P. Carmeliet, M. Brittan, R. Lafyatis, 2021, Cardiovascular research.

Testosterone administration inhibits hepcidin transcription and is associated with increased iron incorporation into red blood cells

T. Travison, M. Muckenthaler, S. Bhasin, 2013, Aging cell.

Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing

S. Chan, Haodi Wu, Ying Tang, 2021, Stem Cell Research.

Outcomes of Pulmonary Arterial Hypertension are Improved in a Specialty Care Center.

M. Simon, S. Chan, M. Nouraie, 2020, Chest.

Hemodynamic and Histopathologic Benefits of Early Treatment with Macitentan in a Rat Model of Pulmonary Arterial Hypertension

Kyung-Hee Kim, S. Chan, Yong Jin Kim, 2018, Korean circulation journal.

Association between income and likelihood of right heart catheterization in individuals with pulmonary hypertension: A US claims database analysis

S. Chan, J. Magnani, E. Schikowski, 2022, Pulmonary circulation.

MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach

Albert-László Barabási, Joseph Loscalzo, Natali Gulbahce, 2012, Circulation.

Impact of four times daily dosing of oral treprostinil on tolerability and daily dose achieved in pulmonary hypertension

M. Simon, J. Coons, S. Chan, 2017, Pulmonary circulation.

Circulating hypoxia-dependent miR-210 is increased in clinical sepsis subtypes: A cohort study

C. Seymour, S. Chan, J. Kennedy, 2022, Journal of Translational Medicine.

Pulmonary Vascular Research Institute GoDeep: A meta‐registry merging deep phenotyping datafrom international PH reference centers

H. Ghofrani, F. Grimminger, S. Orfanos, 2022, Pulmonary circulation.

In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis.

C. Wilmer, J. Flynn, Nathaniel L. Rosi, 2022, Journal of controlled release : official journal of the Controlled Release Society.

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Philip D. Blood, Matthew A. Wyczalkowski, Andrew C. Nelson, 2022, Nature aging.

SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function

Neil J Kelly, Janet S. Lee, F. Sciurba, 2020, JACC. Basic to translational science.

Integration of Complex Data Sources to Provide Biologic Insight into Pulmonary Vascular Disease (2015 Grover Conference Series)

E. Brittain, S. Chan, S. Y. Chan, 2016, Pulmonary circulation.

The Emerging Paradigm of Network Medicine in the Study of Human Disease

J. Loscalzo, S. Chan, S. Y. Chan, 2012, Circulation research.

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.

S. Estrach, D. Bulavin, A. Bozec, 2019, Cell metabolism.

Hypoxamirs and mitochondrial metabolism.

J. Loscalzo, S. Chan, K. Cottrill, 2014, Antioxidants & redox signaling.

MicroRNA-210: A unique and pleiotropic hypoxamir

J. Loscalzo, S. Chan, S. Y. Chan, 2010, Cell cycle.

Translational Advances in the Field of Pulmonary Hypertension. Translating MicroRNA Biology in Pulmonary Hypertension. It Will Take More Than “miR” Words

Sébastien Bonnet, H. Chun, S. Bonnet, 2017, American journal of respiratory and critical care medicine.

Hypoxamirs in Pulmonary Hypertension: Breathing New Life into Pulmonary Vascular Research.

S. Chan, Andrew E Hale, Kevin P. White, 2012, Cardiovascular diagnosis and therapy.

Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension

J. Loscalzo, S. Chan, Kevin P. White, 2012, Pulmonary circulation.

Matrix Stiffening Induces a Pathogenic QKI-miR-7-SRSF1 Signaling Axis in Pulmonary Arterial Endothelial Cells.

T. Bertero, S. Chan, Neha Hafeez, 2021, American journal of physiology. Lung cellular and molecular physiology.

Influence of statins on distinct circulating microRNAs during prolonged aerobic exercise.

P. Thompson, B. Taylor, S. Chan, 2016, Journal of applied physiology.

exercisemicroRNAs after prolonged aerobic Rapid upregulation and clearance of distinct

P. Thompson, Yoshimi Fukuoka, E. Flowers, 2015 .

Rapid upregulation and clearance of distinct circulating microRNAs after prolonged aerobic exercise.

P. Thompson, B. Parker, S. Chan, 2014, Journal of applied physiology.

Current challenges and future directions for engineering extracellular vesicles for heart, lung, blood and sleep diseases

James E. Dahlman, Jennifer K. Lang, G. Vunjak‐Novakovic, 2023, Journal of extracellular vesicles.

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection

M. H. Cheng, D. L. Taylor, I. Bahar, 2021, Molecular systems biology.

Discerning functional hierarchies of microRNAs in pulmonary hypertension.

S. Chan, V. Negi, S. Y. Chan, 2017, JCI insight.

The MicroRNA-130/301 Family Controls Vasoconstriction in Pulmonary Hypertension*

W. Kuebler, T. Bertero, S. Chan, 2014, The Journal of Biological Chemistry.

Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect

S. Chan, K. Cottrill, S. Y. Chan, 2013, European journal of clinical investigation.

A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions

R. Chung, K. Haley, T. Bertero, 2015, Scientific Reports.

Ineffective delivery of diet-derived microRNAs to recipient animal organisms

S. Chan, J. Snow, A. Baggish, 2013, RNA biology.

Endothelial Senescence: A New Age in Pulmonary Hypertension

S. Chan, M. Culley, S. Y. Chan, 2022, Circulation research.

The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension

T. Bertero, S. Chan, Dror Perk, 2019, Expert opinion on therapeutic targets.

MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician.

S. Chan, P. Min, Richard C. Jin, 2013, Journal of the Korean Society of Hypertension.

Post-GWAS functional analysis identifies CUX1 as a regulator of p16INK4a and cellular senescence

Julie A. Phillippi, A. Sawalha, Gang Li, 2022, Nature Aging.

Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)

E. Henske, S. Chan, C. Baglini, 2019, Oncogene.

A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications

Xiangxiang Zeng, Feixiong Cheng, Shuting Jin, 2019, npj Systems Biology and Applications.

Uptake and impact of natural diet-derived small RNA in invertebrates: Implications for ecology and agriculture

S. Chan, J. Snow, S. Y. Chan, 2017, RNA biology.

training in rats ventricular compliance promoted by aerobic exercise MicroRNAs 29 are involved in the improvement of

Saumya Das, B. Parker, M. Irigoyen, 2014 .

Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension

M. Rojas, S. Chan, R. Lafyatis, 2020, Pulmonary circulation.

Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise.

D. Lieberman, J. Gorcsan, S. Chan, 2018, American journal of physiology. Heart and circulatory physiology.

Deciphering the molecular basis of human cardiovascular disease through network biology

J. Loscalzo, S. Chan, Kevin P. White, 2012, Current opinion in cardiology.

Diet-Derived MicroRNAs: Separating the Dream from Reality

S. Chan, K. Cottrill, S. Y. Chan, 2014 .

Emerging Metabolic Therapies in Pulmonary Arterial Hypertension

S. Chan, Lloyd D. Harvey, S. Y. Chan, 2017, Journal of clinical medicine.

Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.

A. Ewald, B. Mari, T. Bertero, 2021, Cell metabolism.

The Search for Disease-Modifying Therapies in Pulmonary Hypertension

S. Chan, Chen-Shan C. Woodcock, S. Y. Chan, 2019, Journal of cardiovascular pharmacology and therapeutics.

Circulating Micro RNA s as Biomarkers in Cardiovascular and Pulmonary Vascular Disease

S. Chan, M. Culley, S. Y. Chan, 2020 .

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells

D. Kwiatkowski, J. Asara, E. Henske, 2017, Oncotarget.

Inflammatory Macrophage Expansion in Pulmonary Hypertension Depends upon Mobilization of Blood-Borne Monocytes

M. Rojas, E. Coppin, Yingze Zhang, 2018, The Journal of Immunology.

Role of extracellular matrix in the pathogenesis of pulmonary arterial hypertension.

E. K. Weir, S. Chan, T. Thenappan, 2018, American journal of physiology. Heart and circulatory physiology.

Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.

Daniel G. Anderson, James E. Dahlman, M. Gladwin, 2021, The Journal of clinical investigation.

Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension

T. Bertero, S. Nouraie, S. Chan, 2020, Circulation research.

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.

Joseph Loscalzo, Jay L Zweier, J. Loscalzo, 2009, Cell metabolism.

Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

S. Chan, M. Culley, S. Y. Chan, 2018, The Journal of clinical investigation.

Pathogenic mechanisms of pulmonary arterial hypertension.

Joseph Loscalzo, J. Loscalzo, S. Chan, 2008, Journal of molecular and cellular cardiology.

Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)

J. Yuan, S. Bonnet, S. Chan, 2017, Pulmonary circulation.

Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training

Thomas J. Wang, G. Lewis, S. Chan, 2011, The Journal of physiology.

RNAi technologies in agricultural biotechnology: The Toxicology Forum 40th Annual Summer Meeting.

J. Petrick, S. Choudhuri, S. Chan, 2015, Regulatory toxicology and pharmacology : RTP.

Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report.

Sanjiv J. Shah, M. Gladwin, G. Beck, 2017, American journal of respiratory and critical care medicine.

An Argonaute 2 switch regulates circulating miR-210 to coordinate hypoxic adaptation across cells.

L. Moore, R. Pande, M. Creager, 2014, Biochimica et biophysica acta.

The mir‐200 family regulates key pathogenic events in ascending aortas of individuals with bicuspid aortic valves

A. Franco‐Cereceda, P. Eriksson, J. Gådin, 2018, Journal of internal medicine.

Evolving Schema for Employing Network Biology Approaches to Understand Pulmonary Hypertension.

S. Chan, Shohini K Ghosh-Choudhary, S. Y. Chan, 2021, Advances in experimental medicine and biology.

Rationale and design of the ranolazine PH–RV study: a multicentred randomised and placebo-controlled study of ranolazine to improve RV function in patients with non-group 2 pulmonary hypertension

Yuchi Han, G. Ramani, S. Chan, 2018, Open Heart.

Negligible uptake and transfer of diet-derived pollen microRNAs in adult honey bees

S. Chan, J. Snow, Maryam Masood, 2016, RNA biology.

M. Gladwin, C. St. Hilaire, E. Goncharova, 2021, Circulation.

Factors Associated with Heritable Pulmonary Arterial Hypertension Exert Convergent Actions on the miR-130/301-Vascular Matrix Feedback Loop

T. Bertero, S. Chan, A. Handen, 2018, International journal of molecular sciences.

Brief Report: Coordinated Modulation of Circulating miR-21 in HIV, HIV-Associated Pulmonary Arterial Hypertension, and HIV/Hepatitis C Virus Coinfection

S. Chan, P. Hsue, P. Yu, 2015, Journal of acquired immune deficiency syndromes.

NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review.

F. Cheng, J. Loscalzo, M. Cho, 2021, Journal of the American College of Cardiology.

NFU1, Iron-Sulfur Biogenesis, and Pulmonary Arterial Hypertension: A (Metabolic) Shift in Our Thinking

S. Chan, M. Culley, D. Perk, 2020, American journal of respiratory cell and molecular biology.

Atrial arrhythmias are associated with increased mortality in pulmonary arterial hypertension

A. Althouse, T. Girard, S. Chan, 2018, Pulmonary circulation.

Mitochondrial and Metabolic Drivers of Pulmonary Vascular Endothelial Dysfunction in Pulmonary Hypertension.

S. Chan, Qiujun Yu, S. Y. Chan, 2017, Advances in experimental medicine and biology.

Analysis of microRNA niches: techniques to measure extracellular microRNA and intracellular microRNA in situ.

S. Chan, V. Parikh, S. Y. Chan, 2013, Methods in molecular biology.

Abstract 15826: SCUBE1 Controls BMPR2-relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension

Neil J Kelly, Janet S. Lee, F. Sciurba, 2020 .