C. Vargeese

发表

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Keith Bowman, B. Polisky, L. Jeffs, 2005, Nature Biotechnology.

Novel liver-specific TORC2 siRNA corrects hyperglycemia in rodent models of type 2 diabetes.

B. Polisky, J. Olefsky, T. Imamura, 2009, American journal of physiology. Endocrinology and metabolism.

Investigational Assay for Haplotype Phasing of the Huntingtin Gene

N. Svrzikapa, S. Levy, K. Longo, 2020, Molecular therapy. Methods & clinical development.

Intimal Hyperplasia Recurs After Removal of PDGF-AB and -BB Inhibition in the Rat Carotid Artery Injury Model

C. Heldin, N. Janjić, K. Pietras, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Impact of guanidine-containing backbone linkages on stereopure antisense oligonucleotides in the CNS

S. Standley, C. Vargeese, K. Bowman, 2022, Nucleic acids research.

Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72-associated ALS or FTD

C. Vargeese, Saurabh Patil, Xuena Lin, 2022, Molecular therapy. Nucleic acids.

Variant-selective stereopure oligonucleotides protect against pathologies associated with C9orf72-repeat expansion in preclinical models

Robert H. Brown, K. Longo, J. Dodart, 2021, Nature Communications.

Biodistribution and Metabolism Studies of LNP-formulated Internally [ 3 H]-labeled siRNA in Mice

M. Stoeckli, F. Natt, I. Beuvink, 2013 .

Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis.

J. Carter, C. Vargeese, W. Pieken, 1998, Nucleic acids research.

Control of backbone chemistry and chirality boost oligonucleotide splice switching activity

M. Wood, C. Vargeese, L. Apponi, 2022, Nucleic acids research.

A Practical and Stereospecific Approach to the Synthesis of 3′-Deoxy-2′,3′-didehydrothymidine (D4T)

C. Vargeese, E. Abushanab, 1992 .

Potent 2'-amino-2'-deoxypyrimidine RNA inhibitors of basic fibroblast growth factor.

C. Vargeese, C. Bell, D. Jellinek, 1995, Biochemistry.

Synthesis and biological evaluation of1',2'-seconucleo-5'- phosphonates.

C. Vargeese, H. El-Subbagh, R. P. Panzica, 1996, Journal of medicinal chemistry.

2'-Amino-2'-deoxyuridine via an Intramolecular Cyclization of a Trichloroacetimidate.

C. Vargeese, D. McGee, Yansheng Zhai, 1996, The Journal of organic chemistry.

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

Naoki Iwamoto, N. Svrzikapa, G. Verdine, 2017, Nature Biotechnology.

2′‐Amino‐2′‐deoxyuridine via an Intramolecular Cyclization of a Trichloroacetimidate.

C. Vargeese, D. McGee, Yansheng Zhai, 1996 .

Efficient Synthesis of 2′-Amino-2′-deoxypyrimidine 5′-Triphosphates

C. Vargeese, W. Pieken, D. McGee, 1995 .

Diastereomeric 5,6-Dihydrothymidines. Preparation, Stereochemical Assignments, and MnO2 Oxidation Studies of Thymidines

C. Vargeese, E. Abushanab, Michael Gregor, 1995 .

Conjugues et compositions

C. Vargeese, P. Haeberli, Weimin Wang, 2004 .

Diastereomeric 5,6‐Dihydrothymidines. Preparation, Stereochemical Assignments, and MnO2 Oxidation Studies to Thymidines.

M. McGregor, C. Vargeese, E. Abushanab, 1995 .

Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

B. Polisky, J. Mcswiggen, Jennifer A. Lockridge, 2005, Hepatology.

Characterization of nuclease‐resistant ribozymes directed against hepatitis B virus RNA *

L. Maloney, L. Beigelman, P. Schmid, 2002, Journal of viral hepatitis.

Biodistribution and Metabolism Studies of Lipid Nanoparticle–Formulated Internally [3H]-Labeled siRNA in Mice

Olivier Heudi, Markus Stoeckli, Keith Bowman, 2014, Drug Metabolism and Disposition.

Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics.

Joshua A. Kritzer, J. Kritzer, M. Debets, 2022, ACS chemical biology.

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

S. Standley, C. Vargeese, L. Apponi, 2022, Nature Biotechnology.

Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species

V. Vathipadiekal, K. Longo, C. Vargeese, 2021, Translational vision science & technology.

Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1

P. Campochiaro, K. Kossen, S. Zinnen, 2006, Gene Therapy.

Real time measurement of PEG shedding from lipid nanoparticles in serum via NMR spectroscopy.

Keith Bowman, Sunita Yadav, Stephen C Wilson, 2015, Molecular pharmaceutics.

Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers.

N. Janjić, S. Gill, J. Floege, 1999, The American journal of pathology.

P.402 WVE-210201, an investigational stereopure oligonucleotide therapy for Duchenne muscular dystrophy, induces Exon 51 skipping and dystrophin protein restoration

M. Wood, S. Standley, C. Vargeese, 2017, Neuromuscular Disorders.

711. Allele-Specific Silencing of Mutant Huntingtin for Huntington's Disease Therapy

Brian L. Gilmore, S. Harper, B. Davidson, 2006 .

Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference

P. Giangrande, C. Vargeese, Subramanian Marappan, 2023, Nucleic acids research.

Adenosine deaminase inhibitors. Synthesis and biological evaluation of putative metabolites of (+)-erythro-9-(2S-hydroxy-3R-nonyl)adenine.

C. Vargeese, J. Stoeckler, S. Y. Li, 1994, Journal of medicinal chemistry.

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

N. Svrzikapa, G. Verdine, S. Standley, 2017, Nature Biotechnology.